DE3874576D1 - 4-(4-(4-(4-((2-(2,4-difluorophenyl)-2-(1h-azolylmethyl)-1,3-dioxolan-4-yl)-methoxy)phenyl)-1-piperazinyl)phenyl)triazolone. - Google Patents

4-(4-(4-(4-((2-(2,4-difluorophenyl)-2-(1h-azolylmethyl)-1,3-dioxolan-4-yl)-methoxy)phenyl)-1-piperazinyl)phenyl)triazolone.

Info

Publication number
DE3874576D1
DE3874576D1 DE8888104473T DE3874576T DE3874576D1 DE 3874576 D1 DE3874576 D1 DE 3874576D1 DE 8888104473 T DE8888104473 T DE 8888104473T DE 3874576 T DE3874576 T DE 3874576T DE 3874576 D1 DE3874576 D1 DE 3874576D1
Authority
DE
Germany
Prior art keywords
phenyl
6alkyl
azolylmethyl
dioxolan
difluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888104473T
Other languages
English (en)
Other versions
DE3874576T2 (de
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Der Veken Louis Jozef Elis Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE3874576D1 publication Critical patent/DE3874576D1/de
Application granted granted Critical
Publication of DE3874576T2 publication Critical patent/DE3874576T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
DE8888104473T 1987-03-25 1988-03-21 4-(4-(4-(4-((2-(2,4-difluorophenyl)-2-(1h-azolylmethyl)-1,3-dioxolan-4-yl)-methoxy)phenyl)-1-piperazinyl)phenyl)triazolone. Expired - Fee Related DE3874576T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3020787A 1987-03-25 1987-03-25

Publications (2)

Publication Number Publication Date
DE3874576D1 true DE3874576D1 (de) 1992-10-22
DE3874576T2 DE3874576T2 (de) 1993-02-18

Family

ID=21853062

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888104473T Expired - Fee Related DE3874576T2 (de) 1987-03-25 1988-03-21 4-(4-(4-(4-((2-(2,4-difluorophenyl)-2-(1h-azolylmethyl)-1,3-dioxolan-4-yl)-methoxy)phenyl)-1-piperazinyl)phenyl)triazolone.

Country Status (25)

Country Link
EP (1) EP0283992B1 (de)
JP (1) JPH0667929B2 (de)
KR (1) KR960012370B1 (de)
CN (1) CN1038588C (de)
AT (1) ATE80626T1 (de)
AU (1) AU600107B2 (de)
CA (1) CA1313875C (de)
CY (1) CY1837A (de)
DE (1) DE3874576T2 (de)
DK (1) DK168336B1 (de)
ES (1) ES2044991T3 (de)
FI (1) FI89798C (de)
GR (1) GR3006420T3 (de)
HK (1) HK50395A (de)
HU (1) HU204819B (de)
IE (1) IE61802B1 (de)
IL (1) IL85823A (de)
MA (1) MA21227A1 (de)
NO (1) NO168476C (de)
NZ (1) NZ223799A (de)
PH (1) PH25023A (de)
PT (1) PT87073B (de)
SU (1) SU1635900A3 (de)
TN (1) TNSN88025A1 (de)
ZA (1) ZA882118B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
US5075309A (en) * 1989-06-09 1991-12-24 Janssen Pharmaceutica N.V. Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
WO1993007847A1 (en) * 1991-10-15 1993-04-29 Kenneth Vincent Mason Anti-seborrhoeic formulation
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
TW218017B (de) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
NZ278882A (en) * 1994-01-24 1997-06-24 Janssen Pharmaceutica Nv Piperazine-containing azole antifungal compounds
CZ286476B6 (en) * 1994-10-27 2000-04-12 Janssen Pharmaceutica Nv Heteroaryl substituted derivatives of 1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-alkyl-3H-1,2,4-triazol-3-one, process and intermediates for their preparation and pharmaceutical preparations containing thereof
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
TW457240B (en) * 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US20030224006A1 (en) 2002-03-01 2003-12-04 Zaworotko Michael J. Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
EP1511490A4 (de) * 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc Neue kristalline conazol-formen und verwandte prozesse, pharmazeutische zusammensetzungen und verfahren
EP1515703A1 (de) 2002-06-21 2005-03-23 Transform Pharmaceuticals, Inc. Pharmazeutische zusammensetzungen mit verbesserter auflösung
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP1742941A1 (de) * 2004-04-22 2007-01-17 Transform Pharmaceuticals, Inc. Neue kristalline formen von saperconazol und zugehörige prozesse, pharmazeutische zusammensetzungen und verfahren
WO2011144653A1 (en) * 2010-05-19 2011-11-24 Sandoz Ag Process for the preparation of chiral triazolones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles

Also Published As

Publication number Publication date
AU1358588A (en) 1988-09-29
FI881404A0 (fi) 1988-03-24
AU600107B2 (en) 1990-08-02
ES2044991T3 (es) 1994-01-16
FI881404A (fi) 1988-09-26
FI89798B (fi) 1993-08-13
ZA882118B (en) 1989-11-29
EP0283992A3 (en) 1989-06-14
NO168476C (no) 1992-02-26
IE880893L (en) 1988-09-25
JPS63277674A (ja) 1988-11-15
CN1038588C (zh) 1998-06-03
GR3006420T3 (de) 1993-06-21
HK50395A (en) 1995-04-13
MA21227A1 (fr) 1988-10-01
DK168336B1 (da) 1994-03-14
DK163288D0 (da) 1988-03-24
IL85823A0 (en) 1988-09-30
ATE80626T1 (de) 1992-10-15
IE61802B1 (en) 1994-11-30
HU204819B (en) 1992-02-28
EP0283992B1 (de) 1992-09-16
IL85823A (en) 1993-05-13
EP0283992A2 (de) 1988-09-28
CY1837A (en) 1995-12-01
PT87073A (pt) 1988-04-01
HUT50333A (en) 1990-01-29
PH25023A (en) 1991-01-28
NZ223799A (en) 1989-12-21
FI89798C (fi) 1993-11-25
KR960012370B1 (ko) 1996-09-20
DE3874576T2 (de) 1993-02-18
NO881306L (no) 1988-09-26
NO881306D0 (no) 1988-03-24
DK163288A (da) 1988-09-26
TNSN88025A1 (fr) 1990-07-10
PT87073B (pt) 1992-07-31
SU1635900A3 (ru) 1991-03-15
CN88101660A (zh) 1988-11-09
JPH0667929B2 (ja) 1994-08-31
CA1313875C (en) 1993-02-23
KR880011147A (ko) 1988-10-26
NO168476B (no) 1991-11-18

Similar Documents

Publication Publication Date Title
DE3874576D1 (de) 4-(4-(4-(4-((2-(2,4-difluorophenyl)-2-(1h-azolylmethyl)-1,3-dioxolan-4-yl)-methoxy)phenyl)-1-piperazinyl)phenyl)triazolone.
DK625586A (da) Derivater af ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoler og -1h-1,2,4-triazoler
NO175477C (no) Analogifremgangsmåte for fremstilling av antifungale 4-(4-(4-(4-((2-(2,4-difluorfenyl)-2-(1H-azolylmetyl)-1,3-dioksolan-4-yl)metoksy)fenyl)-1-piperazinyl)fenyl)triazoloner og -imidazoloner

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee