ATE110415T1 - Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen. - Google Patents

Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.

Info

Publication number
ATE110415T1
ATE110415T1 AT91909768T AT91909768T ATE110415T1 AT E110415 T1 ATE110415 T1 AT E110415T1 AT 91909768 T AT91909768 T AT 91909768T AT 91909768 T AT91909768 T AT 91909768T AT E110415 T1 ATE110415 T1 AT E110415T1
Authority
AT
Austria
Prior art keywords
improved method
living cells
biological substances
introducing biological
introducing
Prior art date
Application number
AT91909768T
Other languages
English (en)
Inventor
Ronald F Bruner
Vit Michael J De
Stephen A Johnston
John C Sanford
Original Assignee
Du Pont
Cornell Res Foundation Inc
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Cornell Res Foundation Inc, Univ Duke filed Critical Du Pont
Application granted granted Critical
Publication of ATE110415T1 publication Critical patent/ATE110415T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8206—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated
    • C12N15/8207—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated by mechanical means, e.g. microinjection, particle bombardment, silicon whiskers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT91909768T 1990-05-29 1991-04-29 Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen. ATE110415T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/529,989 US5204253A (en) 1990-05-29 1990-05-29 Method and apparatus for introducing biological substances into living cells

Publications (1)

Publication Number Publication Date
ATE110415T1 true ATE110415T1 (de) 1994-09-15

Family

ID=24112008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91909768T ATE110415T1 (de) 1990-05-29 1991-04-29 Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.

Country Status (13)

Country Link
US (1) US5204253A (de)
EP (1) EP0535005B1 (de)
JP (1) JP2517813B2 (de)
KR (1) KR960008270B1 (de)
AR (1) AR243603A1 (de)
AT (1) ATE110415T1 (de)
AU (1) AU7878891A (de)
CA (1) CA2083816C (de)
DE (1) DE69103631T2 (de)
DK (1) DK0535005T3 (de)
ES (1) ES2059140T3 (de)
HU (1) HU216738B (de)
WO (1) WO1991018991A1 (de)

Families Citing this family (373)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69031951T2 (de) 1989-11-16 1998-08-13 Cornell Res Foundation Inc Transformation von tierischen Hautzellen mit hilfe von Partikeln
JP3135969B2 (ja) 1992-01-18 2001-02-19 科学技術振興事業団 微粒子発射装置
JP3368603B2 (ja) 1992-02-28 2003-01-20 オリンパス光学工業株式会社 遺伝子治療用処置具
GB9211107D0 (en) * 1992-05-26 1992-07-08 British Tech Group Diamond film deposition
WO1993024626A1 (en) * 1992-05-28 1993-12-09 Scientific Dimensions Usa, Inc. Transgenic animal production with biolistically transformed spermatozoa
WO2004031211A2 (en) 2002-10-03 2004-04-15 Epimmune Inc. Hla binding peptides and their uses
TW404844B (en) * 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
US5405779A (en) * 1993-04-09 1995-04-11 Agracetus, Inc. Apparatus for genetic transformation
GB9321183D0 (en) * 1993-10-14 1993-12-01 Zeneca Ltd A method of plant transformation
US5506125A (en) * 1993-12-22 1996-04-09 Agracetus, Inc. Gene delivery instrument with replaceable cartridges
ES2192573T3 (es) * 1994-01-21 2003-10-16 Powderject Vaccines Inc Instrumento de deposito de genes mediante arrastre gaseoso.
US5899880A (en) * 1994-04-08 1999-05-04 Powderject Research Limited Needleless syringe using supersonic gas flow for particle delivery
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
GB9416663D0 (en) 1994-08-17 1994-10-12 Oxford Bioscience Limited Particle delivery
US5648598A (en) * 1994-12-20 1997-07-15 Institut National De La Recherche Agronomique Ornamental character of scented geraniums by genetic transformation
GB9426379D0 (en) 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
GB9502879D0 (en) * 1995-02-14 1995-04-05 Oxford Biosciences Ltd Particle delivery
DE19510696A1 (de) * 1995-03-14 1996-09-19 Soft Gene Gmbh Vorrichtung zur Druckverteilung im Kopfstück einer Apparatur zum ballistischen Transfer von Zellen
US5780100A (en) * 1995-05-18 1998-07-14 Powderject Vaccines, Inc. Method and apparatus for preparing sample cartridges for particle acceleration device
US5525510A (en) * 1995-06-02 1996-06-11 Agracetus, Inc. Coanda effect gene delivery instrument
US7223739B1 (en) * 1995-06-07 2007-05-29 Powderject Vaccines, Inc. Adjuvanted genetic vaccines
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US6013050A (en) * 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
JP2786139B2 (ja) 1995-12-05 1998-08-13 株式会社日本医化器械製作所 生物学的物質又は生理活性物質を導入する打込装置
US6893664B1 (en) 1996-06-17 2005-05-17 Powderject Research Limited Particle delivery techniques
US5850026A (en) 1996-07-03 1998-12-15 Cargill, Incorporated Canola oil having increased oleic acid and decreased linolenic acid content
US5733600A (en) 1996-11-13 1998-03-31 Powderject Vaccines, Inc. Method and apparatus for preparing sample cartridges for a particle acceleration device
DE19648656B4 (de) * 1996-11-14 2005-08-11 Hiper Ceramics Gmbh Vorrichtung zum Beschleunigen von Partikeln auf Zellen zum ballistischen Transfer
ATE377379T1 (de) * 1997-03-21 2007-11-15 Dobi Medical Systems Inc Dynamische und funktionelle bilderzeugung von biologischen objekten mittels einer verformbaren halterung
US6587578B2 (en) 1997-03-21 2003-07-01 Dobi Medical Systems, Inc. Dynamic-functional imaging of biological objects using a non-rigid object holder
US5749337A (en) * 1997-03-31 1998-05-12 Palatov; Dennis Barrel type internal combustion engine
US6307128B1 (en) * 1997-06-03 2001-10-23 Miami University Fatty acid elongases
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
US6433154B1 (en) * 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US6074360A (en) * 1997-07-21 2000-06-13 Boehringer Mannheim Gmbh Electromagnetic transdermal injection device and methods related thereto
JP2001512687A (ja) * 1997-08-05 2001-08-28 キメラジェン，インコーポレーテッド 植物に局在性遺伝子変化を生じさせるための混合二本鎖オリゴヌクレオチドの使用
US5994624A (en) * 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US6258788B1 (en) 1997-11-20 2001-07-10 The United States Of America As Represented By The Secretary Of The Army DNA vaccines against tick-borne flaviviruses
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
US5973227A (en) * 1998-05-06 1999-10-26 University Of Saskatchewan Flax transformation
CA2328397A1 (en) 1998-05-12 1999-11-18 Temple University - Of The Commonwealth System Of Higher Education Human antithrombin iiis and methods related thereto
US7094953B2 (en) 1998-05-29 2006-08-22 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
US6720479B1 (en) * 1998-05-29 2004-04-13 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
ATE537257T1 (de) 1998-06-02 2011-12-15 Univ Nihon Mit iga-nephropathie assoziierte dns
ATE429247T1 (de) 1998-06-17 2009-05-15 Idm Pharma Inc Hla-bindende peptide und ihre verwendungen
US6281375B1 (en) 1998-08-03 2001-08-28 Cargill, Incorporated Biodegradable high oxidative stability oils
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
IL141774A0 (en) 1998-09-04 2002-03-10 Powderject Res Ltd Monitoring methods using particle delivery methods
US6713117B1 (en) * 1998-10-02 2004-03-30 Dharma Kodali Vegetable oil having elevated stearic acid content
AU766005B2 (en) * 1998-10-19 2003-10-09 Powderject Vaccines, Inc. Minimal promoters and uses thereof
US6881723B1 (en) 1998-11-05 2005-04-19 Powderject Vaccines, Inc. Nucleic acid constructs
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
AU3593200A (en) 1999-02-09 2000-08-29 Powderject Vaccines, Inc. (mycobacterium tuberculosis), immunization
US6987025B1 (en) * 1999-02-11 2006-01-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Dwf4 polynucleotides, polypeptides and uses thereof
EP1586645A3 (de) * 1999-02-25 2006-02-22 Ceres Incorporated DNA-Fragmente mit bestimmter Sequenz und die dadurch kodierte Polypeptide
GB9905933D0 (en) * 1999-03-15 1999-05-05 Powderject Res Ltd Neeedleless syringe
US20040029167A1 (en) * 1999-03-22 2004-02-12 Bernard Fritig Inducible COMT_II promoter, chimeric gene containing same and plants transformed therewith
US6995301B1 (en) * 1999-05-04 2006-02-07 Cargill, Incorporated Plant acyltransferases
DE19926216A1 (de) * 1999-06-09 2001-02-22 Metallgesellschaft Ag Verfahren zur Herstellung von Bariumsulfat, Bariumsulfat und Verwendung des Bariumsulfats
US7485715B2 (en) * 1999-06-18 2009-02-03 Ceres, Inc. Sequence-determined DNA encoding AP2 domain polypeptides
US7399850B2 (en) * 1999-06-18 2008-07-15 Ceres, Inc. Sequence-determined DNA fragments encoding AP2 domain proteins
DE60045005D1 (de) * 1999-06-28 2010-11-04 Oklahoma Med Res Found Inhibitoren des memapsin 2 und ihre verwendung
US7479555B2 (en) * 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
GB9918061D0 (en) * 1999-07-30 1999-10-06 Univ Bath Modified plants
DE19946059A1 (de) * 1999-09-25 2001-03-29 Roche Diagnostics Gmbh System zur transdermalen Gewinnung von Körperflüssigkeit
GB9923306D0 (en) * 1999-10-01 1999-12-08 Isis Innovation Diagnostic and therapeutic epitope, and transgenic plant
AR025996A1 (es) * 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
US7196066B1 (en) * 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
US20040234539A1 (en) * 1999-11-03 2004-11-25 Powderject Research Limited Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
US20060194958A1 (en) * 1999-11-10 2006-08-31 Nickolai Alexandrov Sequence-determined DNA fragments encoding AN1-like zinc finger proteins
US20040109874A1 (en) * 1999-11-10 2004-06-10 Powderject Vaccines, Inc. Induction of mucosal immunity by vaccination via the skin route
JP4776131B2 (ja) 1999-11-18 2011-09-21 エピミューン インコーポレイテッド ヘテロクリティックアナログおよび関連方法
FR2802102B1 (fr) * 1999-12-08 2002-07-12 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un tube d'ejection a section constante
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
JP3365500B2 (ja) * 2000-01-19 2003-01-14 ウシオ電機株式会社 狭帯化ＡｒＦエキシマレーザ装置
FR2804329B1 (fr) * 2000-02-02 2002-12-13 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un opercule contenant le principe actif
WO2001069244A2 (en) 2000-03-10 2001-09-20 Washington University Method for labeling individual cells
GB0008494D0 (en) 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
US7691991B2 (en) * 2000-04-17 2010-04-06 Ceres, Inc. Sequence-determined DNA fragments encoding cytochrome P450 proteins
JP2003531865A (ja) * 2000-04-28 2003-10-28 アメリカ合衆国 Ｄｎａおよびワクシニアウイルスベクターワクチンの組み合わせを用いた免疫原性の改善
CA2409093C (en) 2000-05-16 2009-07-21 Regents Of The University Of Minnesota High mass throughput particle generation using multiple nozzle spraying
ATE403716T1 (de) 2000-08-28 2008-08-15 Agensys Inc Nukleinsäure und korrespondierendes protein 85p1b3, nützlich zur behandlung und detektion von krebserkrankungen
CN1330753C (zh) * 2000-08-30 2007-08-08 北卡罗莱纳州立大学 含有可改变蛋白含量的分子诱导物的转基因植物
MXPA03002974A (es) 2000-10-06 2004-05-05 Kyowa Hakko Kogyo Kk Celulas que producen composiciones de anticuerpo.
GB0025710D0 (en) * 2000-10-20 2000-12-06 Medical Res Council Biolistic device
FR2815969B1 (fr) 2000-10-30 2004-12-10 Aventis Cropscience Sa Plantes tolerantes aux herbicides par contournement de voie metabolique
DE60128149D1 (en) * 2000-11-07 2007-06-06 Univ North Carolina State Putrescin-n-methyltransferasepromotor
AU2002235127A1 (en) * 2000-11-22 2002-06-03 Cargill Incorporated Carotenoid biosynthesis
US7385046B2 (en) * 2001-01-03 2008-06-10 Ceres, Inc. Sequence-determined DNA fragments encoding ethylene responsive element binding proteins
US20040078846A1 (en) * 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
US20050003474A1 (en) * 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
EP1363487A4 (de) 2001-01-29 2005-08-17 Cargill Inc Pilzresistente transgene pflanzen
BR0207369A (pt) * 2001-02-09 2004-06-22 Fujisawa Pharmaceutical Co Método para transferir moléculas selecionadas
US6924358B2 (en) 2001-03-05 2005-08-02 Agensys, Inc. 121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US20040172672A1 (en) * 2001-05-15 2004-09-02 Wilkinson Theresa C. Method for producing transgenic monocotyledonous plants
US7247338B2 (en) * 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
US20060157072A1 (en) * 2001-06-08 2006-07-20 Anthony Albino Method of reducing the harmful effects of orally or transdermally delivered nicotine
CN1638655A (zh) * 2001-06-08 2005-07-13 韦克多烟草有限公司 修饰烟草中烟碱和亚硝胺的水平
CA2451654A1 (en) * 2001-06-22 2003-01-03 Ceres, Inc. Chimeric histone acetyltransferase polypeptides
EP1900815B1 (de) 2001-07-12 2016-09-07 University of Massachusetts In-vivo-Herstellung kleiner interferierender und Genverstummung vermittelnder RNAs
JP4210737B2 (ja) 2001-07-12 2009-01-21 ユニバーシティー オブ マサチューセッツ 遺伝子サイレンシングを仲介する低分子干渉リボ核酸のインビボにおける製造方法
US8061006B2 (en) * 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
WO2003013226A2 (en) * 2001-08-09 2003-02-20 Cibus Genetics Non-transgenic herbicide resistant plants
AU2002336446B2 (en) 2001-09-06 2008-03-06 Agensys, Inc. Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer
KR101291006B1 (ko) 2001-10-19 2013-07-30 스미또모 가가꾸 가부시키가이샤 잡초 방제제 대사 단백질, 그의 유전자 및 그의 용도
WO2003050259A2 (en) * 2001-12-10 2003-06-19 Iowa State University Research Foundation, Inc. Nucleic acids related to plant retroelements
EP1466007A1 (de) 2001-12-17 2004-10-13 Powderject Research Limited Nicht- oder minimal invasive überwachungsverfahren
KR20050002921A (ko) * 2002-04-09 2005-01-10 벡터 토바코 리미티드 니코틴과 니트로사민류를 감소시킨 담배
AU2003301841A1 (en) * 2002-05-01 2004-06-07 National Institutes Of Health Immunotherapy regimens in hiv-infected patients
DE10223196B4 (de) * 2002-05-24 2004-05-13 Dornier Medtech Systems Gmbh Verfahren und Einrichtung zum Transferieren von Molekülen in Zellen
US7482139B2 (en) * 2002-05-31 2009-01-27 University Of Utah Research Foundation Variants of antithrombin III
GB0212885D0 (en) * 2002-06-05 2002-07-17 Isis Innovation Therapeutic epitopes and uses thereof
AU2003274463B2 (en) 2002-06-10 2009-10-29 University Of Rochester Gene differentially expressed in breast and bladder cancer and encoded polypeptides
US20060194959A1 (en) * 2002-07-15 2006-08-31 Nickolai Alexandrov Sequence-determined DNA fragments encoding SRF-type transcription factors
US7364901B2 (en) * 2002-07-15 2008-04-29 University Of Kentucky Research Foundation Recombinant Stokesia epoxygenase gene
WO2004016733A2 (en) 2002-08-16 2004-02-26 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
CA2497338A1 (en) 2002-08-30 2004-03-18 Japan Science And Technology Corporation Method of targeted gene disruption, genome of hyperthermostable bacterium and genome chip using the same
US7476777B2 (en) * 2002-09-17 2009-01-13 Ceres, Inc. Biological containment system
US20050257293A1 (en) * 2002-09-17 2005-11-17 Mascia Peter N Biological containment system
GB2410497B (en) * 2002-09-27 2006-11-22 Powderject Res Ltd Nucleic acid coated particles
WO2004050828A2 (en) 2002-11-27 2004-06-17 Agensys, Inc. Nucleic acid corresponding protein entitled 24p4c12 useful in treatment and detection of cancer
EP1903056A3 (de) 2002-12-10 2008-05-07 Idm Pharma, Inc. HLA-A1, -A2, -A3, -A24, -B7 and -B44 bindende Peptide die Tumorassoziiert-Antigen Epitopen enthalten, und Zusammensetzungen davon
CA2511553C (en) 2002-12-26 2013-07-30 Shin-Ichi Hashimoto Process for producing dipeptides
US7365240B2 (en) * 2003-02-05 2008-04-29 Divergence, Inc. Nucleic acids encoding anthelmintic agents and plants made therefrom
AU2004210975B2 (en) 2003-02-10 2008-04-10 Agensys, Inc. Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
US20040241750A1 (en) * 2003-03-24 2004-12-02 David Nordman Novel methods for determining the negative control value for multi-analyte assays
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
WO2005014780A2 (en) 2003-05-30 2005-02-17 Agensys, Inc. Prostate stem cell antigen (psca) variants and subsequences thereof
EP3502252B1 (de) 2003-06-02 2023-04-05 University of Massachusetts Verfahren und zusammensetzungen zur kontrolle der wirksamkeit von rna-silencing
ATE485394T1 (de) 2003-06-02 2010-11-15 Univ Massachusetts Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai
US7892205B2 (en) * 2003-06-06 2011-02-22 Boston Scientific Scimed, Inc. Device and method for delivering micronized therapeutic agents in the body
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
AU2004282575A1 (en) * 2003-10-14 2005-04-28 Ceres, Inc. Methods and compositions for altering seed phenotypes
US8147426B2 (en) * 2003-12-31 2012-04-03 Nipro Diagnostics, Inc. Integrated diagnostic test system
EP1725868A4 (de) * 2004-01-09 2008-02-06 Univ Utah Res Found Verfahren zur verwendung hochaffiner atiii-varianten
JP2007521806A (ja) * 2004-01-16 2007-08-09 セレス，インコーポレーテッド 受容体ポリペプチドを有する植物細胞
US7368629B2 (en) * 2004-02-04 2008-05-06 Divergence, Inc. Nucleic acids encoding anthelmintic agents and plants made therefrom
US7241937B2 (en) * 2004-04-23 2007-07-10 Ceres, Inc. Methods and materials for improving plant drought tolerance
US10105437B2 (en) 2004-04-28 2018-10-23 Btg International Limited Epitopes related to coeliac disease
EP1755639B1 (de) 2004-04-28 2017-08-16 BTG International Limited Epitope im zusammenhang mit zoliakie
JP4736480B2 (ja) 2004-05-17 2011-07-27 住友化学株式会社 雑草防除方法
PL1753871T3 (pl) 2004-05-28 2016-01-29 Agensys Inc Przeciwciała i powiązane cząsteczki, które wiążą się z antygenem komórek macierzystych prostaty (PSCA)
US20060041952A1 (en) * 2004-08-20 2006-02-23 Cook Zhihong C P450 polynucleotides, polypeptides, and uses thereof
US20060059585A1 (en) * 2004-09-14 2006-03-16 Boris Jankowski Modulating plant sugar levels
WO2006031859A2 (en) 2004-09-14 2006-03-23 Ceres Inc. Modulation of amino acid and sugar content in plants
US7429692B2 (en) * 2004-10-14 2008-09-30 Ceres, Inc. Sucrose synthase 3 promoter from rice and uses thereof
WO2008069878A2 (en) 2006-10-27 2008-06-12 Ceres, Inc. Modulating lignin in plants
WO2007050625A1 (en) * 2005-10-25 2007-05-03 Ceres, Inc. Modulation of triterpenoid content in plants
WO2008076922A1 (en) * 2006-12-15 2008-06-26 Ceres, Inc. Modulation of plant protein levels
WO2007089610A1 (en) * 2006-01-26 2007-08-09 Ceres, Inc. Modulating plant oil levels
WO2007087601A2 (en) * 2006-01-25 2007-08-02 Ceres, Inc. Modulating plant protein levels
US9758790B2 (en) 2004-12-08 2017-09-12 Ceres, Inc. Modulating the level of components within plants
WO2006062971A2 (en) * 2004-12-08 2006-06-15 Ceres Inc. Modulating plant carbon levels
AU2005316863A1 (en) * 2004-12-16 2006-06-22 Ceres Inc. Modulating plant nitrogen levels
US7335760B2 (en) * 2004-12-22 2008-02-26 Ceres, Inc. Nucleic acid sequences encoding zinc finger proteins
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs
AU2006216715A1 (en) * 2005-02-22 2006-08-31 Ceres Inc. Modulating plant alkaloids
AU2006230563B8 (en) 2005-03-31 2010-06-17 Agensys, Inc. Antibodies and related molecules that bind to 161P2F10B proteins
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
WO2006113481A1 (en) * 2005-04-14 2006-10-26 Ceres Inc. Secondary metabolite production via manipulation of genome methylation
US7312376B2 (en) * 2005-04-20 2007-12-25 Ceres, Inc. Regulatory regions from Papaveraceae
WO2006133461A1 (en) * 2005-06-08 2006-12-14 Ceres Inc. Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations
JP5640230B2 (ja) 2005-06-24 2014-12-17 国立大学法人群馬大学 新規生理物質ｎｅｓｆａｔｉｎとその関連物質、およびそれらの用途
AU2006279896A1 (en) * 2005-08-10 2007-02-22 Oklahoma Medical Research Foundation Truncated memapsin 2 for use for treating Alzheimer's disease
WO2007037245A1 (ja) 2005-09-29 2007-04-05 Shionogi & Co., Ltd. 血管新生抑制作用を有するポリペプチド
WO2007041536A2 (en) * 2005-09-30 2007-04-12 Ceres, Inc. Modulating plant tocopherol levels
NZ597682A (en) 2006-01-12 2014-02-28 Incima Ipco B V Epsps mutants
US7951428B2 (en) * 2006-01-31 2011-05-31 Regents Of The University Of Minnesota Electrospray coating of objects
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US9248217B2 (en) * 2006-01-31 2016-02-02 Nanocopocia, LLC Nanoparticle coating of surfaces
US20070199090A1 (en) * 2006-02-22 2007-08-23 Nestor Apuya Modulating alkaloid biosynthesis
WO2007120989A2 (en) * 2006-02-24 2007-10-25 Ceres, Inc. Shade regulatory regions
WO2007117693A2 (en) * 2006-04-07 2007-10-18 Ceres, Inc. Regulatory protein-regulatory region associations related to alkaloid biosynthesis
JP5242382B2 (ja) 2006-04-14 2013-07-24 株式会社医学生物学研究所 エフェクター機能を有するポリペプチド変異体
JP2009536029A (ja) * 2006-05-09 2009-10-08 リライアンス ライフ サイエンシーズ プライベイト リミテッド ヤトロファ・クルカス（Ｊａｔｒｏｐｈａｃｕｒｃａｓ）由来のアセチル−ＣｏＡカルボキシラーゼ（ＡＣＣアーゼ）遺伝子の分子クローニングおよび配列決定
WO2008005619A2 (en) * 2006-05-10 2008-01-10 Ceres, Inc. Shade tolerance in plants
US20100024070A1 (en) * 2006-05-15 2010-01-28 Steven Craig Bobzin Modulation of oil levels in plants
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
WO2007147068A2 (en) * 2006-06-14 2007-12-21 Ceres, Inc. Increasing uv-b tolerance in plants
US20090320165A1 (en) * 2006-06-21 2009-12-24 Steven Craig Bobzin Modulation of protein levels in plants
EP2679687B1 (de) * 2006-06-28 2020-08-19 Cibus Europe B.V. Fettsäuremischungen und ihre Verwendung
US20130191941A1 (en) 2006-07-05 2013-07-25 Shing Kwok Modulating light response pathways in plants, increasing light-related tolerances in plants, and increasing biomass in plants
WO2008006033A1 (en) * 2006-07-05 2008-01-10 Ceres, Inc. Increasing low light tolerance in plants
WO2008038613A1 (fr) 2006-09-25 2008-04-03 Kyowa Hakko Bio Co., Ltd. Procédé de production de dipeptide
US20100199378A1 (en) * 2006-11-20 2010-08-05 Shing Kwok Shade tolerance in plants
US8222388B2 (en) * 2006-11-22 2012-07-17 Ceres, Inc. Broadly expressing regulatory regions
US9040816B2 (en) * 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
EP2119780B1 (de) 2007-01-24 2015-03-25 Kyowa Hakko Kirin Co., Ltd. Genetisch rekombinante antikörperzusammensetzung mit verbesserter effektoraktivität
US20110236374A1 (en) 2007-01-24 2011-09-29 Kyowa Hakko Kirin Co., Ltd. Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2
EP2123751A4 (de) 2007-01-25 2010-06-02 Kyowa Hakko Kirin Co Ltd Neues peptid
EP2221380A1 (de) 2007-09-27 2010-08-25 Shionogi & Co., Ltd. Verfahren zur herstellung von hydroxyliertem adamantan mittels zytochrom p450
CN108342376A (zh) * 2007-10-05 2018-07-31 赛布斯欧洲公司 芸苔属中突变的乙酰羟酸合酶基因
JP5620106B2 (ja) 2007-10-24 2014-11-05 株式会社糖鎖工学研究所 増強されたエフェクター機能を有するポリペプチド
US20100310640A1 (en) * 2007-11-01 2010-12-09 Knutson Keith L Hla-dr binding peptides and their uses
PL2234994T3 (pl) * 2007-12-27 2018-02-28 Cibus Europe B.V. Mieszanki estrów butylowych kwasów tłuszczowych
AU2009244462B2 (en) 2008-05-06 2013-04-11 Cook Medical Technologies Llc Apparatus and methods for delivering therapeutic agents
US20110129499A1 (en) 2008-05-19 2011-06-02 Paulo Maciag Dual delivery system for heterologous antigens
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
US10100334B2 (en) * 2008-05-23 2018-10-16 Nucelis Inc. Production of squalene using yeast
US8419145B2 (en) * 2008-07-25 2013-04-16 Eastman Kodak Company Inkjet printhead and method of printing with multiple drop volumes
WO2010018847A1 (ja) 2008-08-13 2010-02-18 協和発酵キリン株式会社 遺伝子組換えプロテインs組成物
US8298794B2 (en) * 2008-10-09 2012-10-30 Ceres, Inc. Cinnamyl-alcohol dehydrogenases
EP2357228B1 (de) 2008-10-09 2017-05-10 Kyowa Medex CO., LTD. Neuartige fructosyl-peptidyl-oxidase
US8361054B2 (en) * 2008-12-23 2013-01-29 Cook Medical Technologies Llc Apparatus and methods for containing and delivering therapeutic agents
EP2206723A1 (de) 2009-01-12 2010-07-14 Bonas, Ulla Modulare DNA-bindende Domänen
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
US8118777B2 (en) 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
WO2011011412A2 (en) 2009-07-20 2011-01-27 Ceres, Inc. Transgenic plants having increased biomass
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
US8470568B2 (en) 2009-11-23 2013-06-25 Nucelis Inc. Methods and compositions for producing squalene using yeast
CN106834320B (zh) 2009-12-10 2021-05-25 明尼苏达大学董事会 Tal效应子介导的dna修饰
ES2668198T3 (es) 2009-12-23 2018-05-17 Bayer Intellectual Property Gmbh Plantas tolerantes a herbicidas inhibidores de HPPD
UY33139A (es) 2009-12-23 2011-07-29 Bayer Cropscience Ag Plantas tolerantes a herbicidas inhibidores de las hppd
EA201290572A1 (ru) 2009-12-23 2013-05-30 Байер Интеллектуэль Проперти Гмбх Растения, устойчивые к гербицидам - ингибиторам hppd
ES2659086T3 (es) 2009-12-23 2018-03-13 Bayer Intellectual Property Gmbh Plantas tolerantes a herbicidas inhibidores de HPPD
EP2516632B1 (de) 2009-12-23 2018-02-14 Bayer Intellectual Property GmbH Hppd-inhibitorherbizid-resistente pflanzen
US20110159577A1 (en) * 2009-12-30 2011-06-30 E. I. Du Pont De Nemours And Company Divider for use with biolistic bombardment device
AR080128A1 (es) 2010-02-04 2012-03-14 Bayer Cropscience Ag Un metodo para incrementar la fijacion fotosintetica del carbono usando la proteina de fusion multi-subunidad de glicolato deshidrogenasa
US20130052221A1 (en) 2010-02-26 2013-02-28 The Govt. of the U.S, as represented by The Sec. of The Dept. of Health and Human Services Dna-protein vaccination protocols
WO2011108502A1 (ja) 2010-03-02 2011-09-09 協和発酵キリン株式会社 改変抗体組成物
WO2011118739A1 (ja) 2010-03-26 2011-09-29 協和発酵キリン株式会社 新規修飾部位導入抗体および抗体フラグメント
US9441233B2 (en) 2010-05-06 2016-09-13 Ceres, Inc. Transgenic plants having increased biomass
ES3038392T3 (en) 2010-05-14 2025-10-13 Massachusetts Gen Hospital Neoantigen specific cytotoxic t cells for use in treating cancer
JP6208580B2 (ja) 2010-05-17 2017-10-04 サンガモ セラピューティクス， インコーポレイテッド 新規のｄｎａ結合タンパク質及びその使用
CN105671108A (zh) 2010-06-02 2016-06-15 沃维公司 甜菊糖苷的重组生产
JP5058332B2 (ja) 2010-07-14 2012-10-24 住友ゴム工業株式会社 イソプレンオリゴマー、ポリイソプレン、及びこれらの製造方法、ゴム組成物、並びに空気入りタイヤ
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
WO2012138377A2 (en) 2010-10-01 2012-10-11 Trustees Of The University Of Pennsylvania The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
BR112013010278B1 (pt) 2010-10-27 2020-12-29 Ceres, Inc método para produzir uma planta, método para modular a composição de biomassa em uma planta, ácido nucleico isolado e método para alterar a composição de biomassa em uma planta
WO2012125551A1 (en) 2011-03-11 2012-09-20 Advaxis Listeria-based adjuvants
RU2631790C2 (ru) 2011-04-11 2017-09-26 Таргетед Гроус, Инк. Идентификация и применение мутантных krp у растений
EP3514226B1 (de) 2011-08-08 2023-03-29 International Flavors & Fragrances Inc. Zusammensetzungen und verfahren für die biosynthese von vanillin oder vanillin-beta-d-glucosid
WO2013022989A2 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
KR101815063B1 (ko) 2011-08-08 2018-01-05 에볼바 에스아 사프란 화합물의 재조합 생성을 위한 방법 및 물질
WO2013025485A1 (en) 2011-08-12 2013-02-21 Ceres, Inc. Transcription terminators
WO2013067128A1 (en) 2011-11-02 2013-05-10 Ceres, Inc. Transgenic plants having increased tolerance to aluminum
EP3984551A1 (de) 2011-12-02 2022-04-20 Rhode Island Hospital Impfstoff gegen falciparum-malaria
US10323256B2 (en) 2011-12-09 2019-06-18 Ceres, Inc. Transgenic plants having altered biomass composition
SG11201405605VA (en) 2012-03-12 2014-10-30 Advaxis Inc SUPPRESSOR CELL FUNCTION INHIBITION FOLLOWING <i>LISTERIA</i> VACCINE TREATMENT
US20150225734A1 (en) 2012-06-19 2015-08-13 Regents Of The University Of Minnesota Gene targeting in plants using dna viruses
UY35035A (es) 2012-09-14 2014-04-30 Bayer Cropscience Ag ?molécula de ácido nucleico recombinante que codifica una enzima hppd, vector, célula huésped, semilla, planta, polipéptido, producto primario, métodos y usos?.
EP2905290B1 (de) 2012-10-05 2019-12-04 Kyowa Kirin Co., Ltd. Heterodimere proteinzusammensetzung
EP2914094B1 (de) 2012-11-01 2021-07-21 Cellectis Pflanzen zur herstellung therapeutischer proteine
AU2013339881B2 (en) 2012-11-05 2017-08-24 Danstar Ferment Ag Vanillin synthase
PL2934097T3 (pl) 2012-12-21 2018-11-30 Cellectis Ziemniaki o ograniczonej słodkości indukowanej chłodem
SG11201505597SA (en) 2013-02-06 2015-08-28 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
EP2954061B1 (de) 2013-02-11 2023-11-22 Evolva SA Effiziente herstellung von steviolglycosiden in rekombinanten wirtszellen
AU2014236181B2 (en) 2013-03-14 2020-03-19 Cibus Europe B.V. Mutated allene oxide synthase 2 (AOS2) genes
EP2971001A4 (de) 2013-03-14 2016-08-17 Evolutionary Genomics Inc Identifizierung und verwendung von tomatengenen zur kontrolle der toleranz gegenüber trockenheit/salz und obstsüsse
US10113162B2 (en) 2013-03-15 2018-10-30 Cellectis Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
CA3206344A1 (en) 2013-03-15 2014-09-18 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
US12331303B2 (en) 2013-03-15 2025-06-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
EP2966984B1 (de) 2013-03-15 2022-03-02 Cibus US LLC Gezielte genmodifikation durch oligonukleotide um gene zu reparieren
WO2014168874A2 (en) 2013-04-07 2014-10-16 The Broad Institute, Inc. Compositions and methods for personalized neoplasia vaccines
CN105431533B (zh) 2013-07-09 2019-06-28 协和梅迪克斯株式会社 糖化六肽氧化酶及其用途
EP3044320B1 (de) 2013-09-11 2020-02-19 Impossible Foods Inc. Ausscheidung hämhaltiger polypeptide
LT3062606T (lt) 2013-10-29 2019-07-10 Biotech Institute, Llc Specializuotų kanapių selekcija, gamyba, perdirbimas ir panaudojimas
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
JP7060324B2 (ja) 2013-12-20 2022-04-26 ザ・ブロード・インスティテュート・インコーポレイテッド ネオ抗原ワクチンによる併用療法
JP6448194B2 (ja) 2014-01-20 2019-01-09 住友ゴム工業株式会社 シス型プレニルトランスフェラーゼをコードする遺伝子、及び、ＮｏｇｏＢｒｅｃｅｐｔｏｒをコードする遺伝子を宿主に導入することにより、該宿主において、シス型プレニルトランスフェラーゼ及びＮｏｇｏＢｒｅｃｅｐｔｏｒを発現させた形質転換体、並びに該形質転換体を用いたポリイソプレノイドの製造方法
WO2015113569A1 (en) 2014-01-31 2015-08-06 University Of Copenhagen Biosynthesis of forskolin and related compounds
EP3099803A1 (de) 2014-01-31 2016-12-07 University of Copenhagen Verfahren zur herstellung von diterpenen
US10876130B2 (en) 2014-03-11 2020-12-29 BASF Agricultural Solutions Seed US LLC HPPD variants and methods of use
KR102569558B1 (ko) 2014-03-14 2023-08-22 시버스 유에스 엘엘씨 올리고뉴클레오타이드 매개 유전자 보수를 사용한 표적화된 유전자 변형의 효율을 증가시키기 위한 방법 및 조성물
US9101100B1 (en) 2014-04-30 2015-08-11 Ceres, Inc. Methods and materials for high throughput testing of transgene combinations
US9737251B2 (en) 2014-05-28 2017-08-22 Verily Life Sciences Llc Needle-free blood draw
CA2952906A1 (en) 2014-06-20 2015-12-23 Cellectis Potatoes with reduced granule-bound starch synthase
WO2015197075A1 (en) 2014-06-23 2015-12-30 University Of Copenhagen Methods and materials for production of terpenoids
PL3169785T3 (pl) 2014-07-15 2022-05-23 Forage Genetics International, Llc Sposób zwiększania plonu w warunkach stresu abiotycznego
EP3179869A1 (de) 2014-08-11 2017-06-21 Evolva SA Erzeugung von steviolglycosiden in rekombinanten wirten
US10612064B2 (en) 2014-09-09 2020-04-07 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2016070885A1 (en) 2014-11-07 2016-05-12 University Of Copenhagen Biosynthesis of oxidised 13r-mo and related compounds
WO2016075302A1 (en) 2014-11-13 2016-05-19 Evolva Sa Methods and materials for biosynthesis of manoyl oxide
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
CN108337892B (zh) 2015-01-30 2022-06-24 埃沃尔瓦公司 在重组宿主中生产甜菊醇糖苷
JP6719174B2 (ja) 2015-02-23 2020-07-08 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6557990B2 (ja) 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6557989B2 (ja) 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
PL3294762T3 (pl) 2015-05-11 2022-04-25 Impossible Foods Inc. Konstrukty ekspresyjne i sposoby inżynierii genetycznej drożdży metylotroficznych
US20180346520A1 (en) 2015-05-13 2018-12-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Methods and compositions for inducing an immune response using conserved element constructs
IL302102A (en) 2015-05-20 2023-06-01 Dana Farber Cancer Inst Inc shared neoantigens
ES2886483T3 (es) 2015-05-22 2021-12-20 Stcube & Co Inc Métodos de rastreo para dianas para la terapia contra el cáncer
TWI750122B (zh) 2015-06-09 2021-12-21 美商博德研究所有限公司 用於贅瘤疫苗之調配物及其製備方法
CN108271391A (zh) 2015-08-07 2018-07-10 埃沃尔瓦公司 重组宿主中的甜菊醇糖苷的产生
US10837024B2 (en) 2015-09-17 2020-11-17 Cellectis Modifying messenger RNA stability in plant transformations
US20170199961A1 (en) 2015-12-16 2017-07-13 Gritstone Oncology, Inc. Neoantigen Identification, Manufacture, and Use
EP4646936A3 (de) 2016-02-02 2025-11-19 Cellectis Modifizierung der sojaölzusammensetzung durch gezieltes knockout der fad3a/b/c-gene
KR20250117482A (ko) 2016-02-09 2025-08-04 시버스 유에스 엘엘씨 올리고뉴클레오타이드 매개된 유전자 보수를 사용한 표적화된 유전자 변형의 효율을 증가시키기 위한 방법 및 조성물
CA3018748A1 (en) 2016-03-31 2017-10-05 Neon Therapeutics, Inc. Neoantigens and methods of their use
WO2017178632A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
AU2017254477A1 (en) 2016-04-18 2018-11-01 Jennifer G. ABELIN Improved HLA epitope prediction
US11624076B2 (en) 2016-04-21 2023-04-11 BASF Agricultural Solutions Seed US LLC TAL-effector mediated herbicide tolerance
EP3458599A1 (de) 2016-05-16 2019-03-27 Evolva SA Herstellung von steviolglycosiden in rekombinanten wirten
WO2018015512A1 (en) 2016-07-20 2018-01-25 Evolva Sa Biosynthesis of 13r-manoyl oxide derivatives
US11060071B2 (en) 2016-08-09 2021-07-13 River Stone Biotech, LLC Increased biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors in a recombinant host cell
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
UY37482A (es) 2016-11-16 2018-05-31 Cellectis Métodos para alterar el contenido de aminoácidos en plantas mediante mutaciones de desplazamiento de marco
EP3544607A4 (de) 2016-11-23 2020-10-14 Gritstone Oncology, Inc. Virale freisetzung von neoantigenen
CN116102651A (zh) 2017-01-10 2023-05-12 国立大学法人山口大学 抗gpc3抗体
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
BR112019018059A2 (pt) 2017-03-07 2020-08-04 BASF Agricultural Solutions Seed US LLC molécula de ácido nucleico recombinante, célula hospedeira, plantas, sementes transgênicas, polipeptídeo recombinante, método para produzir um polipeptídeo, método de controle de ervas daninhas, uso do ácido nucleico e produto de utilidade
US11180770B2 (en) 2017-03-07 2021-11-23 BASF Agricultural Solutions Seed US LLC HPPD variants and methods of use
CA3055317A1 (en) 2017-03-07 2018-09-13 BASF Agricultural Solutions Seed US LLC Hppd variants and methods of use
CA3058807A1 (en) 2017-04-03 2018-10-11 Neon Therapeutics, Inc. Protein antigens and uses thereof
ES2977620T3 (es) 2017-04-25 2024-08-27 Cellectis Alfalfa con composición reducida de lignina
SG11201910101SA (en) 2017-05-08 2019-11-28 Gritstone Oncology Inc Alphavirus neoantigen vectors
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
CA3066635A1 (en) 2017-06-09 2018-12-13 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use
CN118888004A (zh) 2017-10-10 2024-11-01 磨石生物公司 使用热点进行的新抗原鉴别
US11279944B2 (en) 2017-10-24 2022-03-22 BASF Agricultural Solutions Seed US LLC Of herbicide tolerance to 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors by down-regulation of HPPD expression in soybean
WO2019083808A1 (en) 2017-10-24 2019-05-02 Basf Se IMPROVING HERBICIDE TOLERANCE AGAINST HPPD INHIBITORS BY REGULATION OF PUTATIVE REDUCED 4-HYDROXYPHENYLPYRUVATE REDUCES IN SOYBEANS
US11885815B2 (en) 2017-11-22 2024-01-30 Gritstone Bio, Inc. Reducing junction epitope presentation for neoantigens
KR20200118029A (ko) 2018-01-04 2020-10-14 아이코닉 테라퓨틱스, 인코포레이티드 항-조직 인자 항체, 항체-약물 결합체, 및 관련 방법
WO2019140009A1 (en) 2018-01-09 2019-07-18 Cibus Us Llc Shatterproof genes and mutations
EP3772905A4 (de) 2018-04-04 2022-01-05 Cibus US LLC Fad2-gene und mutationen
US11866788B2 (en) 2018-05-08 2024-01-09 Sanford Burnham Prebys Medical Discovery Institute Role of PVT1 in the diagnosis and treatment of MYC-driven cancer
US20210380684A1 (en) 2018-09-28 2021-12-09 Kyowa Kirin Co., Ltd. Antibody composition
WO2020072700A1 (en) 2018-10-02 2020-04-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
KR102232757B1 (ko) * 2018-11-22 2021-03-26 (주)엑솔런스바이오테크놀로지 체외충격파를 이용한 표적물질 전달 장치
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
WO2020190363A1 (en) 2019-03-19 2020-09-24 Massachusetts Institute Of Technology Control of nitrogen fixation in rhizobia that associate with cereals
US11965167B2 (en) 2019-04-25 2024-04-23 Impossible Foods Inc. Materials and methods for protein production
CN114072516B (zh) 2019-05-30 2025-01-14 磨石生物公司 经修饰的腺病毒
JP2020195326A (ja) 2019-06-03 2020-12-10 住友ゴム工業株式会社 天然ゴムの製造方法、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
US11473086B2 (en) 2019-06-19 2022-10-18 Ut-Battelle, Llc Loss of function alleles of PtEPSP-TF and its regulatory targets in rice
BR112022003790A2 (pt) 2019-09-02 2022-05-31 Inst Nat Sante Rech Med Método para selecionar um peptídeo neoantigênico tumoral, peptídeos neoantigênicos tumorais, peptídeo neoantigênico tumoral isolado, população de células dendríticas autólogas, vacina ou composição imunogênica, anticorpos, método de produção de um anticorpo, receptor de células t, polinucleotídeo, vetor, célula imune, célula t, peptídeo neoantigênico e população de células imunes
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
US20220401539A1 (en) 2019-10-22 2022-12-22 Institut Curie Immunotherapy Targeting Tumor Neoantigenic Peptides
WO2021085564A1 (ja) * 2019-10-30 2021-05-06 株式会社ダイセル 遺伝子銃
JP2021080204A (ja) 2019-11-19 2021-05-27 住友ゴム工業株式会社 融合タンパク質、物質製造方法、ベクター、形質転換細胞、空気入りタイヤの製造方法及びゴム製品の製造方法
US12391964B2 (en) 2020-03-05 2025-08-19 Sumitomo Rubber Industries, Ltd. Method for producing polyisoprenoid, vector, transformed plant, method for producing pneumatic tire, and method for producing rubber product
JP7744330B2 (ja) 2020-04-01 2025-09-25 協和キリン株式会社 抗体組成物
WO2021228999A1 (en) 2020-05-12 2021-11-18 Institut Curie Neoantigenic epitopes associated with sf3b1 mutations
KR20230002873A (ko) 2020-06-05 2023-01-05 쿡 메디컬 테크놀러지스 엘엘씨 치료제 전달을 위한 의료용 스코프
JP2023541108A (ja) 2020-08-06 2023-09-28 グリットストーン バイオ インコーポレイテッド マルチエピトープワクチンカセット
WO2022072846A2 (en) 2020-10-02 2022-04-07 Impossible Foods Inc. Transgenic plants with altered fatty acid profiles and upregulated heme biosynthesis
WO2022072833A2 (en) 2020-10-02 2022-04-07 Impossible Foods Inc. Expression constructs and methods of genetically engineering cells
WO2022074098A1 (en) 2020-10-08 2022-04-14 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Method for the identification of cancer neoantigens
WO2022093977A1 (en) 2020-10-30 2022-05-05 Fortiphyte, Inc. Pathogen resistance in plants
US20230197192A1 (en) 2020-11-06 2023-06-22 Amazon Technologies, Inc. Selecting neoantigens for personalized cancer vaccine
MX2023007003A (es) 2020-12-14 2023-08-18 Biontech Us Inc Antigenos especificos de tejidos para la inmunoterapia del cancer.
EP4281970A1 (de) 2021-01-19 2023-11-29 Amazon Technologies, Inc. Tiefenlernmodell zur vorhersage der tumorspezifischen neoantigen-mhc-klasse-i- oder klasse-ii-immunogenität
WO2022170067A1 (en) 2021-02-05 2022-08-11 Amazon Technologies, Inc. Ranking neoantigens for personalized cancer vaccine
KR20230172630A (ko) 2021-03-11 2023-12-22 므네모 테라퓨틱스 종양 네오 항원성 펩타이드
KR20240006721A (ko) 2021-03-11 2024-01-15 엥스띠뛰 퀴리 막 형질 전환 네오 안티젠 펩타이드
MX2023010641A (es) 2021-03-11 2024-02-07 Mnemo Therapeutics Peptidos neoantigénicos tumorales y usos de los mismos.
US20240087675A1 (en) 2021-03-15 2024-03-14 Amazon Technologies, Inc. Methods for optimizing tumor vaccine antigen coverage for heterogenous malignancies
EP4346884A1 (de) 2021-05-27 2024-04-10 Amazon Technologies, Inc. Chemische mehrkomponentenzusammensetzung eines neoantigenimpfstoffs auf peptidbasis
JP2023040705A (ja) 2021-09-10 2023-03-23 住友ゴム工業株式会社 トランス型ポリイソプレノイドの製造方法、ベクター、形質転換生物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP2023127869A (ja) 2022-03-02 2023-09-14 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ（ｃｐｔ）ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP2023127868A (ja) 2022-03-02 2023-09-14 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ（ｃｐｔ）ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP2023127870A (ja) 2022-03-02 2023-09-14 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ（ｃｐｔ）ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP2025509806A (ja) 2022-03-16 2025-04-11 アマゾン テクノロジーズ， インコーポレイテッド フォローアップネオ抗原がんワクチンのサブクローン透過を改善するための循環腫瘍ｄｎａのモニタリング
US20250302930A1 (en) 2022-03-24 2025-10-02 Institut Curie Immunotherapy targeting tumor transposable element derived neoantigenic peptides in glioblastoma
WO2024015702A1 (en) 2022-07-15 2024-01-18 Amazon Technologies, Inc. Personalized longitudinal analysis of circulating material to monitor and adapt neoantigen cancer vaccines
CN120265780A (zh) 2022-09-09 2025-07-04 埃朗根-纽伦堡弗里德里希-亚历山大大学 植物调控元件及其用途
US12496429B2 (en) 2022-10-18 2025-12-16 Cook Medical Technologies Llc Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents
US12419265B2 (en) 2023-03-27 2025-09-23 Redsea Science And Technology Inc. Tomato plant designated ‘X21-02’
WO2025030048A2 (en) 2023-08-03 2025-02-06 J.R. Simplot Company Fusarium wilt resistance genes
US20250075226A1 (en) 2023-08-29 2025-03-06 University Of Freiburg Proteins for regulation of symbiotic infection and associated regulatory elements

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
IL84459A (en) * 1986-12-05 1993-07-08 Agracetus Apparatus and method for the injection of carrier particles carrying genetic material into living cells
DE3853278T2 (de) * 1988-02-29 1995-07-13 Du Pont Vorrichtung für das Liefern von Substanzen in Zellen und Gewebe auf eine nichtletale Weise.

Also Published As

Publication number Publication date
DK0535005T3 (da) 1994-09-26
HU9203554D0 (en) 1993-03-29
JPH05508316A (ja) 1993-11-25
HU216738B (hu) 1999-08-30
WO1991018991A1 (en) 1991-12-12
US5204253A (en) 1993-04-20
EP0535005B1 (de) 1994-08-24
ES2059140T3 (es) 1994-11-01
JP2517813B2 (ja) 1996-07-24
CA2083816C (en) 2005-06-28
DE69103631D1 (de) 1994-09-29
AU7878891A (en) 1991-12-31
EP0535005A1 (de) 1993-04-07
CA2083816A1 (en) 1991-11-30
KR960008270B1 (ko) 1996-06-21
HUT67533A (en) 1995-04-28
AR243603A1 (es) 1993-08-31
DE69103631T2 (de) 1995-02-23

Similar Documents

Publication Publication Date Title
ATE110415T1 (de) Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.
DE3788026D1 (de) Verfahren und Vorrichtung zur Kultivierung von Zellen.
DK475386D0 (da) Fremgangsmaade og apparat til fremstilling af biologiske stoffer
DE69803344D1 (de) Vorrichtung zum nachweis von strahlung und verfahren zu ihrer herstellung
DE69740113D1 (de) Vorrichtung und verfahren zur inkubation von zellen
DE3788058D1 (de) Zelltoxischer antikörperkomplex und verfahren zu seiner herstellung.
DE69931085D1 (de) System und Verfahren zum Separieren von biologischen Zellen
DE69636398D1 (de) Blutbehandlungssystem und Verfahren zur Gewinnung von mononuklearen Zellen
ATE538205T1 (de) Verfahren, medien und vorrichtung zur einführung von molekülen in pflanzenzellen und bakterien mittels aerosolstrahlen
DK1088212T3 (da) Apparat og fremgangsmåde til indsamling og førstebehandling af vævsprøver til molekylærgenetisk diagnostik
DE3783103D1 (de) Elektrochemischer gassensor und verfahren zu seiner herstellung.
DE3382359D1 (de) Verfahren zur kultivierung und isolierung von zellen.
DE69837440D1 (de) Apparat, geeignet zum transport und lagerung von kernbrennstoffstäben und verfahren zur verwendung des apparats
FI931303A7 (fi) Menetelmät vieraan DNA:n viemiseksi soluihin
DE69816272D1 (de) Cyanidfreie lytische reagenzzusammensetzung und verfahren zur hämoglobin- und zellanalyse
DE69735547D1 (de) Verfahren zur induzierung von immunsupprimierten zellen und vorrichtung zu deren kultivierung
ATE214612T1 (de) Biologisch aktive substanzen, verfahren zur herstellung und sie enthaltende zusammensetzungen
DE3482594D1 (de) Analytische testzusammensetzung, vorrichtung, verfahren zu ihrer herstellung und zur bestimmung von peroxidatisch wirkenden substanzen.
EP1222249A4 (de) Verfahren und vorrichtung zur kultivierung von zellen
DE68919256D1 (de) Verfahren und Vorrichtung zur Ermittlung von Zelleigenschaften.
DE68912661D1 (de) Verfahren und Vorrichtung für Zellkultur.
DE68909997D1 (de) Vorrichtung zur Kultur von tierischen Zellen, Kulturmethode und Mittel zum Nachweis der Kultur.
ATE447413T1 (de) Konjugate und verfahren zu deren herstellung sowie deren verwendung zum transport von molekülen über biologische membranen
DE69509104D1 (de) Testsatz und verfahren zum nachweiss zielzellen und moleküle
ATA79991A (de) Verfahren zum, insbesondere beschleunigten, aeroben mikrobiologischen abbau von biologischen substanzen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties