DK0556332T3 - Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet - Google Patents
Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemetInfo
- Publication number
- DK0556332T3 DK0556332T3 DK92901652.5T DK92901652T DK0556332T3 DK 0556332 T3 DK0556332 T3 DK 0556332T3 DK 92901652 T DK92901652 T DK 92901652T DK 0556332 T3 DK0556332 T3 DK 0556332T3
- Authority
- DK
- Denmark
- Prior art keywords
- nervous system
- central nervous
- agents
- hydroxypiperidines
- treatment
- Prior art date
Links
- LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical class ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004853 tetrahydropyridinyl group Chemical class N1(CCCC=C1)* 0.000 title abstract 2
- 210000003169 central nervous system Anatomy 0.000 title 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 239000003576 central nervous system agent Substances 0.000 abstract 1
- 229940125693 central nervous system agent Drugs 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
- 230000003291 dopaminomimetic effect Effects 0.000 abstract 1
- 208000031424 hyperprolactinemia Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60927490A | 1990-11-05 | 1990-11-05 | |
| US07/778,248 US5273977A (en) | 1990-11-05 | 1991-10-24 | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0556332T3 true DK0556332T3 (da) | 1996-06-03 |
Family
ID=27085995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92901652.5T DK0556332T3 (da) | 1990-11-05 | 1991-10-29 | Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US5273977A (es) |
| EP (1) | EP0556332B1 (es) |
| JP (1) | JP3047470B2 (es) |
| AT (1) | ATE135690T1 (es) |
| AU (1) | AU670532B2 (es) |
| CA (1) | CA2094702C (es) |
| DE (1) | DE69118198T2 (es) |
| DK (1) | DK0556332T3 (es) |
| ES (1) | ES2084339T3 (es) |
| GR (1) | GR3019782T3 (es) |
| WO (1) | WO1992007831A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5273977A (en) * | 1990-11-05 | 1993-12-28 | Warner-Lambert Company | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents |
| DE4425145A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung von Thiazol- und Thiadiazolverbindungen |
| GB9523462D0 (en) * | 1995-11-16 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| ZA9610741B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
| ZA9610736B (en) | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| US6420375B1 (en) * | 1997-02-21 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Fused ring compounds, process for producing the same and use thereof |
| DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
| EP1200086A4 (en) * | 1999-08-04 | 2009-05-27 | Icagen Inc | THERAPEUTIC OR PROPHYLACTIC METHODS OF PAIN AND ANXIETY |
| US6495550B2 (en) | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| DE60037321T4 (de) | 1999-08-04 | 2010-01-07 | Icagen, Inc. | Benzanilide als öffner des kaliumkanals |
| TR200201075T2 (tr) * | 1999-10-22 | 2002-11-21 | Sanofi-Synthelabo | Fenil-ve piridil-tetrahidropiridinler, bunların preparasyonu için proses ve bunları ihtiva eden farmasötik kompozisyonlar |
| FR2803593B1 (fr) | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| GB0413605D0 (en) * | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
| US8546381B2 (en) | 2008-03-24 | 2013-10-01 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
| JP5869484B2 (ja) | 2009-09-23 | 2016-02-24 | メディベイション テクノロジーズ， インコーポレイテッド | 架橋複素環化合物およびその使用 |
| EP2480078A4 (en) | 2009-09-23 | 2013-03-06 | Medivation Technologies Inc | PYRIDO- [4,3-B] INDOLE AND USE METHOD THEREFOR |
| US8785649B2 (en) * | 2010-11-05 | 2014-07-22 | Otsuka Agritechno Co., Ltd. | Ethynylphenylamidine compound or salt thereof, method for producing same, and fungicide for agricultural and horticultural use |
| JP2014505737A (ja) | 2011-02-18 | 2014-03-06 | メディベイション テクノロジーズ， インコーポレイテッド | 糖尿病を処置する化合物および方法 |
| CN106243088B (zh) | 2015-06-03 | 2019-01-04 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE633474A (es) * | ||||
| GB1055548A (en) * | 1965-08-23 | 1967-01-18 | Acraf | New substituted 1-aryl-3-aminopropynes and process for their preparation |
| FR1490501A (fr) * | 1966-02-23 | 1967-08-04 | Docteur Jacques Auciair Lab Du | Nouveaux dérivés du butyne-2 et leur procédé de préparation |
| US4208415A (en) * | 1978-02-06 | 1980-06-17 | E. R. Squibb & Sons, Inc. | 4-[2-(2-Substituted phenyl)ethenyl]-N-alkenyl or alkinyl substituted 1,2,3,6-tetrahydropyridines |
| JP2660407B2 (ja) * | 1986-09-26 | 1997-10-08 | 住友製薬株式会社 | 新規なイミド誘導体 |
| EP0507863A4 (en) * | 1989-12-28 | 1993-07-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| US5034392A (en) * | 1990-04-16 | 1991-07-23 | Hoechst-Roussel Pharmaceuticals Incorporated | 4-(3-(4-oxothiazolidinyl)butynylamines |
| US5273977A (en) * | 1990-11-05 | 1993-12-28 | Warner-Lambert Company | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents |
-
1991
- 1991-10-24 US US07/778,248 patent/US5273977A/en not_active Expired - Lifetime
- 1991-10-29 ES ES92901652T patent/ES2084339T3/es not_active Expired - Lifetime
- 1991-10-29 DE DE69118198T patent/DE69118198T2/de not_active Expired - Fee Related
- 1991-10-29 AT AT92901652T patent/ATE135690T1/de not_active IP Right Cessation
- 1991-10-29 CA CA002094702A patent/CA2094702C/en not_active Expired - Fee Related
- 1991-10-29 EP EP92901652A patent/EP0556332B1/en not_active Expired - Lifetime
- 1991-10-29 AU AU91231/91A patent/AU670532B2/en not_active Ceased
- 1991-10-29 DK DK92901652.5T patent/DK0556332T3/da active
- 1991-10-29 JP JP4502236A patent/JP3047470B2/ja not_active Expired - Fee Related
- 1991-10-29 WO PCT/US1991/008017 patent/WO1992007831A1/en active IP Right Grant
-
1993
- 1993-09-29 US US08/128,923 patent/US5466698A/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/469,127 patent/US5620988A/en not_active Expired - Fee Related
-
1996
- 1996-04-29 GR GR960401162T patent/GR3019782T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2084339T3 (es) | 1996-05-01 |
| AU670532B2 (en) | 1996-07-25 |
| CA2094702A1 (en) | 1992-05-06 |
| US5273977A (en) | 1993-12-28 |
| US5466698A (en) | 1995-11-14 |
| JPH06501952A (ja) | 1994-03-03 |
| EP0556332A1 (en) | 1993-08-25 |
| GR3019782T3 (en) | 1996-07-31 |
| US5620988A (en) | 1997-04-15 |
| ATE135690T1 (de) | 1996-04-15 |
| AU9123191A (en) | 1992-05-26 |
| DE69118198T2 (de) | 1996-11-14 |
| CA2094702C (en) | 2002-02-12 |
| JP3047470B2 (ja) | 2000-05-29 |
| EP0556332B1 (en) | 1996-03-20 |
| DE69118198D1 (de) | 1996-04-25 |
| WO1992007831A1 (en) | 1992-05-14 |
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