DK3207928T3 - Sammensat præparat, der indeholder hidtil ukendt 3-(4-(benzyloxy)phenyl)hex-4-inonsyrederivat og en anden aktiv bestanddel, til forebyggelse eller behandling af metaboliske sygdomme - Google Patents
Sammensat præparat, der indeholder hidtil ukendt 3-(4-(benzyloxy)phenyl)hex-4-inonsyrederivat og en anden aktiv bestanddel, til forebyggelse eller behandling af metaboliske sygdomme Download PDFInfo
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- DK3207928T3 DK3207928T3 DK15850582.6T DK15850582T DK3207928T3 DK 3207928 T3 DK3207928 T3 DK 3207928T3 DK 15850582 T DK15850582 T DK 15850582T DK 3207928 T3 DK3207928 T3 DK 3207928T3
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- benzyloxy
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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KR20140141216 | 2014-10-17 | ||
PCT/KR2015/010976 WO2016060517A2 (ko) | 2014-10-17 | 2015-10-16 | 신규한 3-(4- (벤질옥시)페닐)핵스- 4-이노익 산 유도체 및 다른 유효 성분을 포함하는 대사성 질환의 예방 또는 치료용 복합제제 |
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DK3207928T3 true DK3207928T3 (da) | 2021-04-26 |
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DK15850582.6T DK3207928T3 (da) | 2014-10-17 | 2015-10-16 | Sammensat præparat, der indeholder hidtil ukendt 3-(4-(benzyloxy)phenyl)hex-4-inonsyrederivat og en anden aktiv bestanddel, til forebyggelse eller behandling af metaboliske sygdomme |
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US (1) | US10821110B2 (da) |
EP (1) | EP3207928B1 (da) |
JP (1) | JP6458136B2 (da) |
KR (1) | KR101728900B1 (da) |
CN (2) | CN111423408A (da) |
AU (1) | AU2015331074B2 (da) |
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MX (1) | MX2017004614A (da) |
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RU (1) | RU2680248C1 (da) |
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Families Citing this family (8)
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KR102090079B1 (ko) * | 2017-12-01 | 2020-03-17 | 현대약품 주식회사 | 3-(4-(벤질옥시)페닐)헥스-4-이노익산 유도체의 신규 용도 |
AU2019205093B2 (en) * | 2018-01-08 | 2024-03-07 | Celon Pharma S.A. | 3-phenyl-4-hexynoic acid derivatives as GPR40 agonists |
JP7062792B2 (ja) | 2018-02-13 | 2022-05-06 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
WO2019204609A1 (en) | 2018-04-19 | 2019-10-24 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
CN112399874B (zh) | 2018-07-13 | 2024-03-22 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
MX2021014751A (es) * | 2019-05-31 | 2022-01-18 | Hyundai Pharm Co Ltd | Forma cristalina novedosa de derivado de acido 3-(4-(benciloxi)fenil)hex-4-inoico. |
KR102270026B1 (ko) | 2020-01-31 | 2021-06-28 | 현대약품 주식회사 | (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법 |
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EA011010B1 (ru) * | 2004-02-27 | 2008-12-30 | Эмджен, Инк. | Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина |
WO2005095338A1 (ja) * | 2004-03-30 | 2005-10-13 | Takeda Pharmaceutical Company Limited | アルコキシフェニルプロパン酸誘導体 |
PE20080993A1 (es) * | 2006-06-27 | 2008-10-06 | Takeda Pharmaceutical | Compuestos ciclicos fusionados como moduladores del receptor gpr40 |
CA2662242C (en) | 2006-09-07 | 2012-06-12 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
KR20090088854A (ko) * | 2006-09-13 | 2009-08-20 | 다케다 야쿠힌 고교 가부시키가이샤 | 2-6-(3-아미노-피페리딘-엘-일)-3-메틸-2,4-디옥소-3,4-디하이드로-2h-피리미딘-1-일메틸-4-플루오로-벤조니트릴의 용도 |
WO2008130514A1 (en) * | 2007-04-16 | 2008-10-30 | Amgen Inc. | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
DE102009020897A1 (de) * | 2009-05-08 | 2010-11-11 | Aesculap Ag | Faden mit beschichteten Verankerungsstrukturen zur Verankerung in biologischen Geweben und ein Verfahren zu seiner Herstellung |
AR078522A1 (es) * | 2009-10-15 | 2011-11-16 | Lilly Co Eli | Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis |
MX364651B (es) * | 2009-11-27 | 2019-05-03 | Boehringer Ingelheim Int Gmbh Star | Inhibidores de dpp-iv, tales como la linagliptina, y composiciones farmacéuticas o combinaciones que comprenden los mismos, para usarse en el tratamiento de pacientes diabéticos tipificados genéticamente. |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
WO2013167554A1 (en) * | 2012-05-09 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
KR101569522B1 (ko) * | 2013-04-18 | 2015-11-17 | 현대약품 주식회사 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
IN2013MU03577A (da) * | 2013-11-14 | 2015-07-31 | Cadila Healthcare Ltd | |
CN104740635A (zh) | 2013-12-26 | 2015-07-01 | 上海复星医药产业发展有限公司 | 一种糖尿病药物组合物及其应用 |
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2015
- 2015-10-16 WO PCT/KR2015/010976 patent/WO2016060517A2/ko active Application Filing
- 2015-10-16 PL PL15850582T patent/PL3207928T3/pl unknown
- 2015-10-16 CN CN202010089772.2A patent/CN111423408A/zh active Pending
- 2015-10-16 JP JP2017515685A patent/JP6458136B2/ja active Active
- 2015-10-16 KR KR1020150144852A patent/KR101728900B1/ko active IP Right Grant
- 2015-10-16 DK DK15850582.6T patent/DK3207928T3/da active
- 2015-10-16 MX MX2017004614A patent/MX2017004614A/es unknown
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- 2015-10-16 AU AU2015331074A patent/AU2015331074B2/en active Active
- 2015-10-16 ES ES15850582T patent/ES2869910T3/es active Active
- 2015-10-16 US US15/511,955 patent/US10821110B2/en active Active
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KR101728900B1 (ko) | 2017-04-24 |
CN106715409B (zh) | 2020-09-11 |
JP6458136B2 (ja) | 2019-01-23 |
SA517381320B1 (ar) | 2021-07-12 |
CN106715409A (zh) | 2017-05-24 |
US10821110B2 (en) | 2020-11-03 |
MX2017004614A (es) | 2017-06-20 |
US20170296539A1 (en) | 2017-10-19 |
EP3207928A2 (en) | 2017-08-23 |
WO2016060517A2 (ko) | 2016-04-21 |
ES2869910T8 (es) | 2022-02-01 |
EP3207928A4 (en) | 2018-03-14 |
CA2960944C (en) | 2019-09-10 |
CA2960944A1 (en) | 2016-04-21 |
WO2016060517A3 (ko) | 2016-09-15 |
BR112017007720B1 (pt) | 2023-01-17 |
ES2869910T3 (es) | 2021-10-26 |
EP3207928B1 (en) | 2021-03-10 |
AU2015331074B2 (en) | 2018-11-15 |
AU2015331074A1 (en) | 2017-05-18 |
BR112017007720A2 (pt) | 2017-12-19 |
KR20160046306A (ko) | 2016-04-28 |
RU2680248C1 (ru) | 2019-02-19 |
PL3207928T3 (pl) | 2021-08-23 |
JP2017534582A (ja) | 2017-11-24 |
CN111423408A (zh) | 2020-07-17 |
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