FI941022A - Spirosykliset piperidiinijohdannaiset - Google Patents

Spirosykliset piperidiinijohdannaiset Download PDF

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Publication number
FI941022A
FI941022A FI941022A FI941022A FI941022A FI 941022 A FI941022 A FI 941022A FI 941022 A FI941022 A FI 941022A FI 941022 A FI941022 A FI 941022A FI 941022 A FI941022 A FI 941022A
Authority
FI
Finland
Prior art keywords
pct
compounds
piperidine derivatives
spirocyclic piperidine
sec
Prior art date
Application number
FI941022A
Other languages
English (en)
Swedish (sv)
Other versions
FI941022A0 (fi
FI105916B (fi
Inventor
Manoj C Desai
Lawrence A Vincent
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI941022A0 publication Critical patent/FI941022A0/fi
Publication of FI941022A publication Critical patent/FI941022A/fi
Application granted granted Critical
Publication of FI105916B publication Critical patent/FI105916B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
FI941022A 1993-03-04 1994-03-03 Menetelmä terapeuttisesti käyttökelpoisten 3R-3,7-difenyyli-1,8-diatsaspiro[5,5]undekaanijohdannaisten valmistamiseksi FI105916B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2638293A 1993-03-04 1993-03-04
US2638293 1993-03-04

Publications (3)

Publication Number Publication Date
FI941022A0 FI941022A0 (fi) 1994-03-03
FI941022A true FI941022A (fi) 1994-09-05
FI105916B FI105916B (fi) 2000-10-31

Family

ID=21831515

Family Applications (1)

Application Number Title Priority Date Filing Date
FI941022A FI105916B (fi) 1993-03-04 1994-03-03 Menetelmä terapeuttisesti käyttökelpoisten 3R-3,7-difenyyli-1,8-diatsaspiro[5,5]undekaanijohdannaisten valmistamiseksi

Country Status (13)

Country Link
US (1) US5688806A (fi)
EP (1) EP0687268B1 (fi)
JP (1) JP2832754B2 (fi)
CN (1) CN1099035A (fi)
AT (1) ATE166650T1 (fi)
AU (1) AU6226494A (fi)
CA (1) CA2157117C (fi)
DE (1) DE69318854T2 (fi)
DK (1) DK0687268T3 (fi)
ES (1) ES2116587T3 (fi)
FI (1) FI105916B (fi)
IL (1) IL108769A0 (fi)
WO (1) WO1994020500A1 (fi)

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GB9613969D0 (en) * 1996-07-03 1996-09-04 Merck Sharp & Dohme Therapeutic agents
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US5929094A (en) * 1996-10-25 1999-07-27 Merck & Co., Inc. Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists
US5789422A (en) * 1996-10-28 1998-08-04 Schering Corporation Substituted arylalkylamines as neurokinin antagonists
US5945428A (en) * 1996-11-01 1999-08-31 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
JP2001504853A (ja) * 1996-12-02 2001-04-10 メルク シヤープ エンド ドーム リミテツド 物質使用障害の治療のためのｎｋ−１受容体拮抗薬の使用
GB9708484D0 (en) 1997-04-25 1997-06-18 Merck Sharp & Dohme Therapeutic agents
GB9711114D0 (en) * 1997-05-29 1997-07-23 Merck Sharp & Dohme Therapeutic agents
US7101547B1 (en) 1999-01-22 2006-09-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies
GB9902881D0 (en) 1999-02-09 1999-03-31 Merck Sharp & Dohme Therapeutic agents
CA2324116A1 (en) * 1999-10-25 2001-04-25 Susan Beth Sobolov-Jaynes Nk-1 receptor antagonists and eletriptan for the treatment of migraine
US7235531B2 (en) 1999-12-21 2007-06-26 Takeda Pharmaceutical Company Tachykinin-like polypeptides and use thereof
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
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PL367944A1 (en) * 2001-07-20 2005-03-07 Pfizer Products Inc. Use of nk-1 receptor antagonists to modify unwanted behavior in dogs, cats and horses
ZA200701232B (en) 2004-07-15 2008-08-27 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
RU2387647C9 (ru) * 2004-08-20 2011-05-27 Таргасепт, Инк. Применение n-арилдиазаспироциклических соединений для лечения зависимостей
ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
EP1904069B1 (en) 2005-07-15 2018-06-13 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US8293900B2 (en) 2005-09-29 2012-10-23 Merck Sharp & Dohme Corp Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
CA2664113C (en) 2006-09-22 2013-05-28 Merck & Co., Inc. Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
BRPI0806245B1 (pt) 2007-01-10 2022-01-25 Msd Italia S.R.L. Compostos de fórmula i e seus usos
CA2682727C (en) 2007-04-02 2016-03-22 Banyu Pharmaceutical Co., Ltd. Indoledione derivative
EP2170076B1 (en) 2007-06-27 2016-05-18 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8598184B2 (en) 2008-03-03 2013-12-03 Tiger Pharmatech Protein kinase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
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US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
US8946216B2 (en) 2010-09-01 2015-02-03 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
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JP2014514321A (ja) 2011-04-21 2014-06-19 メルク・シャープ・アンド・ドーム・コーポレーション インスリン様増殖因子１受容体阻害剤
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Also Published As

Publication number Publication date
FI941022A0 (fi) 1994-03-03
JPH08503226A (ja) 1996-04-09
US5688806A (en) 1997-11-18
FI105916B (fi) 2000-10-31
AU6226494A (en) 1994-09-26
DE69318854D1 (de) 1998-07-02
JP2832754B2 (ja) 1998-12-09
DE69318854T2 (de) 1998-10-08
CA2157117A1 (en) 1994-09-15
EP0687268A1 (en) 1995-12-20
CN1099035A (zh) 1995-02-22
CA2157117C (en) 1999-01-05
WO1994020500A1 (en) 1994-09-15
DK0687268T3 (da) 1998-10-12
ATE166650T1 (de) 1998-06-15
IL108769A0 (en) 1994-06-24
EP0687268B1 (en) 1998-05-27
ES2116587T3 (es) 1998-07-16

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