CY1119423T1 - Παραγωγο κυκλοαλκυλ-υποκατεστημενης ιμιδαζολης - Google Patents

Παραγωγο κυκλοαλκυλ-υποκατεστημενης ιμιδαζολης

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Publication number
CY1119423T1
CY1119423T1 CY20171101044T CY171101044T CY1119423T1 CY 1119423 T1 CY1119423 T1 CY 1119423T1 CY 20171101044 T CY20171101044 T CY 20171101044T CY 171101044 T CY171101044 T CY 171101044T CY 1119423 T1 CY1119423 T1 CY 1119423T1
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CY
Cyprus
Prior art keywords
group
hydrogen atom
cerebral
cycloalkyl
groups
Prior art date
Application number
CY20171101044T
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English (en)
Inventor
Tsutomu Nagata
Masahiro Inoue
Yuka Ashida
Kengo Noguchi
Makoto Ono
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Daiichi Sankyo Company, Limited
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Filing date
Publication date
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Publication of CY1119423T1 publication Critical patent/CY1119423T1/el

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

Ενώσεις που αναπαρίστανται από τον γενικό χημικό τύπο (I) (όπου το Α αναπαριστά μια ομάδα C3-12 κυκλοαλκυλίου προαιρετικώς υποκατεστημένη από 1-3 υποκατάστατα που επιλέγονται από φθοροομάδες, ομάδες υδροξειδίου και/ή ομάδες C1-6 αλκυλίου· τα R1, R2 και R3 αναπαριστούν το κάθε ένα μεμονωμένα ένα άτομο υδρογόνου, μια φθοροομάδα ή μια ομάδα C1-6 αλκυλίου· το R4 αναπαριστά ένα άτομο υδρογόνου ή μια ομάδα προφαρμάκου· και το Υ αναπαριστά -CH2-CHR5-CH2-NHR6, στο οποίο το R5 αναπαριστά ένα άτομο υδρογόνου, μια ομάδα C1-6 αλκυλίου ή μια C1-6 αλκοξυομάδα και το R6 αναπαριστά ένα άτομο υδρογόνου ή μια ομάδα προφαρμάκου) και φαρμακολογικώς-αποδεκτά άλατα εξ' αυτών εκδηλώνουν μια ανασταλτική δραστηριότητα του TAFIa, και τοιουτοτρόπως είναι χρήσιμες ως θεραπευτικά φάρμακα για μυοκαρδιακή έμφραξη, στηθάγχη, οξύ στεφανιαίο σύνδρομο, εγκεφαλική έμφραξη, θρόμβωση εν τω βάθει φλεβών, πνευμονικό εμβολισμό, κλπ.
CY20171101044T 2010-03-18 2017-10-06 Παραγωγο κυκλοαλκυλ-υποκατεστημενης ιμιδαζολης CY1119423T1 (el)

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PCT/JP2011/055953 WO2011115064A1 (ja) 2010-03-18 2011-03-14 シクロアルキル基で置換されたイミダゾール誘導体

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