MX2015013893A - Nuevo derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico, metodo de preparacion del mismo y composicion farmaceutica para la prevencion y tratamiento de la enfermedad metabolica que incluye el mismo como ingrediente activo. - Google Patents

Nuevo derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico, metodo de preparacion del mismo y composicion farmaceutica para la prevencion y tratamiento de la enfermedad metabolica que incluye el mismo como ingrediente activo.

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Publication number
MX2015013893A
MX2015013893A MX2015013893A MX2015013893A MX2015013893A MX 2015013893 A MX2015013893 A MX 2015013893A MX 2015013893 A MX2015013893 A MX 2015013893A MX 2015013893 A MX2015013893 A MX 2015013893A MX 2015013893 A MX2015013893 A MX 2015013893A
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Mexico
Prior art keywords
benzyloxy
hex
phenyl
novel
acid derivative
Prior art date
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MX2015013893A
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English (en)
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MX367769B (es
Inventor
Jin Yang
Jin Woong Kim
Han Kyu Lee
Jae Hyun Kim
Chang Mo Son
Kyu Hwan Lee
Hyung-Ho Choi
Daehoon Kim
Tae-Young Ha
Jaekeol Rhee
Original Assignee
Hyundai Pharm Co Ltd
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Application filed by Hyundai Pharm Co Ltd filed Critical Hyundai Pharm Co Ltd
Publication of MX2015013893A publication Critical patent/MX2015013893A/es
Publication of MX367769B publication Critical patent/MX367769B/es

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Abstract

La presente invención se refiere a un nuevo derivado del ácido 3-(4-(benciloxi) fenil) hex-4-inoico, a un método de preparación del mismo, y a una composición farmacéutica para la prevención y el tratamiento de una enfermedad metabólica que incluye el mismo como ingrediente efectivo. El nuevo derivado del ácido 3-(4-(benciloxi) fenil) hex-4-inoico, el isómero óptico del mismo, o la sal del mismo farmacéuticamente aceptable, de acuerdo con la presente invención, tienen un excelente efecto sobre la activación de la proteína de GPR40 y por consiguiente tienen un efecto promotor excelente de secreción de insulina; no son tóxicos cuando son co-administrados con otros fármacos y posiblemente son co-administrados con otros fármacos; y tienen un excelente efecto de eficacia de la activación de la proteína de GPR40 in vivo. Por lo tanto, una composición que incluye el nuevo derivado del ácido 3-(4-(benciloxi) fenil) hex-4-inoico, el isómero óptico del mismo, o la sal del mismo farmacéuticamente aceptable, pueden ser utilizados adecuadamente en una composición farmacéutica para prevenir y tratar una enfermedad metabólica tal como la obesidad, la diabetes del tipo I, la diabetes del tipo II, la tolerancia a la glucosa incompatible, la tolerancia a la insulina, la hiperglucemia, la hiperlipidemia, la hipertrigliceridemia, la hipercolesterolemia, la dislipidemia, el síndrome X, etc.
MX2015013893A 2013-04-18 2014-04-17 Nuevo derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico, metodo de preparacion del mismo y composicion farmaceutica para la prevencion y tratamiento de la enfermedad metabolica que incluye el mismo como ingrediente activo. MX367769B (es)

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KR20130043100 2013-04-18
KR1020140045343A KR101569522B1 (ko) 2013-04-18 2014-04-16 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
PCT/KR2014/003355 WO2014171762A1 (ko) 2013-04-18 2014-04-17 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물

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JP2017149747A (ja) 2017-08-31
CA2908398A1 (en) 2014-10-23
BR112015025072A2 (pt) 2017-07-18
RU2015141278A (ru) 2017-05-25
KR20140126248A (ko) 2014-10-30
ES2745746T3 (es) 2020-03-03
MX367769B (es) 2019-09-05
CN105121423B (zh) 2017-06-09
DK2987791T3 (da) 2019-10-14
AU2014254555A1 (en) 2015-10-29
AU2014254555B2 (en) 2016-11-10
BR112015025072B1 (pt) 2022-03-15
PT2987791T (pt) 2019-10-24
CA2908398C (en) 2019-01-15
PL2987791T3 (pl) 2020-03-31
US9969723B2 (en) 2018-05-15
KR101569522B1 (ko) 2015-11-17
JP6174784B2 (ja) 2017-08-02
EP2987791B1 (en) 2019-07-17
EP2987791A4 (en) 2016-11-23
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EP2987791A1 (en) 2016-02-24
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