ATE110415T1 - Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen. - Google Patents

Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.

Info

Publication number
ATE110415T1
ATE110415T1 AT91909768T AT91909768T ATE110415T1 AT E110415 T1 ATE110415 T1 AT E110415T1 AT 91909768 T AT91909768 T AT 91909768T AT 91909768 T AT91909768 T AT 91909768T AT E110415 T1 ATE110415 T1 AT E110415T1
Authority
AT
Austria
Prior art keywords
improved method
living cells
biological substances
introducing biological
introducing
Prior art date
Application number
AT91909768T
Other languages
English (en)
Inventor
Ronald F Bruner
Vit Michael J De
Stephen A Johnston
John C Sanford
Original Assignee
Du Pont
Cornell Res Foundation Inc
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Cornell Res Foundation Inc, Univ Duke filed Critical Du Pont
Application granted granted Critical
Publication of ATE110415T1 publication Critical patent/ATE110415T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8206—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated
    • C12N15/8207—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated by mechanical means, e.g. microinjection, particle bombardment, silicon whiskers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT91909768T 1990-05-29 1991-04-29 Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen. ATE110415T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/529,989 US5204253A (en) 1990-05-29 1990-05-29 Method and apparatus for introducing biological substances into living cells

Publications (1)

Publication Number Publication Date
ATE110415T1 true ATE110415T1 (de) 1994-09-15

Family

ID=24112008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91909768T ATE110415T1 (de) 1990-05-29 1991-04-29 Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.

Country Status (13)

Country Link
US (1) US5204253A (de)
EP (1) EP0535005B1 (de)
JP (1) JP2517813B2 (de)
KR (1) KR960008270B1 (de)
AR (1) AR243603A1 (de)
AT (1) ATE110415T1 (de)
AU (1) AU7878891A (de)
CA (1) CA2083816C (de)
DE (1) DE69103631T2 (de)
DK (1) DK0535005T3 (de)
ES (1) ES2059140T3 (de)
HU (1) HU216738B (de)
WO (1) WO1991018991A1 (de)

Families Citing this family (377)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69031951T2 (de) * 1989-11-16 1998-08-13 Cornell Res Foundation Inc Transformation von tierischen Hautzellen mit hilfe von Partikeln
JP3135969B2 (ja) 1992-01-18 2001-02-19 科学技術振興事業団 微粒子発射装置
JP3368603B2 (ja) 1992-02-28 2003-01-20 オリンパス光学工業株式会社 遺伝子治療用処置具
GB9211107D0 (en) * 1992-05-26 1992-07-08 British Tech Group Diamond film deposition
AU2146092A (en) * 1992-05-28 1993-12-30 Scientific Dimensions Usa, Inc. Transgenic animal production with biolistically transformed spermatozoa
TW360548B (en) 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
US5405779A (en) * 1993-04-09 1995-04-11 Agracetus, Inc. Apparatus for genetic transformation
GB9321183D0 (en) * 1993-10-14 1993-12-01 Zeneca Ltd A method of plant transformation
US5506125A (en) * 1993-12-22 1996-04-09 Agracetus, Inc. Gene delivery instrument with replaceable cartridges
RU2134295C1 (ru) * 1994-01-21 1999-08-10 Паудерджект Вэксинс, Инк. Инструмент для подачи генетического материала, гильза для использования в приводимом в действие газом инструменте для подачи генетического материала (варианты) и способ подачи генетического материала
US5899880A (en) * 1994-04-08 1999-05-04 Powderject Research Limited Needleless syringe using supersonic gas flow for particle delivery
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
GB9416663D0 (en) 1994-08-17 1994-10-12 Oxford Bioscience Limited Particle delivery
US5648598A (en) * 1994-12-20 1997-07-15 Institut National De La Recherche Agronomique Ornamental character of scented geraniums by genetic transformation
GB9426379D0 (en) 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
GB9502879D0 (en) * 1995-02-14 1995-04-05 Oxford Biosciences Ltd Particle delivery
DE19510696A1 (de) * 1995-03-14 1996-09-19 Soft Gene Gmbh Vorrichtung zur Druckverteilung im Kopfstück einer Apparatur zum ballistischen Transfer von Zellen
US5780100A (en) * 1995-05-18 1998-07-14 Powderject Vaccines, Inc. Method and apparatus for preparing sample cartridges for particle acceleration device
US5525510A (en) * 1995-06-02 1996-06-11 Agracetus, Inc. Coanda effect gene delivery instrument
US7223739B1 (en) * 1995-06-07 2007-05-29 Powderject Vaccines, Inc. Adjuvanted genetic vaccines
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US6013050A (en) * 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
JP2786139B2 (ja) 1995-12-05 1998-08-13 株式会社日本医化器械製作所 生物学的物質又は生理活性物質を導入する打込装置
US6893664B1 (en) 1996-06-17 2005-05-17 Powderject Research Limited Particle delivery techniques
US5850026A (en) 1996-07-03 1998-12-15 Cargill, Incorporated Canola oil having increased oleic acid and decreased linolenic acid content
US5733600A (en) 1996-11-13 1998-03-31 Powderject Vaccines, Inc. Method and apparatus for preparing sample cartridges for a particle acceleration device
DE19648656B4 (de) * 1996-11-14 2005-08-11 Hiper Ceramics Gmbh Vorrichtung zum Beschleunigen von Partikeln auf Zellen zum ballistischen Transfer
US6587578B2 (en) 1997-03-21 2003-07-01 Dobi Medical Systems, Inc. Dynamic-functional imaging of biological objects using a non-rigid object holder
DE69838670D1 (de) * 1997-03-21 2007-12-20 Dobi Medical Systems Inc Dynamische und funktionelle bilderzeugung von biologischen objekten mittels einer verformbaren halterung
US5749337A (en) * 1997-03-31 1998-05-12 Palatov; Dennis Barrel type internal combustion engine
US6307128B1 (en) * 1997-06-03 2001-10-23 Miami University Fatty acid elongases
US6586661B1 (en) * 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
US6433154B1 (en) 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US6074360A (en) * 1997-07-21 2000-06-13 Boehringer Mannheim Gmbh Electromagnetic transdermal injection device and methods related thereto
KR20010022652A (ko) * 1997-08-05 2001-03-26 키메라젠, 인크. 식물에서 국소적인 유전자변형을 유발하기 위한 혼성 이중나선올리고뉴클레오티드의 용도
US5994624A (en) * 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US6258788B1 (en) 1997-11-20 2001-07-10 The United States Of America As Represented By The Secretary Of The Army DNA vaccines against tick-borne flaviviruses
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
US5973227A (en) * 1998-05-06 1999-10-26 University Of Saskatchewan Flax transformation
IL139531A0 (en) 1998-05-12 2001-11-25 Human antithrombin iii, methods for the production thereof and pharmaceutical compositions containing the same
US7094953B2 (en) 1998-05-29 2006-08-22 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
US6720479B1 (en) * 1998-05-29 2004-04-13 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
EP1975175A3 (de) 1998-06-02 2008-10-29 Nihon University IgA-Nierenleiden-bezogene DNA
JP2002518346A (ja) 1998-06-17 2002-06-25 エピミューン， インコーポレイテッド Ｈｌａ結合ペプチドおよびそれらの用途
US6281375B1 (en) 1998-08-03 2001-08-28 Cargill, Incorporated Biodegradable high oxidative stability oils
US6207400B1 (en) 1998-09-04 2001-03-27 Powderject Research Limited Non- or minimally invasive monitoring methods using particle delivery methods
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
US6713117B1 (en) * 1998-10-02 2004-03-30 Dharma Kodali Vegetable oil having elevated stearic acid content
NZ511798A (en) * 1998-10-19 2004-01-30 Powderject Vaccines Inc Minimal promoters comprising a promoter not linked to its native enhancer and such minimal promoters linked to an antigen
US6881723B1 (en) 1998-11-05 2005-04-19 Powderject Vaccines, Inc. Nucleic acid constructs
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US7022320B1 (en) 1999-02-09 2006-04-04 Powderject Vaccines, Inc. Mycobacterium tuberculosis immunization
US6987025B1 (en) * 1999-02-11 2006-01-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Dwf4 polynucleotides, polypeptides and uses thereof
EP1586645A3 (de) * 1999-02-25 2006-02-22 Ceres Incorporated DNA-Fragmente mit bestimmter Sequenz und die dadurch kodierte Polypeptide
GB9905933D0 (en) * 1999-03-15 1999-05-05 Powderject Res Ltd Neeedleless syringe
US20040029167A1 (en) * 1999-03-22 2004-02-12 Bernard Fritig Inducible COMT_II promoter, chimeric gene containing same and plants transformed therewith
US6995301B1 (en) * 1999-05-04 2006-02-07 Cargill, Incorporated Plant acyltransferases
US20060073150A1 (en) 2001-09-06 2006-04-06 Mary Faris Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer
DE19926216A1 (de) * 1999-06-09 2001-02-22 Metallgesellschaft Ag Verfahren zur Herstellung von Bariumsulfat, Bariumsulfat und Verwendung des Bariumsulfats
US7485715B2 (en) * 1999-06-18 2009-02-03 Ceres, Inc. Sequence-determined DNA encoding AP2 domain polypeptides
US7399850B2 (en) * 1999-06-18 2008-07-15 Ceres, Inc. Sequence-determined DNA fragments encoding AP2 domain proteins
EP1196609A2 (de) * 1999-06-28 2002-04-17 Oklahoma Medical Research Foundation Katalytisch wirksame rekombinierte memapsin und verfahren zur verwendung davon
US7479555B2 (en) * 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
GB9918061D0 (en) * 1999-07-30 1999-10-06 Univ Bath Modified plants
DE19946059A1 (de) * 1999-09-25 2001-03-29 Roche Diagnostics Gmbh System zur transdermalen Gewinnung von Körperflüssigkeit
GB9923306D0 (en) * 1999-10-01 1999-12-08 Isis Innovation Diagnostic and therapeutic epitope, and transgenic plant
AR025996A1 (es) 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
US20040234539A1 (en) * 1999-11-03 2004-11-25 Powderject Research Limited Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
US7196066B1 (en) 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
US20060194958A1 (en) * 1999-11-10 2006-08-31 Nickolai Alexandrov Sequence-determined DNA fragments encoding AN1-like zinc finger proteins
US20040109874A1 (en) * 1999-11-10 2004-06-10 Powderject Vaccines, Inc. Induction of mucosal immunity by vaccination via the skin route
JP4776131B2 (ja) 1999-11-18 2011-09-21 エピミューン インコーポレイテッド ヘテロクリティックアナログおよび関連方法
FR2802102B1 (fr) * 1999-12-08 2002-07-12 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un tube d'ejection a section constante
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
JP3365500B2 (ja) * 2000-01-19 2003-01-14 ウシオ電機株式会社 狭帯化ＡｒＦエキシマレーザ装置
FR2804329B1 (fr) * 2000-02-02 2002-12-13 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un opercule contenant le principe actif
JP2003527604A (ja) 2000-03-10 2003-09-16 ワシントン・ユニバーシティ 個々の細胞の標識方法
GB0008494D0 (en) 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
US7691991B2 (en) * 2000-04-17 2010-04-06 Ceres, Inc. Sequence-determined DNA fragments encoding cytochrome P450 proteins
JP2003531865A (ja) * 2000-04-28 2003-10-28 アメリカ合衆国 Ｄｎａおよびワクシニアウイルスベクターワクチンの組み合わせを用いた免疫原性の改善
AU6162501A (en) 2000-05-16 2001-11-26 Univ Minnesota High mass throughput particle generation using multiple nozzle spraying
ATE403716T1 (de) 2000-08-28 2008-08-15 Agensys Inc Nukleinsäure und korrespondierendes protein 85p1b3, nützlich zur behandlung und detektion von krebserkrankungen
WO2002018607A2 (en) * 2000-08-30 2002-03-07 North Carolina State University Transgenic plants containing molecular decoys that alter protein content therein
HU231090B1 (hu) 2000-10-06 2020-07-28 Kyowa Kirin Co., Ltd. Antitest-kompozíciót termelő sejt
GB0025710D0 (en) * 2000-10-20 2000-12-06 Medical Res Council Biolistic device
FR2815969B1 (fr) 2000-10-30 2004-12-10 Aventis Cropscience Sa Plantes tolerantes aux herbicides par contournement de voie metabolique
AU2002230691A1 (en) * 2000-11-07 2002-05-21 North Carolina State University Putrescine-n-methyltransferase promoter
US20050260699A1 (en) * 2000-11-22 2005-11-24 Desouza Mervyn L Carotenoid biosynthesis
US7385046B2 (en) * 2001-01-03 2008-06-10 Ceres, Inc. Sequence-determined DNA fragments encoding ethylene responsive element binding proteins
US20040078846A1 (en) * 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
US20050003474A1 (en) * 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
EP1363487A4 (de) * 2001-01-29 2005-08-17 Cargill Inc Pilzresistente transgene pflanzen
EP1365021B1 (de) * 2001-02-09 2006-07-05 BBK Bio Corporation Verfahren zur übertragung ausgewählter moleküle
US6924358B2 (en) 2001-03-05 2005-08-02 Agensys, Inc. 121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
WO2002092824A1 (en) * 2001-05-15 2002-11-21 Wilkinson Thesesa C Method for producing transgenic monocotyledonous plants
US7247338B2 (en) * 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
CN1638655A (zh) * 2001-06-08 2005-07-13 韦克多烟草有限公司 修饰烟草中烟碱和亚硝胺的水平
US20060157072A1 (en) * 2001-06-08 2006-07-20 Anthony Albino Method of reducing the harmful effects of orally or transdermally delivered nicotine
EP1409514A4 (de) * 2001-06-22 2005-02-02 Ceres Inc Chimere histon-acetyltransferase-polypeptide
EP1900815B1 (de) 2001-07-12 2016-09-07 University of Massachusetts In-vivo-Herstellung kleiner interferierender und Genverstummung vermittelnder RNAs
EP1412371B1 (de) 2001-07-12 2016-02-24 University of Massachusetts IN-VIVO-HERSTELLUNG VON KLEINEN INTERFERIERENDEN RNAs, DIE DAS ABSCHALTEN VON GENEN VERMITTELN
US8061006B2 (en) * 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
AU2002322435A1 (en) * 2001-08-09 2003-02-24 Cibus Genetics Non-transgenic herbicide resistant plants
BR122014018568B1 (pt) 2001-10-19 2015-12-01 Sumitomo Chemical Co métodos para conferir a uma planta resistência a um herbicida, controle de ervas daninhas, bem como avaliar a resistência de uma célula ou planta a um composto herbicida
EP1461432A2 (de) * 2001-12-10 2004-09-29 Iowa State University Research Foundation, Inc. Mit pflanzen-retroelementen verwandte nukleinsäuren
US20050176084A1 (en) 2001-12-17 2005-08-11 Burkoth Terry L. Non-or minimally invasive monitoring methods
AP2004003146A0 (en) * 2002-04-09 2004-09-30 Vector Tobacco Ltd Tobacco having reduced nicotine and nitrosamines
US20060094006A1 (en) * 2002-05-01 2006-05-04 Genoveffa Franchini Immunotherapy regimens in hiv-infected patients
DE10223196B4 (de) * 2002-05-24 2004-05-13 Dornier Medtech Systems Gmbh Verfahren und Einrichtung zum Transferieren von Molekülen in Zellen
CA2487901A1 (en) * 2002-05-31 2003-12-11 University Of Utah Research Foundation Variants of antithrombin iii
GB0212885D0 (en) * 2002-06-05 2002-07-17 Isis Innovation Therapeutic epitopes and uses thereof
CN100418981C (zh) 2002-06-10 2008-09-17 瓦西尼斯公司 在乳腺癌和膀胱癌中差异表达的基因及编码多肽
US20060194959A1 (en) * 2002-07-15 2006-08-31 Nickolai Alexandrov Sequence-determined DNA fragments encoding SRF-type transcription factors
US7364901B2 (en) * 2002-07-15 2008-04-29 University Of Kentucky Research Foundation Recombinant Stokesia epoxygenase gene
US20040081653A1 (en) 2002-08-16 2004-04-29 Raitano Arthur B. Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
EP1548105A4 (de) 2002-08-30 2006-03-01 Japan Science & Tech Agency Verfahren zur gezielten genunterbrechung, genom eines hyperthermostabilen bakteriums und genom-chip damit
US7476777B2 (en) * 2002-09-17 2009-01-13 Ceres, Inc. Biological containment system
MXPA05003003A (es) * 2002-09-17 2005-11-23 Ceres Inc Sistema de contencion biologico.
WO2004028560A1 (en) * 2002-09-27 2004-04-08 Powderject Research Limited Nucleic acid coated particles
AU2003291632A1 (en) 2002-10-03 2004-04-23 Epimmune Inc Hla binding peptides and their uses
AU2002352976B2 (en) 2002-11-27 2007-11-08 Agensys, Inc. Nucleic acid corresponding protein entitled 24P4C12 useful in treatment and detection of cancer
EP1903056A3 (de) 2002-12-10 2008-05-07 Idm Pharma, Inc. HLA-A1, -A2, -A3, -A24, -B7 and -B44 bindende Peptide die Tumorassoziiert-Antigen Epitopen enthalten, und Zusammensetzungen davon
KR101043562B1 (ko) 2002-12-26 2011-06-22 교와 핫꼬 바이오 가부시키가이샤 디펩티드의 제조법
WO2004071168A2 (en) * 2003-02-05 2004-08-26 Divergence, Inc. Nucleic acids encoding anthelmintic agents and plants made therefrom
CA2515699C (en) 2003-02-10 2015-01-27 Aya Jakobovits Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers
EP2207036B1 (de) * 2003-03-24 2012-12-12 Gen-Probe Transplant Diagnostics, Inc. Methoden zur Messung der Negativkontrolle in Mehrfachanalyt-Assays
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
NZ572940A (en) 2003-05-30 2010-04-30 Agensys Inc Prostate stem cell antigen (PSCA) variants and subsequences thereof
ES2357116T5 (es) 2003-06-02 2021-09-03 Univ Massachusetts Métodos y composiciones para mejorar la eficacia y especificad de FNAi
DK1633767T3 (en) 2003-06-02 2019-03-25 Univ Massachusetts METHODS AND COMPOSITIONS FOR MANAGING THE EFFECT OF RNA SILENCING
US7892205B2 (en) * 2003-06-06 2011-02-22 Boston Scientific Scimed, Inc. Device and method for delivering micronized therapeutic agents in the body
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
WO2005038040A2 (en) * 2003-10-14 2005-04-28 Ceres, Inc. Methods and compositions for altering seed phenotypes
US8147426B2 (en) * 2003-12-31 2012-04-03 Nipro Diagnostics, Inc. Integrated diagnostic test system
US20070259809A1 (en) * 2004-01-09 2007-11-08 Bock Susan C Methods of Using High Affinity Atiii Variants
EP1709188A1 (de) * 2004-01-16 2006-10-11 Ceres, Inc. Pflanzenzellen enthaltend rezepture polypeptide
US7368629B2 (en) * 2004-02-04 2008-05-06 Divergence, Inc. Nucleic acids encoding anthelmintic agents and plants made therefrom
MXPA06012262A (es) * 2004-04-23 2007-01-31 Ceres Inc Metodos y materiales para mejorar la tolerancia de las plantas a la sequia.
US10105437B2 (en) 2004-04-28 2018-10-23 Btg International Limited Epitopes related to coeliac disease
CN104056251B (zh) 2004-04-28 2019-09-17 英国技术集团国际有限公司 与腹部疾病有关的表位
JP4736480B2 (ja) 2004-05-17 2011-07-27 住友化学株式会社 雑草防除方法
JP4651663B2 (ja) 2004-05-28 2011-03-16 アジェンシス，インコーポレイテッド Ｐｓｃａタンパク質に結合する抗体および関連分子
WO2006023766A2 (en) * 2004-08-20 2006-03-02 Ceres Inc. P450 polynucleotides, polypeptides, and uses thereof
US20060059585A1 (en) * 2004-09-14 2006-03-16 Boris Jankowski Modulating plant sugar levels
US7595433B2 (en) 2004-09-14 2009-09-29 Ceres, Inc. Modulations of amino acid and sugar content in plants
US7429692B2 (en) * 2004-10-14 2008-09-30 Ceres, Inc. Sucrose synthase 3 promoter from rice and uses thereof
WO2006062971A2 (en) * 2004-12-08 2006-06-15 Ceres Inc. Modulating plant carbon levels
WO2007089610A1 (en) * 2006-01-26 2007-08-09 Ceres, Inc. Modulating plant oil levels
US9758790B2 (en) 2004-12-08 2017-09-12 Ceres, Inc. Modulating the level of components within plants
WO2008069878A2 (en) 2006-10-27 2008-06-12 Ceres, Inc. Modulating lignin in plants
WO2006065552A2 (en) * 2004-12-16 2006-06-22 Ceres Inc. Modulating plant nitrogen levels
US7335760B2 (en) * 2004-12-22 2008-02-26 Ceres, Inc. Nucleic acid sequences encoding zinc finger proteins
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs
AU2006216715A1 (en) * 2005-02-22 2006-08-31 Ceres Inc. Modulating plant alkaloids
EP2444099A1 (de) 2005-03-31 2012-04-25 Agensys, Inc. An 161P2F10B-Proteine bindende Antikörper und zugehörige Moleküle
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
WO2006113481A1 (en) * 2005-04-14 2006-10-26 Ceres Inc. Secondary metabolite production via manipulation of genome methylation
US7312376B2 (en) * 2005-04-20 2007-12-25 Ceres, Inc. Regulatory regions from Papaveraceae
WO2006133461A1 (en) * 2005-06-08 2006-12-14 Ceres Inc. Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations
KR20080028888A (ko) 2005-06-24 2008-04-02 데이진 화-마 가부시키가이샤 신규 생리 물질 ｎｅｓｆａｔｉｎ과 그 관련 물질, 및그들의 용도
AU2006279896A1 (en) * 2005-08-10 2007-02-22 Oklahoma Medical Research Foundation Truncated memapsin 2 for use for treating Alzheimer's disease
EP1930344A4 (de) 2005-09-29 2008-12-31 Shionogi & Co Polypeptid mit antiangiogener wirkung
US20100062137A1 (en) * 2005-09-30 2010-03-11 Steven Craig Bobzin Modulating plant tocopherol levels
US20090178160A1 (en) * 2005-10-25 2009-07-09 Joon-Hyun Park Modulation of Triterpenoid Content in Plants
AU2007207813B2 (en) 2006-01-12 2013-09-12 Cibus Europe B.V. EPSPS mutants
US20090304901A1 (en) * 2006-01-25 2009-12-10 Steven Craig Bobzin Modulating plant protein levels
CA2637883C (en) 2006-01-31 2015-07-07 Regents Of The University Of Minnesota Electrospray coating of objects
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US9248217B2 (en) * 2006-01-31 2016-02-02 Nanocopocia, LLC Nanoparticle coating of surfaces
US20070199090A1 (en) * 2006-02-22 2007-08-23 Nestor Apuya Modulating alkaloid biosynthesis
WO2007120989A2 (en) * 2006-02-24 2007-10-25 Ceres, Inc. Shade regulatory regions
WO2007117693A2 (en) * 2006-04-07 2007-10-18 Ceres, Inc. Regulatory protein-regulatory region associations related to alkaloid biosynthesis
EP2011870A4 (de) 2006-04-14 2010-09-15 Medical & Biol Lab Co Ltd Mutantes polypeptid mit effektorfunktion
EP2018397A2 (de) * 2006-05-09 2009-01-28 Reliance Life Sciences Pvt., Ltd. Molekulare klonung und sequenzierung des acetyl-coa-carboxylase-gens aus jatropha curcas
WO2008005619A2 (en) * 2006-05-10 2008-01-10 Ceres, Inc. Shade tolerance in plants
US20100024070A1 (en) * 2006-05-15 2010-01-28 Steven Craig Bobzin Modulation of oil levels in plants
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
WO2007147068A2 (en) * 2006-06-14 2007-12-21 Ceres, Inc. Increasing uv-b tolerance in plants
WO2007149570A2 (en) * 2006-06-21 2007-12-27 Ceres, Inc. Modulation of protein levels in plants
CA2893168C (en) 2006-06-28 2017-11-07 Nucelis Inc. Fatty acid blends and uses therefor
US20130191941A1 (en) 2006-07-05 2013-07-25 Shing Kwok Modulating light response pathways in plants, increasing light-related tolerances in plants, and increasing biomass in plants
WO2008064222A2 (en) * 2006-11-20 2008-05-29 Ceres, Inc. Shade tolerance in plants
US8344210B2 (en) * 2006-07-05 2013-01-01 Ceres, Inc. Increasing low light tolerance in plants
ATE553194T1 (de) 2006-09-25 2012-04-15 Kyowa Hakko Bio Co Ltd Verfahren zur dipeptidherstellung
WO2008064128A2 (en) * 2006-11-22 2008-05-29 Ceres, Inc. Broadly expressing regulatory regions
US9040816B2 (en) * 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
US20100151109A1 (en) * 2006-12-15 2010-06-17 Amr Saad Ragab Modulation of plant protein levels
AU2008208288B2 (en) 2007-01-24 2014-04-03 Kyowa Kirin Co., Ltd. Genetically recombinant antibody composition having enhanced effector activity
WO2008090960A1 (ja) 2007-01-24 2008-07-31 Kyowa Hakko Kirin Co., Ltd. ガングリオシドgm2に特異的に結合する遺伝子組換え抗体組成物
WO2008090678A1 (ja) 2007-01-25 2008-07-31 Kyowa Hakko Kirin Co., Ltd. 新規ペプチド
JP5550041B2 (ja) 2007-09-27 2014-07-16 塩野義製薬株式会社 チトクロームｐ４５０を用いたアダマンタン水酸化体の製造方法
LT2700721T (lt) 2007-10-05 2019-04-10 Cibus Europe B.V. Mutuoti brassica acetohidroksirūgšties sintazės genai
US20120047586A9 (en) 2007-10-24 2012-02-23 Otsuka Chemical Co., Ltd Polypeptide having enhanced effector function
US20100310640A1 (en) * 2007-11-01 2010-12-09 Knutson Keith L Hla-dr binding peptides and their uses
EP2234994B1 (de) * 2007-12-27 2017-09-27 Cibus Europe B.V. Fettsäure butyl ester mischungen
JP2011519679A (ja) 2008-05-06 2011-07-14 ウィルソン−クック・メディカル・インコーポレーテッド 治療薬を送達するための器具及び方法
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
ES2741730T3 (es) 2008-05-19 2020-02-12 Advaxis Inc Sistema de administración doble para antígenos heterólogos que comprende una cepa de Listeria recombinante atenuada por la mutación de dal/dat y la deleción de ActA que comprende una molécula de ácido nucleico que codifica una proteína de fusión de listeriolisina O - antígeno prostático específico
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
KR20170010072A (ko) * 2008-05-23 2017-01-25 누셀리스 인크. 효모를 사용한 스쿠알렌 생산
US8419145B2 (en) * 2008-07-25 2013-04-16 Eastman Kodak Company Inkjet printhead and method of printing with multiple drop volumes
WO2010018847A1 (ja) 2008-08-13 2010-02-18 協和発酵キリン株式会社 遺伝子組換えプロテインs組成物
US8304249B2 (en) 2008-10-09 2012-11-06 Kyowa Medex Co., Ltd. Fructosyl peptide oxidase
US8298794B2 (en) * 2008-10-09 2012-10-30 Ceres, Inc. Cinnamyl-alcohol dehydrogenases
EP2375960B1 (de) * 2008-12-23 2018-10-31 Cook Medical Technologies LLC Gerät zur aufnahme und abgabe von therapeutischen mitteln
EP2206723A1 (de) 2009-01-12 2010-07-14 Bonas, Ulla Modulare DNA-bindende Domänen
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US8118777B2 (en) 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US20120297505A1 (en) 2009-07-20 2012-11-22 Chuan-Yin Wu Transgenic plants having increased biomass
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
UA111813C2 (uk) 2009-11-23 2016-06-24 Нукеліс, Інк. Спосіб одержання сквалену з застосуванням дріжджів
DK2816112T3 (en) 2009-12-10 2018-11-19 Univ Minnesota TAL effector-mediated DNA modification
AR079972A1 (es) 2009-12-23 2012-03-07 Bayer Cropscience Ag Plantas tolerantes a herbicidas inhibidores de las hppd
ES2668198T3 (es) 2009-12-23 2018-05-17 Bayer Intellectual Property Gmbh Plantas tolerantes a herbicidas inhibidores de HPPD
AR080353A1 (es) 2009-12-23 2012-04-04 Bayer Cropscience Ag Plantas tolerantes a herbicidas inhibidores de las hppd
BR112012015692A2 (pt) 2009-12-23 2015-08-25 Bayer Intelectual Property Gmbh Plantas tolerantes a herbicida inibidor de hppds.
BR112012015697A2 (pt) 2009-12-23 2015-08-25 Bayer Intelectual Property Gmbh Plantas tolerantes a herbicidas inibidores de hppd.
WO2011082194A2 (en) * 2009-12-30 2011-07-07 E.I. Dupont De Nemours And Company Divider for use with biolistic bombardment device
RU2651501C2 (ru) 2010-02-04 2018-04-19 Байер Кропсайенс Аг Способ увеличения фотосинтетической фиксации углерода с использованием белка слияния из многих субъединиц гликолатдегидрогеназы
WO2011106705A2 (en) 2010-02-26 2011-09-01 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Dna-protein vaccination protocols
CA2791652C (en) 2010-03-02 2018-06-12 Kyowa Kirin Co., Ltd. Modified antibody composition
WO2011118739A1 (ja) 2010-03-26 2011-09-29 協和発酵キリン株式会社 新規修飾部位導入抗体および抗体フラグメント
US9441233B2 (en) 2010-05-06 2016-09-13 Ceres, Inc. Transgenic plants having increased biomass
CA2797868C (en) 2010-05-14 2023-06-20 The General Hospital Corporation Compositions and methods of identifying tumor specific neoantigens
WO2011146121A1 (en) 2010-05-17 2011-11-24 Sangamo Biosciences, Inc. Novel dna-binding proteins and uses thereof
NZ708078A (en) 2010-06-02 2017-01-27 Evolva Nutrition Inc Recombinant production of steviol glycosides
JP5058332B2 (ja) 2010-07-14 2012-10-24 住友ゴム工業株式会社 イソプレンオリゴマー、ポリイソプレン、及びこれらの製造方法、ゴム組成物、並びに空気入りタイヤ
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
CN107412756A (zh) 2010-10-01 2017-12-01 宾夕法尼亚大学理事会 李斯特菌疫苗载体用于在寄生虫感染的个体中扭转免疫无应答的用途
WO2012058223A1 (en) 2010-10-27 2012-05-03 Ceres, Inc. Transgenic plants having altered biomass composition
EP2683400A4 (de) 2011-03-11 2014-09-17 Advaxis Adjuvanzien auf listerien-basis
RU2631790C2 (ru) 2011-04-11 2017-09-26 Таргетед Гроус, Инк. Идентификация и применение мутантных krp у растений
BR122021015508B1 (pt) 2011-08-08 2022-03-29 Evolva Sa Método para produzir um glicosídeo de esteviol alvo
CA2843549A1 (en) 2011-08-08 2013-02-14 Shriram RAGHAVAN Methods and materials for recombinant production of saffron compounds
ES2719304T3 (es) 2011-08-08 2019-07-09 Int Flavors & Fragrances Inc Composiciones y métodos para la biosíntesis de vainillina o beta-D-glucósido de vainillina
US9562236B2 (en) 2011-08-12 2017-02-07 Ceres, Inc. Transcription terminators
BR112014010546B1 (pt) 2011-11-02 2021-04-13 Ceres, Inc Método de aumento do rendimento de planta em solo contendo níveis elevados de al3+, método de aumento da tolerância de uma planta
ES2894724T3 (es) 2011-12-02 2022-02-15 Rhode Island Hospital Vacuna contra la malaria falciparum
US10323256B2 (en) 2011-12-09 2019-06-18 Ceres, Inc. Transgenic plants having altered biomass composition
WO2013138337A1 (en) 2012-03-12 2013-09-19 Advaxis Suppressor cell function inhibition following listeria vaccine treatment
US20150225734A1 (en) 2012-06-19 2015-08-13 Regents Of The University Of Minnesota Gene targeting in plants using dna viruses
MX369284B (es) 2012-09-14 2019-11-04 Bayer Cropscience Lp Variantes de hppd y metodos de uso.
JP6273205B2 (ja) 2012-10-05 2018-01-31 協和発酵キリン株式会社 ヘテロダイマータンパク質組成物
CN104968193B (zh) 2012-11-01 2021-02-09 塞尔克蒂斯股份有限公司 用于生成治疗性蛋白质的植物
EP2914733A1 (de) 2012-11-05 2015-09-09 Evolva SA Vanillinsynthase
PL2934097T3 (pl) 2012-12-21 2018-11-30 Cellectis Ziemniaki o ograniczonej słodkości indukowanej chłodem
MY190346A (en) 2013-02-06 2022-04-15 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
EP2954061B1 (de) 2013-02-11 2023-11-22 Evolva SA Effiziente herstellung von steviolglycosiden in rekombinanten wirtszellen
EP2971003A4 (de) 2013-03-14 2016-11-16 Cibus Us Llc Mutierte allenoxidsynthase-2-(aos2)-gene
US9862962B2 (en) 2013-03-14 2018-01-09 EG Corp Science, Inc. Identification and use of tomato genes controlling salt/drought tolerance and fruit sweetness
MY183741A (en) 2013-03-15 2021-03-10 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US12331303B2 (en) 2013-03-15 2025-06-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
RS63188B1 (sr) 2013-03-15 2022-06-30 Cibus Us Llc Ciljana genska modifikacija primenom popravke gena posredovane oligonukleotidom
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
US10113162B2 (en) 2013-03-15 2018-10-30 Cellectis Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes
JP6702855B2 (ja) 2013-04-07 2020-06-03 ザ・ブロード・インスティテュート・インコーポレイテッド 個別化された新生物ワクチンの組成物及び方法
JP6328115B2 (ja) 2013-07-09 2018-05-23 協和メデックス株式会社 糖化ヘキサペプチドオキシダーゼとその利用
LT3044320T (lt) 2013-09-11 2020-06-10 Impossible Foods Inc. Hemo turinčių polipeptidų sekrecija
EP3062606B1 (de) 2013-10-29 2019-03-20 Biotech Institute, LLC Zucht, herstellung, verarbeitung und verwendung von speziellem cannabis
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
CN120695169A (zh) 2013-12-20 2025-09-26 博德研究所 使用新抗原疫苗的联合疗法
JP6448194B2 (ja) 2014-01-20 2019-01-09 住友ゴム工業株式会社 シス型プレニルトランスフェラーゼをコードする遺伝子、及び、ＮｏｇｏＢｒｅｃｅｐｔｏｒをコードする遺伝子を宿主に導入することにより、該宿主において、シス型プレニルトランスフェラーゼ及びＮｏｇｏＢｒｅｃｅｐｔｏｒを発現させた形質転換体、並びに該形質転換体を用いたポリイソプレノイドの製造方法
WO2015113569A1 (en) 2014-01-31 2015-08-06 University Of Copenhagen Biosynthesis of forskolin and related compounds
EP3099803A1 (de) 2014-01-31 2016-12-07 University of Copenhagen Verfahren zur herstellung von diterpenen
CN106459986B (zh) 2014-03-11 2020-06-30 拜耳作物科学有限合伙公司 Hppd变体和使用方法
EP3116305B1 (de) 2014-03-14 2023-12-06 Cibus US LLC Verfahren und zusammensetzungen zur erhöhung der effizienz von gezielter genmodifizierung mit oligonukleotidvermittelter genreparatur
US9101100B1 (en) 2014-04-30 2015-08-11 Ceres, Inc. Methods and materials for high throughput testing of transgene combinations
US9737251B2 (en) * 2014-05-28 2017-08-22 Verily Life Sciences Llc Needle-free blood draw
EP3158072B1 (de) 2014-06-20 2021-01-13 Cellectis Kartoffeln mit reduzierter granule-bound-starch-synthase
WO2015197075A1 (en) 2014-06-23 2015-12-30 University Of Copenhagen Methods and materials for production of terpenoids
WO2016011179A2 (en) 2014-07-15 2016-01-21 Ceres, Inc. Methods of increasing crop yield under abiotic stress
JP2017528125A (ja) 2014-08-11 2017-09-28 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． 組み換え宿主におけるステビオールグリコシドの産生
WO2016038095A2 (en) 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
US20190194706A1 (en) 2014-11-07 2019-06-27 University Of Copenhagen Biosynthesis of Oxidised 13R-MO and Related Compounds
US10208326B2 (en) 2014-11-13 2019-02-19 Evolva Sa Methods and materials for biosynthesis of manoyl oxide
WO2016100975A1 (en) 2014-12-19 2016-06-23 Massachsetts Institute Ot Technology Molecular biomarkers for cancer immunotherapy
WO2016100977A1 (en) 2014-12-19 2016-06-23 The Broad Institute Inc. Methods for profiling the t-cel- receptor repertoire
CN108337892B (zh) 2015-01-30 2022-06-24 埃沃尔瓦公司 在重组宿主中生产甜菊醇糖苷
JP6557989B2 (ja) 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6557990B2 (ja) 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6719174B2 (ja) 2015-02-23 2020-07-08 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
CN115851470B (zh) 2015-03-16 2025-09-02 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
LT3294762T (lt) 2015-05-11 2022-04-11 Impossible Foods Inc. Metilotrofinių mielių genų inžinerijos ekspresijos konstruktai ir būdai
EP4276106A3 (de) 2015-05-13 2024-01-24 The United States of America as represented by the Secretary of the Department of Health and Human Services Methoden und zusammensetzungen beruhend auf konstruktenenthaltend konservierte elemente zur induktion einer immunantwort
EP3297660A2 (de) 2015-05-20 2018-03-28 The Broad Institute Inc. Gemeinsam genutzte neoantigene
EP3603651B1 (de) 2015-05-22 2021-07-21 STCube & Co., Inc. Screeningverfahren für targets zur krebstherapie
TWI750122B (zh) 2015-06-09 2021-12-21 美商博德研究所有限公司 用於贅瘤疫苗之調配物及其製備方法
WO2017025362A1 (en) 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts
US10837024B2 (en) 2015-09-17 2020-11-17 Cellectis Modifying messenger RNA stability in plant transformations
BR112018012374A2 (pt) 2015-12-16 2018-12-04 Gritstone Oncology, Inc. identificação, fabricação e uso de neoantígeno
ES3039237T3 (en) 2016-02-02 2025-10-20 Cellectis Modifying soybean oil composition through targeted knockout of the fad3a/b/c genes
US11542515B2 (en) 2016-02-09 2023-01-03 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
KR20220163523A (ko) 2016-03-31 2022-12-09 바이오엔테크 유에스 인크. 신생항원 및 이것의 사용 방법
US10982249B2 (en) 2016-04-13 2021-04-20 Evolva Sa Production of steviol glycosides in recombinant hosts
US20190346442A1 (en) 2016-04-18 2019-11-14 The Broad Institute, Inc. Improved hla epitope prediction
US11624076B2 (en) 2016-04-21 2023-04-11 BASF Agricultural Solutions Seed US LLC TAL-effector mediated herbicide tolerance
CN109312378A (zh) 2016-05-16 2019-02-05 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
WO2018015512A1 (en) 2016-07-20 2018-01-25 Evolva Sa Biosynthesis of 13r-manoyl oxide derivatives
WO2018029282A1 (en) 2016-08-09 2018-02-15 Evolva Sa Biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors
EP3535406A1 (de) 2016-11-07 2019-09-11 Evolva SA Herstellung von steviolglycosiden in rekombinanten wirten
UY37482A (es) 2016-11-16 2018-05-31 Cellectis Métodos para alterar el contenido de aminoácidos en plantas mediante mutaciones de desplazamiento de marco
PE20191345A1 (es) 2016-11-23 2019-09-30 Gritstone Oncology Inc Administracion viral de neoantigenos
TWI780102B (zh) 2017-01-10 2022-10-11 國立大學法人山口大學 抗gpc3抗體
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
US11371056B2 (en) 2017-03-07 2022-06-28 BASF Agricultural Solutions Seed US LLC HPPD variants and methods of use
CA3055389A1 (en) 2017-03-07 2018-09-13 BASF Agricultural Solutions Seed US LLC Hppd variants and methods of use
WO2018165091A1 (en) 2017-03-07 2018-09-13 Bayer Cropscience Lp Hppd variants and methods of use
CN118370809A (zh) 2017-04-03 2024-07-23 百欧恩泰美国公司 蛋白质抗原及其用途
AU2018260469B2 (en) 2017-04-25 2024-09-05 Cellectis Alfalfa with reduced lignin composition
BR112019023477A2 (pt) 2017-05-08 2020-06-30 Gritstone Oncology, Inc. vetores de neoantígeno de alfavírus
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
SG11201911620PA (en) 2017-06-09 2020-01-30 Gritstone Oncology Inc Neoantigen identification, manufacture, and use
EP4576103A3 (de) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigenidentifizierung mit hotspots
BR112020008092A2 (pt) 2017-10-24 2020-09-15 BASF Agricultural Solutions Seed US LLC método para conferir tolerância a um herbicida e planta de soja transgênica
WO2019083808A1 (en) 2017-10-24 2019-05-02 Basf Se IMPROVING HERBICIDE TOLERANCE AGAINST HPPD INHIBITORS BY REGULATION OF PUTATIVE REDUCED 4-HYDROXYPHENYLPYRUVATE REDUCES IN SOYBEANS
IL274799B2 (en) 2017-11-22 2025-05-01 Gritstone Bio Inc Reducing junction epitope presentation for neoantigens
MX2020007077A (es) 2018-01-04 2020-10-28 Iconic Therapeutics Inc Anticuerpos anti-factor tisular, conjugados anticuerpo-farmaco y metodos relacionados.
UA128937C2 (uk) 2018-01-09 2024-12-04 Сайбас Юес Ллс Рослина brassica napus, що має знижену сприйнятливість до розстріскування плодів до збирання урожаю, та спосіб її одержання
US12559763B2 (en) 2018-04-04 2026-02-24 Cibus Us Llc FAD2 genes and mutations
WO2019217572A1 (en) 2018-05-08 2019-11-14 Sanford Burnham Prebys Medical Discovery Institute Role of pvt1 in the diagnosis and treatment of myc-driven cancer
CN112368386A (zh) 2018-05-23 2021-02-12 磨石肿瘤生物技术公司 共有抗原
TW202028467A (zh) 2018-09-28 2020-08-01 日商協和麒麟股份有限公司 抗體組合物
US20210382068A1 (en) 2018-10-02 2021-12-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
KR102232757B1 (ko) * 2018-11-22 2021-03-26 (주)엑솔런스바이오테크놀로지 체외충격파를 이용한 표적물질 전달 장치
US20220062394A1 (en) 2018-12-17 2022-03-03 The Broad Institute, Inc. Methods for identifying neoantigens
WO2020190363A1 (en) 2019-03-19 2020-09-24 Massachusetts Institute Of Technology Control of nitrogen fixation in rhizobia that associate with cereals
CA3137581A1 (en) 2019-04-25 2020-10-29 Impossible Foods Inc. Strains and methods for production of heme-containing proteins
WO2020243719A1 (en) 2019-05-30 2020-12-03 Gritstone Oncology, Inc. Modified adenoviruses
JP2020195326A (ja) 2019-06-03 2020-12-10 住友ゴム工業株式会社 天然ゴムの製造方法、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
US11473086B2 (en) 2019-06-19 2022-10-18 Ut-Battelle, Llc Loss of function alleles of PtEPSP-TF and its regulatory targets in rice
BR112022003790A2 (pt) 2019-09-02 2022-05-31 Inst Nat Sante Rech Med Método para selecionar um peptídeo neoantigênico tumoral, peptídeos neoantigênicos tumorais, peptídeo neoantigênico tumoral isolado, população de células dendríticas autólogas, vacina ou composição imunogênica, anticorpos, método de produção de um anticorpo, receptor de células t, polinucleotídeo, vetor, célula imune, célula t, peptídeo neoantigênico e população de células imunes
US12516085B2 (en) 2019-09-19 2026-01-06 Sanford Burnham Prebys Medical Discovery Institute Methods and compositions for treating Myc-driven cancers
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
WO2021078910A1 (en) 2019-10-22 2021-04-29 Institut Curie Immunotherapy targeting tumor neoantigenic peptides
WO2021085564A1 (ja) * 2019-10-30 2021-05-06 株式会社ダイセル 遺伝子銃
JP2021080204A (ja) 2019-11-19 2021-05-27 住友ゴム工業株式会社 融合タンパク質、物質製造方法、ベクター、形質転換細胞、空気入りタイヤの製造方法及びゴム製品の製造方法
WO2021177074A1 (ja) 2020-03-05 2021-09-10 住友ゴム工業株式会社 ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
EP4130270A4 (de) 2020-04-01 2024-10-23 Kyowa Kirin Co., Ltd. Antikörperzusammensetzung
WO2021228999A1 (en) 2020-05-12 2021-11-18 Institut Curie Neoantigenic epitopes associated with sf3b1 mutations
CN115697176A (zh) 2020-06-05 2023-02-03 库克医学技术有限责任公司 用于递送治疗剂的医疗窥镜
IL300026A (en) 2020-08-06 2023-03-01 Gritstone Bio Inc Multiepitope vaccine cassettes
WO2022072833A2 (en) 2020-10-02 2022-04-07 Impossible Foods Inc. Expression constructs and methods of genetically engineering cells
WO2022072846A2 (en) 2020-10-02 2022-04-07 Impossible Foods Inc. Transgenic plants with altered fatty acid profiles and upregulated heme biosynthesis
WO2022074098A1 (en) 2020-10-08 2022-04-14 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Method for the identification of cancer neoantigens
US11530419B2 (en) 2020-10-30 2022-12-20 Fortiphyte, Inc. Pathogen resistance in plants
EP4241274A1 (de) 2020-11-06 2023-09-13 Amazon Technologies, Inc. Neoantigeneauswahl für personalisierten krebsimpfstoff
MX2023007003A (es) 2020-12-14 2023-08-18 Biontech Us Inc Antigenos especificos de tejidos para la inmunoterapia del cancer.
EP4281970A1 (de) 2021-01-19 2023-11-29 Amazon Technologies, Inc. Tiefenlernmodell zur vorhersage der tumorspezifischen neoantigen-mhc-klasse-i- oder klasse-ii-immunogenität
WO2022170067A1 (en) 2021-02-05 2022-08-11 Amazon Technologies, Inc. Ranking neoantigens for personalized cancer vaccine
KR20230172047A (ko) 2021-03-11 2023-12-21 므네모 테라퓨틱스 종양 신생항원 펩타이드 및 이의 용도
WO2022189620A1 (en) 2021-03-11 2022-09-15 Institut Curie Transmembrane neoantigenic peptides
EP4304632A2 (de) 2021-03-11 2024-01-17 Mnemo Therapeutics Tumorneoantigene peptide
CN117321690A (zh) 2021-03-15 2023-12-29 亚马逊科技公司 用于优化肿瘤疫苗抗原对异质性恶性肿瘤的覆盖的方法
JP2024520477A (ja) 2021-05-27 2024-05-24 アマゾン テクノロジーズ インコーポレイテッド ペプチドに基づくネオ抗原ワクチンの多成分化学組成物
WO2023287654A1 (en) 2021-07-14 2023-01-19 Cook Medical Technologies, LLC Systems and methods for preventing clogging of a delivery system
JP7829849B2 (ja) 2021-09-10 2026-03-16 住友ゴム工業株式会社 トランス型ポリイソプレノイドの製造方法、ベクター、形質転換生物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP7799274B2 (ja) 2022-03-02 2026-01-15 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ（ｃｐｔ）ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP7799273B2 (ja) 2022-03-02 2026-01-15 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ（ｃｐｔ）ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP7799272B2 (ja) 2022-03-02 2026-01-15 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ（ｃｐｔ）ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP2025509806A (ja) 2022-03-16 2025-04-11 アマゾン テクノロジーズ， インコーポレイテッド フォローアップネオ抗原がんワクチンのサブクローン透過を改善するための循環腫瘍ｄｎａのモニタリング
JP2025510795A (ja) 2022-03-24 2025-04-15 アンスティテュ・クリー 神経膠芽腫における腫瘍転位因子由来のネオ抗原ペプチドを標的化する免疫療法
US20250003004A1 (en) 2022-07-15 2025-01-02 Amazon Technologies, Inc. Personalized Longitudinal Analysis of Circulating Material to Monitor and Adapt Neoantigen Cancer Vaccines
AU2023337091A1 (en) 2022-09-09 2025-03-06 Eidgenössische Technische Hochschule Zürich Plant regulatory elements and uses thereof
US12496429B2 (en) 2022-10-18 2025-12-16 Cook Medical Technologies Llc Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents
US12239091B2 (en) 2023-03-27 2025-03-04 Redsea Science And Technology Inc. Tomato plant designated ‘MX20-06’
WO2025030048A2 (en) 2023-08-03 2025-02-06 J.R. Simplot Company Fusarium wilt resistance genes
US20250075226A1 (en) 2023-08-29 2025-03-06 University Of Freiburg Proteins for regulation of symbiotic infection and associated regulatory elements
EP4702988A1 (de) 2024-08-28 2026-03-04 Biotechnology Assets S.A. Kombinationsprodukt zur behandlung von leishmaniose

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
IL84459A (en) * 1986-12-05 1993-07-08 Agracetus Apparatus and method for the injection of carrier particles carrying genetic material into living cells
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
DE3853278T2 (de) * 1988-02-29 1995-07-13 Du Pont Vorrichtung für das Liefern von Substanzen in Zellen und Gewebe auf eine nichtletale Weise.

Also Published As

Publication number Publication date
US5204253A (en) 1993-04-20
AR243603A1 (es) 1993-08-31
DE69103631T2 (de) 1995-02-23
KR960008270B1 (ko) 1996-06-21
CA2083816C (en) 2005-06-28
CA2083816A1 (en) 1991-11-30
HU216738B (hu) 1999-08-30
ES2059140T3 (es) 1994-11-01
WO1991018991A1 (en) 1991-12-12
JP2517813B2 (ja) 1996-07-24
EP0535005A1 (de) 1993-04-07
HUT67533A (en) 1995-04-28
DK0535005T3 (da) 1994-09-26
EP0535005B1 (de) 1994-08-24
AU7878891A (en) 1991-12-31
HU9203554D0 (en) 1993-03-29
DE69103631D1 (de) 1994-09-29
JPH05508316A (ja) 1993-11-25

Similar Documents

Publication Publication Date Title
ATE110415T1 (de) Verbessertes verfahren und apparat, um biologische substanzen in lebenden zellen einzuführen.
DE3788026D1 (de) Verfahren und Vorrichtung zur Kultivierung von Zellen.
DK475386D0 (da) Fremgangsmaade og apparat til fremstilling af biologiske stoffer
DE69803344D1 (de) Vorrichtung zum nachweis von strahlung und verfahren zu ihrer herstellung
DE69740113D1 (de) Vorrichtung und verfahren zur inkubation von zellen
DE3788058D1 (de) Zelltoxischer antikörperkomplex und verfahren zu seiner herstellung.
DE69931085D1 (de) System und Verfahren zum Separieren von biologischen Zellen
DE69636398D1 (de) Blutbehandlungssystem und Verfahren zur Gewinnung von mononuklearen Zellen
ATE538205T1 (de) Verfahren, medien und vorrichtung zur einführung von molekülen in pflanzenzellen und bakterien mittels aerosolstrahlen
DK1088212T3 (da) Apparat og fremgangsmåde til indsamling og førstebehandling af vævsprøver til molekylærgenetisk diagnostik
DE3382359D1 (de) Verfahren zur kultivierung und isolierung von zellen.
DE69837440D1 (de) Apparat, geeignet zum transport und lagerung von kernbrennstoffstäben und verfahren zur verwendung des apparats
FI931303A7 (fi) Menetelmät vieraan DNA:n viemiseksi soluihin
DE69816272D1 (de) Cyanidfreie lytische reagenzzusammensetzung und verfahren zur hämoglobin- und zellanalyse
DE69825222D1 (de) Verfahren und Vorrichtung zur optischen Verstärkung und System, das eine solche Vorrichtung umfasst
DE69507689D1 (de) Verfahren zur mehrstufigen pflanzenzucht und dazu geeigneter apparat
DE69735547D1 (de) Verfahren zur induzierung von immunsupprimierten zellen und vorrichtung zu deren kultivierung
ATE214612T1 (de) Biologisch aktive substanzen, verfahren zur herstellung und sie enthaltende zusammensetzungen
DE3482594D1 (de) Analytische testzusammensetzung, vorrichtung, verfahren zu ihrer herstellung und zur bestimmung von peroxidatisch wirkenden substanzen.
DE3483934D1 (de) Verfahren und apparat zum einpflanzen eines fremdstoffes in lebende zelle.
DE68919256D1 (de) Verfahren und Vorrichtung zur Ermittlung von Zelleigenschaften.
DE69534698D1 (de) Verfahren und Vorrichtung zum Vermittlen von Zellen
DE69005987D1 (de) Dichtung, Vorrichtung und Verfahren zur ihrer Herstellung.
DE68912661D1 (de) Verfahren und Vorrichtung für Zellkultur.
DE68909997D1 (de) Vorrichtung zur Kultur von tierischen Zellen, Kulturmethode und Mittel zum Nachweis der Kultur.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties