MX338514B - Preparacion de intermediarios de posaconazol. - Google Patents

Preparacion de intermediarios de posaconazol.

Info

Publication number
MX338514B
MX338514B MX2012013332A MX2012013332A MX338514B MX 338514 B MX338514 B MX 338514B MX 2012013332 A MX2012013332 A MX 2012013332A MX 2012013332 A MX2012013332 A MX 2012013332A MX 338514 B MX338514 B MX 338514B
Authority
MX
Mexico
Prior art keywords
preparation
posaconazole
intermediates
posaconazole intermediates
formula
Prior art date
Application number
MX2012013332A
Other languages
English (en)
Other versions
MX2012013332A (es
Inventor
Dominic De Souza
Shreerang V Joshi
Sachin Bhuta
Abhinay C Pise
Dattatraya N Chavan
Shashikant D Metkar
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of MX2012013332A publication Critical patent/MX2012013332A/es
Publication of MX338514B publication Critical patent/MX338514B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)

Abstract

La presente invención se refiere a un proceso para la preparación de un compuesto quiral de la fórmula (IX) o una sal del mismo, en donde Y1 y Y2 son independientemente E o CI, de preferencia F, al compuesto cristalino de la fórmula (IX) como tal, y a su uso para la preparación de un agente antimicótico.
MX2012013332A 2010-05-19 2011-05-18 Preparacion de intermediarios de posaconazol. MX338514B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10163215 2010-05-19
PCT/EP2011/058036 WO2011144656A1 (en) 2010-05-19 2011-05-18 Preparation of posaconazole intermediates

Publications (2)

Publication Number Publication Date
MX2012013332A MX2012013332A (es) 2013-02-01
MX338514B true MX338514B (es) 2016-04-20

Family

ID=42341764

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013332A MX338514B (es) 2010-05-19 2011-05-18 Preparacion de intermediarios de posaconazol.

Country Status (10)

Country Link
US (1) US9073904B2 (es)
EP (1) EP2571868B1 (es)
JP (1) JP2013532131A (es)
CN (1) CN102892762B (es)
AU (1) AU2011254657B2 (es)
BR (1) BR112012029226A2 (es)
CA (1) CA2798007C (es)
MX (1) MX338514B (es)
RU (1) RU2580318C2 (es)
WO (1) WO2011144656A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9206146B2 (en) 2010-05-19 2015-12-08 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
US9040539B2 (en) 2010-05-19 2015-05-26 Sandoz Ag Process for the preparation of chiral triazolones
EP2571847B1 (en) 2010-05-19 2016-09-21 Sandoz AG Process for the preparation of chiral hydrazides
CN108329303A (zh) 2011-06-16 2018-07-27 桑多斯股份公司 制备手性化合物的方法
EP2746266A1 (en) * 2012-12-19 2014-06-25 Basf Se New substituted triazoles and imidazoles and their use as fungicides
CN103086885B (zh) * 2013-02-28 2015-04-01 天津大学仁爱学院 一种泊沙康唑中间体的制备方法
EP2789610A1 (en) * 2013-04-10 2014-10-15 Sandoz Ag Purification of Posaconazole Intermediates
CN105777720B (zh) * 2014-12-26 2018-09-21 博瑞生物医药（苏州）股份有限公司 一种泊沙康唑中间体的新晶型及制备方法
WO2017051342A1 (en) * 2015-09-23 2017-03-30 Biocon Limited Crystalline forms of posaconazole intermediate and process for the preparation of amorphous posaconazole
CN105622413B (zh) * 2016-01-14 2017-11-24 宁波新凯生物科技有限公司 2‑[2‑(2，4‑二氟苯基)烯丙基]‑1，3‑丙二酸二乙酯的合成方法
CN105753693B (zh) * 2016-03-30 2017-12-22 宁波新凯生物科技有限公司 2‑甲基丙酸‑[(2s)‑4‑(2，4‑二氟苯基)‑2‑羟甲基‑4‑戊烯‑1‑基]酯的合成方法
CN105777486B (zh) * 2016-03-30 2018-09-11 浙江大学宁波理工学院 一种2-[2-(2，4-二氟苯基)-2-丙烯-1-基]-1，3-丙二醇的合成方法
CN105732310B (zh) * 2016-03-30 2018-01-23 宁波新凯生物科技有限公司 2‑[2‑(2，4‑二氟苯基)‑2‑丙烯‑1‑基]‑1，3‑丙二醇的合成方法

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Also Published As

Publication number Publication date
EP2571868A1 (en) 2013-03-27
US9073904B2 (en) 2015-07-07
WO2011144656A1 (en) 2011-11-24
AU2011254657A1 (en) 2012-12-20
CA2798007C (en) 2018-10-23
CN102892762A (zh) 2013-01-23
AU2011254657B2 (en) 2016-02-04
BR112012029226A2 (pt) 2015-10-20
RU2012154807A (ru) 2014-06-27
CN102892762B (zh) 2016-04-20
RU2580318C2 (ru) 2016-04-10
CA2798007A1 (en) 2011-11-24
JP2013532131A (ja) 2013-08-15
US20130203994A1 (en) 2013-08-08
EP2571868B1 (en) 2016-05-04
MX2012013332A (es) 2013-02-01

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