CY1113715T1 - Αναλογα πυριδονης και πυριδαζονης ως ρυθμιστες toy gpr119 - Google Patents

Αναλογα πυριδονης και πυριδαζονης ως ρυθμιστες toy gpr119

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Publication number
CY1113715T1
CY1113715T1 CY20131100168T CY131100168T CY1113715T1 CY 1113715 T1 CY1113715 T1 CY 1113715T1 CY 20131100168 T CY20131100168 T CY 20131100168T CY 131100168 T CY131100168 T CY 131100168T CY 1113715 T1 CY1113715 T1 CY 1113715T1
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CY
Cyprus
Prior art keywords
gpr119
regulators
protein
pyrason
pyridon
Prior art date
Application number
CY20131100168T
Other languages
English (en)
Inventor
Dean A Wacker
Karen A Rossi
Ying Wang
Gang Wu
Original Assignee
Bristol-Myers Squibb Company
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Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1113715T1 publication Critical patent/CY1113715T1/el

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

Παρέχονται νέες ενώσεις του συντακτικού Τύπου (I) ή ένα εναντιομερές, διαστερεομερές, ή φαρμακευτικώς αποδεκτό άλας αυτών, όπου τα Ζ, R1, R2, R21, Τ1, Τ2, Τ3 και Τ4 ορίζονται στο παρόν, που είναι ρυθμιστές συζευγμένων σε πρωτεΐνη G υποδοχέων του GPR119. Οι ρυθμιστές συζευγμένων σε πρωτεΐνη G υποδοχέων του GPR119 είναι χρήσιμοι στη θεραπευτική αγωγή, πρόληψη, ή επιβράδυνση της προόδου ασθενειών που απαιτούν θεραπεία με ρυθμιστές συζευγμένων σε πρωτεΐνη G υποδοχέων του GPR119. Έτσι, η αποκάλυψη αφορά επίσης συνθέσεις που αποτελούνται από αυτές τις νέες ενώσεις και μεθόδους θεραπευτικής αγωγής ασθενειών ή καταστάσεων που σχετίζονται με τη δραστικότητα του συζευγμένου σε πρωτεΐνη G υποδοχέα του GPR119 χρησιμοποιώντας οποιαδήποτε από αυτές τις νέες ενώσεις ή οποιαδήποτε σύνθεση αποτελείται από οποιαδήποτε από τέτοιου είδους νέες ενώσεις.
CY20131100168T 2008-07-16 2013-02-22 Αναλογα πυριδονης και πυριδαζονης ως ρυθμιστες toy gpr119 CY1113715T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8105808P 2008-07-16 2008-07-16
US8106908P 2008-07-16 2008-07-16
US8106008P 2008-07-16 2008-07-16
EP09790426A EP2313395B1 (en) 2008-07-16 2009-07-15 Pyridone and pyridazone analogues as gpr119 modulators

Publications (1)

Publication Number Publication Date
CY1113715T1 true CY1113715T1 (el) 2016-06-22

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Country Link
US (2) US8372837B2 (el)
EP (1) EP2313395B1 (el)
JP (1) JP2011528362A (el)
CN (1) CN102159566A (el)
AR (1) AR073254A1 (el)
BR (1) BRPI0915918A2 (el)
CA (1) CA2730929A1 (el)
CY (1) CY1113715T1 (el)
DK (1) DK2313395T3 (el)
EA (1) EA018268B1 (el)
ES (1) ES2400587T3 (el)
HR (1) HRP20130120T1 (el)
MX (1) MX2011000394A (el)
PL (1) PL2313395T3 (el)
PT (1) PT2313395E (el)
SI (1) SI2313395T1 (el)
SM (1) SMT201300040B (el)
TW (1) TW201006821A (el)
WO (1) WO2010009183A1 (el)

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