ES2140381T3 - Nuevas 4h-pirido-(1,2-a)pirimidin-4-onas disustituidas en 2,9. - Google Patents

Nuevas 4h-pirido-(1,2-a)pirimidin-4-onas disustituidas en 2,9.

Info

Publication number
ES2140381T3
ES2140381T3 ES91200897T ES91200897T ES2140381T3 ES 2140381 T3 ES2140381 T3 ES 2140381T3 ES 91200897 T ES91200897 T ES 91200897T ES 91200897 T ES91200897 T ES 91200897T ES 2140381 T3 ES2140381 T3 ES 2140381T3
Authority
ES
Spain
Prior art keywords
sub
alkyl
compounds
methyl
furanyll
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91200897T
Other languages
English (en)
Inventor
Ludo Edmond Josephine Kennis
Jan Vandenberk
Heertum Albertus Hendricus Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2140381T3 publication Critical patent/ES2140381T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)

Abstract

COMPUESTOS DE LA FORMULA SUS SALES DE ADICION ACIDA ACEPTABLES FARMACEUTICAMENTE, Y SUS FORMAS ISOMERICAS ESTEROQUIMICAS, DONDE ALK ES ALCANEDIL C SUB 1 EVADO 1 REPRESENTA ALQUILO C SUB 1-4, HIDROXIALQUILO C SUB 1-4, CARBOXALDEIDO, CARBOXIL, ALQUILCARBONILOXI C SUB 1-10 ALQUILO C SUB 1-4; CADA R (AL CUADRADO) REPRESENTA HIDROGENO O ALQUILO C SUB 1-4; R ELEVADO 3 REPRESENTA ALQUILO C SUB 1-4, HIDROXI ALQUILO C SUB 1-4 O METILO SUSTITUIDO CON FENILO, 5-METILO-2-FURANILO O 3-PIRIDINILO; Y R ELEVADO 4 REPRESENTA ALQUILO C SUB 1-3, FENILO, 5-METILO-2-FURANILO O 3 PIRIDINILO, CUYO COMPUESTOS SON ANTAGONISTAS POTENTES DE DOPAMINA Y SON UTILES TERAPEUTICAMENTE EN TRATAR A PACIENTES QUE SUFREN DE PSICOSIS AGUDA. COMPOSICIONES CONTENIENDO ESTOS COMPUESTOS COMO INGREDIENTE ACTIVO Y PROCESOS DE PREPARAR DICHOS COMPUESTOS Y COMPOSICIONES.
ES91200897T 1990-04-19 1991-04-16 Nuevas 4h-pirido-(1,2-a)pirimidin-4-onas disustituidas en 2,9. Expired - Lifetime ES2140381T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909008850A GB9008850D0 (en) 1990-04-19 1990-04-19 Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

Publications (1)

Publication Number Publication Date
ES2140381T3 true ES2140381T3 (es) 2000-03-01

Family

ID=10674694

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91200897T Expired - Lifetime ES2140381T3 (es) 1990-04-19 1991-04-16 Nuevas 4h-pirido-(1,2-a)pirimidin-4-onas disustituidas en 2,9.

Country Status (26)

Country Link
US (1) US5482943A (es)
EP (1) EP0453042B1 (es)
JP (1) JP3216889B2 (es)
KR (1) KR100190297B1 (es)
CN (1) CN1027506C (es)
AT (1) ATE186301T1 (es)
AU (1) AU636969B2 (es)
BG (2) BG60394B1 (es)
CA (1) CA2040086C (es)
CZ (1) CZ281135B6 (es)
DE (1) DE69131759T2 (es)
DK (1) DK0453042T3 (es)
ES (1) ES2140381T3 (es)
FI (1) FI96206C (es)
GB (1) GB9008850D0 (es)
GR (1) GR3032122T3 (es)
HU (1) HUT57763A (es)
IE (1) IE911301A1 (es)
IL (1) IL97892A (es)
NO (1) NO176840C (es)
NZ (1) NZ237713A (es)
PL (2) PL169740B1 (es)
PT (1) PT97395B (es)
RU (1) RU2037495C1 (es)
SK (1) SK279005B6 (es)
ZA (1) ZA912913B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2050069B1 (es) * 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
AU669196B2 (en) 1992-07-13 1996-05-30 Janssen Pharmaceutica N.V. Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them
CA2175372C (en) * 1993-11-23 2006-02-21 Jan Vandenberk Novel 9-hydroxy-pyrido[1,2-a]pyrimidin-4-one ether derivatives
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
ES2141671B1 (es) * 1997-12-26 2001-01-01 Vita Invest Sa Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
HU227118B1 (en) * 2001-11-13 2010-07-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
ES2197801B1 (es) * 2002-03-05 2005-03-16 Ferrer Internacional,S.A Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
WO2004009591A1 (en) * 2002-07-22 2004-01-29 Aurobindo Pharma Ltd. A process for the preparation of antipsychotic risperidone
AU2003256006A1 (en) * 2002-08-30 2004-03-19 Sunil Sadanand Nadkarni Improved process for preparation of risperidone
KR20040025224A (ko) * 2002-09-18 2004-03-24 주식회사 대웅 2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-3-일)아세트알데히드 및 그 제조방법
CN100390146C (zh) * 2002-11-13 2008-05-28 斯索恩有限公司 制备利培酮的方法和用于该方法的中间体
EP1615924A1 (en) * 2003-04-22 2006-01-18 Synthon B.V. Water soluble salts of risperidone
HUP0401379A3 (en) * 2004-07-08 2006-04-28 Richter Gedeon Vegyeszet Process for the preparation of risperidon
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone
EP1690540A1 (en) * 2005-02-15 2006-08-16 Neuro3D Composition comprising ocaperidone
EP1695973A1 (en) * 2005-02-24 2006-08-30 Neuro3D Ocaperidone salt and pharmaceutical compositions containing the same
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
WO2009077551A1 (en) * 2007-12-18 2009-06-25 Janssen Pharmaceutica Nv Process for preparing risperidone
AU2023207848A1 (en) 2022-01-11 2024-07-04 Suven Life Sciences Limited Heteroalicyclic derivatives and their use in the treatment of cns disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4777252A (en) * 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives

Also Published As

Publication number Publication date
NZ237713A (en) 1992-09-25
EP0453042B1 (en) 1999-11-03
CA2040086C (en) 2003-12-30
RU2037495C1 (ru) 1995-06-19
AU636969B2 (en) 1993-05-13
IL97892A (en) 1995-03-30
CZ281135B6 (cs) 1996-06-12
NO176840B (no) 1995-02-27
IE911301A1 (en) 1991-10-23
IL97892A0 (en) 1992-06-21
GB9008850D0 (en) 1990-06-13
FI96206B (fi) 1996-02-15
DE69131759T2 (de) 2000-06-21
PT97395A (pt) 1992-01-31
CN1027506C (zh) 1995-01-25
JP3216889B2 (ja) 2001-10-09
NO911525L (no) 1991-10-21
CS9101099A2 (en) 1991-11-12
KR910018380A (ko) 1991-11-30
AU7436691A (en) 1991-10-24
NO176840C (no) 1995-06-07
HU911301D0 (en) 1991-10-28
EP0453042A1 (en) 1991-10-23
DE69131759D1 (de) 1999-12-09
ATE186301T1 (de) 1999-11-15
GR3032122T3 (en) 2000-04-27
FI911885A0 (fi) 1991-04-18
BG60394B1 (bg) 1995-02-28
CA2040086A1 (en) 1991-10-20
CN1055929A (zh) 1991-11-06
SK279005B6 (sk) 1998-05-06
FI96206C (fi) 1996-05-27
DK0453042T3 (da) 2000-04-25
PL169740B1 (pl) 1996-08-30
ZA912913B (en) 1992-12-30
FI911885A (fi) 1991-10-20
BG95241A (bg) 1993-12-24
HUT57763A (en) 1991-12-30
KR100190297B1 (ko) 1999-06-01
JPH04234882A (ja) 1992-08-24
PL169744B1 (pl) 1996-08-30
BG94282A (bg) 1993-12-24
US5482943A (en) 1996-01-09
PL289935A1 (en) 1992-04-06
NO911525D0 (no) 1991-04-18
PT97395B (pt) 1998-08-31

Similar Documents

Publication Publication Date Title
ES2140381T3 (es) Nuevas 4h-pirido-(1,2-a)pirimidin-4-onas disustituidas en 2,9.
DK51986A (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som insecticide midler
ES2118835T3 (es) 2-etil-1h-imidazo(4,5-c)quinolin-4-aminas antiviricas.
DE69618231D1 (de) TETRAHYDROIMIDAZOPYRIDOINDOLDIONE ALS cGMP SPEZIFISCHE PDE HEMMER
ES2053524T3 (es) Un procedimiento para preparar un compuesto quimico.
AR016762A1 (es) Compuestos del acido 4-bromo o 4-yodo fenilamino benzohidroxamico, formulaciones farmaceuticas y uso del mismo
DE69516540T2 (de) AMINO-IMIDAZO [4,5-c] CHINOLINE
ES2053508T3 (es) Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos.
SE8204879D0 (sv) Novel chemical intermediates
NO971538L (no) Purin- og guaninforbindelser som inhibitorer for PNP
YU47116B (sh) Postupak za dobijanje novih n-supstituisanih benzimidazolskih derivata
DE3065304D1 (en) Morpholine derivatives, pharmaceutical compositions containing them and processes for their preparation
HUP0002272A2 (hu) Piperazinszármazékok, eljárás előállításukra, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
HUP0103203A2 (hu) Azaadamantánszármazékok és ezeket tartalmazó gyógyszerkészítmények
AR007108A1 (es) Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes.
NO163735C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive alkyl-beta-carboliner.
ES2046671T3 (es) Un procedimiento para la preparacion de tetrahidroimidazo(1,4)benzodiazepin-2-tionas.
NO963331L (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
ES2131574T3 (es) Derivados de 1-(arilalquil-aminoalquil)imidazol, procedimientos de preparacion y uso como agentes terapeuticos.
MX9306394A (es) Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contiene
ES2052850T3 (es) Un procedimiento para preparar un compuesto de hidrazona.
EP0168921A3 (en) Chemical compounds
DK0888356T3 (da) Kondenserede 2,3-benzodiazepinderivater og deres anvendelse som AMPA-receptohaemmere
ATE282608T1 (de) Chinoxalindionen
HUP0003548A2 (hu) Tachikinin receptor antagonista hatású 2-acilamino-propán-aminok és az ezeket tartalmazó gyógyszerkészítmények

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 453042

Country of ref document: ES