US20150299696A1 - SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS - Google Patents

SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS Download PDF

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Publication number
US20150299696A1
US20150299696A1 US14/398,300 US201314398300A US2015299696A1 US 20150299696 A1 US20150299696 A1 US 20150299696A1 US 201314398300 A US201314398300 A US 201314398300A US 2015299696 A1 US2015299696 A1 US 2015299696A1
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US
United States
Prior art keywords
linker
strand
comprises
composition according
inverted abasic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US14/398,300
Inventor
Brian Allen Carr
Vasant R. Jadhav
Denise M. Kenski
David M. Tellers
Aarron T. Willingham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sirna Therapeutics Inc
Merck Sharp and Dohme Corp
Original Assignee
Sirna Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261641626P priority Critical
Application filed by Sirna Therapeutics Inc filed Critical Sirna Therapeutics Inc
Priority to US14/398,300 priority patent/US20150299696A1/en
Priority to PCT/US2013/038305 priority patent/WO2013165816A2/en
Publication of US20150299696A1 publication Critical patent/US20150299696A1/en
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CARR, Brian Allen, WILLINGHAM, AARRON T., KENSKI, DENISE M., JADHAV, VASANT R., TELLERS, DAVID M.
Assigned to SIRNA THERAPEUTICS, INC. reassignment SIRNA THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MERCK SHARP & DOHME CORP.
Application status is Abandoned legal-status Critical

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