CY1112642T1 - Παραγωγα 4-(πυριδιν-4-υλο)-1η-[1,3,5]τριαζιν-2-ονης ως αναστολεις της gsκ3-βετα για τη θεραπεια των νευροεκφυλιστικων ασθενειων - Google Patents

Παραγωγα 4-(πυριδιν-4-υλο)-1η-[1,3,5]τριαζιν-2-ονης ως αναστολεις της gsκ3-βετα για τη θεραπεια των νευροεκφυλιστικων ασθενειων

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Publication number
CY1112642T1
CY1112642T1 CY20121100288T CY121100288T CY1112642T1 CY 1112642 T1 CY1112642 T1 CY 1112642T1 CY 20121100288 T CY20121100288 T CY 20121100288T CY 121100288 T CY121100288 T CY 121100288T CY 1112642 T1 CY1112642 T1 CY 1112642T1
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Cyprus
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denotes
group
optionally substituted
neurodegenerative diseases
gsk3
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CY20121100288T
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English (en)
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Alistair Lochead
Mourad Saady
Philippe Yaiche
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Mitsubishi Tanabe Pharma Corporation
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Publication of CY1112642T1 publication Critical patent/CY1112642T1/el

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Ένα παράγωγο τριαζινόνης που δηλώνεται από τον τύπο (Ι) όπου : Το Ζ δηλώνει έναν δεσμό, μια ομάδα καρβονυλίου, μια ομάδα μεθυλένιου προαιρετικά υποκαθιστούμενη από μία ή δύο ομάδες που επιλέγονται από μια ομάδα C1-6 αλκυλίου, μια ομάδα υδροξυλίου, μια ομάδα Ci-β αλκοξέος, το R1 δηλώνει έναν δακτύλιο 4-πυριδίνης, το R2 δηλώνει ένα άτομο υδρογόνου, ένα C1-6 αλκύλιο, το R3 δηλώνει ένα άτομο υδρογόνου, μια ομάδα C1-6 αλκυλίου, το R2 και το R3 μπορούν να σχηματίσουν από κοινού ένα 6-μελή κύκλο με τα άζωτα να φέρουν το R2 και το R3 προαιρετικά υποκαθιστούμενα, και το R4 δηλώνει : έναν δακτύλιο φαινυλίου, προαιρετικά υποκαθιστούμενο, το n δηλώνει 0 έως 2, με τη μορφή μιας ελεύθερης βάσης ή ενός άλατος προσθήκης με ένα οξύ. Οι ενώσεις της παρούσας εφεύρεσης έχουν μια ανασταλτική δραστηριότητα GSΚ3β και είναι χρήσιμες ως ένα δραστικό συστατικό στοιχείο ενός φαρμάκου για την προληπτική ή/και θεραπευτική θεραπεία των ασθενειών που οφείλονται στη μη φυσιολογική δραστηριότητα της GSΚ3β και πιο συγκεκριμένα νευροεκφυλιστικών ασθενειών.
CY20121100288T 2008-06-26 2012-03-16 Παραγωγα 4-(πυριδιν-4-υλο)-1η-[1,3,5]τριαζιν-2-ονης ως αναστολεις της gsκ3-βετα για τη θεραπεια των νευροεκφυλιστικων ασθενειων CY1112642T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290617A EP2138488A1 (en) 2008-06-26 2008-06-26 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP09769671A EP2321295B1 (en) 2008-06-26 2009-06-25 4-(pyridin-4-yl)-1h-[1,3,5]triazin-2-one derivatives as gsk3-beta inhibitors for the treatment of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
CY1112642T1 true CY1112642T1 (el) 2016-02-10

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US (1) US8592580B2 (el)
EP (2) EP2138488A1 (el)
JP (1) JP5581318B2 (el)
KR (1) KR20110025219A (el)
CN (1) CN102137854A (el)
AR (1) AR072227A1 (el)
AT (1) ATE538114T1 (el)
AU (1) AU2009263846A1 (el)
BR (1) BRPI0914662A2 (el)
CA (1) CA2729115A1 (el)
CY (1) CY1112642T1 (el)
DK (1) DK2321295T3 (el)
EA (1) EA201170095A1 (el)
ES (1) ES2379220T3 (el)
IL (1) IL210174A0 (el)
MX (1) MX2010014235A (el)
NZ (1) NZ590116A (el)
PL (1) PL2321295T3 (el)
PT (1) PT2321295E (el)
SI (1) SI2321295T1 (el)
TW (1) TW201004935A (el)
WO (1) WO2009156860A2 (el)
ZA (1) ZA201100026B (el)

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EP2138494A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
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EP2138495A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives

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IL210174A0 (en) 2011-03-31
CA2729115A1 (en) 2009-12-30
NZ590116A (en) 2011-10-28
PL2321295T3 (pl) 2012-06-29
US8592580B2 (en) 2013-11-26
EP2138488A1 (en) 2009-12-30
JP2011525905A (ja) 2011-09-29
ATE538114T1 (de) 2012-01-15
SI2321295T1 (sl) 2012-04-30
JP5581318B2 (ja) 2014-08-27
MX2010014235A (es) 2011-06-24
AR072227A1 (es) 2010-08-11
US20110144114A1 (en) 2011-06-16
EP2321295B1 (en) 2011-12-21
WO2009156860A2 (en) 2009-12-30
EA201170095A1 (ru) 2011-08-30
EP2321295A2 (en) 2011-05-18
CN102137854A (zh) 2011-07-27
PT2321295E (pt) 2012-03-23
BRPI0914662A2 (pt) 2015-10-20
ES2379220T3 (es) 2012-04-23
AU2009263846A1 (en) 2009-12-30
TW201004935A (en) 2010-02-01
KR20110025219A (ko) 2011-03-09
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