KR910004599A - 1,3-디하이드로-1-(피리디닐아미노)-2h-인돌-2-온, 이들의 제조방법 및 이들의 약제로서의 용도 - Google Patents
1,3-디하이드로-1-(피리디닐아미노)-2h-인돌-2-온, 이들의 제조방법 및 이들의 약제로서의 용도 Download PDFInfo
- Publication number
- KR910004599A KR910004599A KR1019900011818A KR900011818A KR910004599A KR 910004599 A KR910004599 A KR 910004599A KR 1019900011818 A KR1019900011818 A KR 1019900011818A KR 900011818 A KR900011818 A KR 900011818A KR 910004599 A KR910004599 A KR 910004599A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- lower alkyl
- indol
- dihydro
- pharmaceutically acceptable
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (14)
- 하기 일반식(I)의 화합물, 이의 약제학적으로 허용되는 산부가염 및, 적용되는 경우, 이의 광학적, 기하학적 및 입체 이성체 및 이들의 라세미체 혼합물.상기식에서, R1, R2및 R3는 독립적으로 수소, 저급 알킬, 아릴 또는 아릴저급알킬이거나, 피리디닐메틸, 피리디닐에틸, 티에닐메틸 및 티에닐에틸로 이루어진 그룹중에서 선택된 헤테로아릴저급알킬이거나, R2및 R3은 함께 탄소수 4 내지 6의 사이클로알칸 환 또는 피페리딘 및 테트라하이드록피란으로 이루어진 그룹중에서 선택된 스피로-융합된 아릴 사이클로알칸 또는 헤테로사이클로알킬을 형성하고, X 및 Y는 독립적으로 수소, 할로겐 하이드록시, 저급알킬, 저급 알콕시, 니트로, 아미노 또는 트리플루오로메틸이고, m 및 n은 독립적으로 1 내지 3의 정수이다.
- 제1항에 있어서, R1이 수소 또는 저급알킬이고, X 및 Y가 독립적으로 수소, 할로겐 또는 저급 알콕시이며, m 및 n이 1인 화합물.
- 제2항에 있어서, R2및 R3가 독립적으로 수소, 저급알킬 또는 헤테로아릴저급알킬이거나, R2및 R3이 함께 탄소수 4 내지 6의 사이클로알칸환, 피페리딘 및 테트라하이드로피란으로 이루어진 그룹 중에서 선택된 헤테로사이클로알킬 또는 스피로-융합된 아릴 사이클로알칸을 형성하는 화합물.
- 제3항에 있어서, R2및 R3이 독립적으로 수소, 저급 알킬인 화합물.
- 제1항에 있어서, 1,3-디하이드로-1-(프로필-4-피리디닐아미노)-2H-인돌-2-온 또는 이의 약제학적으로 허용되는 산 부가염인 화합물.
- 제1항에 있어서, 1,3-디하이드로-1-(4-피리디닐아미노)-2H-인돌-2-온 또는 이의 약제학적으로 허용되는 산 부가염인 화합물.
- 제1항에 있어서, 1,3-디하이드로-3,3-디메틸-1-(프로필-4-피리디닐아미노)-2H-인돌-2-온 또는 이의 약제학적으로 허용되는 산 부가염인 화합물.
- 제1항에 있어서, 1,3-디하이드로-1-[(3-플루오로-4-피리디닐)아미노]-3-메틸-2H-인돌-2-온 또는 이의 약제학적으로 허용되는 산 부가염인 화합물.
- 제1항에 있어서, 1,3-디하이드로-3,3-디메틸-1-[4-(3-플루오로피리디닐)-프로필아미노]-2H-인돌-2-온 또는 이의 약제학적으로 허용되는 산 부가염인 화합물.
- 제1항에 있어서, 1,3-디하이드로-1-[(3-플루오로-4-피리디닐)-프로필아미노]-2H-인돌-2-온 또는 이의 약제학적으로 허용되는 산 부가염인 화합물.
- 일반식(II)의 화합물.상기식에서, R2, R3, Y 및 n은 제1항에서 정의한 바와 같고, 단, R2, R3및 Y가 수소이고 n이 1인 경우는 제외한다.
- 활성성분으로서 제1항 또는 11항의 화합물 및 이에 적합한 담체를 함유함을 특징으로 하는 약제학적 조성물.
- 진통활성, 진경활성 및/또는 기억증강활성을 갖는 약제를 제조하기 위란 제1항 또는 제11항의 화합물의 용도.
- 일반식(III)의 화합물을 일반식(IV)의 화합물과 반응시킴을 특징으로 하여, 제1항에 따른 일반식(I)의 화합물을 제조하는 방법.상기식에서, R1, R2, R3, Y, n, X 및 m은 제1항에서 정의한 바와 같고, Hal은 할로겐이며, p는 1 또는 2이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019980024262A KR0175639B1 (en) | 1989-08-02 | 1998-06-26 | 1,3-dihydro-1-amino-2h-indol-2-ones |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US388437 | 1989-08-02 | ||
US388,437 | 1989-08-02 | ||
US07/388,437 US5006537A (en) | 1989-08-02 | 1989-08-02 | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
US535640 | 1990-06-11 | ||
US07/535,640 US5053511A (en) | 1989-08-02 | 1990-06-11 | 1,3-dihydro-1-(pyridinylamino)-2h-indol-2-ones |
US535,640 | 1990-06-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910004599A true KR910004599A (ko) | 1991-03-29 |
KR0169108B1 KR0169108B1 (ko) | 1999-01-15 |
Family
ID=27012314
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900011818A KR0169108B1 (ko) | 1989-08-02 | 1990-08-01 | 1,3-디하이드로-1-(피리디닐아미노)-2h-인돌-2-온, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
KR1019980024262A KR0175639B1 (en) | 1989-08-02 | 1998-06-26 | 1,3-dihydro-1-amino-2h-indol-2-ones |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019980024262A KR0175639B1 (en) | 1989-08-02 | 1998-06-26 | 1,3-dihydro-1-amino-2h-indol-2-ones |
Country Status (18)
Country | Link |
---|---|
US (2) | US5006537A (ko) |
EP (1) | EP0415102B1 (ko) |
JP (1) | JPH0674265B2 (ko) |
KR (2) | KR0169108B1 (ko) |
AT (1) | ATE118001T1 (ko) |
AU (2) | AU628202B2 (ko) |
CA (1) | CA2022486C (ko) |
DE (1) | DE69016530T2 (ko) |
DK (1) | DK0415102T3 (ko) |
ES (1) | ES2068293T3 (ko) |
FI (1) | FI903819A0 (ko) |
GR (1) | GR3015227T3 (ko) |
IE (1) | IE67045B1 (ko) |
IL (1) | IL95252A0 (ko) |
NO (1) | NO903389L (ko) |
NZ (1) | NZ234725A (ko) |
PT (1) | PT94879B (ko) |
ZA (1) | ZA906050B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100507145B1 (ko) * | 2002-06-20 | 2005-08-09 | 현대자동차주식회사 | 차량의 전원제어장치 |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
US5296488A (en) * | 1989-08-02 | 1994-03-22 | Hoechst-Roussel Pharmaceuticals Inc. | Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory |
US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
US5076835A (en) * | 1990-05-31 | 1991-12-31 | America Cyanamid Company | Aryloxyspiroalkylindolinone herbicides |
US5102891A (en) * | 1990-07-23 | 1992-04-07 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates |
US5264442A (en) * | 1990-08-13 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs |
US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
US5185350A (en) * | 1991-09-23 | 1993-02-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles |
US5246947A (en) * | 1991-09-23 | 1993-09-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression |
AU3425493A (en) * | 1992-01-16 | 1993-08-03 | Du Pont Merck Pharmaceutical Company, The | Novel neurotransmitter releasers useful for cognition enhancement |
RU2051151C1 (ru) * | 1992-01-16 | 1995-12-27 | Дзе Дюпон Мерк Фармасьютикал Компани | Азотсодержащие гетероциклические производные флуорена |
US5278162A (en) * | 1992-09-18 | 1994-01-11 | The Du Pont Merck Pharmaceutical Company | 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man |
US5296478A (en) * | 1992-10-07 | 1994-03-22 | The Dupont Merck Pharmaceutical Co. | 1-substituted oxindoles as cognition enhancers |
FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
AU1884595A (en) * | 1994-04-29 | 1995-11-29 | Pfizer Inc. | Novel acyclic and cyclic amides as neurotransmitter release enhancers |
HUP9802413A3 (en) * | 1995-07-27 | 2002-02-28 | Aventis Pharmaceuticals Inc Br | Use of n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents and for the preparation of a pharmaceutical composition for the treatment of convulsions |
DE69707659T2 (de) * | 1996-04-12 | 2002-05-08 | Aventis Pharma Inc | Isatinderivate als acetylcholinesterase-inhibitoren und analgetika |
US6100276A (en) * | 1996-04-12 | 2000-08-08 | Aventis Pharmaceuticals Inc. | Isatin derivatives as acetylcholinesterase inhibitors and analgesics |
WO1998029407A2 (en) * | 1996-12-27 | 1998-07-09 | Hoechst Marion Roussel, Inc. | N-(pyridinylamino)isoindolines for treating alzheimer's and depression |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4260767A (en) * | 1979-12-26 | 1981-04-07 | American Cyanamid Company | 2-Pyridylhydrazides |
US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
ATE115143T1 (de) * | 1987-04-24 | 1994-12-15 | Hoechst Roussel Pharma | N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel. |
US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
-
1989
- 1989-08-02 US US07/388,437 patent/US5006537A/en not_active Expired - Lifetime
-
1990
- 1990-06-11 US US07/535,640 patent/US5053511A/en not_active Expired - Lifetime
- 1990-07-31 DE DE69016530T patent/DE69016530T2/de not_active Expired - Lifetime
- 1990-07-31 AT AT90114660T patent/ATE118001T1/de not_active IP Right Cessation
- 1990-07-31 ES ES90114660T patent/ES2068293T3/es not_active Expired - Lifetime
- 1990-07-31 IL IL95252A patent/IL95252A0/xx active IP Right Grant
- 1990-07-31 EP EP90114660A patent/EP0415102B1/en not_active Expired - Lifetime
- 1990-07-31 DK DK90114660.5T patent/DK0415102T3/da active
- 1990-07-31 FI FI903819A patent/FI903819A0/fi not_active Application Discontinuation
- 1990-07-31 NZ NZ234725A patent/NZ234725A/xx unknown
- 1990-08-01 PT PT94879A patent/PT94879B/pt not_active IP Right Cessation
- 1990-08-01 NO NO90903389A patent/NO903389L/no unknown
- 1990-08-01 KR KR1019900011818A patent/KR0169108B1/ko not_active IP Right Cessation
- 1990-08-01 AU AU60004/90A patent/AU628202B2/en not_active Ceased
- 1990-08-01 IE IE278790A patent/IE67045B1/en not_active IP Right Cessation
- 1990-08-01 JP JP2202618A patent/JPH0674265B2/ja not_active Expired - Lifetime
- 1990-08-01 CA CA002022486A patent/CA2022486C/en not_active Expired - Lifetime
- 1990-08-01 ZA ZA906050A patent/ZA906050B/xx unknown
-
1992
- 1992-07-14 AU AU19630/92A patent/AU641595B2/en not_active Expired - Fee Related
-
1995
- 1995-02-28 GR GR950400432T patent/GR3015227T3/el unknown
-
1998
- 1998-06-26 KR KR1019980024262A patent/KR0175639B1/ko not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100507145B1 (ko) * | 2002-06-20 | 2005-08-09 | 현대자동차주식회사 | 차량의 전원제어장치 |
Also Published As
Publication number | Publication date |
---|---|
NO903389D0 (no) | 1990-08-01 |
DE69016530T2 (de) | 1995-07-06 |
DE69016530D1 (de) | 1995-03-16 |
FI903819A0 (fi) | 1990-07-31 |
CA2022486C (en) | 2001-04-03 |
AU1963092A (en) | 1992-10-01 |
JPH0674265B2 (ja) | 1994-09-21 |
PT94879A (pt) | 1991-04-18 |
IL95252A0 (en) | 1991-06-10 |
US5053511A (en) | 1991-10-01 |
IE902787A1 (en) | 1991-02-27 |
EP0415102B1 (en) | 1995-02-01 |
EP0415102A1 (en) | 1991-03-06 |
KR0169108B1 (ko) | 1999-01-15 |
NZ234725A (en) | 1992-12-23 |
US5006537A (en) | 1991-04-09 |
ZA906050B (en) | 1991-05-29 |
KR0175639B1 (en) | 1999-10-01 |
JPH03118377A (ja) | 1991-05-20 |
AU6000490A (en) | 1991-02-07 |
ES2068293T3 (es) | 1995-04-16 |
GR3015227T3 (en) | 1995-05-31 |
DK0415102T3 (da) | 1995-06-19 |
AU628202B2 (en) | 1992-09-10 |
AU641595B2 (en) | 1993-09-23 |
NO903389L (no) | 1991-02-04 |
CA2022486A1 (en) | 1991-02-03 |
IE67045B1 (en) | 1996-02-21 |
PT94879B (pt) | 1997-08-29 |
ATE118001T1 (de) | 1995-02-15 |
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