ES2150642T3 - Nuevos derivados piridinicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. - Google Patents
Nuevos derivados piridinicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2150642T3 ES2150642T3 ES96400778T ES96400778T ES2150642T3 ES 2150642 T3 ES2150642 T3 ES 2150642T3 ES 96400778 T ES96400778 T ES 96400778T ES 96400778 T ES96400778 T ES 96400778T ES 2150642 T3 ES2150642 T3 ES 2150642T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- aryl
- new
- substd
- arylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A LOS COMPUESTOS DE FORMULA (I) EN LA QUE R{SUB,5} REPRESENTA UN GRUPO DE FORMULA -A-B-Y EN EL QUE A REPRESENTA UNA CADENA (C{SUB,1-6})ALQUILENO NO SUSTITUIDA O SUSTITUIDA POR UNO O VARIOS ALQUILOS, -B REPRESENTA UN GRUPO B{SUB,1}, B{SUB,2} O B{SUB,3}, Y X REPRESENTA UN OXIGENO, UN AZUFRE O EN GRUPO. LOS COMPUESTOS DE LA INVENCION Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA MELATONINERGICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9504504A FR2732969B1 (fr) | 1995-04-14 | 1995-04-14 | Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2150642T3 true ES2150642T3 (es) | 2000-12-01 |
Family
ID=9478127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96400778T Expired - Lifetime ES2150642T3 (es) | 1995-04-14 | 1996-04-11 | Nuevos derivados piridinicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5714495A (es) |
EP (1) | EP0737685B1 (es) |
JP (1) | JP3723274B2 (es) |
CN (1) | CN1058967C (es) |
AT (1) | ATE194839T1 (es) |
AU (1) | AU700071B2 (es) |
CA (1) | CA2174033C (es) |
DE (1) | DE69609371T2 (es) |
DK (1) | DK0737685T5 (es) |
ES (1) | ES2150642T3 (es) |
FR (1) | FR2732969B1 (es) |
GR (1) | GR3034620T3 (es) |
NO (1) | NO305988B1 (es) |
NZ (1) | NZ286360A (es) |
PT (1) | PT737685E (es) |
ZA (1) | ZA962934B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1178045T3 (da) * | 1997-04-09 | 2003-06-23 | Pfizer | Azaindol-ethylaminderivater som nikotinacetylcholinreceptor-bindingsmidler |
US5977131A (en) * | 1997-04-09 | 1999-11-02 | Pfizer Inc. | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents |
FR2763335B1 (fr) * | 1997-05-16 | 2000-11-24 | Adir | Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AU745579B2 (en) | 1997-10-20 | 2002-03-21 | F. Hoffmann-La Roche Ag | Bicyclic kinase inhibitors |
US6228867B1 (en) | 1998-04-02 | 2001-05-08 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6025366A (en) * | 1998-04-02 | 2000-02-15 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
WO1999051231A1 (en) * | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
JP2002510631A (ja) * | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
JP2002510629A (ja) * | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
AU3210799A (en) * | 1998-04-02 | 1999-10-25 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6110931A (en) * | 1998-04-02 | 2000-08-29 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
US6696439B1 (en) | 1999-02-26 | 2004-02-24 | Eli Lilly And Company | 5-HT1F agonists |
IL144355A0 (en) * | 1999-02-26 | 2002-05-23 | Lilly Co Eli | 5-ht1f agonists |
FR2799757B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
IL150388A0 (en) * | 1999-12-24 | 2002-12-01 | Aventis Pharma Ltd | Azaindoles |
GB0108770D0 (en) | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
US6921762B2 (en) | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
EP1474420B1 (en) * | 2002-02-01 | 2012-03-14 | AstraZeneca AB | Quinazoline compounds |
JP2005534619A (ja) | 2002-03-28 | 2005-11-17 | エーザイ株式会社 | C−junn−末端キナーゼ阻害剤としてのアザインドール |
IL164187A0 (en) | 2002-03-28 | 2005-12-18 | Eisai Co Ltd | 7-Azaindole derivatives and pharmaceutical compositions containing the same |
ES2294330T3 (es) | 2002-08-02 | 2008-04-01 | MERCK & CO., INC. | Derivados de furo(2,3-b)piridina sustituidos. |
GB0305142D0 (en) * | 2003-03-06 | 2003-04-09 | Eisai London Res Lab Ltd | Synthesis |
EP2295433A3 (en) * | 2003-03-06 | 2011-07-06 | Eisai R&D Management Co., Ltd. | JNK inhibitors |
EP1628975A2 (en) | 2003-05-16 | 2006-03-01 | Eisai Co., Ltd. | Jnk inhibitors |
GB0405055D0 (en) * | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
KR100958829B1 (ko) * | 2004-09-03 | 2010-05-25 | 주식회사유한양행 | 피롤로[2,3-c]피리딘 유도체 및 그의 제조방법 |
ES2426920T3 (es) * | 2004-09-03 | 2013-10-25 | Yuhan Corporation | Derivados de pirrolo[3,2-B]piridina y procesos para su preparación |
US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
GB0516156D0 (en) * | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
JP2009507024A (ja) * | 2005-09-01 | 2009-02-19 | アレイ バイオファーマ、インコーポレイテッド | Raf阻害剤化合物およびその使用方法 |
CL2007002617A1 (es) | 2006-09-11 | 2008-05-16 | Sanofi Aventis | Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto. |
EP2100895B1 (en) * | 2006-12-08 | 2012-03-07 | Takeda Pharmaceutical Company Limited | Tricyclic compound and medical use thereof |
WO2011109932A1 (en) * | 2010-03-09 | 2011-09-15 | F.Hoffmann-La Roche Ag | Novel process for the manufacture of 5-halogenated-7-azaindoles |
EP2940022B1 (en) * | 2014-04-30 | 2020-09-02 | Masarykova Univerzita | Furopyridines as inhibitors of protein kinases |
CN106045995B (zh) * | 2016-06-13 | 2017-07-11 | 菏泽学院 | 一种5‑溴‑1H‑吡咯并[2,3‑b]吡啶的合成方法 |
CN113874015B (zh) | 2018-12-21 | 2024-05-24 | 细胞基因公司 | Ripk2的噻吩并吡啶抑制剂 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
US5552428A (en) * | 1992-06-24 | 1996-09-03 | Instituto Farmacologico Lombardo-Iflo, S.A.S. | Compounds effective in the treatment of circadian rhythms and related disorders, the novel pharmaceutical preparations and novel method of application |
WO1995033748A1 (en) * | 1994-06-09 | 1995-12-14 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
US5965582A (en) * | 1994-08-03 | 1999-10-12 | Asta Medica Aktiengesellschaft | N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect |
US5541228A (en) * | 1994-10-14 | 1996-07-30 | Bristol-Myers Squibb Co. | Melatonergic agents |
-
1995
- 1995-04-14 FR FR9504504A patent/FR2732969B1/fr not_active Expired - Fee Related
-
1996
- 1996-04-11 PT PT96400778T patent/PT737685E/pt unknown
- 1996-04-11 DE DE69609371T patent/DE69609371T2/de not_active Expired - Fee Related
- 1996-04-11 ES ES96400778T patent/ES2150642T3/es not_active Expired - Lifetime
- 1996-04-11 DK DK96400778T patent/DK0737685T5/da active
- 1996-04-11 AT AT96400778T patent/ATE194839T1/de not_active IP Right Cessation
- 1996-04-11 EP EP96400778A patent/EP0737685B1/fr not_active Expired - Lifetime
- 1996-04-12 CA CA002174033A patent/CA2174033C/fr not_active Expired - Fee Related
- 1996-04-12 AU AU50629/96A patent/AU700071B2/en not_active Ceased
- 1996-04-12 US US08/631,234 patent/US5714495A/en not_active Expired - Fee Related
- 1996-04-12 CN CN96104624A patent/CN1058967C/zh not_active Expired - Fee Related
- 1996-04-12 NZ NZ286360A patent/NZ286360A/en unknown
- 1996-04-12 ZA ZA962934A patent/ZA962934B/xx unknown
- 1996-04-12 NO NO961457A patent/NO305988B1/no unknown
- 1996-04-15 JP JP09242896A patent/JP3723274B2/ja not_active Expired - Fee Related
-
2000
- 2000-10-13 GR GR20000402305T patent/GR3034620T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GR3034620T3 (en) | 2001-01-31 |
CA2174033C (fr) | 2001-07-24 |
NO961457L (no) | 1996-10-15 |
DK0737685T5 (da) | 2001-01-02 |
NO961457D0 (no) | 1996-04-12 |
AU5062996A (en) | 1996-10-24 |
CN1058967C (zh) | 2000-11-29 |
ATE194839T1 (de) | 2000-08-15 |
JPH08291172A (ja) | 1996-11-05 |
DE69609371D1 (de) | 2000-08-24 |
DK0737685T3 (da) | 2000-10-09 |
PT737685E (pt) | 2000-10-31 |
EP0737685B1 (fr) | 2000-07-19 |
NO305988B1 (no) | 1999-08-30 |
FR2732969B1 (fr) | 1997-05-16 |
DE69609371T2 (de) | 2001-02-22 |
NZ286360A (en) | 1997-09-22 |
FR2732969A1 (fr) | 1996-10-18 |
CN1139111A (zh) | 1997-01-01 |
EP0737685A1 (fr) | 1996-10-16 |
US5714495A (en) | 1998-02-03 |
AU700071B2 (en) | 1998-12-17 |
CA2174033A1 (fr) | 1996-10-15 |
JP3723274B2 (ja) | 2005-12-07 |
ZA962934B (en) | 1996-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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