KR920008017A - 피페라진 유도체 - Google Patents

피페라진 유도체 Download PDF

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KR920008017A
KR920008017A KR1019910017391A KR910017391A KR920008017A KR 920008017 A KR920008017 A KR 920008017A KR 1019910017391 A KR1019910017391 A KR 1019910017391A KR 910017391 A KR910017391 A KR 910017391A KR 920008017 A KR920008017 A KR 920008017A
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methoxyphenyl
phenyl
piperazine
ethyl
compound
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KR1019910017391A
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KR100191362B1 (ko
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제임스 워드 테렌스
존 워렐로우 그래함
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폴 에이 레커
존 와이어스 앤드 브라더 리미티드
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

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  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음

Description

피페라진 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식( I )의 화합물 또는 이의 약제학적으로 허용되는 산 부가염.
    ( I )
    상기식에서 A는 하나 이상의 저급알킬 그룹에 의해 임의로 치환된 탄소수 1내지 2의 아킬렌쇄이고, R은 수소 또는 저급 알킬이며, R1은 아릴 또는 헤테로아릴 라디칼이고, R2는 모노-또는 바이사이클릭 헤테로사이클릭 라디칼이며, R3는 수소, 저급알킬 또는 하이드록시이고, R4는 아릴 또는 헤테로아릴 라디칼이다.
  2. 제1항에 있어서, A가 -CH3- 또는 -CH2CH2-인 화합물.
  3. 제1항 또는 제2항에 있어서, R1이 하나 이상의 저급알킬, 저급알콕시, 할로겐, 할로(저급)알킬, 니트로, 아미노, 저급(알킬)아미노, 디(저급)알킬아미노, 페닐, 할로페닐, (저급)알킬페닐 또는 (저급)알콕시페닐 치환체에 의해 임의로 치환된 페닐 또는 나프틸 라디칼인 화합물.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, R2가 임의로 치환된 피리디닐, 피리미디닐, 피라지닐, 이미다졸릴, 피라졸릴, 트리아졸릴, 벤즈이미다졸릴, 옥사디아졸릴, 이미다졸리닐, 옥사졸리닐, 피롤리디닐, 피페리디닐, 모르폴리닐 또는 아제피닐인 화합물.
  5. 제1항에 있어서, 1-(2-메톡시페닐)-4-[2-(1H-이미다졸-1-일)-2-(페닐)에틸]피페라진, 1-(2-메톡시페닐)-4-[2-(2-메틸-[1H]이미다졸-1-일)-2-(페닐)에틸]피페라진, 1-(2-메톡시페닐)-4-[2-(1-피롤리디닐)-2-(페닐)에틸]피페라진, 1-(2-메톡시페닐)-4-[2-(1H-이미다졸-2-(4-플루오로페닐)에틸]피페라진, 1-(2-메톡시페닐)-4-[2-페닐-2-(4-페닐-1H-이미다졸-1-일)에틸]피페라진, 1-(2-메톡시페닐)-4-[2-(1H-벤지마돌-1-일)-2-페닐에틸]피페라진, (S)-[1-(2-메톡시페닐)-4-(2-(1H-이미다졸-1-일)-2-페닐에틸]피페라진, 1-(2-메톡시페닐)-4-[3-(1H-이미다졸-1-일)-3-페닐)프로필]피페라진, 1-(2-메톡시페닐)-4-[2-(4-메틸-1H-이미다졸-1-일)-2-(페닐)에틸]피페라진, 5-(3-(4-(2-메톡시페닐)피페라진-1-일)-1-페닐프로필)-3-메틸-1,2,4-옥사디아졸 또는 5-[2-(4-(2-메톡시페닐)피페라진-1-일)-1-페닐에틸]-3-메틸-1,2,4-옥사디아졸인 화합물 또는 이의 약제학적으로 허용되는 산 부가염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019910017391A 1990-10-03 1991-10-02 피페라진 유도체 KR100191362B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9021453.7 1990-10-03
GB909021453A GB9021453D0 (en) 1990-10-03 1990-10-03 Piperazine derivatives

Publications (2)

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KR920008017A true KR920008017A (ko) 1992-05-27
KR100191362B1 KR100191362B1 (ko) 1999-06-15

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US (1) US5177078A (ko)
EP (1) EP0479546B1 (ko)
JP (1) JPH04257570A (ko)
KR (1) KR100191362B1 (ko)
AT (1) ATE144772T1 (ko)
CA (1) CA2052619A1 (ko)
DE (1) DE69122941T2 (ko)
DK (1) DK0479546T3 (ko)
ES (1) ES2094204T3 (ko)
GB (2) GB9021453D0 (ko)
GR (1) GR3022257T3 (ko)
HU (2) HU217813B (ko)
IE (1) IE65377B1 (ko)
PT (1) PT99134B (ko)

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KR100347672B1 (ko) * 2000-05-15 2002-08-07 중앙섬유기계 주식회사 컴퓨터가 부착된 양두 성형 환편기

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CN102241664B (zh) * 2010-05-13 2014-11-12 上海医药工业研究院 芳烷二胺类衍生物及其作为抗抑郁症药物的应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100347672B1 (ko) * 2000-05-15 2002-08-07 중앙섬유기계 주식회사 컴퓨터가 부착된 양두 성형 환편기

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JPH04257570A (ja) 1992-09-11
PT99134B (pt) 1999-03-31
DK0479546T3 (da) 1996-11-25
KR100191362B1 (ko) 1999-06-15
GB9021453D0 (en) 1990-11-14
GB9120856D0 (en) 1991-11-13
ES2094204T3 (es) 1997-01-16
HU913160D0 (en) 1992-01-28
EP0479546A3 (en) 1992-06-03
GR3022257T3 (en) 1997-04-30
IE65377B1 (en) 1995-10-18
GB2248616B (en) 1994-06-15
EP0479546A2 (en) 1992-04-08
CA2052619A1 (en) 1992-04-04
AU8488391A (en) 1992-04-09
PT99134A (pt) 1992-08-31
HU217813B (hu) 2000-04-28
US5177078A (en) 1993-01-05
AU642532B2 (en) 1993-10-21
HUT59394A (en) 1992-05-28
EP0479546B1 (en) 1996-10-30
IE913471A1 (en) 1992-04-08
HU211737A9 (en) 1995-12-28
ATE144772T1 (de) 1996-11-15
DE69122941T2 (de) 1997-04-03
DE69122941D1 (de) 1996-12-05
GB2248616A (en) 1992-04-15

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