PT87308A - N-(pyridinyl)-1h-indole-1-amines a process for their preparation and their use as medicaments - Google Patents

N-(pyridinyl)-1h-indole-1-amines a process for their preparation and their use as medicaments

Info

Publication number
PT87308A
PT87308A PT87308A PT8730888A PT87308A PT 87308 A PT87308 A PT 87308A PT 87308 A PT87308 A PT 87308A PT 8730888 A PT8730888 A PT 8730888A PT 87308 A PT87308 A PT 87308A
Authority
PT
Portugal
Prior art keywords
loweralkyl
arylloweralkyl
sec
aryl
halogen
Prior art date
Application number
PT87308A
Other languages
English (en)
Other versions
PT87308B (pt
Inventor
Richard Charles Effland
Joseph Thomas Klein
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of PT87308A publication Critical patent/PT87308A/pt
Publication of PT87308B publication Critical patent/PT87308B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT87308A 1987-04-24 1988-04-22 Processo para a preparacao de n-(piridinil)-1h-indol-1-aminas e de composicoes farmaceuticas que os contem PT87308B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4207987A 1987-04-24 1987-04-24

Publications (2)

Publication Number Publication Date
PT87308A true PT87308A (pt) 1988-05-01
PT87308B PT87308B (pt) 1992-08-31

Family

ID=21919923

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87308A PT87308B (pt) 1987-04-24 1988-04-22 Processo para a preparacao de n-(piridinil)-1h-indol-1-aminas e de composicoes farmaceuticas que os contem

Country Status (17)

Country Link
EP (1) EP0287982B1 (pt)
JP (1) JP2683360B2 (pt)
KR (1) KR960015003B1 (pt)
AT (1) ATE115143T1 (pt)
AU (1) AU594876B2 (pt)
CA (1) CA1330661C (pt)
DE (1) DE3852335T2 (pt)
DK (1) DK172153B1 (pt)
ES (1) ES2065324T3 (pt)
FI (1) FI90978C (pt)
IE (1) IE65349B1 (pt)
IL (1) IL86154A (pt)
NO (1) NO168104C (pt)
NZ (1) NZ224338A (pt)
PH (1) PH26127A (pt)
PT (1) PT87308B (pt)
ZA (1) ZA882810B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868190A (en) * 1988-12-27 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. N-pyridinyl-9H-carbazol-9-amines
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US5179119A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof
US5179099A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 2,3-dihydro-1-(pyridinylamino)-indoles
ES2068294T3 (es) * 1989-08-02 1995-04-16 Hoechst Roussel Pharma 2,3-dihidro-1-(piridinilamino)-indoles, un procedimiento para su preparacion y su uso como medicamentos.
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US4983608A (en) 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
US5214038A (en) * 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5185350A (en) * 1991-09-23 1993-02-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en) * 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
HUP9802413A3 (en) * 1995-07-27 2002-02-28 Aventis Pharmaceuticals Inc Br Use of n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents and for the preparation of a pharmaceutical composition for the treatment of convulsions
CN1184969C (zh) * 1995-07-27 2005-01-19 阿温蒂斯药物公司 未取代和取代的n－(吡咯－1－基)吡啶胺作为抗惊厥药的用途
DK0950056T3 (da) * 1996-12-27 2003-01-27 Aventis Pharma Inc N-(pyridinylamino)isoindoliner og beslægtede forbindelser
JP4683166B2 (ja) * 1999-03-10 2011-05-11 東ソー株式会社 含窒素複素環化合物の製造方法
JP4779185B2 (ja) * 1999-03-10 2011-09-28 東ソー株式会社 含窒素複素環化合物及びその製造方法
DE60016068T2 (de) * 1999-03-10 2005-11-03 Tosoh Corp., Shinnanyo Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
GB0119435D0 (en) 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
US7538227B2 (en) 2004-01-13 2009-05-26 Sanofi-Aventis Deutschland Gmbh Process for stabilizing 4-halopyridines
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
FR2911780A1 (fr) * 2007-01-26 2008-08-01 Urogene Traitement de l'incontinence fecale.
AU2008238379A1 (en) * 2007-04-13 2008-10-23 Sanofi-Aventis A transition metal catalyzed synthesis of N-aminoindoles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3242185A (en) * 1963-10-07 1966-03-22 Merck & Co Inc Lower aliphatic acids, salts and derivatives thereof
DE1670184A1 (de) * 1967-01-20 1971-01-21 Boehringer Sohn Ingelheim Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
CH603581A5 (pt) * 1974-03-29 1978-08-31 Siegfried Ag
US4260767A (en) * 1979-12-26 1981-04-07 American Cyanamid Company 2-Pyridylhydrazides
JPS60142955A (ja) * 1983-12-28 1985-07-29 Fuji Photo Film Co Ltd インド−ル誘導体の製造方法
US4792562A (en) * 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity

Also Published As

Publication number Publication date
PT87308B (pt) 1992-08-31
EP0287982A3 (en) 1991-03-27
FI90978B (fi) 1994-01-14
FI90978C (fi) 1994-04-25
ZA882810B (en) 1988-10-20
IL86154A (en) 1992-03-29
EP0287982A2 (en) 1988-10-26
FI881874A (fi) 1988-10-25
IE881213L (en) 1988-10-24
NO168104B (no) 1991-10-07
AU1510088A (en) 1988-10-27
ATE115143T1 (de) 1994-12-15
KR960015003B1 (ko) 1996-10-23
JP2683360B2 (ja) 1997-11-26
IE65349B1 (en) 1995-10-18
DE3852335D1 (de) 1995-01-19
CA1330661C (en) 1994-07-12
NO881776L (no) 1988-10-25
NZ224338A (en) 1991-07-26
KR880012591A (ko) 1988-11-28
ES2065324T3 (es) 1995-02-16
NO168104C (no) 1992-01-15
NO881776D0 (no) 1988-04-22
EP0287982B1 (en) 1994-12-07
AU594876B2 (en) 1990-03-15
FI881874A0 (fi) 1988-04-21
DK223488D0 (da) 1988-04-22
DK223488A (da) 1988-10-25
PH26127A (en) 1992-02-24
DK172153B1 (da) 1997-12-01
IL86154A0 (en) 1988-11-15
JPS63280079A (ja) 1988-11-17
DE3852335T2 (de) 1995-05-11

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PT87308A (pt) N-(pyridinyl)-1h-indole-1-amines a process for their preparation and their use as medicaments
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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920207

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20080422