ATE115143T1 - N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel. - Google Patents

N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel.

Info

Publication number
ATE115143T1
ATE115143T1 AT88106121T AT88106121T ATE115143T1 AT E115143 T1 ATE115143 T1 AT E115143T1 AT 88106121 T AT88106121 T AT 88106121T AT 88106121 T AT88106121 T AT 88106121T AT E115143 T1 ATE115143 T1 AT E115143T1
Authority
AT
Austria
Prior art keywords
loweralkyl
arylloweralkyl
sec
aryl
halogen
Prior art date
Application number
AT88106121T
Other languages
English (en)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE115143T1 publication Critical patent/ATE115143T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT88106121T 1987-04-24 1988-04-18 N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel. ATE115143T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4207987A 1987-04-24 1987-04-24

Publications (1)

Publication Number Publication Date
ATE115143T1 true ATE115143T1 (de) 1994-12-15

Family

ID=21919923

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88106121T ATE115143T1 (de) 1987-04-24 1988-04-18 N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel.

Country Status (17)

Country Link
EP (1) EP0287982B1 (de)
JP (1) JP2683360B2 (de)
KR (1) KR960015003B1 (de)
AT (1) ATE115143T1 (de)
AU (1) AU594876B2 (de)
CA (1) CA1330661C (de)
DE (1) DE3852335T2 (de)
DK (1) DK172153B1 (de)
ES (1) ES2065324T3 (de)
FI (1) FI90978C (de)
IE (1) IE65349B1 (de)
IL (1) IL86154A (de)
NO (1) NO168104C (de)
NZ (1) NZ224338A (de)
PH (1) PH26127A (de)
PT (1) PT87308B (de)
ZA (1) ZA882810B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868190A (en) * 1988-12-27 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. N-pyridinyl-9H-carbazol-9-amines
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
IL95251A (en) * 1989-08-02 1996-08-04 Hoechst Roussel Pharma 2,3-Dihydro-1- (pyridinylamino) - indoles, a method for their preparation and use as drugs
US5179099A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 2,3-dihydro-1-(pyridinylamino)-indoles
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5179119A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof
US4983608A (en) 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
US5214038A (en) * 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5185350A (en) * 1991-09-23 1993-02-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en) 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
US5776955A (en) * 1995-07-27 1998-07-07 Hoechst Marion Roussel, Inc. Use of unsubstituted and substituted n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents
ES2174081T3 (es) * 1995-07-27 2002-11-01 Aventis Pharma Inc Uso de n-(pirrol-1-il)piridinaminas sustituidas y no sustituidas como agentes anticonvulsivos.
BR9714189A (pt) * 1996-12-27 2000-02-29 Hoechst Marion Roussel Inc N-(piridinilamino) isoindolinas e compostos relacionados
JP4779185B2 (ja) * 1999-03-10 2011-09-28 東ソー株式会社 含窒素複素環化合物及びその製造方法
DE60016068T2 (de) * 1999-03-10 2005-11-03 Tosoh Corp., Shinnanyo Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
JP4683166B2 (ja) * 1999-03-10 2011-05-11 東ソー株式会社 含窒素複素環化合物の製造方法
GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
US7538227B2 (en) 2004-01-13 2009-05-26 Sanofi-Aventis Deutschland Gmbh Process for stabilizing 4-halopyridines
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
FR2911780A1 (fr) * 2007-01-26 2008-08-01 Urogene Traitement de l'incontinence fecale.
CA2683578A1 (en) * 2007-04-13 2008-10-23 Sanofi-Aventis A transition metal catalyzed synthesis of n-aminoindoles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3242185A (en) * 1963-10-07 1966-03-22 Merck & Co Inc Lower aliphatic acids, salts and derivatives thereof
DE1670184A1 (de) * 1967-01-20 1971-01-21 Boehringer Sohn Ingelheim Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
CH603581A5 (de) * 1974-03-29 1978-08-31 Siegfried Ag
US4260767A (en) * 1979-12-26 1981-04-07 American Cyanamid Company 2-Pyridylhydrazides
JPS60142955A (ja) * 1983-12-28 1985-07-29 Fuji Photo Film Co Ltd インド−ル誘導体の製造方法
US4792562A (en) * 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity

Also Published As

Publication number Publication date
CA1330661C (en) 1994-07-12
FI881874A0 (fi) 1988-04-21
FI90978B (fi) 1994-01-14
DE3852335D1 (de) 1995-01-19
EP0287982B1 (de) 1994-12-07
FI90978C (fi) 1994-04-25
AU594876B2 (en) 1990-03-15
EP0287982A2 (de) 1988-10-26
NO881776D0 (no) 1988-04-22
IE881213L (en) 1988-10-24
DK223488D0 (da) 1988-04-22
DK223488A (da) 1988-10-25
NZ224338A (en) 1991-07-26
PT87308A (pt) 1988-05-01
IE65349B1 (en) 1995-10-18
FI881874A (fi) 1988-10-25
NO881776L (no) 1988-10-25
PH26127A (en) 1992-02-24
IL86154A (en) 1992-03-29
ZA882810B (en) 1988-10-20
KR960015003B1 (ko) 1996-10-23
PT87308B (pt) 1992-08-31
DK172153B1 (da) 1997-12-01
IL86154A0 (en) 1988-11-15
NO168104C (no) 1992-01-15
AU1510088A (en) 1988-10-27
JPS63280079A (ja) 1988-11-17
KR880012591A (ko) 1988-11-28
ES2065324T3 (es) 1995-02-16
DE3852335T2 (de) 1995-05-11
JP2683360B2 (ja) 1997-11-26
NO168104B (no) 1991-10-07
EP0287982A3 (de) 1991-03-27

Similar Documents

Publication Publication Date Title
ATE115143T1 (de) N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel.
HU912756D0 (en) Process for producing 6,7-dihydro-3-phenyl-1,2-benz-isoxazole-4(5h)-ones and -oles as well as pharmaceutical preparatives containing said compounds
AU8121691A (en) 1-(substituted pyridinylamino)-1h-indole-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments
ATE168689T1 (de) Substituierte (pyridinylamino)-benzisoxazole und -benzisothiazole, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IL85401A0 (en) 9-amino-1,4-ethano-1,2,3,4-tetra-hydroacridine and related compounds,process for their preparation and pharmaceutical compositions containing same
DE3853895D1 (de) Substituierte 9-Amino-spiro[cycloalkyl[b]chinolin-2,1'cycloalkane], Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
ATE92046T1 (de) 9-hydroxyamino-tetrahydroacridine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time