CN101041626B - 四氟苄基衍生物及含有其成分的药物组合物 - Google Patents
四氟苄基衍生物及含有其成分的药物组合物 Download PDFInfo
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- CN101041626B CN101041626B CN2007100008003A CN200710000800A CN101041626B CN 101041626 B CN101041626 B CN 101041626B CN 2007100008003 A CN2007100008003 A CN 2007100008003A CN 200710000800 A CN200710000800 A CN 200710000800A CN 101041626 B CN101041626 B CN 101041626B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/49—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Description
%C | %H | %N | %F | %O | |
计算值 | 47.01 | 2.10 | 3.66 | 34.70 | 12.53 |
测量值 | 47.00 | 2.03 | 3.69 |
%C | %H | %N | %F | %O | |
计算值 | 43.71 | 1.71 | 6.80 | 32.36 | 15.53 |
测量值 | 43.37 | 1.68 | 6.50 |
%C | %H | %N | %F | %O | |
计算值 | 44.85 | 1.76 | 3.49 | 33.11 | 7.97 |
测量值 | 44.83 | 2.31 | 3.43 |
%C | %H | %N | %Br | %F | %O | |
计算值 | 40.38 | 1.58 | 3.14 | 17.91 | 29.81 | 7.17 |
测量值 | 44.62 | 1.57 | 3.79 |
%C | %H | %N | %F | %O | |
计算值 | 54.72 | 3.37 | 4.25 | 23.08 | 14.58 |
测量值 | 54.90 | 3.60 | 4.06 |
%C | %H | %N | %F | %O | |
计算值 | 50.41 | 2.64 | 3.53 | 33.48 | 12.08 |
测量值 | 50.40 | 2.60 | 3.39 |
%C | %H | %N | %F | %O | |
计算值 | 48.38 | 2.54 | 3.53 | 33.48 | 12.08 |
测量值 | 47.50 | 2.20 | 3.39 |
%C | %H | %N | %F | %O | |
计算值 | 42.59 | 1.56 | 3.0 | 42.10 | 10.64 |
测量值 | 41.24 | 2.20 | 3.39 |
%C | %H | %N | %F | %O | |
计算值 | 43.65 | 2.09 | 7.27 | 28.46 | 13.69 |
测量值 | 43.68 | 2.05 | 7.26 |
%C | %H | %N | %C1 | %F | %O | |
计算值 | 42.00 | 1.89 | 3.75 | 9.49 | 35.59 | 4.28 |
测量值 | 45.23 | 1.49 | 3.74 |
%C | %H | %N | %F | %O | |
计算值 | 48.38 | 2.54 | 3.53 | 33.48 | 12.08 |
测量值 | 48.12 | 2.54 | 3.43 |
%C | %H | %N | %F | %O | |
计算值 | 48.01 | 2.37 | 3.29 | 31.27 | 15.05 |
测量值 | 48.05 | 2.39 | 3.29 |
%C | %H | %N | %F | %O | |
计算值 | 49.22 | 2.75 | 3.19 | 30.27 | 14.57 |
测量值 | 49.20 | 2.76 | 3.20 |
%C | %H | %N | %F | %O | |
计算值 | 53.56 | 3.68 | 2.84 | 26.96 | 12.97 |
测量值 | 53.58 | 3.65 | 2.85 |
Claims (22)
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KR20020034259 | 2002-06-19 | ||
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CNB038167522A Division CN1309703C (zh) | 2002-06-19 | 2003-06-19 | 四氟苄基衍生物及含有其成分的用于治疗和预防中枢神经系统的急慢性神经变性疾病的药物组合物 |
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CN2007100008003A Expired - Lifetime CN101041626B (zh) | 2002-06-19 | 2003-06-19 | 四氟苄基衍生物及含有其成分的药物组合物 |
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EP (1) | EP1551793B1 (zh) |
JP (1) | JP4113957B2 (zh) |
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CN (2) | CN1309703C (zh) |
AU (1) | AU2003245070C1 (zh) |
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US5527814A (en) * | 1992-03-06 | 1996-06-18 | Rhone Poulenc Rorer S.A. | Use of 2-amino-6-(trifluoromethoxy)benzothiazole for obtaining a medicament for the treatment of amyotrophic lateral sclerosis |
Also Published As
Publication number | Publication date |
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US7189878B2 (en) | 2007-03-13 |
DK1551793T3 (en) | 2016-04-25 |
CN101041626A (zh) | 2007-09-26 |
EP1551793A1 (en) | 2005-07-13 |
EP1551793A4 (en) | 2007-04-04 |
KR100545745B1 (ko) | 2006-01-24 |
CA2490120A1 (en) | 2003-12-31 |
AU2003245070B2 (en) | 2007-08-09 |
KR20050105433A (ko) | 2005-11-04 |
EP1551793B1 (en) | 2016-01-20 |
AU2003245070A1 (en) | 2004-01-06 |
US20080227859A1 (en) | 2008-09-18 |
US7511074B2 (en) | 2009-03-31 |
AU2003245070C1 (en) | 2008-02-28 |
US7371896B2 (en) | 2008-05-13 |
US20070078183A1 (en) | 2007-04-05 |
WO2004000786A1 (en) | 2003-12-31 |
US20050239896A1 (en) | 2005-10-27 |
KR20030097706A (ko) | 2003-12-31 |
HK1077808A1 (zh) | 2006-02-24 |
CN1309703C (zh) | 2007-04-11 |
US7319160B2 (en) | 2008-01-15 |
CA2490120C (en) | 2010-06-01 |
US20060235239A1 (en) | 2006-10-19 |
US20040209957A1 (en) | 2004-10-21 |
CN1668576A (zh) | 2005-09-14 |
JP2005529972A (ja) | 2005-10-06 |
US6927303B2 (en) | 2005-08-09 |
ES2568491T3 (es) | 2016-04-29 |
JP4113957B2 (ja) | 2008-07-09 |
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