BR112012029226A2 - processo para a preparação de um composto quiral, composto quiral cristalino, sal de hcl do composto quiral cristalino, composto quiral e uso do composto - Google Patents

processo para a preparação de um composto quiral, composto quiral cristalino, sal de hcl do composto quiral cristalino, composto quiral e uso do composto

Info

Publication number
BR112012029226A2
BR112012029226A2 BR112012029226A BR112012029226A BR112012029226A2 BR 112012029226 A2 BR112012029226 A2 BR 112012029226A2 BR 112012029226 A BR112012029226 A BR 112012029226A BR 112012029226 A BR112012029226 A BR 112012029226A BR 112012029226 A2 BR112012029226 A2 BR 112012029226A2
Authority
BR
Brazil
Prior art keywords
chiral compound
crystalline
preparation
hcl salt
compound
Prior art date
Application number
BR112012029226A
Other languages
English (en)
Inventor
Abhinay C Pise
Dattatraya N Chavan
Dominic De Souza
Sachim Bhuta
Shashikant D Metkar
Shreerang V Josh
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of BR112012029226A2 publication Critical patent/BR112012029226A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BR112012029226A 2010-05-19 2011-05-18 processo para a preparação de um composto quiral, composto quiral cristalino, sal de hcl do composto quiral cristalino, composto quiral e uso do composto BR112012029226A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10163215 2010-05-19
PCT/EP2011/058036 WO2011144656A1 (en) 2010-05-19 2011-05-18 Preparation of posaconazole intermediates

Publications (1)

Publication Number Publication Date
BR112012029226A2 true BR112012029226A2 (pt) 2015-10-20

Family

ID=42341764

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012029226A BR112012029226A2 (pt) 2010-05-19 2011-05-18 processo para a preparação de um composto quiral, composto quiral cristalino, sal de hcl do composto quiral cristalino, composto quiral e uso do composto

Country Status (10)

Country Link
US (1) US9073904B2 (pt)
EP (1) EP2571868B1 (pt)
JP (1) JP2013532131A (pt)
CN (1) CN102892762B (pt)
AU (1) AU2011254657B2 (pt)
BR (1) BR112012029226A2 (pt)
CA (1) CA2798007C (pt)
MX (1) MX338514B (pt)
RU (1) RU2580318C2 (pt)
WO (1) WO2011144656A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2585760C2 (ru) 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
MX337804B (es) 2010-05-19 2016-03-18 Sandoz Ag Proceso para la preparacion de hidrazinas quirales.
MX2012013331A (es) 2010-05-19 2013-02-01 Sandoz Ag Purificacion de posaconazol y de intermediarios de posaconazol.
CN103635465A (zh) 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
EP2746266A1 (en) * 2012-12-19 2014-06-25 Basf Se New substituted triazoles and imidazoles and their use as fungicides
CN103086885B (zh) * 2013-02-28 2015-04-01 天津大学仁爱学院 一种泊沙康唑中间体的制备方法
EP2789610A1 (en) * 2013-04-10 2014-10-15 Sandoz Ag Purification of Posaconazole Intermediates
CN105777720B (zh) * 2014-12-26 2018-09-21 博瑞生物医药（苏州）股份有限公司 一种泊沙康唑中间体的新晶型及制备方法
JP7054381B2 (ja) * 2015-09-23 2022-04-13 バイオコン・リミテッド 結晶形態のポサコナゾール中間体および非晶質ポサコナゾールの調製のためのプロセス
CN105622413B (zh) * 2016-01-14 2017-11-24 宁波新凯生物科技有限公司 2‑[2‑(2，4‑二氟苯基)烯丙基]‑1，3‑丙二酸二乙酯的合成方法
CN105753693B (zh) * 2016-03-30 2017-12-22 宁波新凯生物科技有限公司 2‑甲基丙酸‑[(2s)‑4‑(2，4‑二氟苯基)‑2‑羟甲基‑4‑戊烯‑1‑基]酯的合成方法
CN105732310B (zh) * 2016-03-30 2018-01-23 宁波新凯生物科技有限公司 2‑[2‑(2，4‑二氟苯基)‑2‑丙烯‑1‑基]‑1，3‑丙二醇的合成方法
CN105777486B (zh) * 2016-03-30 2018-09-11 浙江大学宁波理工学院 一种2-[2-(2，4-二氟苯基)-2-丙烯-1-基]-1，3-丙二醇的合成方法

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US5595872A (en) 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
US5403937A (en) * 1993-04-30 1995-04-04 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents
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AU2005210259A1 (en) 2004-02-02 2005-08-18 Pfizer Products Inc. Process for preparation of 1-(2S,3S)-2-benzhydr yl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine
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WO2009141837A2 (en) 2008-05-21 2009-11-26 Ind-Swift Laboratories Limited Process for preparing posaconazole and intermediates thereof
EP2141159A1 (en) 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
RU2011136624A (ru) 2009-02-05 2013-03-10 Тарджетед Деливери Текнолоджиз Лимитед Способы уменьшения пролиферации и жизнеспособности микробных агентов
MX2012013331A (es) 2010-05-19 2013-02-01 Sandoz Ag Purificacion de posaconazol y de intermediarios de posaconazol.
MX337804B (es) 2010-05-19 2016-03-18 Sandoz Ag Proceso para la preparacion de hidrazinas quirales.
RU2585760C2 (ru) 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
CN104379132A (zh) 2012-06-14 2015-02-25 桑多斯股份公司 包含结晶泊沙康唑的药物组合物

Also Published As

Publication number Publication date
US20130203994A1 (en) 2013-08-08
EP2571868B1 (en) 2016-05-04
JP2013532131A (ja) 2013-08-15
AU2011254657A1 (en) 2012-12-20
EP2571868A1 (en) 2013-03-27
CN102892762A (zh) 2013-01-23
WO2011144656A1 (en) 2011-11-24
MX338514B (es) 2016-04-20
CA2798007A1 (en) 2011-11-24
MX2012013332A (es) 2013-02-01
CA2798007C (en) 2018-10-23
RU2012154807A (ru) 2014-06-27
RU2580318C2 (ru) 2016-04-10
US9073904B2 (en) 2015-07-07
CN102892762B (zh) 2016-04-20
AU2011254657B2 (en) 2016-02-04

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 405/06

Ipc: C07D 405/06 (2006.01), A61P 31/10 (2006.01), C07D

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements