EA201790568A1 - Применение двойного агониста рецепторов glp-1/глюкагона пролонгированного действия для лечения неалкогольной жировой болезни печени - Google Patents

Применение двойного агониста рецепторов glp-1/глюкагона пролонгированного действия для лечения неалкогольной жировой болезни печени

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EA201790568A1
EA201790568A1 EA201790568A EA201790568A EA201790568A1 EA 201790568 A1 EA201790568 A1 EA 201790568A1 EA 201790568 A EA201790568 A EA 201790568A EA 201790568 A EA201790568 A EA 201790568A EA 201790568 A1 EA201790568 A1 EA 201790568A1
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glp
liver disease
prolonged action
treatment
double
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EA201790568A
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Санг Йоун Хванг
Дзин Йоунг Ким
Сеунг Су Ким
Ин Янг Чой
Сунг Юб Дзунг
Се Чанг Квон
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Ханми Фарм. Ко., Лтд.
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Application filed by Ханми Фарм. Ко., Лтд. filed Critical Ханми Фарм. Ко., Лтд.
Publication of EA201790568A1 publication Critical patent/EA201790568A1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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  • Peptides Or Proteins (AREA)
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  • Inorganic Chemistry (AREA)

Abstract

Настоящее изобретение относится к фармацевтической композиции для профилактики или лечения неалкогольной жировой болезни печени, включающей двойной агонист рецепторов GLP-1/глюкагона пролонгированного действия, и к способу профилактики или лечения неалкогольной жировой болезни печени, включающему введение композиции. Композиция настоящего изобретения либо не имеет побочного эффекта в виде набора веса, либо снижает побочный эффект в виде набора веса, который является побочным эффектом применения стандартных лекарственных средств для лечения неалкогольной жировой болезни печени, а также снижает количество введений двойного агониста рецепторов GLP-1/глюкагона пролонгированного действия, таким образом, значительно повышая удобство для пациента. В дополнение двойной агонист рецепторов GLP-1/глюкагона пролонгированного действия настоящего изобретения улучшает надежность и стабильность in vivo
EA201790568A 2014-09-16 2015-09-16 Применение двойного агониста рецепторов glp-1/глюкагона пролонгированного действия для лечения неалкогольной жировой болезни печени EA201790568A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20140122862 2014-09-16
PCT/KR2015/009753 WO2016043533A1 (en) 2014-09-16 2015-09-16 Use of a long acting glp-1/glucagon receptor dual agonist for the treatment of non-alcoholic fatty liver disease

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EA201790568A1 true EA201790568A1 (ru) 2017-07-31

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US (2) US10233230B2 (ru)
EP (1) EP3197483A4 (ru)
JP (2) JP6832273B2 (ru)
KR (2) KR102541971B1 (ru)
CN (1) CN107106660B (ru)
AR (1) AR101896A1 (ru)
AU (2) AU2015318881A1 (ru)
CA (1) CA2960657A1 (ru)
CL (1) CL2017000638A1 (ru)
CO (1) CO2017002689A2 (ru)
CR (1) CR20170129A (ru)
EA (1) EA201790568A1 (ru)
EC (1) ECSP17022931A (ru)
GT (1) GT201700056A (ru)
IL (2) IL251060B (ru)
MA (1) MA40466A (ru)
MX (2) MX2017003438A (ru)
MY (2) MY195618A (ru)
NI (1) NI201700032A (ru)
NZ (1) NZ730799A (ru)
PE (1) PE20170778A1 (ru)
PH (1) PH12017500486A1 (ru)
SG (1) SG11201701841WA (ru)
TW (2) TWI772252B (ru)
WO (1) WO2016043533A1 (ru)
ZA (2) ZA201701847B (ru)

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