MX338514B - Preparacion de intermediarios de posaconazol. - Google Patents
Preparacion de intermediarios de posaconazol.Info
- Publication number
- MX338514B MX338514B MX2012013332A MX2012013332A MX338514B MX 338514 B MX338514 B MX 338514B MX 2012013332 A MX2012013332 A MX 2012013332A MX 2012013332 A MX2012013332 A MX 2012013332A MX 338514 B MX338514 B MX 338514B
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- posaconazole
- intermediates
- posaconazole intermediates
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
Abstract
La presente invención se refiere a un proceso para la preparación de un compuesto quiral de la fórmula (IX) o una sal del mismo, en donde Y1 y Y2 son independientemente E o CI, de preferencia F, al compuesto cristalino de la fórmula (IX) como tal, y a su uso para la preparación de un agente antimicótico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10163215 | 2010-05-19 | ||
PCT/EP2011/058036 WO2011144656A1 (en) | 2010-05-19 | 2011-05-18 | Preparation of posaconazole intermediates |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012013332A MX2012013332A (es) | 2013-02-01 |
MX338514B true MX338514B (es) | 2016-04-20 |
Family
ID=42341764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013332A MX338514B (es) | 2010-05-19 | 2011-05-18 | Preparacion de intermediarios de posaconazol. |
Country Status (10)
Country | Link |
---|---|
US (1) | US9073904B2 (es) |
EP (1) | EP2571868B1 (es) |
JP (1) | JP2013532131A (es) |
CN (1) | CN102892762B (es) |
AU (1) | AU2011254657B2 (es) |
BR (1) | BR112012029226A2 (es) |
CA (1) | CA2798007C (es) |
MX (1) | MX338514B (es) |
RU (1) | RU2580318C2 (es) |
WO (1) | WO2011144656A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9206146B2 (en) | 2010-05-19 | 2015-12-08 | Sandoz Ag | Purification of posaconazole and of posaconazole intermediates |
US9040539B2 (en) | 2010-05-19 | 2015-05-26 | Sandoz Ag | Process for the preparation of chiral triazolones |
EP2571847B1 (en) | 2010-05-19 | 2016-09-21 | Sandoz AG | Process for the preparation of chiral hydrazides |
CN108329303A (zh) | 2011-06-16 | 2018-07-27 | 桑多斯股份公司 | 制备手性化合物的方法 |
EP2746266A1 (en) * | 2012-12-19 | 2014-06-25 | Basf Se | New substituted triazoles and imidazoles and their use as fungicides |
CN103086885B (zh) * | 2013-02-28 | 2015-04-01 | 天津大学仁爱学院 | 一种泊沙康唑中间体的制备方法 |
EP2789610A1 (en) * | 2013-04-10 | 2014-10-15 | Sandoz Ag | Purification of Posaconazole Intermediates |
CN105777720B (zh) * | 2014-12-26 | 2018-09-21 | 博瑞生物医药(苏州)股份有限公司 | 一种泊沙康唑中间体的新晶型及制备方法 |
WO2017051342A1 (en) * | 2015-09-23 | 2017-03-30 | Biocon Limited | Crystalline forms of posaconazole intermediate and process for the preparation of amorphous posaconazole |
CN105622413B (zh) * | 2016-01-14 | 2017-11-24 | 宁波新凯生物科技有限公司 | 2‑[2‑(2,4‑二氟苯基)烯丙基]‑1,3‑丙二酸二乙酯的合成方法 |
CN105753693B (zh) * | 2016-03-30 | 2017-12-22 | 宁波新凯生物科技有限公司 | 2‑甲基丙酸‑[(2s)‑4‑(2,4‑二氟苯基)‑2‑羟甲基‑4‑戊烯‑1‑基]酯的合成方法 |
CN105777486B (zh) * | 2016-03-30 | 2018-09-11 | 浙江大学宁波理工学院 | 一种2-[2-(2,4-二氟苯基)-2-丙烯-1-基]-1,3-丙二醇的合成方法 |
CN105732310B (zh) * | 2016-03-30 | 2018-01-23 | 宁波新凯生物科技有限公司 | 2‑[2‑(2,4‑二氟苯基)‑2‑丙烯‑1‑基]‑1,3‑丙二醇的合成方法 |
Family Cites Families (41)
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GB8307232D0 (en) * | 1983-03-16 | 1983-04-20 | Pfizer Ltd | Antifungal agents |
DE3544983A1 (de) | 1985-12-19 | 1987-06-25 | Hoechst Ag | Antimykotisch wirksamer nagellack |
IL103558A0 (en) | 1991-10-30 | 1993-03-15 | Schering Corp | Tri-substituted tetrahydrofuran antifungals |
US5595872A (en) | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
US5349099A (en) * | 1993-12-13 | 1994-09-20 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
US5693626A (en) | 1993-12-21 | 1997-12-02 | Schering Corporation | Tetrahydrofuran antifungals |
US5710154A (en) | 1993-12-21 | 1998-01-20 | Schering Corporation | Tetrahydrofuran antifungals |
CO4520281A1 (es) * | 1993-12-21 | 1997-10-15 | Schering Corp | Antifungicos de tetrahidrofurano |
US5714490A (en) | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
NZ270418A (en) | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
US5486625A (en) * | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
US5616777A (en) | 1995-04-19 | 1997-04-01 | Schering Corporation | Chiral hydrazine derivatives |
US5625064A (en) | 1995-04-19 | 1997-04-29 | Schering Corporation | Process for the preparation of triazolones |
NZ309281A (en) * | 1995-06-02 | 1998-07-28 | Schering Corp | (2r-cis)-4-[4-[4-[4-[[(5-(2,4-dihalophenyl)-tetrahydro-5-(1h-1,2,4-tr iazol-1-ylmethyl)-tetrahydrofuran-3-yl]methoxy]phenyl]2,4-dihydro-2-[ esters and ethers of mono- or dihydroxy-substituted (c4-c5) alkyl]-3h-1,2,4-triazol-3-one |
IL118668A0 (en) * | 1995-06-19 | 1996-10-16 | Schering Corp | Tetrahydrofuran antifungals |
NZ324616A (en) | 1995-12-20 | 1999-05-28 | Schering Corp | Process for preparation of hydrazides using hydrazones and grignard reagents |
NZ325566A (en) | 1995-12-20 | 1999-05-28 | Schering Corp | Process for preparing a crystalline chiral hydroxy ester intermediate for the synthesis of antifungal agents |
EP0885394B1 (de) | 1996-03-08 | 2000-08-16 | Octapharma AG | Verfahren zur eignungsprüfung von faktor viii-haltigen proteinfraktionen |
US5834472A (en) | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
US5972381A (en) | 1996-06-28 | 1999-10-26 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
CN1125067C (zh) | 1997-10-07 | 2003-10-22 | 先灵公司 | 结晶抗真菌多晶型物 |
US6713481B1 (en) | 1997-10-17 | 2004-03-30 | David R. Andrews | Crystalline antifungal polymorph |
MXPA02004545A (es) | 1999-11-08 | 2002-09-02 | Schering Corp | Procedimiento para preparar n-( a-hidroxifenil)-n'-(4'-aminofenil)-piperazina. |
US6355801B1 (en) | 1999-11-08 | 2002-03-12 | Schering Corporation | Process for preparing N-(4-hydroxyphenyl)-N′-(4′-aminophenyl)-piperazine |
WO2002080678A1 (en) | 2001-04-03 | 2002-10-17 | Schering Corporation | Antifungal composition with enhanced bioavailability |
DE602005003791T2 (de) | 2004-02-02 | 2008-05-29 | Pfizer Products Inc., Groton | Verfahren zur herstellung von 1-(2s,3s)-2-benzhydril-n-(5-tert.-butyl-2-methoxybenzyl)chinuklidin-3-amin |
PE20060291A1 (es) | 2004-05-28 | 2006-04-14 | Schering Corp | Composiciones farmaceuticas inyectables de posaconazol con particulas estabilizadas |
EP3269713A1 (en) | 2004-07-01 | 2018-01-17 | OPKO Health, Inc. | Piperidine derivatives as nk1 antagonists |
MX2008013406A (es) | 2006-04-20 | 2008-11-04 | Glaxo Group Ltd | Derivados de 4-bencilftalazinona 2-sustituida como antagonistas de la histamina h1 y h3. |
BRPI0712130A2 (pt) | 2006-05-30 | 2012-01-17 | Elan Pharma Int Ltd | formulações de posaconazol em nanopartìculas |
EP2143723A4 (en) | 2007-04-27 | 2011-05-18 | Eisai R&D Man Co Ltd | SALT OF A PYRIDINE DERIVATIVE SUBSTITUTED BY HETEROCYCLE OR CRYSTALS OF THE SAME |
EP2220078B1 (en) | 2007-10-29 | 2013-05-22 | Amgen, Inc | Benzomorpholine derivatives and methods of use |
WO2009129297A1 (en) | 2008-04-15 | 2009-10-22 | Schering Corporation | Semi-solid oral pharmaceutical compositions |
WO2009141837A2 (en) * | 2008-05-21 | 2009-11-26 | Ind-Swift Laboratories Limited | Process for preparing posaconazole and intermediates thereof |
EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
WO2010090654A1 (en) | 2009-02-05 | 2010-08-12 | Tdt, Ltd. | Methods of reducing the proliferation and viability of microbial agents |
EP2571847B1 (en) | 2010-05-19 | 2016-09-21 | Sandoz AG | Process for the preparation of chiral hydrazides |
US9040539B2 (en) | 2010-05-19 | 2015-05-26 | Sandoz Ag | Process for the preparation of chiral triazolones |
US9206146B2 (en) | 2010-05-19 | 2015-12-08 | Sandoz Ag | Purification of posaconazole and of posaconazole intermediates |
WO2013186320A1 (en) | 2012-06-14 | 2013-12-19 | Sandoz Ag | Pharmaceutical composition comprising crystalline posaconazole |
-
2011
- 2011-05-18 CN CN201180024632.6A patent/CN102892762B/zh not_active Expired - Fee Related
- 2011-05-18 CA CA2798007A patent/CA2798007C/en not_active Expired - Fee Related
- 2011-05-18 EP EP11720108.7A patent/EP2571868B1/en not_active Not-in-force
- 2011-05-18 MX MX2012013332A patent/MX338514B/es active IP Right Grant
- 2011-05-18 JP JP2013510613A patent/JP2013532131A/ja active Pending
- 2011-05-18 WO PCT/EP2011/058036 patent/WO2011144656A1/en active Application Filing
- 2011-05-18 US US13/697,802 patent/US9073904B2/en not_active Expired - Fee Related
- 2011-05-18 RU RU2012154807/04A patent/RU2580318C2/ru active
- 2011-05-18 BR BR112012029226A patent/BR112012029226A2/pt not_active Application Discontinuation
- 2011-05-18 AU AU2011254657A patent/AU2011254657B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP2571868A1 (en) | 2013-03-27 |
US9073904B2 (en) | 2015-07-07 |
WO2011144656A1 (en) | 2011-11-24 |
AU2011254657A1 (en) | 2012-12-20 |
CA2798007C (en) | 2018-10-23 |
CN102892762A (zh) | 2013-01-23 |
AU2011254657B2 (en) | 2016-02-04 |
BR112012029226A2 (pt) | 2015-10-20 |
RU2012154807A (ru) | 2014-06-27 |
CN102892762B (zh) | 2016-04-20 |
RU2580318C2 (ru) | 2016-04-10 |
CA2798007A1 (en) | 2011-11-24 |
JP2013532131A (ja) | 2013-08-15 |
US20130203994A1 (en) | 2013-08-08 |
EP2571868B1 (en) | 2016-05-04 |
MX2012013332A (es) | 2013-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |