IL81421A - 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2h,4h)-diones,their preparation and anti-protozoal compositions containing them - Google Patents
5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2h,4h)-diones,their preparation and anti-protozoal compositions containing themInfo
- Publication number
- IL81421A IL81421A IL81421A IL8142187A IL81421A IL 81421 A IL81421 A IL 81421A IL 81421 A IL81421 A IL 81421A IL 8142187 A IL8142187 A IL 8142187A IL 81421 A IL81421 A IL 81421A
- Authority
- IL
- Israel
- Prior art keywords
- diones
- triazine
- dihydro
- substituted phenyl
- compositions containing
- Prior art date
Links
- 239000003904 antiprotozoal agent Substances 0.000 title abstract 2
- 230000000842 anti-protozoal effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- -1 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-diones Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Fodder In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL9692587A IL96925A (en) | 1986-01-30 | 1987-01-29 | 2-phenyl-1,2,4-triazine-3,5-dione derivatives,their preparation and anti-protozoal compositions containing them |
IL96925A IL96925A0 (en) | 1986-01-30 | 1991-01-11 | 2-phenyl-1,2,4-triazine-3,5-dione derivatives,their preparation and anti-protozoal compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868602342A GB8602342D0 (en) | 1986-01-30 | 1986-01-30 | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
Publications (2)
Publication Number | Publication Date |
---|---|
IL81421A0 IL81421A0 (en) | 1987-08-31 |
IL81421A true IL81421A (en) | 1991-11-21 |
Family
ID=10592258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL81421A IL81421A (en) | 1986-01-30 | 1987-01-29 | 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2h,4h)-diones,their preparation and anti-protozoal compositions containing them |
Country Status (21)
Country | Link |
---|---|
US (3) | US4767760A (xx) |
EP (1) | EP0232932B1 (xx) |
JP (2) | JPH0813806B2 (xx) |
CN (1) | CN1017049B (xx) |
AT (1) | ATE59644T1 (xx) |
AU (1) | AU586731B2 (xx) |
CA (2) | CA1288772C (xx) |
DE (1) | DE3766839D1 (xx) |
DK (2) | DK169032B1 (xx) |
ES (1) | ES2031876T3 (xx) |
FI (1) | FI94634C (xx) |
GB (1) | GB8602342D0 (xx) |
GR (1) | GR3001392T3 (xx) |
IE (1) | IE59510B1 (xx) |
IL (1) | IL81421A (xx) |
NO (1) | NO172690C (xx) |
NZ (1) | NZ218973A (xx) |
PT (1) | PT84218B (xx) |
RU (1) | RU2017736C1 (xx) |
SU (1) | SU1595339A3 (xx) |
ZA (1) | ZA87672B (xx) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4097779A (en) * | 1976-04-05 | 1978-06-27 | Gte Sylvania Incorporated | Fluorescent lamp containing a cathode heater circuit disconnect device |
US4156831A (en) * | 1978-05-24 | 1979-05-29 | Gte Sylvania Incorporated | Fluorescent lamp having heater circuit disconnect device |
GB8602342D0 (en) * | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
DE3826058A1 (de) * | 1988-07-30 | 1990-02-08 | Bayer Ag | Mittel gegen fischparasiten |
EP0377903A3 (de) * | 1989-01-09 | 1991-07-17 | Bayer Ag | Substituierte Hexahydro-1,2,4-triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
DE58905324D1 (de) * | 1989-01-09 | 1993-09-23 | Bayer Ag | Mittel gegen protozoen bei insekten. |
CN1044905A (zh) * | 1989-02-16 | 1990-08-29 | 赫彻斯特股份公司 | 鱼和昆虫寄生虫对抗剂 |
CA2012004A1 (en) * | 1989-03-15 | 1990-09-15 | Frank Ellis | Chemical compounds |
DE4120138A1 (de) * | 1991-06-19 | 1992-12-24 | Bayer Ag | Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung |
EP0476439A1 (de) * | 1990-09-18 | 1992-03-25 | Bayer Ag | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
US5994355A (en) | 1993-10-15 | 1999-11-30 | Takeda Chemical Industries, Ltd. | 1, 2, 4-Triazin-3-one derivatives, production and use thereof |
EP0737672B1 (en) * | 1995-04-14 | 2001-10-04 | Takeda Schering-Plough Animal Health K.K. | Method of producing triazine derivatives |
US5747476A (en) * | 1996-07-17 | 1998-05-05 | Mortar & Pestle Veterinary Pharmacy, Inc. | Treatment of equine protozoal myeloencephalitis |
EP0831088B1 (en) * | 1996-08-30 | 2002-11-27 | Takeda Schering-Plough Animal Health K.K. | 1,2,4-Triazine-3,5-dione derivatives as anticoccidial agents |
US5883095A (en) * | 1997-08-07 | 1999-03-16 | University Of Kentucky Research Foundation | Formulations and methods to treat and prevent equine protozoal myeloencephalitis |
BR9808114A (pt) * | 1997-03-31 | 2000-03-08 | David Granstrom | Formulação de ração para cavalos utilizável para tratar epm, processos para tratar pm em um cavalo que necessita deste tratamento, para prevenir infecção com s. neutrona em cavalos, e, para exterminar s. neurona em cavalos |
US5830893A (en) * | 1997-04-23 | 1998-11-03 | Mortar & Pestle Veterinary Pharmacy, Inc. | Treatment of equine protozoan myeloencephalitis using triazinediones |
EP1000040B1 (en) * | 1997-07-10 | 2007-06-13 | Janssen Pharmaceutica N.V. | Il-5 inhibiting 6-azauracil derivatives |
US6867207B2 (en) * | 1997-07-10 | 2005-03-15 | Janssen Pharmaceutica N.V. | IL-5 inhibiting 6-azauracil derivatives |
TR199903249T2 (xx) | 1997-07-10 | 2000-09-21 | Janssen Pharmaceutica N.V. | �l-5 inhibit�rleri olarak 6-Azaurasil t�revleri. |
US6294536B1 (en) | 1997-08-29 | 2001-09-25 | Takeda Schering-Plough Animal Health K.K. | Triazine derivatives, their production and use |
WO2000006172A1 (en) * | 1998-07-27 | 2000-02-10 | Mortar & Pestle Veterinary Pharmacy, Inc. | Treatment of equine protozoan myeloencephalitis using triazinediones |
EP0987265A1 (en) | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
CN1189175C (zh) * | 1998-10-08 | 2005-02-16 | 高新研究公司 | 用于预防和治疗原虫病的组合物和方法 |
NZ512748A (en) * | 1998-12-18 | 2004-05-28 | Janssen Pharmaceutica Nv | IL-5 inhibiting 6-azauracil derivatives |
IL147976A0 (en) | 1999-08-06 | 2002-09-12 | Janssen Pharmaceutica Nv | Interleukin-5 inhibiting 6-azauracil derivatives |
PA8591801A1 (es) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
GB0622472D0 (en) * | 2006-11-10 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel heterocyclic derivatives |
CN107746390B (zh) * | 2017-11-21 | 2021-03-16 | 连云港市亚晖医药化工有限公司 | 抗球虫药地克珠利的制备方法 |
CN113999139A (zh) * | 2021-12-03 | 2022-02-01 | 杭州臻峰科技有限公司 | 制备2,6-二氯-α-(4-氯代苯基) -4-硝基苯乙腈的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3905971A (en) * | 1971-03-29 | 1975-09-16 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
US3912723A (en) * | 1971-03-29 | 1975-10-14 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
GB1448696A (en) * | 1973-05-29 | 1976-09-08 | Pfizer | 2-phqnyl-astriazine-3,4-2h,4h-diones |
DE3408924A1 (de) * | 1984-03-12 | 1985-09-26 | Hoechst Ag, 6230 Frankfurt | Substituierte 2-phenyl-hexahydro-1,2,4-triazin-3,5-dione, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
CA1244024A (en) * | 1984-08-01 | 1988-11-01 | Gustaaf M. Boeckx | .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES |
US4631278A (en) * | 1984-08-01 | 1986-12-23 | Janssen Pharmaceutica N.V. | Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor |
GB8602342D0 (en) * | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
-
1986
- 1986-01-30 GB GB868602342A patent/GB8602342D0/en active Pending
- 1986-12-29 CA CA000526395A patent/CA1288772C/en not_active Expired - Fee Related
-
1987
- 1987-01-16 NZ NZ218973A patent/NZ218973A/xx unknown
- 1987-01-16 RU SU874028812A patent/RU2017736C1/ru active
- 1987-01-21 EP EP87200088A patent/EP0232932B1/en not_active Expired - Lifetime
- 1987-01-21 US US07/005,550 patent/US4767760A/en not_active Expired - Lifetime
- 1987-01-21 ES ES198787200088T patent/ES2031876T3/es not_active Expired - Lifetime
- 1987-01-21 DE DE8787200088T patent/DE3766839D1/de not_active Expired - Fee Related
- 1987-01-21 AT AT87200088T patent/ATE59644T1/de not_active IP Right Cessation
- 1987-01-29 AU AU68134/87A patent/AU586731B2/en not_active Ceased
- 1987-01-29 IE IE23187A patent/IE59510B1/en not_active IP Right Cessation
- 1987-01-29 ZA ZA87672A patent/ZA87672B/xx unknown
- 1987-01-29 DK DK048187A patent/DK169032B1/da not_active IP Right Cessation
- 1987-01-29 PT PT84218A patent/PT84218B/pt not_active IP Right Cessation
- 1987-01-29 IL IL81421A patent/IL81421A/xx not_active IP Right Cessation
- 1987-01-29 NO NO870378A patent/NO172690C/no unknown
- 1987-01-30 FI FI870421A patent/FI94634C/fi not_active IP Right Cessation
- 1987-01-30 JP JP62018748A patent/JPH0813806B2/ja not_active Expired - Lifetime
- 1987-02-02 CN CN87100531A patent/CN1017049B/zh not_active Expired
-
1988
- 1988-04-22 US US07/184,740 patent/US4912106A/en not_active Expired - Lifetime
- 1988-06-09 SU SU884355878A patent/SU1595339A3/ru active
-
1989
- 1989-07-06 CA CA000604998A patent/CA1302411C/en not_active Expired - Fee Related
- 1989-11-24 US US07/440,828 patent/US4952570A/en not_active Expired - Lifetime
-
1991
- 1991-01-29 GR GR91400093T patent/GR3001392T3/el unknown
-
1993
- 1993-06-04 DK DK93651A patent/DK65193D0/da unknown
-
1995
- 1995-04-06 JP JP7104622A patent/JP2622510B2/ja not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |