MX2018005193A - Proteinas de doble funcion y composicion farmaceutica que comprende las mismas. - Google Patents
Proteinas de doble funcion y composicion farmaceutica que comprende las mismas.Info
- Publication number
- MX2018005193A MX2018005193A MX2018005193A MX2018005193A MX2018005193A MX 2018005193 A MX2018005193 A MX 2018005193A MX 2018005193 A MX2018005193 A MX 2018005193A MX 2018005193 A MX2018005193 A MX 2018005193A MX 2018005193 A MX2018005193 A MX 2018005193A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- dual function
- pharmaceutical composition
- same
- present
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 230000009977 dual effect Effects 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 2
- 230000000144 pharmacologic effect Effects 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 102000008300 Mutant Proteins Human genes 0.000 abstract 1
- 108010021466 Mutant Proteins Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factors [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
La presente invención provee una proteína de doble función preparada uniendo una proteína biológicamente activa y una proteína mutante de FGF a una región Fc de una inmunoglobulina, que tiene una eficacia farmacológica, duración in vivo y estabilidad proteica mejoradas. Una proteína de doble función de conformidad con la presente invención presenta eficacia farmacológica, duración in vivo y estabilidad proteica mejoradas, y una composición farmacóutica que contiene la proteína de doble función como ingrediente activo puede usarse eficazmente como agente terapóutico para diabetes, obesidad, dislipidemia, síndrome metabólico, enfermedades del hígado graso no alcohólico, esteatohepatitis no alcohólica o enfermedades cardiovasculares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020150150576A KR20170049320A (ko) | 2015-10-28 | 2015-10-28 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
PCT/KR2016/012300 WO2017074123A1 (en) | 2015-10-28 | 2016-10-28 | Dual function proteins and pharmaceutical composition comprising same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018005193A true MX2018005193A (es) | 2018-07-06 |
Family
ID=58630627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018005193A MX2018005193A (es) | 2015-10-28 | 2016-10-28 | Proteinas de doble funcion y composicion farmaceutica que comprende las mismas. |
Country Status (13)
Country | Link |
---|---|
US (2) | US11136364B2 (es) |
EP (1) | EP3368555A4 (es) |
JP (2) | JP2019500013A (es) |
KR (1) | KR20170049320A (es) |
CN (4) | CN115925978A (es) |
AU (1) | AU2016346870B2 (es) |
BR (1) | BR112018008805A8 (es) |
CA (1) | CA3003115A1 (es) |
HK (1) | HK1257373A1 (es) |
MX (1) | MX2018005193A (es) |
RU (1) | RU2741345C2 (es) |
WO (1) | WO2017074123A1 (es) |
ZA (1) | ZA201802003B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20170049320A (ko) | 2015-10-28 | 2017-05-10 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
KR20170049319A (ko) | 2015-10-28 | 2017-05-10 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技(上海)有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
CN107759697B (zh) | 2016-08-19 | 2023-03-24 | 安源医药科技(上海)有限公司 | 制备融合蛋白的方法 |
AU2017358289A1 (en) * | 2016-11-10 | 2019-06-20 | Yuhan Corporation | Pharmaceutical composition for preventing or treating hepatitis, hepatic fibrosis, and hepatic cirrhosis comprising fusion proteins |
EA201992516A1 (ru) * | 2017-04-21 | 2020-04-09 | Юхан Корпорейшн | Способ получения бифункциональных белков и их производных |
CN116143939A (zh) * | 2017-11-24 | 2023-05-23 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的多重活性蛋白 |
CN110028587B (zh) * | 2018-01-11 | 2021-10-08 | 安源医药科技(上海)有限公司 | 用于调节血糖和脂质的增效型双功能蛋白 |
WO2019154189A1 (en) | 2018-02-08 | 2019-08-15 | Sunshine Lake Pharma Co., Ltd. | Fgf21 variant, fusion protein and application thereof |
US20210275643A1 (en) * | 2018-06-21 | 2021-09-09 | Sanofi | Fgf21 compound / glp-1r agonist combinations with optimized activity ratio |
CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
US20220064244A1 (en) * | 2019-03-05 | 2022-03-03 | Sunshine Lake Pharma Co., Ltd. | A polypeptide molecule and application thereof |
CN111944055B (zh) * | 2019-05-16 | 2022-08-02 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
WO2021107689A1 (ko) * | 2019-11-27 | 2021-06-03 | (주)지아이이노베이션 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 면역관문 억제제를 포함하는 암 치료용 약학 조성물 |
CN113597434B (zh) | 2019-12-31 | 2022-07-01 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
WO2021139763A1 (zh) * | 2020-01-08 | 2021-07-15 | 上海翰森生物医药科技有限公司 | Fgf21突变体蛋白及其融合蛋白 |
CN113728013B (zh) | 2020-01-11 | 2022-06-14 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
CN113265007B (zh) * | 2021-06-10 | 2022-02-15 | 江南大学 | 一种治疗代谢疾病的融合蛋白及其制备方法和应用 |
CN117510646A (zh) * | 2022-08-03 | 2024-02-06 | 无锡市华盛康肽生物技术有限公司 | 一种双功能融合蛋白及其用途 |
CN117143242B (zh) * | 2023-10-30 | 2024-03-29 | 南京佰抗生物科技有限公司 | 抗Galectin-3蛋白的单克隆抗体组合物及应用 |
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JPH0387173A (ja) | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体 |
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MX2015002985A (es) * | 2012-09-07 | 2015-06-22 | Sanofi Sa | Proteinas de fusion para el tratamiento de un sindrome metabolico. |
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AU2014318579A1 (en) * | 2013-09-13 | 2016-04-14 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
CN114805532A (zh) | 2014-10-24 | 2022-07-29 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
KR20170049319A (ko) | 2015-10-28 | 2017-05-10 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
KR20170049320A (ko) | 2015-10-28 | 2017-05-10 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
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WO2018166461A1 (en) | 2017-03-14 | 2018-09-20 | Sunshine Lake Pharma Co., Ltd. | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
EA201992516A1 (ru) | 2017-04-21 | 2020-04-09 | Юхан Корпорейшн | Способ получения бифункциональных белков и их производных |
-
2015
- 2015-10-28 KR KR1020150150576A patent/KR20170049320A/ko active IP Right Grant
-
2016
- 2016-10-28 CN CN202210972247.4A patent/CN115925978A/zh active Pending
- 2016-10-28 CA CA3003115A patent/CA3003115A1/en active Pending
- 2016-10-28 WO PCT/KR2016/012300 patent/WO2017074123A1/en active Application Filing
- 2016-10-28 MX MX2018005193A patent/MX2018005193A/es unknown
- 2016-10-28 AU AU2016346870A patent/AU2016346870B2/en active Active
- 2016-10-28 CN CN202210973282.8A patent/CN115925979A/zh active Pending
- 2016-10-28 CN CN202210973281.3A patent/CN116333160A/zh active Pending
- 2016-10-28 RU RU2018118025A patent/RU2741345C2/ru active
- 2016-10-28 CN CN201680062638.5A patent/CN108350054B/zh active Active
- 2016-10-28 JP JP2018522147A patent/JP2019500013A/ja active Pending
- 2016-10-28 BR BR112018008805A patent/BR112018008805A8/pt active Search and Examination
- 2016-10-28 US US15/768,865 patent/US11136364B2/en active Active
- 2016-10-28 EP EP16860306.6A patent/EP3368555A4/en active Pending
-
2018
- 2018-03-26 ZA ZA2018/02003A patent/ZA201802003B/en unknown
- 2018-12-26 HK HK18116581.1A patent/HK1257373A1/zh unknown
-
2021
- 2021-09-17 US US17/478,628 patent/US20220002368A1/en active Pending
-
2022
- 2022-10-12 JP JP2022164154A patent/JP2023011644A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN108350054A (zh) | 2018-07-31 |
JP2019500013A (ja) | 2019-01-10 |
ZA201802003B (en) | 2019-05-29 |
CN116333160A (zh) | 2023-06-27 |
KR20170049320A (ko) | 2017-05-10 |
CN115925978A (zh) | 2023-04-07 |
HK1257373A1 (zh) | 2019-10-18 |
CA3003115A1 (en) | 2017-05-04 |
EP3368555A1 (en) | 2018-09-05 |
BR112018008805A8 (pt) | 2019-02-26 |
CN108350054B (zh) | 2022-09-02 |
US11136364B2 (en) | 2021-10-05 |
JP2023011644A (ja) | 2023-01-24 |
WO2017074123A1 (en) | 2017-05-04 |
AU2016346870B2 (en) | 2021-04-22 |
EP3368555A4 (en) | 2019-11-20 |
RU2741345C2 (ru) | 2021-01-25 |
CN115925979A (zh) | 2023-04-07 |
US20200024318A1 (en) | 2020-01-23 |
RU2018118025A3 (es) | 2020-03-24 |
AU2016346870A1 (en) | 2018-05-10 |
BR112018008805A2 (pt) | 2018-10-30 |
RU2018118025A (ru) | 2019-11-28 |
US20220002368A1 (en) | 2022-01-06 |
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