DK0535005T3 - Forbedret fremgangsmåde og apparat til indføring af biologiske substanser i levende celler - Google Patents

Forbedret fremgangsmåde og apparat til indføring af biologiske substanser i levende celler

Info

Publication number
DK0535005T3
DK0535005T3 DK91909768.3T DK91909768T DK0535005T3 DK 0535005 T3 DK0535005 T3 DK 0535005T3 DK 91909768 T DK91909768 T DK 91909768T DK 0535005 T3 DK0535005 T3 DK 0535005T3
Authority
DK
Denmark
Prior art keywords
improved method
living cells
biological substances
introducing biological
introducing
Prior art date
Application number
DK91909768.3T
Other languages
English (en)
Inventor
Stephen A Johnston
John C Sanford
Ronald F Bruner
Vit Michael J De
Original Assignee
Du Pont
Cornell Res Foundation Inc
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Cornell Res Foundation Inc, Univ Duke filed Critical Du Pont
Application granted granted Critical
Publication of DK0535005T3 publication Critical patent/DK0535005T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8206Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated
    • C12N15/8207Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by physical or chemical, i.e. non-biological, means, e.g. electroporation, PEG mediated by mechanical means, e.g. microinjection, particle bombardment, silicon whiskers
DK91909768.3T 1990-05-29 1991-04-29 Forbedret fremgangsmåde og apparat til indføring af biologiske substanser i levende celler DK0535005T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/529,989 US5204253A (en) 1990-05-29 1990-05-29 Method and apparatus for introducing biological substances into living cells

Publications (1)

Publication Number Publication Date
DK0535005T3 true DK0535005T3 (da) 1994-09-26

Family

ID=24112008

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91909768.3T DK0535005T3 (da) 1990-05-29 1991-04-29 Forbedret fremgangsmåde og apparat til indføring af biologiske substanser i levende celler

Country Status (13)

Country Link
US (1) US5204253A (da)
EP (1) EP0535005B1 (da)
JP (1) JP2517813B2 (da)
KR (1) KR960008270B1 (da)
AR (1) AR243603A1 (da)
AT (1) ATE110415T1 (da)
AU (1) AU7878891A (da)
CA (1) CA2083816C (da)
DE (1) DE69103631T2 (da)
DK (1) DK0535005T3 (da)
ES (1) ES2059140T3 (da)
HU (1) HU216738B (da)
WO (1) WO1991018991A1 (da)

Families Citing this family (360)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6964191A (en) 1989-11-16 1991-06-13 Cornell Research Foundation Inc. Particle-mediated transformation of animal tissue cells
JP3368603B2 (ja) * 1992-02-28 2003-01-20 オリンパス光学工業株式会社 遺伝子治療用処置具
GB9211107D0 (en) * 1992-05-26 1992-07-08 British Tech Group Diamond film deposition
AU2146092A (en) * 1992-05-28 1993-12-30 Scientific Dimensions Usa, Inc. Transgenic animal production with biolistically transformed spermatozoa
WO2004031211A2 (en) 2002-10-03 2004-04-15 Epimmune Inc. Hla binding peptides and their uses
TW360548B (en) 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
US5405779A (en) * 1993-04-09 1995-04-11 Agracetus, Inc. Apparatus for genetic transformation
GB9321183D0 (en) * 1993-10-14 1993-12-01 Zeneca Ltd A method of plant transformation
US5506125A (en) * 1993-12-22 1996-04-09 Agracetus, Inc. Gene delivery instrument with replaceable cartridges
CN1112943C (zh) * 1994-01-21 2003-07-02 粉剂注射疫苗股份有限公司 气体驱动的基因送递装置
US5899880A (en) * 1994-04-08 1999-05-04 Powderject Research Limited Needleless syringe using supersonic gas flow for particle delivery
EP0695941B1 (en) * 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
GB9416663D0 (en) 1994-08-17 1994-10-12 Oxford Bioscience Limited Particle delivery
US5648598A (en) * 1994-12-20 1997-07-15 Institut National De La Recherche Agronomique Ornamental character of scented geraniums by genetic transformation
GB9426379D0 (en) 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
GB9502879D0 (en) * 1995-02-14 1995-04-05 Oxford Biosciences Ltd Particle delivery
DE19510696A1 (de) * 1995-03-14 1996-09-19 Soft Gene Gmbh Vorrichtung zur Druckverteilung im Kopfstück einer Apparatur zum ballistischen Transfer von Zellen
US5780100A (en) * 1995-05-18 1998-07-14 Powderject Vaccines, Inc. Method and apparatus for preparing sample cartridges for particle acceleration device
US5525510A (en) * 1995-06-02 1996-06-11 Agracetus, Inc. Coanda effect gene delivery instrument
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US7223739B1 (en) 1995-06-07 2007-05-29 Powderject Vaccines, Inc. Adjuvanted genetic vaccines
US6013050A (en) * 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
JP2786139B2 (ja) 1995-12-05 1998-08-13 株式会社日本医化器械製作所 生物学的物質又は生理活性物質を導入する打込装置
US6893664B1 (en) 1996-06-17 2005-05-17 Powderject Research Limited Particle delivery techniques
US5850026A (en) 1996-07-03 1998-12-15 Cargill, Incorporated Canola oil having increased oleic acid and decreased linolenic acid content
US5733600A (en) * 1996-11-13 1998-03-31 Powderject Vaccines, Inc. Method and apparatus for preparing sample cartridges for a particle acceleration device
DE19648656B4 (de) * 1996-11-14 2005-08-11 Hiper Ceramics Gmbh Vorrichtung zum Beschleunigen von Partikeln auf Zellen zum ballistischen Transfer
US6587578B2 (en) 1997-03-21 2003-07-01 Dobi Medical Systems, Inc. Dynamic-functional imaging of biological objects using a non-rigid object holder
CA2303380A1 (en) 1997-03-21 1998-10-01 Dobi Medical Systems, Llc Dynamic-functional imaging of biological objects using a non-rigid object holder
US5749337A (en) * 1997-03-31 1998-05-12 Palatov; Dennis Barrel type internal combustion engine
US6307128B1 (en) 1997-06-03 2001-10-23 Miami University Fatty acid elongases
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
US6433154B1 (en) * 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US6074360A (en) * 1997-07-21 2000-06-13 Boehringer Mannheim Gmbh Electromagnetic transdermal injection device and methods related thereto
EP1007712A4 (en) * 1997-08-05 2004-06-30 Kimeragen Inc USE OF DUPLEX OLIGONUCLEOTIDES TO AFFECT LOCAL GENETIC CHANGES IN PLANTS
US5994624A (en) * 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
EP1047448B1 (en) 1997-11-20 2006-02-01 United States Army Medical Research and Materiel Command Dna vaccines against tick-borne flaviviruses
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
US5973227A (en) * 1998-05-06 1999-10-26 University Of Saskatchewan Flax transformation
IL139531A0 (en) 1998-05-12 2001-11-25 Human antithrombin iii, methods for the production thereof and pharmaceutical compositions containing the same
US6720479B1 (en) * 1998-05-29 2004-04-13 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
US7094953B2 (en) 1998-05-29 2006-08-22 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
EP1085090B1 (en) 1998-06-02 2011-12-14 Nihon University IgA NEPHROPATHY-ASSOCIATED DNA
EP1089757B1 (en) 1998-06-17 2009-04-22 IDM Pharma, Inc. Hla binding peptides and their uses
US6281375B1 (en) 1998-08-03 2001-08-28 Cargill, Incorporated Biodegradable high oxidative stability oils
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
WO2000013573A1 (en) 1998-09-04 2000-03-16 Powderject Research Limited Monitoring methods using particle delivery methods
US6713117B1 (en) * 1998-10-02 2004-03-30 Dharma Kodali Vegetable oil having elevated stearic acid content
DK1123396T3 (da) * 1998-10-19 2006-07-10 Powderject Vaccines Inc Minimale promotorer og anvendelser deraf
US6881723B1 (en) 1998-11-05 2005-04-19 Powderject Vaccines, Inc. Nucleic acid constructs
US7510841B2 (en) 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
WO2000047227A2 (en) 1999-02-09 2000-08-17 Powderject Vaccines, Inc. Mycobacterium tuberculosis, immunization
US6987025B1 (en) * 1999-02-11 2006-01-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Dwf4 polynucleotides, polypeptides and uses thereof
EP1586645A3 (en) * 1999-02-25 2006-02-22 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
GB9905933D0 (en) * 1999-03-15 1999-05-05 Powderject Res Ltd Neeedleless syringe
US20040029167A1 (en) * 1999-03-22 2004-02-12 Bernard Fritig Inducible COMT_II promoter, chimeric gene containing same and plants transformed therewith
US6995301B1 (en) 1999-05-04 2006-02-07 Cargill, Incorporated Plant acyltransferases
DE19926216A1 (de) * 1999-06-09 2001-02-22 Metallgesellschaft Ag Verfahren zur Herstellung von Bariumsulfat, Bariumsulfat und Verwendung des Bariumsulfats
US7399850B2 (en) * 1999-06-18 2008-07-15 Ceres, Inc. Sequence-determined DNA fragments encoding AP2 domain proteins
US7485715B2 (en) * 1999-06-18 2009-02-03 Ceres, Inc. Sequence-determined DNA encoding AP2 domain polypeptides
WO2001000665A2 (en) * 1999-06-28 2001-01-04 Oklahoma Medical Research Foundation Inhibitors of memapsin 2 and use thereof
US7479555B2 (en) * 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
GB9918061D0 (en) * 1999-07-30 1999-10-06 Univ Bath Modified plants
DE19946059A1 (de) * 1999-09-25 2001-03-29 Roche Diagnostics Gmbh System zur transdermalen Gewinnung von Körperflüssigkeit
GB9923306D0 (en) 1999-10-01 1999-12-08 Isis Innovation Diagnostic and therapeutic epitope, and transgenic plant
AR025996A1 (es) 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
US7196066B1 (en) 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
US20040234539A1 (en) * 1999-11-03 2004-11-25 Powderject Research Limited Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
US20060194958A1 (en) * 1999-11-10 2006-08-31 Nickolai Alexandrov Sequence-determined DNA fragments encoding AN1-like zinc finger proteins
US20040109874A1 (en) * 1999-11-10 2004-06-10 Powderject Vaccines, Inc. Induction of mucosal immunity by vaccination via the skin route
DE60043158D1 (de) 1999-11-18 2009-11-26 Pharmexa Inc Heteroklitische analoga von klasse-i epitopen
FR2802102B1 (fr) 1999-12-08 2002-07-12 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un tube d'ejection a section constante
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
JP3365500B2 (ja) * 2000-01-19 2003-01-14 ウシオ電機株式会社 狭帯化ArFエキシマレーザ装置
FR2804329B1 (fr) * 2000-02-02 2002-12-13 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un opercule contenant le principe actif
CA2401270A1 (en) 2000-03-10 2001-09-20 Jeff W. Lichtman Method for labeling individual cells
GB0008494D0 (en) 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
US7691991B2 (en) * 2000-04-17 2010-04-06 Ceres, Inc. Sequence-determined DNA fragments encoding cytochrome P450 proteins
EP1278541A1 (en) * 2000-04-28 2003-01-29 The Government of The United States of America, as represented by The Department of Health and Human Services Improved immunogenicity using a combination of dna and vaccinia virus vector vaccines
AU6162501A (en) 2000-05-16 2001-11-26 Univ Minnesota High mass throughput particle generation using multiple nozzle spraying
EP1313850B1 (en) 2000-08-28 2008-08-06 Agensys, Inc. Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer
WO2002018607A2 (en) * 2000-08-30 2002-03-07 North Carolina State University Transgenic plants containing molecular decoys that alter protein content therein
PL218428B1 (pl) 2000-10-06 2014-12-31 Kyowa Hakko Kogyo Kk Komórka, sposoby wytwarzania przeciwciał, leki zawierające przeciwciała, komórka CHO i przeciwciało klasy IgG
GB0025710D0 (en) * 2000-10-20 2000-12-06 Medical Res Council Biolistic device
FR2815969B1 (fr) 2000-10-30 2004-12-10 Aventis Cropscience Sa Plantes tolerantes aux herbicides par contournement de voie metabolique
WO2002038588A2 (en) * 2000-11-07 2002-05-16 North Carolina State University Putrescine-n-methyltransferase promoter
AU2002235127A1 (en) * 2000-11-22 2002-06-03 Cargill Incorporated Carotenoid biosynthesis
US7385046B2 (en) * 2001-01-03 2008-06-10 Ceres, Inc. Sequence-determined DNA fragments encoding ethylene responsive element binding proteins
US20040078846A1 (en) * 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
US20050003474A1 (en) * 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
CA2436528A1 (en) * 2001-01-29 2002-08-08 Cargill Incorporated Fungal resistant transgenic plants
BR0207369A (pt) * 2001-02-09 2004-06-22 Fujisawa Pharmaceutical Co Método para transferir moléculas selecionadas
US6924358B2 (en) 2001-03-05 2005-08-02 Agensys, Inc. 121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US20040172672A1 (en) * 2001-05-15 2004-09-02 Wilkinson Theresa C. Method for producing transgenic monocotyledonous plants
US7247338B2 (en) * 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
US20060157072A1 (en) * 2001-06-08 2006-07-20 Anthony Albino Method of reducing the harmful effects of orally or transdermally delivered nicotine
HUP0400161A2 (hu) * 2001-06-08 2004-08-30 Vector Tobacco Ltd., Módosított nikotin- és nitrozamintartalmú dohány
WO2003000715A1 (en) * 2001-06-22 2003-01-03 Ceres, Inc. Chimeric histone acetyltransferase polypeptides
CA2453183C (en) 2001-07-12 2016-05-10 University Of Massachusetts In vivo production of small interfering rnas that mediate gene silencing
EP1900815B1 (en) 2001-07-12 2016-09-07 University of Massachusetts In vivo production of small interfering RNAs that mediate gene silencing
US8061006B2 (en) * 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
WO2003013226A2 (en) * 2001-08-09 2003-02-20 Cibus Genetics Non-transgenic herbicide resistant plants
EP2287186B1 (en) 2001-09-06 2014-12-31 Agensys, Inc. Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer
RU2372404C2 (ru) 2001-10-19 2009-11-10 Сумитомо Кемикал Компани, Лимитед Метаболизирующий гербицид белок, его ген и их применение
EP1461432A2 (en) * 2001-12-10 2004-09-29 Iowa State University Research Foundation, Inc. Nucleic acids related to plant retroelements
CA2470772A1 (en) 2001-12-17 2003-06-26 Terry L. Burkoth Non-or minimally invasive monitoring methods
CA2481167A1 (en) * 2002-04-09 2003-10-23 Vector Tobacco Ltd. Tobacco having reduced nicotine and nitrosamines
US20060094006A1 (en) * 2002-05-01 2006-05-04 Genoveffa Franchini Immunotherapy regimens in hiv-infected patients
DE10223196B4 (de) * 2002-05-24 2004-05-13 Dornier Medtech Systems Gmbh Verfahren und Einrichtung zum Transferieren von Molekülen in Zellen
CA2487901A1 (en) * 2002-05-31 2003-12-11 University Of Utah Research Foundation Variants of antithrombin iii
GB0212885D0 (en) 2002-06-05 2002-07-17 Isis Innovation Therapeutic epitopes and uses thereof
AU2003274463B2 (en) 2002-06-10 2009-10-29 University Of Rochester Gene differentially expressed in breast and bladder cancer and encoded polypeptides
US20060194959A1 (en) * 2002-07-15 2006-08-31 Nickolai Alexandrov Sequence-determined DNA fragments encoding SRF-type transcription factors
US7364901B2 (en) * 2002-07-15 2008-04-29 University Of Kentucky Research Foundation Recombinant Stokesia epoxygenase gene
AU2003243151A1 (en) 2002-08-16 2004-03-03 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
WO2004022736A1 (ja) 2002-08-30 2004-03-18 Japan Science And Technology Corporation 遺伝子のターゲティング破壊法および超耐熱菌ゲノム、ならびにこれらを利用したゲノムチップ
WO2004027038A2 (en) * 2002-09-17 2004-04-01 Ceres, Inc. Biological containment system
US7476777B2 (en) * 2002-09-17 2009-01-13 Ceres, Inc. Biological containment system
CA2500215C (en) * 2002-09-27 2012-02-28 Powderject Research Limited Nucleic acid coated particles
EP1565200A4 (en) 2002-11-27 2009-06-24 Agensys Inc NUCLEIC ACID 24P4C12 AND CORRESPONDING PROTEIN FOR THE TREATMENT AND DETECTION OF CANCER
EP1903056A3 (en) 2002-12-10 2008-05-07 Idm Pharma, Inc. HLA-A1, -A2 -A3, -A24, -B7, and -B44 binding peptides comprising tumor associated antigen epitopes, and compositions thereof
WO2004058960A1 (ja) 2002-12-26 2004-07-15 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
US7365240B2 (en) * 2003-02-05 2008-04-29 Divergence, Inc. Nucleic acids encoding anthelmintic agents and plants made therefrom
EP1594892A2 (en) 2003-02-10 2005-11-16 Agensys, Inc. Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers
EP2207036B1 (en) * 2003-03-24 2012-12-12 Gen-Probe Transplant Diagnostics, Inc. Methods for determining the negative control value for multi-analyte assays
DK2319524T3 (da) 2003-05-30 2013-11-11 Agensys Inc Varianter af prostatastamcelleantigen (PSCA) og undersekvenser deraf
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
PT1633767T (pt) 2003-06-02 2019-02-27 Univ Massachusetts Métodos e composições para controlar a eficácia do silenciamento de arn
EP2314692B1 (en) 2003-06-02 2021-02-24 University of Massachusetts Methods and compositions for enhancing the efficacy and specificity of RNAi
US7892205B2 (en) * 2003-06-06 2011-02-22 Boston Scientific Scimed, Inc. Device and method for delivering micronized therapeutic agents in the body
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
AU2004282575A1 (en) * 2003-10-14 2005-04-28 Ceres, Inc. Methods and compositions for altering seed phenotypes
US8147426B2 (en) * 2003-12-31 2012-04-03 Nipro Diagnostics, Inc. Integrated diagnostic test system
AU2005206806A1 (en) * 2004-01-09 2005-08-04 University Of Utah Research Foundation Methods of using high affinity ATIII variants
EP1709188A1 (en) * 2004-01-16 2006-10-11 Ceres, Inc. Plant cells having receptor polypeptides
US7368629B2 (en) * 2004-02-04 2008-05-06 Divergence, Inc. Nucleic acids encoding anthelmintic agents and plants made therefrom
CA2564807A1 (en) * 2004-04-23 2005-11-10 Ceres Inc. Methods and materials for improving plant drought tolerance
US10105437B2 (en) 2004-04-28 2018-10-23 Btg International Limited Epitopes related to coeliac disease
MXPA06012322A (es) 2004-04-28 2007-01-31 Btg Int Ltd Epitopes relacionados con enfermedad celiaca.
JP4736480B2 (ja) 2004-05-17 2011-07-27 住友化学株式会社 雑草防除方法
EP2583981A3 (en) 2004-05-28 2013-07-31 Agensys, Inc. Antibodies and related molecules that bind to PSCA proteins
WO2006023766A2 (en) * 2004-08-20 2006-03-02 Ceres Inc. P450 polynucleotides, polypeptides, and uses thereof
US20060059585A1 (en) * 2004-09-14 2006-03-16 Boris Jankowski Modulating plant sugar levels
US7595433B2 (en) 2004-09-14 2009-09-29 Ceres, Inc. Modulations of amino acid and sugar content in plants
US7429692B2 (en) * 2004-10-14 2008-09-30 Ceres, Inc. Sucrose synthase 3 promoter from rice and uses thereof
WO2006062971A2 (en) * 2004-12-08 2006-06-15 Ceres Inc. Modulating plant carbon levels
WO2007050625A1 (en) * 2005-10-25 2007-05-03 Ceres, Inc. Modulation of triterpenoid content in plants
WO2007087601A2 (en) * 2006-01-25 2007-08-02 Ceres, Inc. Modulating plant protein levels
WO2007089610A1 (en) * 2006-01-26 2007-08-09 Ceres, Inc. Modulating plant oil levels
US9758790B2 (en) 2004-12-08 2017-09-12 Ceres, Inc. Modulating the level of components within plants
CA2590923A1 (en) * 2004-12-16 2006-06-22 Ceres Inc. Modulating plant nitrogen levels
US7335760B2 (en) * 2004-12-22 2008-02-26 Ceres, Inc. Nucleic acid sequences encoding zinc finger proteins
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs
EP1866418A2 (en) * 2005-02-22 2007-12-19 Ceres Inc. Modulating plant alkaloids
EP1863848A4 (en) 2005-03-31 2009-09-23 Agensys Inc CORRESPONDING ANTIBODIES AND MOLECULES THAT ATTACH PROTEINS 161P2F10B
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
WO2006113481A1 (en) * 2005-04-14 2006-10-26 Ceres Inc. Secondary metabolite production via manipulation of genome methylation
US7312376B2 (en) * 2005-04-20 2007-12-25 Ceres, Inc. Regulatory regions from Papaveraceae
WO2006133461A1 (en) * 2005-06-08 2006-12-14 Ceres Inc. Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations
CN101300346B (zh) 2005-06-24 2013-04-24 帝人制药株式会社 新型生理物质nesfatin及其相关物质、以及它们的用途
JP2009505979A (ja) * 2005-08-10 2009-02-12 オクラホマ メディカル リサーチ ファンデーション アルツハイマー病の治療に使用するためのトランケート型メマプシン2
WO2007037245A1 (ja) 2005-09-29 2007-04-05 Shionogi & Co., Ltd. 血管新生抑制作用を有するポリペプチド
WO2007041536A2 (en) * 2005-09-30 2007-04-12 Ceres, Inc. Modulating plant tocopherol levels
SI2465341T1 (sl) * 2006-01-12 2015-04-30 Cibus Europe B.V. Mutantni epsps
CA2637883C (en) * 2006-01-31 2015-07-07 Regents Of The University Of Minnesota Electrospray coating of objects
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
EP2529761B1 (en) * 2006-01-31 2017-06-14 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US20070199090A1 (en) * 2006-02-22 2007-08-23 Nestor Apuya Modulating alkaloid biosynthesis
WO2007120989A2 (en) * 2006-02-24 2007-10-25 Ceres, Inc. Shade regulatory regions
WO2007117693A2 (en) * 2006-04-07 2007-10-18 Ceres, Inc. Regulatory protein-regulatory region associations related to alkaloid biosynthesis
US20100080794A1 (en) 2006-04-14 2010-04-01 Takashi Tsuji Mutant polypeptide having effector function
JP2009536029A (ja) * 2006-05-09 2009-10-08 リライアンス ライフ サイエンシーズ プライベイト リミテッド ヤトロファ・クルカス(Jatrophacurcas)由来のアセチル−CoAカルボキシラーゼ(ACCアーゼ)遺伝子の分子クローニングおよび配列決定
US20100154082A1 (en) * 2006-05-10 2010-06-17 Ceres, Inc. Shade tolerance in plants
US20100024070A1 (en) * 2006-05-15 2010-01-28 Steven Craig Bobzin Modulation of oil levels in plants
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
US20100005549A1 (en) * 2006-06-14 2010-01-07 Shing Kwok Increasing uv-b tolerance in plants
WO2007149570A2 (en) * 2006-06-21 2007-12-27 Ceres, Inc. Modulation of protein levels in plants
CA2982638A1 (en) * 2006-06-28 2008-01-03 Nucelis Inc. Fatty acid blends and uses therefor
US20130191941A1 (en) 2006-07-05 2013-07-25 Shing Kwok Modulating light response pathways in plants, increasing light-related tolerances in plants, and increasing biomass in plants
WO2008064222A2 (en) * 2006-11-20 2008-05-29 Ceres, Inc. Shade tolerance in plants
WO2008006033A1 (en) 2006-07-05 2008-01-10 Ceres, Inc. Increasing low light tolerance in plants
US7939294B2 (en) 2006-09-25 2011-05-10 Kyowa Hakko Bio Co., Ltd. DNA encoding proteins having dipeptide-synthesizing activity and methods of using the same
US8362322B2 (en) 2006-10-27 2013-01-29 Ceres, Inc. Modulating lignin in plants
US8222388B2 (en) * 2006-11-22 2012-07-17 Ceres, Inc. Broadly expressing regulatory regions
US9040816B2 (en) * 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
US20100151109A1 (en) * 2006-12-15 2010-06-17 Amr Saad Ragab Modulation of plant protein levels
AU2008208288B2 (en) 2007-01-24 2014-04-03 Kyowa Kirin Co., Ltd. Genetically recombinant antibody composition having enhanced effector activity
WO2008090960A1 (ja) 2007-01-24 2008-07-31 Kyowa Hakko Kirin Co., Ltd. ガングリオシドgm2に特異的に結合する遺伝子組換え抗体組成物
US20100075343A1 (en) 2007-01-25 2010-03-25 Motoo Yamasaki Novel peptides
JP5550041B2 (ja) 2007-09-27 2014-07-16 塩野義製薬株式会社 チトクロームp450を用いたアダマンタン水酸化体の製造方法
AU2008308530A1 (en) 2007-10-05 2009-04-09 Cibus Europe B.V. Mutated acetohydroxyacid synthase genes in Brassica
EP2230300A4 (en) 2007-10-24 2012-08-08 Otsuka Chemical Holdings Co Ltd POLYPEPTIDE WITH IMPROVED EFFECTOR FUNCTION
CA2704397C (en) 2007-11-01 2018-01-23 Mayo Foundation For Medical Education And Research Hla-dr binding peptides and their uses
CA2710767C (en) * 2007-12-27 2016-09-27 Cibus Llc Alkylester fatty acid blends and uses therefor
US9839772B2 (en) 2008-05-06 2017-12-12 Cook Medical Technologies Llc Apparatus and methods for delivering therapeutic agents
DK2853269T3 (da) 2008-05-19 2019-08-05 Advaxis Inc Dobbelt indgivelsessystem til heterologe antigener, der omfatter en rekombinant Listeria-stamme svækket ved mutation af dal/dat og deletion af ActA, der omfatter et nukleinsyremolekyle, der koder for et listeriolysin O-prostataspecifikt antigenfusionsprotein
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
WO2009143490A1 (en) 2008-05-23 2009-11-26 Cibus International, L.P. Production of squalene using yeast
US8419145B2 (en) * 2008-07-25 2013-04-16 Eastman Kodak Company Inkjet printhead and method of printing with multiple drop volumes
WO2010018847A1 (ja) 2008-08-13 2010-02-18 協和発酵キリン株式会社 遺伝子組換えプロテインs組成物
US8298794B2 (en) * 2008-10-09 2012-10-30 Ceres, Inc. Cinnamyl-alcohol dehydrogenases
CA2739881A1 (en) 2008-10-09 2010-04-15 Kyowa Medex Co., Ltd. Novel fructosyl peptide oxidase
WO2010074949A1 (en) * 2008-12-23 2010-07-01 Wilson-Cook Medical Inc. Apparatus and methods for containing and delivering therapeutic agents
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US8118777B2 (en) 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
EP2659771B1 (en) 2009-07-20 2018-10-03 Ceres, Inc. Transgenic plants having increased biomass
US8586526B2 (en) 2010-05-17 2013-11-19 Sangamo Biosciences, Inc. DNA-binding proteins and uses thereof
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
EP3219815B1 (en) * 2009-11-23 2019-10-02 Cibus Europe B.V. Methods and compositions for producing squalene using yeast
SG181601A1 (en) 2009-12-10 2012-07-30 Univ Minnesota Tal effector-mediated dna modification
AR080353A1 (es) 2009-12-23 2012-04-04 Bayer Cropscience Ag Plantas tolerantes a herbicidas inhibidores de las hppd
WO2011076882A1 (en) 2009-12-23 2011-06-30 Bayer Cropscience Ag Plants tolerant to hppd inhibitor herbicides
EA201290560A1 (ru) 2009-12-23 2014-05-30 Байер Интеллектуэль Проперти Гмбх Растения, устойчивые к гербицидам - ингибиторам hppd
UY33142A (es) 2009-12-23 2011-07-29 Bayer Cropscience Ag Plantas tolerantes a herbicidas inhibidores de las hppd
ES2658990T3 (es) 2009-12-23 2018-03-13 Bayer Intellectual Property Gmbh Plantas tolerantes a herbicidas inhibidores de HPPD
WO2011082194A2 (en) * 2009-12-30 2011-07-07 E.I. Dupont De Nemours And Company Divider for use with biolistic bombardment device
BR112012019365A2 (pt) 2010-02-04 2020-08-25 Bayer Cropscience Ag método para aumentar a produção de biomassa, ácido nucleico, célula vegetal transgênica, planta transgênica e semente transgênica
WO2011106705A2 (en) 2010-02-26 2011-09-01 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Dna-protein vaccination protocols
CN102782131B (zh) 2010-03-02 2015-08-05 协和发酵麒麟株式会社 修饰抗体组合物
EP2554669B1 (en) 2010-03-26 2018-09-19 Kyowa Hakko Kirin Co., Ltd. Novel antibody having modification site introduced therein, and antibody fragment
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
KR102447139B1 (ko) 2010-05-14 2022-09-23 더 제너럴 하스피톨 코포레이션 종양 특이적 신생항원을 확인하는 조성물 및 방법
NZ604915A (en) 2010-06-02 2014-10-31 Evolva Nutrition Inc Recombinant production of steviol glycosides
JP5058332B2 (ja) 2010-07-14 2012-10-24 住友ゴム工業株式会社 イソプレンオリゴマー、ポリイソプレン、及びこれらの製造方法、ゴム組成物、並びに空気入りタイヤ
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
EP2621527A4 (en) 2010-10-01 2015-12-09 Univ Pennsylvania USE OF LISTERIA VACCINE VECTORS TO REVERSE VACCINE IMMUNITY IN PATIENTS WITH PARASITIC INFECTIONS
BR112013010278B1 (pt) 2010-10-27 2020-12-29 Ceres, Inc método para produzir uma planta, método para modular a composição de biomassa em uma planta, ácido nucleico isolado e método para alterar a composição de biomassa em uma planta
WO2012125551A1 (en) 2011-03-11 2012-09-20 Advaxis Listeria-based adjuvants
RU2017129844A (ru) 2011-04-11 2019-02-06 Таргетед Гроус, Инк. Идентификация и применение мутантных krp у растений
WO2013022881A1 (en) 2011-08-08 2013-02-14 International Flavors & Fragrances Inc. Compositions and methods for the biosynthesis of vanillin or vanillin beta-d-glucoside
BR122020019161B1 (pt) 2011-08-08 2022-04-05 Evolva Sa Hospedeiro recombinante
BR112014002924A2 (pt) 2011-08-08 2018-10-09 Evolva Sa métodos e materiais para produção recombinante de compostos do açafrão
AR087510A1 (es) 2011-08-12 2014-03-26 Ceres Inc Terminadores de transcripcion
BR122020026837B1 (pt) 2011-11-02 2021-04-13 Ceres, Inc Método de aumento do rendimento de planta em solo contendo níveis elevados de al3+, método de aumento da tolerância de uma planta
ES2894724T3 (es) 2011-12-02 2022-02-15 Rhode Island Hospital Vacuna contra la malaria falciparum
WO2013086499A2 (en) 2011-12-09 2013-06-13 Ceres, Inc. Transgenic plants having altered biomass composition
WO2013138337A1 (en) 2012-03-12 2013-09-19 Advaxis Suppressor cell function inhibition following listeria vaccine treatment
BR112014031891A2 (pt) 2012-06-19 2017-08-01 Univ Minnesota direcionamento genético nas plantas utilizando vírus de dna
UY35035A (es) 2012-09-14 2014-04-30 Bayer Cropscience Ag ?molécula de ácido nucleico recombinante que codifica una enzima hppd, vector, célula huésped, semilla, planta, polipéptido, producto primario, métodos y usos?.
WO2014054804A1 (ja) 2012-10-05 2014-04-10 協和発酵キリン株式会社 ヘテロダイマータンパク質組成物
AU2013337832B2 (en) 2012-11-01 2019-04-04 Cellectis Plants for production of therapeutic proteins
CN104769121B (zh) 2012-11-05 2021-06-01 埃沃尔瓦公司 香草醛合酶
US10513698B2 (en) 2012-12-21 2019-12-24 Cellectis Potatoes with reduced cold-induced sweetening
AU2014214004B2 (en) 2013-02-06 2018-05-24 Evolva Sa Methods for improved production of Rebaudioside D and Rebaudioside M
US10017804B2 (en) 2013-02-11 2018-07-10 Evolva Sa Efficient production of steviol glycosides in recombinant hosts
WO2014153178A2 (en) 2013-03-14 2014-09-25 Cibus Us Llc Mutated allene oxide synthase 2 (aos2) genes
WO2014153032A1 (en) 2013-03-14 2014-09-25 Evolutionary Genomics, Inc. Identification and use of tomato genes controlling salt/drought tolerance and fruit sweetness
EP2966980A4 (en) 2013-03-15 2016-12-28 Cibus Us Llc METHODS AND COMPOSITIONS FOR INCREASING THE EFFICACY OF THE ENHANCED EFFICACY OF TARGETED GENE MODIFICATION USING OLIGONUCLEOTIDE MEDIATED GENE REPAIR
US10113162B2 (en) 2013-03-15 2018-10-30 Cellectis Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US11434494B2 (en) 2013-03-15 2022-09-06 Cibus Us Llc Targeted gene modification using oligonucleotide-mediated gene repair
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
CA2908434C (en) 2013-04-07 2021-12-28 The Broad Institute, Inc. Compositions and methods for personalized neoplasia vaccines
EP3020810B1 (en) 2013-07-09 2019-04-10 Kyowa Medex Co., Ltd. Glycated hexapeptide oxidase and use thereof
DK3044320T3 (da) 2013-09-11 2020-03-16 Impossible Foods Inc Sekretion af hæmholdige polypeptider
DK3552482T3 (da) 2013-10-29 2022-09-26 Biotech Inst Llc Dyrkning, produktion, forarbejdning og brug af special cannabis
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
KR20160101073A (ko) 2013-12-20 2016-08-24 더 브로드 인스티튜트, 인코퍼레이티드 신생항원 백신과의 병용 요법
JP6448194B2 (ja) 2014-01-20 2019-01-09 住友ゴム工業株式会社 シス型プレニルトランスフェラーゼをコードする遺伝子、及び、NogoBreceptorをコードする遺伝子を宿主に導入することにより、該宿主において、シス型プレニルトランスフェラーゼ及びNogoBreceptorを発現させた形質転換体、並びに該形質転換体を用いたポリイソプレノイドの製造方法
US20180037912A1 (en) 2014-01-31 2018-02-08 University Of Copenhagen Methods for Producing Diterpenes
WO2015113569A1 (en) 2014-01-31 2015-08-06 University Of Copenhagen Biosynthesis of forskolin and related compounds
EP3117003B1 (en) 2014-03-11 2019-10-30 BASF Agricultural Solutions Seed US LLC Hppd variants and methods of use
EP3116305B1 (en) 2014-03-14 2023-12-06 Cibus US LLC Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US9101100B1 (en) 2014-04-30 2015-08-11 Ceres, Inc. Methods and materials for high throughput testing of transgene combinations
US9737251B2 (en) * 2014-05-28 2017-08-22 Verily Life Sciences Llc Needle-free blood draw
WO2015193858A1 (en) 2014-06-20 2015-12-23 Cellectis Potatoes with reduced granule-bound starch synthase
WO2015197075A1 (en) 2014-06-23 2015-12-30 University Of Copenhagen Methods and materials for production of terpenoids
WO2016011179A2 (en) 2014-07-15 2016-01-21 Ceres, Inc. Methods of increasing crop yield under abiotic stress
CN106572688B (zh) 2014-08-11 2022-01-25 埃沃尔瓦公司 在重组宿主中生产甜菊醇糖苷
CA2960693A1 (en) 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2016070885A1 (en) 2014-11-07 2016-05-12 University Of Copenhagen Biosynthesis of oxidised 13r-mo and related compounds
US10208326B2 (en) 2014-11-13 2019-02-19 Evolva Sa Methods and materials for biosynthesis of manoyl oxide
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
JP2018503388A (ja) 2015-01-30 2018-02-08 エヴォルヴァ エスアー.Evolva Sa. 組み換え宿主におけるステビオールグリコシドの生産
JP6557989B2 (ja) 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6557990B2 (ja) 2015-02-23 2019-08-14 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
JP6719174B2 (ja) 2015-02-23 2020-07-08 住友ゴム工業株式会社 特定のプロモーター及び特定の蛋白質をコードする遺伝子を含むベクター、該ベクターが導入された形質転換植物、並びに、該ベクターを植物に導入することにより、ポリイソプレノイドの生産量を向上させる方法
WO2016146711A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
EP3294762B1 (en) 2015-05-11 2022-01-19 Impossible Foods Inc. Expression constructs and methods of genetically engineering methylotrophic yeast
WO2016183420A1 (en) 2015-05-13 2016-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods and compositions for inducing an immune response using conserved element constructs
CN116196401A (zh) 2015-05-20 2023-06-02 博德研究所 共有的新抗原
KR102562733B1 (ko) 2015-05-22 2023-08-03 주식회사 에스티큐브앤컴퍼니 암 치료용 표적에 대한 스크리닝 방법
TWI750122B (zh) 2015-06-09 2021-12-21 美商博德研究所有限公司 用於贅瘤疫苗之調配物及其製備方法
JP2018522569A (ja) 2015-08-07 2018-08-16 エヴォルヴァ エスアー.Evolva Sa. 組換え宿主内でのステビオールグリコシドの産生
US10837024B2 (en) 2015-09-17 2020-11-17 Cellectis Modifying messenger RNA stability in plant transformations
KR20180107102A (ko) 2015-12-16 2018-10-01 그릿스톤 온콜로지, 인코포레이티드 신생항원 동정, 제조, 및 용도
WO2017134601A1 (en) 2016-02-02 2017-08-10 Cellectis Modifying soybean oil composition through targeted knockout of the fad3a/b/c genes
JP2019506170A (ja) 2016-02-09 2019-03-07 キブス ユーエス エルエルシー オリゴヌクレオチド介在性遺伝子修復を利用した標的遺伝子修飾の効率を上昇させるための方法および組成物
KR20180132696A (ko) 2016-04-13 2018-12-12 에볼바 에스아 재조합 숙주에서의 스테비올 글리코사이드의 생산
WO2017184590A1 (en) 2016-04-18 2017-10-26 The Broad Institute Inc. Improved hla epitope prediction
WO2017184727A1 (en) 2016-04-21 2017-10-26 Bayer Cropscience Lp Tal-effector mediated herbicide tolerance
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
WO2018015512A1 (en) 2016-07-20 2018-01-25 Evolva Sa Biosynthesis of 13r-manoyl oxide derivatives
AU2017309313B2 (en) 2016-08-09 2023-11-02 River Stone Biotech, Inc. Biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors
US11396669B2 (en) 2016-11-07 2022-07-26 Evolva Sa Production of steviol glycosides in recombinant hosts
CA3042857A1 (en) 2016-11-16 2018-05-24 Cellectis Methods for altering amino acid content in plants through frameshift mutations
CA3044840A1 (en) 2016-11-23 2018-05-31 Gritstone Oncology, Inc. Viral delivery of neoantigens
WO2018131586A1 (ja) 2017-01-10 2018-07-19 国立大学法人山口大学 抗gpc3抗体
EP3574116A1 (en) 2017-01-24 2019-12-04 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
WO2018165091A1 (en) 2017-03-07 2018-09-13 Bayer Cropscience Lp Hppd variants and methods of use
CA3055396A1 (en) 2017-03-07 2018-09-13 BASF Agricultural Solutions Seed US LLC Hppd variants and methods of use
CA3055389A1 (en) 2017-03-07 2018-09-13 BASF Agricultural Solutions Seed US LLC Hppd variants and methods of use
CN111093691A (zh) 2017-04-03 2020-05-01 内恩疗法公司 蛋白质抗原及其用途
US11479782B2 (en) 2017-04-25 2022-10-25 Cellectis Alfalfa with reduced lignin composition
TW201907937A (zh) 2017-05-08 2019-03-01 美商葛利史東腫瘤科技公司 阿爾法病毒新抗原載體
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
CA3078744A1 (en) 2017-10-10 2019-04-18 Gritstone Oncology, Inc. Neoantigen identification using hotspots
US20210032651A1 (en) 2017-10-24 2021-02-04 Basf Se Improvement of herbicide tolerance to hppd inhibitors by down-regulation of putative 4-hydroxyphenylpyruvate reductases in soybean
BR112020008092A2 (pt) 2017-10-24 2020-09-15 BASF Agricultural Solutions Seed US LLC método para conferir tolerância a um herbicida e planta de soja transgênica
CN111630602A (zh) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 减少新抗原的接合表位呈递
CA3087537A1 (en) 2018-01-04 2019-07-11 Jan-willem THEUNISSEN Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
WO2019140009A1 (en) 2018-01-09 2019-07-18 Cibus Us Llc Shatterproof genes and mutations
WO2019217572A1 (en) 2018-05-08 2019-11-14 Sanford Burnham Prebys Medical Discovery Institute Role of pvt1 in the diagnosis and treatment of myc-driven cancer
EP3858994A4 (en) 2018-09-28 2022-06-22 Kyowa Kirin Co., Ltd. ANTIBODY COMPOSITION
US20210382068A1 (en) 2018-10-02 2021-12-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
KR102232757B1 (ko) * 2018-11-22 2021-03-26 (주)엑솔런스바이오테크놀로지 체외충격파를 이용한 표적물질 전달 장치
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
WO2020190363A1 (en) 2019-03-19 2020-09-24 Massachusetts Institute Of Technology Control of nitrogen fixation in rhizobia that associate with cereals
CN114072516A (zh) 2019-05-30 2022-02-18 磨石生物公司 经修饰的腺病毒
JP2020195326A (ja) 2019-06-03 2020-12-10 住友ゴム工業株式会社 天然ゴムの製造方法、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
US11473086B2 (en) 2019-06-19 2022-10-18 Ut-Battelle, Llc Loss of function alleles of PtEPSP-TF and its regulatory targets in rice
AU2020343407A1 (en) 2019-09-02 2022-03-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Immunotherapy targeting tumor neoantigenic peptides
EP4048304A1 (en) 2019-10-22 2022-08-31 Institut Curie Immunotherapy targeting tumor neoantigenic peptides
JP2021080204A (ja) 2019-11-19 2021-05-27 住友ゴム工業株式会社 融合タンパク質、物質製造方法、ベクター、形質転換細胞、空気入りタイヤの製造方法及びゴム製品の製造方法
EP4116423A4 (en) 2020-03-05 2024-04-17 Sumitomo Rubber Ind METHOD FOR PRODUCING POLYISOPRENOID, VECTOR, TRANSFORMED PLANT, METHOD FOR PRODUCING A PNEUMATIC TIRE AND METHOD FOR PRODUCING A RUBBER PRODUCT
WO2021201236A1 (ja) 2020-04-01 2021-10-07 協和キリン株式会社 抗体組成物
US20230212243A1 (en) 2020-05-12 2023-07-06 Institut Curie Neoantigenic Epitopes Associated with SF3B1 Mutations
IL300026A (en) 2020-08-06 2023-03-01 Gritstone Bio Inc Multiepitope vaccine cassettes
WO2022072833A2 (en) 2020-10-02 2022-04-07 Impossible Foods Inc. Expression constructs and methods of genetically engineering cells
WO2022072846A2 (en) 2020-10-02 2022-04-07 Impossible Foods Inc. Transgenic plants with altered fatty acid profiles and upregulated heme biosynthesis
WO2022074098A1 (en) 2020-10-08 2022-04-14 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Method for the identification of cancer neoantigens
WO2022093977A1 (en) 2020-10-30 2022-05-05 Fortiphyte, Inc. Pathogen resistance in plants
US20230197192A1 (en) 2020-11-06 2023-06-22 Amazon Technologies, Inc. Selecting neoantigens for personalized cancer vaccine
KR20230142704A (ko) 2020-12-14 2023-10-11 바이오엔테크 유에스 인크. 암 면역요법을 위한 조직 특이적 항원
US20230074591A1 (en) 2021-01-19 2023-03-09 Amazon Technologies, Inc. A deep learning model for predicting tumor-specific neoantigen mhc class i or class ii immunogenicity
CN117157713A (zh) 2021-02-05 2023-12-01 亚马逊科技公司 对用于个性化癌症疫苗的新抗原进行排序
AU2022235060A1 (en) 2021-03-11 2023-09-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Tumor neoantigenic peptides and uses thereof
EP4304632A2 (en) 2021-03-11 2024-01-17 Mnemo Therapeutics Tumor neoantigenic peptides
EP4304634A1 (en) 2021-03-11 2024-01-17 Institut Curie Transmembrane neoantigenic peptides
JP2024512462A (ja) 2021-03-15 2024-03-19 アマゾン テクノロジーズ インコーポレイテッド 不均一な悪性腫瘍についての腫瘍ワクチン抗原カバレッジを最適化するための方法
US20230173046A1 (en) 2021-05-27 2023-06-08 Amazon Technologies, Inc. Multicomponent chemical composition of a peptide-based neoantigen vaccine
JP2023040705A (ja) 2021-09-10 2023-03-23 住友ゴム工業株式会社 トランス型ポリイソプレノイドの製造方法、ベクター、形質転換生物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP2023127868A (ja) 2022-03-02 2023-09-14 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ(cpt)ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP2023127869A (ja) 2022-03-02 2023-09-14 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ(cpt)ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
JP2023127870A (ja) 2022-03-02 2023-09-14 住友ゴム工業株式会社 変異シス型プレニルトランスフェラーゼ(cpt)ファミリー蛋白質、ポリイソプレノイドの製造方法、ベクター、形質転換植物、空気入りタイヤの製造方法及びゴム製品の製造方法
WO2023178229A1 (en) 2022-03-16 2023-09-21 Amazon Technologies, Inc. Monitoring circulating tumor dna to improve subclone penetration of follow-up neoantigen cancer vaccines
WO2023180552A1 (en) 2022-03-24 2023-09-28 Institut Curie Immunotherapy targeting tumor transposable element derived neoantigenic peptides in glioblastoma
WO2024015702A1 (en) 2022-07-15 2024-01-18 Amazon Technologies, Inc. Personalized longitudinal analysis of circulating material to monitor and adapt neoantigen cancer vaccines
WO2024052856A1 (en) 2022-09-09 2024-03-14 Friedrich Alexander Universität Erlangen-Nürnberg Plant regulatory elements and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
IL84459A (en) * 1986-12-05 1993-07-08 Agracetus Apparatus and method for the injection of carrier particles carrying genetic material into living cells
EP0331855B1 (en) * 1988-02-29 1995-03-08 E.I. DU PONT DE NEMOURS & COMPANY, INC. Apparatus for delivering substances into cells and tissues in a non-lethal manner

Also Published As

Publication number Publication date
DE69103631D1 (de) 1994-09-29
CA2083816C (en) 2005-06-28
ATE110415T1 (de) 1994-09-15
AR243603A1 (es) 1993-08-31
KR960008270B1 (ko) 1996-06-21
HUT67533A (en) 1995-04-28
EP0535005B1 (en) 1994-08-24
HU216738B (hu) 1999-08-30
DE69103631T2 (de) 1995-02-23
ES2059140T3 (es) 1994-11-01
HU9203554D0 (en) 1993-03-29
JP2517813B2 (ja) 1996-07-24
CA2083816A1 (en) 1991-11-30
EP0535005A1 (en) 1993-04-07
US5204253A (en) 1993-04-20
AU7878891A (en) 1991-12-31
WO1991018991A1 (en) 1991-12-12
JPH05508316A (ja) 1993-11-25

Similar Documents

Publication Publication Date Title
DK0535005T3 (da) Forbedret fremgangsmåde og apparat til indføring af biologiske substanser i levende celler
DK475386D0 (da) Fremgangsmaade og apparat til fremstilling af biologiske stoffer
DK235490D0 (da) Fremgangsmaade og apparat til understoetning af cirkulation
DK264790D0 (da) Fremgangsmaade og apparat til generering af elektriske impulser til stimulering af biologiske emner
DK0460235T3 (da) Fremgangsmåde og apparat til behandlig af træ
DK259189D0 (da) Fremgangsmaade og apparat til fremstilling af mikrokapsler
DK418188D0 (da) Fremgangsmaade og apparat til rensning af spildgasser eller spildluft
FI102292B1 (fi) Laite ja menetelmä solujen säteilyttämiseksi
DK152204C (da) Fremgangsmåde og apparat til behandling af biologisk affald ved hjælpaf kompostering
DK179187A (da) Apparat og fremgangsmaade til hoestning af afgroeder
DK222682A (da) Fremgangsmaade og apparat til kvantitativ bestemmelse af haemoglobinniveauet i en biologisk proeve
NO891643D0 (no) Fremgangsmaate og apparat til rensing av vann.
DK524488D0 (da) Fremgangsmaade og apparat til elektrolytisk behandling af slam
DK163066C (da) Fremgangsmaade og apparat til udfoerelse af en fermentering
DK661688D0 (da) Fremgangsmaade og apparat til fremstilling af draaber
DK561488A (da) Fremgangsmaade og apparat til anaerob rensning af spildevand
DK125585D0 (da) Fremgangsmaade og apparat til paavisning af biologisk aktive midler
DK567688A (da) Fremgangsmaade og apparat til stoerrelsessortering af levende fisk
DK0405696T3 (da) Fremgangsmåde og apparat til at indføre materiale i biologiske celler
DK0504157T3 (da) Fremgangsmåde og apparat til udrugning af æg
DK475188D0 (da) Fremgangsmaade og apparat til indkassering
DK159190D0 (da) Fremgangsmaade og apparat til skanning af et objekt
DK458288D0 (da) Fremgangsmaade og apparat til maaling af loddemiddeltykkelse
DK262187A (da) Fremgangsmaade og apparat til bestemmelse af diameteren i dyretarme
DK335182A (da) Fremgangsmaade og apparat til dyrkning af cellevaev