ATE239711T1 - Neue allythiopyridazinderivate und verfahren zu ihrer herstellung - Google Patents
Neue allythiopyridazinderivate und verfahren zu ihrer herstellungInfo
- Publication number
- ATE239711T1 ATE239711T1 AT98961671T AT98961671T ATE239711T1 AT E239711 T1 ATE239711 T1 AT E239711T1 AT 98961671 T AT98961671 T AT 98961671T AT 98961671 T AT98961671 T AT 98961671T AT E239711 T1 ATE239711 T1 AT E239711T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- allythiopyridazine
- derivatives
- new
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Retarders (AREA)
- General Details Of Gearings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019980001153A KR100261139B1 (ko) | 1998-01-16 | 1998-01-16 | 신규한 알릴티오피리다진 유도체 및 그의 제조방법 |
PCT/KR1998/000473 WO1999036407A1 (en) | 1998-01-16 | 1998-12-28 | Novel allylthiopyridazine derivatives and process for preparing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE239711T1 true ATE239711T1 (de) | 2003-05-15 |
Family
ID=19531606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98961671T ATE239711T1 (de) | 1998-01-16 | 1998-12-28 | Neue allythiopyridazinderivate und verfahren zu ihrer herstellung |
Country Status (9)
Country | Link |
---|---|
US (1) | US5942511A (de) |
EP (1) | EP1058681B1 (de) |
JP (1) | JP3417926B2 (de) |
KR (1) | KR100261139B1 (de) |
CN (1) | CN1147477C (de) |
AT (1) | ATE239711T1 (de) |
CA (1) | CA2317673C (de) |
DE (1) | DE69814473T9 (de) |
WO (1) | WO1999036407A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7078045B2 (en) * | 2000-03-02 | 2006-07-18 | Sang-Geon Kim | Pharmaceutical composition for treatment and prevention of liver fibrosis and cirrhosis |
CA2404915A1 (en) * | 2000-04-07 | 2001-10-18 | Sang Geon Kim | Prophylactic and therapeutic use of oltipraz as an antifibrotic and anticirrhotic agent in the liver and pharmaceutical composition containing oltipraz |
KR20030067935A (ko) * | 2002-02-09 | 2003-08-19 | 김상건 | 올티프라즈를 포함하는 간경화(간경변증) 치료를 위한 간 조직 재생용 제약 조성물 |
KR100446103B1 (ko) * | 2002-04-19 | 2004-08-30 | 주식회사 서울제약 | 알릴티오피리다진 유도체를 함유하는 간암 예방 및 치료용의약 조성물 |
KR100823891B1 (ko) * | 2004-08-31 | 2008-04-21 | 주식회사파마킹 | 항암활성을 갖는 알릴티오피리다진 유도체 |
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
WO2007058394A1 (en) * | 2005-11-16 | 2007-05-24 | Seoul Pharm. Co., Ltd. | Medicinal composition comprising 3-alkoxy-6-allylthiopyridazines for prevention or treatment of cancer of the pancreas |
JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
RS52518B (en) | 2007-04-23 | 2013-04-30 | Janssen Pharmaceutica N.V. | 4-ALCOXYPYRIDASINE DERIVATIVES AS A FAST DISSOCATING DOPAMINE 2 RECEPTOR ANTAGONISTS |
CN101663299A (zh) | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 作为快速解离性多巴胺2受体拮抗剂的噻(二)唑类化合物 |
WO2010000456A1 (en) | 2008-07-03 | 2010-01-07 | Janssen Pharmaceutica Nv | Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists |
HUE033768T2 (en) | 2008-07-31 | 2017-12-28 | Janssen Pharmaceutica Nv | Piperazin-1-yl-trifluoromethyl-substituted pyridines as rapidly dissociating dopamine-2 receptor antagonists |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2627075A1 (de) * | 1976-06-16 | 1977-12-29 | Bayer Ag | Substituierte pyridazinyl(thiono)(thiol)-phosphor(phosphon)-saeureesterderivate, verfahren zu ihrer herstellung und ihre verwendung als insektizide und akarizide |
US5550134A (en) * | 1995-05-10 | 1996-08-27 | Eli Lilly And Company | Methods for inhibiting bone loss |
-
1998
- 1998-01-16 KR KR1019980001153A patent/KR100261139B1/ko not_active IP Right Cessation
- 1998-06-16 US US09/098,275 patent/US5942511A/en not_active Expired - Fee Related
- 1998-12-28 EP EP98961671A patent/EP1058681B1/de not_active Expired - Lifetime
- 1998-12-28 CN CNB988131242A patent/CN1147477C/zh not_active Expired - Fee Related
- 1998-12-28 CA CA002317673A patent/CA2317673C/en not_active Expired - Fee Related
- 1998-12-28 JP JP2000540123A patent/JP3417926B2/ja not_active Expired - Fee Related
- 1998-12-28 WO PCT/KR1998/000473 patent/WO1999036407A1/en active IP Right Grant
- 1998-12-28 AT AT98961671T patent/ATE239711T1/de not_active IP Right Cessation
- 1998-12-28 DE DE69814473T patent/DE69814473T9/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1058681A1 (de) | 2000-12-13 |
DE69814473D1 (de) | 2003-06-12 |
WO1999036407A1 (en) | 1999-07-22 |
KR19990065727A (ko) | 1999-08-05 |
JP2002509138A (ja) | 2002-03-26 |
CN1147477C (zh) | 2004-04-28 |
JP3417926B2 (ja) | 2003-06-16 |
DE69814473T9 (de) | 2005-02-03 |
CA2317673C (en) | 2004-09-21 |
CN1285825A (zh) | 2001-02-28 |
CA2317673A1 (en) | 1999-07-22 |
US5942511A (en) | 1999-08-24 |
KR100261139B1 (ko) | 2000-08-01 |
EP1058681B1 (de) | 2003-05-07 |
DE69814473T2 (de) | 2004-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |