NO168476C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-(4-(4-(4-(((2,4-difluorfenyl)-2-(1h-azolylmetyl)-1,3-dioxolan-4-yl)metoksy)fenyl)-1-piperazinyl)fenyl)triazoloner. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-(4-(4-(4-(((2,4-difluorfenyl)-2-(1h-azolylmetyl)-1,3-dioxolan-4-yl)metoksy)fenyl)-1-piperazinyl)fenyl)triazoloner.

Info

Publication number
NO168476C
NO168476C NO881306A NO881306A NO168476C NO 168476 C NO168476 C NO 168476C NO 881306 A NO881306 A NO 881306A NO 881306 A NO881306 A NO 881306A NO 168476 C NO168476 C NO 168476C
Authority
NO
Norway
Prior art keywords
phenyl
6alkyl
azolylmethyl
dioxolan
piperazinyl
Prior art date
Application number
NO881306A
Other languages
English (en)
Other versions
NO881306L (no
NO881306D0 (no
NO168476B (no
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Louis Jozef Elisabeth Va Veken
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO881306D0 publication Critical patent/NO881306D0/no
Publication of NO881306L publication Critical patent/NO881306L/no
Publication of NO168476B publication Critical patent/NO168476B/no
Publication of NO168476C publication Critical patent/NO168476C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
NO881306A 1987-03-25 1988-03-24 Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-(4-(4-(4-(((2,4-difluorfenyl)-2-(1h-azolylmetyl)-1,3-dioxolan-4-yl)metoksy)fenyl)-1-piperazinyl)fenyl)triazoloner. NO168476C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3020787A 1987-03-25 1987-03-25

Publications (4)

Publication Number Publication Date
NO881306D0 NO881306D0 (no) 1988-03-24
NO881306L NO881306L (no) 1988-09-26
NO168476B NO168476B (no) 1991-11-18
NO168476C true NO168476C (no) 1992-02-26

Family

ID=21853062

Family Applications (1)

Application Number Title Priority Date Filing Date
NO881306A NO168476C (no) 1987-03-25 1988-03-24 Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-(4-(4-(4-(((2,4-difluorfenyl)-2-(1h-azolylmetyl)-1,3-dioxolan-4-yl)metoksy)fenyl)-1-piperazinyl)fenyl)triazoloner.

Country Status (25)

Country Link
EP (1) EP0283992B1 (no)
JP (1) JPH0667929B2 (no)
KR (1) KR960012370B1 (no)
CN (1) CN1038588C (no)
AT (1) ATE80626T1 (no)
AU (1) AU600107B2 (no)
CA (1) CA1313875C (no)
CY (1) CY1837A (no)
DE (1) DE3874576T2 (no)
DK (1) DK168336B1 (no)
ES (1) ES2044991T3 (no)
FI (1) FI89798C (no)
GR (1) GR3006420T3 (no)
HK (1) HK50395A (no)
HU (1) HU204819B (no)
IE (1) IE61802B1 (no)
IL (1) IL85823A (no)
MA (1) MA21227A1 (no)
NO (1) NO168476C (no)
NZ (1) NZ223799A (no)
PH (1) PH25023A (no)
PT (1) PT87073B (no)
SU (1) SU1635900A3 (no)
TN (1) TNSN88025A1 (no)
ZA (1) ZA882118B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
US5075309A (en) * 1989-06-09 1991-12-24 Janssen Pharmaceutica N.V. Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
DK0608308T3 (da) * 1991-10-15 2000-04-17 Kenneth Vincent Mason Anti-seboréformulering
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
TW218017B (no) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
ATE186540T1 (de) * 1994-01-24 1999-11-15 Janssen Pharmaceutica Nv Wasserlösliche azol-antifungus
DK0788496T3 (da) * 1994-10-27 2001-06-18 Janssen Pharmaceutica Nv Inhibitorer for syntese af apolipoprotein-B
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
TW457240B (en) * 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
US20030224006A1 (en) 2002-03-01 2003-12-04 Zaworotko Michael J. Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7078526B2 (en) 2002-05-31 2006-07-18 Transform Pharmaceuticals, Inc. CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
IL165383A0 (en) 2002-06-21 2006-01-15 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
WO2005118577A1 (en) * 2004-04-22 2005-12-15 Transform Pharmaceuticals, Inc. Novel saperconazole crystalline forms and related processes, pharmaceutical compositions and methods
AU2011254654B2 (en) * 2010-05-19 2016-01-07 Sandoz Ag Process for the preparation of chiral triazolones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles

Also Published As

Publication number Publication date
HK50395A (en) 1995-04-13
PT87073B (pt) 1992-07-31
JPH0667929B2 (ja) 1994-08-31
KR960012370B1 (ko) 1996-09-20
FI881404A (fi) 1988-09-26
EP0283992A3 (en) 1989-06-14
FI89798C (fi) 1993-11-25
IL85823A (en) 1993-05-13
FI881404A0 (fi) 1988-03-24
PT87073A (pt) 1988-04-01
IE880893L (en) 1988-09-25
FI89798B (fi) 1993-08-13
CY1837A (en) 1995-12-01
DK168336B1 (da) 1994-03-14
KR880011147A (ko) 1988-10-26
ATE80626T1 (de) 1992-10-15
CA1313875C (en) 1993-02-23
JPS63277674A (ja) 1988-11-15
TNSN88025A1 (fr) 1990-07-10
NO881306L (no) 1988-09-26
EP0283992B1 (en) 1992-09-16
MA21227A1 (fr) 1988-10-01
HU204819B (en) 1992-02-28
ES2044991T3 (es) 1994-01-16
NZ223799A (en) 1989-12-21
CN1038588C (zh) 1998-06-03
EP0283992A2 (en) 1988-09-28
DK163288A (da) 1988-09-26
IE61802B1 (en) 1994-11-30
AU600107B2 (en) 1990-08-02
DK163288D0 (da) 1988-03-24
ZA882118B (en) 1989-11-29
GR3006420T3 (no) 1993-06-21
DE3874576T2 (de) 1993-02-18
NO881306D0 (no) 1988-03-24
CN88101660A (zh) 1988-11-09
IL85823A0 (en) 1988-09-30
DE3874576D1 (de) 1992-10-22
HUT50333A (en) 1990-01-29
PH25023A (en) 1991-01-28
NO168476B (no) 1991-11-18
SU1635900A3 (ru) 1991-03-15
AU1358588A (en) 1988-09-29

Similar Documents

Publication Publication Date Title
NO168476C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-(4-(4-(4-(((2,4-difluorfenyl)-2-(1h-azolylmetyl)-1,3-dioxolan-4-yl)metoksy)fenyl)-1-piperazinyl)fenyl)triazoloner.
NO167917C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive, nye derivater av ((4-(4-(4-fenyl-1-piperazinyl)fenoksymetyl)-1,3-dioksolan-2-yl)metyl)-1h-imidazoler og -1h-1,2,4-triazoler
NO175477C (no) Analogifremgangsmåte for fremstilling av antifungale 4-(4-(4-(4-((2-(2,4-difluorfenyl)-2-(1H-azolylmetyl)-1,3-dioksolan-4-yl)metoksy)fenyl)-1-piperazinyl)fenyl)triazoloner og -imidazoloner

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