BR112018008805A2 - proteínas de função dupla e composição farmacêutica que compreende a mesma - Google Patents

proteínas de função dupla e composição farmacêutica que compreende a mesma

Info

Publication number
BR112018008805A2
BR112018008805A2 BR112018008805A BR112018008805A BR112018008805A2 BR 112018008805 A2 BR112018008805 A2 BR 112018008805A2 BR 112018008805 A BR112018008805 A BR 112018008805A BR 112018008805 A BR112018008805 A BR 112018008805A BR 112018008805 A2 BR112018008805 A2 BR 112018008805A2
Authority
BR
Brazil
Prior art keywords
protein
dual
pharmaceutical composition
function
same
Prior art date
Application number
BR112018008805A
Other languages
English (en)
Other versions
BR112018008805A8 (pt
Inventor
Kim Dohoon
Ho Choi Hyun
Gyun KIM Jong
Park Ju-Young
Hwan Kim Jun
Kyeong JU Mi
Seo Minji
LIM Sangmyoun
Gi Kim Seul
LIM Seyoung
Youn Nam Su
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of BR112018008805A2 publication Critical patent/BR112018008805A2/pt
Publication of BR112018008805A8 publication Critical patent/BR112018008805A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção fornece uma proteína de função dupla preparada por meio da ligação de uma proteína biologicamente ativa e uma proteína mutante fgf a uma região fc de uma imunoglobulina, que tem eficácia farmacológica aperfeiçoada, duração in vivo e estabilidade de proteína. uma proteína de função dupla de acordo com a presente invenção exibe eficácia farmacológica aperfeiçoada, duração in vivo e estabilidade de proteína, e uma composição farmacêutica que contém a proteína de função dupla como um ingrediente ativo pode ser usada de maneira eficaz como um agente terapêutico para diabetes, obesidade, dislipidemia, síndrome metabólica, doenças do fígado gorduroso não alcoólico, esteato-hepatite não alcoólica ou doenças cardiovasculares.
BR112018008805A 2015-10-28 2016-10-28 proteínas de função dupla e composição farmacêutica que compreende a mesma BR112018008805A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020150150576A KR102670157B1 (ko) 2015-10-28 2015-10-28 이중 작용 단백질 및 이를 포함하는 약학적 조성물
PCT/KR2016/012300 WO2017074123A1 (en) 2015-10-28 2016-10-28 Dual function proteins and pharmaceutical composition comprising same

Publications (2)

Publication Number Publication Date
BR112018008805A2 true BR112018008805A2 (pt) 2018-10-30
BR112018008805A8 BR112018008805A8 (pt) 2019-02-26

Family

ID=58630627

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018008805A BR112018008805A8 (pt) 2015-10-28 2016-10-28 proteínas de função dupla e composição farmacêutica que compreende a mesma

Country Status (13)

Country Link
US (2) US11136364B2 (pt)
EP (1) EP3368555A4 (pt)
JP (2) JP2019500013A (pt)
KR (2) KR102670157B1 (pt)
CN (4) CN108350054B (pt)
AU (1) AU2016346870B2 (pt)
BR (1) BR112018008805A8 (pt)
CA (1) CA3003115A1 (pt)
HK (1) HK1257373A1 (pt)
MX (1) MX2018005193A (pt)
RU (1) RU2741345C2 (pt)
WO (1) WO2017074123A1 (pt)
ZA (1) ZA201802003B (pt)

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KR102668200B1 (ko) 2015-10-28 2024-05-23 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
CN106279437B (zh) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
CN107759694B (zh) 2016-08-19 2023-01-13 安源医药科技（上海）有限公司 双特异性抗体及其制备方法与用途
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MX2019012331A (es) 2017-04-21 2020-01-23 Yuhan Corp Metodo para producir proteinas de doble funcion y sus derivados.
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CN113366024A (zh) * 2020-01-08 2021-09-07 上海翰森生物医药科技有限公司 Fgf21突变体蛋白及其融合蛋白
WO2021139744A1 (en) 2020-01-11 2021-07-15 Beijing Ql Biopharmaceutical Co., Ltd. Conjugates of fusion proteins of glp-1 and fgf21
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation
CN113265007B (zh) * 2021-06-10 2022-02-15 江南大学 一种治疗代谢疾病的融合蛋白及其制备方法和应用
CN117510646A (zh) * 2022-08-03 2024-02-06 无锡市华盛康肽生物技术有限公司 一种双功能融合蛋白及其用途
CN117143242B (zh) * 2023-10-30 2024-03-29 南京佰抗生物科技有限公司 抗Galectin-3蛋白的单克隆抗体组合物及应用

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Also Published As

Publication number Publication date
HK1257373A1 (zh) 2019-10-18
CA3003115A1 (en) 2017-05-04
US11136364B2 (en) 2021-10-05
JP2023011644A (ja) 2023-01-24
CN108350054B (zh) 2022-09-02
RU2018118025A3 (pt) 2020-03-24
WO2017074123A1 (en) 2017-05-04
KR20240078629A (ko) 2024-06-04
CN115925979A (zh) 2023-04-07
CN108350054A (zh) 2018-07-31
CN116333160A (zh) 2023-06-27
RU2741345C2 (ru) 2021-01-25
KR20170049320A (ko) 2017-05-10
AU2016346870B2 (en) 2021-04-22
RU2018118025A (ru) 2019-11-28
BR112018008805A8 (pt) 2019-02-26
US20200024318A1 (en) 2020-01-23
US20220002368A1 (en) 2022-01-06
EP3368555A1 (en) 2018-09-05
KR102670157B1 (ko) 2024-05-29
JP2019500013A (ja) 2019-01-10
EP3368555A4 (en) 2019-11-20
AU2016346870A1 (en) 2018-05-10
CN115925978A (zh) 2023-04-07
ZA201802003B (en) 2019-05-29
MX2018005193A (es) 2018-07-06

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