BRPI0510980A - derivados de pirimidina para o tratamento do crescimento anormal de células - Google Patents
derivados de pirimidina para o tratamento do crescimento anormal de célulasInfo
- Publication number
- BRPI0510980A BRPI0510980A BRPI0510980-9A BRPI0510980A BRPI0510980A BR PI0510980 A BRPI0510980 A BR PI0510980A BR PI0510980 A BRPI0510980 A BR PI0510980A BR PI0510980 A BRPI0510980 A BR PI0510980A
- Authority
- BR
- Brazil
- Prior art keywords
- cell growth
- abnormal cell
- treatment
- pyrimidine derivatives
- mammals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS DE PIRIMIDINA PARA O TRATAMENTO DO CRESCIMENTO ANORMAL DE CéLULAS A presente invenção está relacionada a um composto apresentando fórmula (1) ou a um seu sal, solvato, hidrato, ou prodroga farmaceuticamente aceitável, onde R¬ 1¬-R¬ 4¬ e Ar são como definidos aqui. Tais derivados pirimidina são úteis no tratamento do crescimento anormal de células, tais como o câncer em mamíferos. Essa invenção está também relacionada a um método de utilização de tais compostos no tratamento do crescimento anormal de células em mamíferos, especialmente humanos, e a composições farmacêuticas contendo tais compostos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57119704P | 2004-05-14 | 2004-05-14 | |
PCT/IB2005/001192 WO2005111022A1 (en) | 2004-05-14 | 2005-05-02 | Pyrimidines derivatives for the treatment of abnormal cell growth |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0510980A true BRPI0510980A (pt) | 2007-11-27 |
Family
ID=34966615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0510980-9A BRPI0510980A (pt) | 2004-05-14 | 2005-05-02 | derivados de pirimidina para o tratamento do crescimento anormal de células |
Country Status (9)
Country | Link |
---|---|
US (1) | US7145008B2 (pt) |
EP (1) | EP1751142A1 (pt) |
JP (1) | JP2007537230A (pt) |
AR (1) | AR049169A1 (pt) |
BR (1) | BRPI0510980A (pt) |
CA (1) | CA2566332A1 (pt) |
MX (1) | MXPA06013164A (pt) |
TW (1) | TW200536833A (pt) |
WO (1) | WO2005111022A1 (pt) |
Families Citing this family (27)
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ES2338545T3 (es) | 2002-12-20 | 2010-05-10 | Pfizer Products Inc. | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
US20060205945A1 (en) * | 2004-05-14 | 2006-09-14 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
US7754717B2 (en) * | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
EP1966192B1 (en) * | 2005-12-01 | 2012-10-17 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
WO2008051547A1 (en) | 2006-10-23 | 2008-05-02 | Cephalon, Inc. | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors |
US8168661B2 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8178564B2 (en) | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
DK2146779T3 (en) * | 2007-04-18 | 2016-11-28 | Pfizer Prod Inc | Sulfonylamid derivatives to treat abnormal cell growth. |
KR101294731B1 (ko) * | 2007-06-04 | 2013-08-16 | 삼성디스플레이 주식회사 | 어레이 기판, 이를 갖는 표시패널 및 이의 제조방법 |
FR2926554B1 (fr) * | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
CL2009000600A1 (es) * | 2008-03-20 | 2010-05-07 | Bayer Cropscience Ag | Uso de compuestos de diaminopirimidina como agentes fitosanitarios; compuestos de diaminopirimidina; su procedimiento de preparacion; agente que los contiene; procedimiento para la preparacion de dicho agente; y procedimiento para combatir plagas de animales y/u hongos dañinos patogenos de plantas. |
EP2377850A1 (en) | 2010-03-30 | 2011-10-19 | Pharmeste S.r.l. | TRPV1 vanilloid receptor antagonists with a bicyclic portion |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
US8546443B2 (en) * | 2010-12-21 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Benzylic oxindole pyrimidines |
CA2827172C (en) | 2011-02-17 | 2019-02-26 | Cancer Therapeutics Crc Pty Limited | Selective fak inhibitors |
JP5937111B2 (ja) | 2011-02-17 | 2016-06-22 | カンサー・セラピューティクス・シーアールシー・プロプライエタリー・リミテッドCancer Therapeutics Crc Pty Limited | Fak阻害剤 |
CN104169272A (zh) | 2011-12-23 | 2014-11-26 | 赛尔佐姆有限公司 | 作为激酶抑制剂的嘧啶-2,4-二胺衍生物 |
JPWO2014174745A1 (ja) * | 2013-04-26 | 2017-02-23 | 国立大学法人京都大学 | Eg5阻害剤 |
US10738016B2 (en) | 2015-10-13 | 2020-08-11 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | BRD4-kinase inhibitors as cancer therapeutics |
US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
CN111732548B (zh) * | 2020-06-11 | 2022-06-17 | 浙江大学 | N2-氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途 |
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WO2003095448A1 (en) | 2002-05-06 | 2003-11-20 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
ES2338545T3 (es) * | 2002-12-20 | 2010-05-10 | Pfizer Products Inc. | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
-
2005
- 2005-05-02 WO PCT/IB2005/001192 patent/WO2005111022A1/en not_active Application Discontinuation
- 2005-05-02 MX MXPA06013164A patent/MXPA06013164A/es not_active Application Discontinuation
- 2005-05-02 CA CA002566332A patent/CA2566332A1/en not_active Abandoned
- 2005-05-02 JP JP2007512551A patent/JP2007537230A/ja active Pending
- 2005-05-02 BR BRPI0510980-9A patent/BRPI0510980A/pt not_active IP Right Cessation
- 2005-05-02 EP EP05731767A patent/EP1751142A1/en not_active Withdrawn
- 2005-05-05 US US11/122,515 patent/US7145008B2/en not_active Expired - Fee Related
- 2005-05-12 AR ARP050101937A patent/AR049169A1/es unknown
- 2005-05-13 TW TW094115579A patent/TW200536833A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2566332A1 (en) | 2005-11-24 |
WO2005111022A1 (en) | 2005-11-24 |
AR049169A1 (es) | 2006-07-05 |
US20050256125A1 (en) | 2005-11-17 |
US7145008B2 (en) | 2006-12-05 |
TW200536833A (en) | 2005-11-16 |
JP2007537230A (ja) | 2007-12-20 |
MXPA06013164A (es) | 2007-02-13 |
EP1751142A1 (en) | 2007-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A E 6 ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE A 8.6 NA RPI 2099 DE 29/03/2011. |