ATE348152T1 - Verfahren zum screening von diabetes- heilverfahren - Google Patents
Verfahren zum screening von diabetes- heilverfahrenInfo
- Publication number
- ATE348152T1 ATE348152T1 AT01998193T AT01998193T ATE348152T1 AT E348152 T1 ATE348152 T1 AT E348152T1 AT 01998193 T AT01998193 T AT 01998193T AT 01998193 T AT01998193 T AT 01998193T AT E348152 T1 ATE348152 T1 AT E348152T1
- Authority
- AT
- Austria
- Prior art keywords
- screening diabetes
- cure
- diabetes cure
- screening
- cell
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000367349 | 2000-12-01 | ||
| JP2001243841 | 2001-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE348152T1 true ATE348152T1 (de) | 2007-01-15 |
Family
ID=26605096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01998193T ATE348152T1 (de) | 2000-12-01 | 2001-11-30 | Verfahren zum screening von diabetes- heilverfahren |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20030180813A1 (de) |
| EP (2) | EP1770159A1 (de) |
| JP (1) | JP3438186B2 (de) |
| AT (1) | ATE348152T1 (de) |
| AU (1) | AU2002218509A1 (de) |
| DE (1) | DE60125227T2 (de) |
| ES (1) | ES2280435T3 (de) |
| WO (1) | WO2002044362A1 (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7816492B2 (en) * | 1998-11-20 | 2010-10-19 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors |
| USRE42190E1 (en) | 1998-11-20 | 2011-03-01 | Arena Pharmaceuticals, Inc. | Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors |
| US20030017528A1 (en) | 1998-11-20 | 2003-01-23 | Ruoping Chen | Human orphan G protein-coupled receptors |
| US20030125539A1 (en) * | 1999-02-22 | 2003-07-03 | Synaptic Pharmaceutical Corporation | DNA encoding SNORF25 receptor |
| JP2002130117A (ja) * | 2000-10-18 | 2002-05-09 | Mikuni Corp | 電磁駆動型プランジャポンプ |
| EP1770159A1 (de) * | 2000-12-01 | 2007-04-04 | Astellas Pharma Inc. | Verfahren zur Herstellung eines Arzneimittels zur Behandlung von Diabetes |
| GB0031527D0 (en) * | 2000-12-22 | 2001-02-07 | Smithkline Beecham Plc | New use |
| US7241579B2 (en) | 2000-12-22 | 2007-07-10 | Smithkline Beecham Corporation | Method of screening for GPR40 ligands |
| EP1538217A4 (de) * | 2002-09-11 | 2006-09-27 | Astellas Pharma Inc | Screening-verfahren für insulingehalt-enhancer |
| RS20050532A (sr) | 2003-01-14 | 2007-12-31 | Arena Pharmaceuticals Inc., | Derivati 1,2,3-trisupstituisanog arila i heteroarila kao modulatori metabolizma za profilaksu i tretman poremećaja povezanih sa njim, kao što su dijebetes i hiperglikemija |
| WO2004084944A1 (ja) * | 2003-03-25 | 2004-10-07 | Sumitomo Pharmaceuticals Co., Ltd. | 新規血糖調節薬及びそのスクリーニング方法 |
| US7083933B1 (en) | 2003-05-09 | 2006-08-01 | Prosidion Limited | Methods for identification of modulators of OSGPR116 activity |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| WO2005009469A1 (ja) * | 2003-07-28 | 2005-02-03 | Sumitomo Pharmaceuticals Co., Ltd. | 新規血糖調節薬及びそのスクリーニング方法 |
| DOP2006000008A (es) * | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| NZ571110A (en) | 2006-04-11 | 2011-03-31 | Arena Pharm Inc | Methods of using GPR119 receptor to identify Glucose-dependent Insulinotropic Peptide (GIP) secretagogue compounds useful for increasing bone mass in an individual |
| WO2008130581A1 (en) * | 2007-04-20 | 2008-10-30 | Schering Corporation | Pyrimidinone derivatives and methods of use thereof |
| WO2008130584A1 (en) * | 2007-04-20 | 2008-10-30 | Schering Corporation | Pyrimidinone derivatives and methods of use thereof |
| PE20090222A1 (es) | 2007-05-04 | 2009-03-27 | Bristol Myers Squibb Co | Compuestos [6,6] y [6,7]-biciclicos como agonistas del receptor acoplado a la proteina g gpr119 |
| EP2152707B1 (de) | 2007-05-04 | 2012-06-20 | Bristol-Myers Squibb Company | An gpr119-g-protein gekoppelte [6,5]-bicyclische rezeptoragonisten |
| PL2170864T3 (pl) | 2007-07-17 | 2012-02-29 | Bristol Myers Squibb Co | Agoniści receptora gpr119 sprężonego z białkiem g - pirydon |
| CA2703203C (en) | 2007-10-22 | 2015-12-15 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
| EP2146210A1 (de) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Verfahren zur Verwendung eines AG-Protein-gekoppelten Rezeptors zur Identifikation von Peptid-YY (PPY)-Sekretagogen sowie Verbindungen zur Behandlung durch PYY modulierter Leiden |
| CA2724426A1 (en) | 2008-05-19 | 2009-11-26 | Schering Corporation | Bicyclic heterocycle derivatives and use thereof as gpr119 modulators |
| TW201006821A (en) | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
| JP2011528369A (ja) | 2008-07-16 | 2011-11-17 | シェーリング コーポレイション | 二環式ヘテロ環誘導体およびそれらの使用方法 |
| MX2011000664A (es) | 2008-07-16 | 2011-02-24 | Schering Corp | Derivados biciclicos heterociclicos y uso de los mismos como moduladores de gpr119. |
| AU2009330208A1 (en) | 2008-12-23 | 2011-08-04 | Merck Sharp & Dohme Corp. | Bicyclic heterocycle derivatives and methods of use thereof |
| WO2010075273A1 (en) | 2008-12-23 | 2010-07-01 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
| EP2382204B1 (de) | 2008-12-23 | 2018-07-11 | Merck Sharp & Dohme Corp. | Pyrimidinderivate als gpcr-modulatoren zur verwendung bei der behandlung von obesitas und diabetes |
| EP2414348B1 (de) | 2009-04-03 | 2013-11-20 | Merck Sharp & Dohme Corp. | Bicyclische piperidin- und piperazinderivate als gpcr-modulatoren zur behandlung von obesitas, diabetes und anderen stoffwechselkrankheiten |
| AR076024A1 (es) | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
| AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
| CA2778684A1 (en) | 2009-10-29 | 2011-05-05 | Schering Corporation | Bridged bicyclic piperidine derivatives and methods of use thereof |
| WO2011062885A1 (en) | 2009-11-23 | 2011-05-26 | Schering Corporation | Fused bicyclic pyrimidine derivatives and methods of use thereof |
| US8912206B2 (en) | 2009-11-23 | 2014-12-16 | Merck Sharp & Dohme Corp. | Pyrimidine ether derivatives and methods of use thereof |
| US9301929B2 (en) | 2009-11-24 | 2016-04-05 | Merck Sharp & Dohme Corp. | Substituted biaryl derivatives and methods of use thereof |
| JP2013522279A (ja) | 2010-03-18 | 2013-06-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病及び関連状態の治療で用いるgpr119作動薬とddp−iv阻害薬リナグリプチンの組合せ |
| JP2013523819A (ja) | 2010-04-06 | 2013-06-17 | アリーナ ファーマシューティカルズ, インコーポレイテッド | Gpr119レセプターのモジュレーターおよびそれに関連する障害の処置 |
| US8415367B2 (en) | 2010-04-08 | 2013-04-09 | Bristol-Myers Squibb Company | Pyrimidinylpiperidinyloxypyridinone analogues as GPR119 modulators |
| EP2566862B1 (de) | 2010-05-06 | 2015-09-16 | Bristol-Myers Squibb Company | Benzofuranyl-analoga als gpr119-modulatoren |
| CN102971311B (zh) | 2010-05-06 | 2015-07-08 | 百时美施贵宝公司 | 作为gpr119调节剂的二环杂芳基化合物 |
| CN103221410B (zh) | 2010-09-22 | 2017-09-15 | 艾尼纳制药公司 | Gpr119受体调节剂和对与其相关的障碍的治疗 |
| WO2012115640A1 (en) * | 2011-02-23 | 2012-08-30 | Elona Biotechnologies | Liquid insulin- containing compositions and methods of making the same |
| US20140018371A1 (en) | 2011-04-01 | 2014-01-16 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012145603A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| KR101913619B1 (ko) | 2011-06-09 | 2018-12-28 | 리젠 파마슈티컬스 소시에떼 아노님 | Gpr-119의 조절제로서의 신규한 화합물 |
| WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US9174965B2 (en) | 2012-05-16 | 2015-11-03 | Bristol-Myers Squibb Company | Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators |
| WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
| WO2016049200A1 (en) * | 2014-09-24 | 2016-03-31 | University Of Oregon | Proteins increasing pancreatic beta cell number and methods of use |
| CA3002540C (en) | 2015-01-06 | 2023-11-07 | Arena Pharmaceuticals, Inc. | Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor |
| JP6838744B2 (ja) | 2015-06-22 | 2021-03-03 | アリーナ ファーマシューティカルズ, インコーポレイテッド | S1P1レセプター関連障害における使用のための(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸(化合物1)の結晶性L−アルギニン塩 |
| CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
| JP7397011B2 (ja) | 2018-06-06 | 2023-12-12 | アリーナ ファーマシューティカルズ, インコーポレイテッド | S1p1受容体に関連する状態を治療する方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL126750C (de) * | 1960-12-05 | |||
| DE3530767A1 (de) * | 1985-08-28 | 1987-03-12 | Max Planck Gesellschaft | Mittel gegen multiple sklerose |
| IT1256191B (it) * | 1992-12-03 | 1995-11-29 | Impiego di lisolecitine nel trattamento della impotenza maschile e dell'alopecia e relative composizioni atte a tale impiego. | |
| NZ510712A (en) | 1998-10-13 | 2004-11-26 | Arena Pharm Inc | Non-endogenous, constitutively activated human G protein-coupled receptors |
| ATE301673T1 (de) | 1998-11-20 | 2005-08-15 | Arena Pharm Inc | Menschliche, an ein g-protein gekoppelter rezeptor rup3 ohne bekannten ligand |
| US20030017528A1 (en) * | 1998-11-20 | 2003-01-23 | Ruoping Chen | Human orphan G protein-coupled receptors |
| JP2002535369A (ja) * | 1999-01-29 | 2002-10-22 | ベイヤー、カミル・エフ | 糖尿病を治療するための組成物及び方法 |
| US6221660B1 (en) | 1999-02-22 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding SNORF25 receptor |
| GB9923177D0 (en) | 1999-09-30 | 1999-12-01 | Pfizer Ltd | Novel polypeptide |
| EP1226250A2 (de) * | 1999-11-03 | 2002-07-31 | MERCK PATENT GmbH | Gpcr-kd5 polypeptide und dns sequenzen davon |
| CA2388865A1 (en) | 1999-11-16 | 2001-05-25 | Pharmacia & Upjohn Company | Novel g protein-coupled receptors |
| CA2392961A1 (en) | 1999-12-10 | 2001-06-14 | Incyte Genomics, Inc. | G-protein coupled receptors |
| EP1287133B1 (de) * | 2000-05-18 | 2006-12-13 | Bayer HealthCare AG | Regulation eines menschlichen dopamine-ähnlichen g-protein gekoppelten rezeptor. |
| US20040067499A1 (en) | 2000-08-04 | 2004-04-08 | Tatsuya Haga | Novel g protein-coupled receptor |
| EP1770159A1 (de) | 2000-12-01 | 2007-04-04 | Astellas Pharma Inc. | Verfahren zur Herstellung eines Arzneimittels zur Behandlung von Diabetes |
| WO2002061087A2 (en) | 2000-12-19 | 2002-08-08 | Lifespan Biosciences, Inc. | Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides |
| WO2002064789A1 (en) | 2001-02-14 | 2002-08-22 | Pharmacia & Upjohn Company | Protein-coupled receptor |
-
2001
- 2001-11-30 EP EP06020589A patent/EP1770159A1/de not_active Ceased
- 2001-11-30 EP EP01998193A patent/EP1338651B9/de not_active Revoked
- 2001-11-30 ES ES01998193T patent/ES2280435T3/es not_active Expired - Lifetime
- 2001-11-30 AT AT01998193T patent/ATE348152T1/de active
- 2001-11-30 AU AU2002218509A patent/AU2002218509A1/en not_active Abandoned
- 2001-11-30 JP JP2002546710A patent/JP3438186B2/ja not_active Expired - Lifetime
- 2001-11-30 US US10/240,540 patent/US20030180813A1/en not_active Abandoned
- 2001-11-30 WO PCT/JP2001/010472 patent/WO2002044362A1/ja not_active Ceased
- 2001-11-30 DE DE60125227T patent/DE60125227T2/de not_active Expired - Lifetime
-
2004
- 2004-10-29 US US10/975,367 patent/US7662775B2/en not_active Expired - Fee Related
-
2009
- 2009-11-19 US US12/622,010 patent/US20100144677A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002218509A1 (en) | 2002-06-11 |
| JPWO2002044362A1 (ja) | 2004-04-02 |
| WO2002044362A1 (en) | 2002-06-06 |
| ES2280435T3 (es) | 2007-09-16 |
| EP1338651B1 (de) | 2006-12-13 |
| EP1338651A4 (de) | 2005-04-27 |
| US7662775B2 (en) | 2010-02-16 |
| EP1338651B9 (de) | 2007-05-09 |
| US20100144677A1 (en) | 2010-06-10 |
| EP1338651A1 (de) | 2003-08-27 |
| DE60125227D1 (de) | 2007-01-25 |
| JP3438186B2 (ja) | 2003-08-18 |
| EP1770159A1 (de) | 2007-04-04 |
| US20050136484A1 (en) | 2005-06-23 |
| US20030180813A1 (en) | 2003-09-25 |
| DE60125227T2 (de) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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