CN105732310B - 2‑[2‑(2,4‑二氟苯基)‑2‑丙烯‑1‑基]‑1,3‑丙二醇的合成方法 - Google Patents
2‑[2‑(2,4‑二氟苯基)‑2‑丙烯‑1‑基]‑1,3‑丙二醇的合成方法 Download PDFInfo
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- CN105732310B CN105732310B CN201610191133.0A CN201610191133A CN105732310B CN 105732310 B CN105732310 B CN 105732310B CN 201610191133 A CN201610191133 A CN 201610191133A CN 105732310 B CN105732310 B CN 105732310B
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- difluorophenyl
- propylene
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
- C07C17/357—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by dehydrogenation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610191133.0A CN105732310B (zh) | 2016-03-30 | 2016-03-30 | 2‑[2‑(2,4‑二氟苯基)‑2‑丙烯‑1‑基]‑1,3‑丙二醇的合成方法 |
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CN201610191133.0A CN105732310B (zh) | 2016-03-30 | 2016-03-30 | 2‑[2‑(2,4‑二氟苯基)‑2‑丙烯‑1‑基]‑1,3‑丙二醇的合成方法 |
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CN105732310A CN105732310A (zh) | 2016-07-06 |
CN105732310B true CN105732310B (zh) | 2018-01-23 |
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CN201610191133.0A Active CN105732310B (zh) | 2016-03-30 | 2016-03-30 | 2‑[2‑(2,4‑二氟苯基)‑2‑丙烯‑1‑基]‑1,3‑丙二醇的合成方法 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102643194A (zh) * | 2012-03-27 | 2012-08-22 | 福州大学 | 一种泊沙康唑中间体的制备方法 |
CN102892762A (zh) * | 2010-05-19 | 2013-01-23 | 桑多斯股份公司 | 制备泊沙康唑中间体 |
EP2789610A1 (en) * | 2013-04-10 | 2014-10-15 | Sandoz Ag | Purification of Posaconazole Intermediates |
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2016
- 2016-03-30 CN CN201610191133.0A patent/CN105732310B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102892762A (zh) * | 2010-05-19 | 2013-01-23 | 桑多斯股份公司 | 制备泊沙康唑中间体 |
CN102643194A (zh) * | 2012-03-27 | 2012-08-22 | 福州大学 | 一种泊沙康唑中间体的制备方法 |
EP2789610A1 (en) * | 2013-04-10 | 2014-10-15 | Sandoz Ag | Purification of Posaconazole Intermediates |
Non-Patent Citations (1)
Title |
---|
唑类抗真菌药的合成评述;周伟澄,周后元;《中国医药工业杂志》;20061231;第37卷(第2期);128-131 * |
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