MX2019001558A - Biosintesis de alcaloides de bencilisoquinolina y precursores alcaloides de bencilisoquinolina. - Google Patents
Biosintesis de alcaloides de bencilisoquinolina y precursores alcaloides de bencilisoquinolina.Info
- Publication number
- MX2019001558A MX2019001558A MX2019001558A MX2019001558A MX2019001558A MX 2019001558 A MX2019001558 A MX 2019001558A MX 2019001558 A MX2019001558 A MX 2019001558A MX 2019001558 A MX2019001558 A MX 2019001558A MX 2019001558 A MX2019001558 A MX 2019001558A
- Authority
- MX
- Mexico
- Prior art keywords
- benzylisoquinoline
- alkaloids
- biosynthesis
- alkaloid precursors
- precursors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01006—Glycerol dehydrogenase (1.1.1.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01021—Aldehyde reductase (1.1.1.21), i.e. aldose-reductase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01026—Glyoxylate reductase (1.1.1.26)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01034—Hydroxymethylglutaryl-CoA reductase (NADPH) (1.1.1.34)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01035—3-Hydroxyacyl-CoA dehydrogenase (1.1.1.35)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01041—Isocitrate dehydrogenase (NAD+) (1.1.1.41)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01046—L-Arabinose 1-dehydrogenase (1.1.1.46)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01049—Glucose-6-phosphate dehydrogenase (1.1.1.49)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01076—(S,S)-Butanediol dehydrogenase (1.1.1.76)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/0109—Aryl-alcohol dehydrogenase (1.1.1.90)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/05—Oxidoreductases acting on the CH-OH group of donors (1.1) with a quinone or similar compound as acceptor (1.1.5)
- C12Y101/05003—Glycerol-3-phosphate dehydrogenase (1.1.5.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Se describen microorganismos, plantas y celulas vegetales recombinantes que se modificaron geneticamente para tener niveles o actividad reducidos de una o mas alcohol deshidrogenasas o aldehido reductasas, mediante lo cual se aumenta la produccion de alcaloides de bencilisoquinolina y/o precursores alcaloides de bencilisoquinolina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662372356P | 2016-08-09 | 2016-08-09 | |
US201762524120P | 2017-06-23 | 2017-06-23 | |
PCT/EP2017/070253 WO2018029282A1 (en) | 2016-08-09 | 2017-08-09 | Biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019001558A true MX2019001558A (es) | 2019-06-10 |
Family
ID=59656047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019001558A MX2019001558A (es) | 2016-08-09 | 2017-08-09 | Biosintesis de alcaloides de bencilisoquinolina y precursores alcaloides de bencilisoquinolina. |
Country Status (6)
Country | Link |
---|---|
US (2) | US11060071B2 (es) |
EP (1) | EP3497212A1 (es) |
AU (2) | AU2017309313B2 (es) |
CA (1) | CA3033246A1 (es) |
MX (1) | MX2019001558A (es) |
WO (1) | WO2018029282A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3865580A1 (en) | 2013-03-15 | 2021-08-18 | The Board of Trustees of the Leland Stanford Junior University | Benzylisoquinoline alkaloids (bia) producing microbes, and methods of making and using the same |
EP3770267A1 (en) | 2013-11-04 | 2021-01-27 | The Board of Trustees of the Leland Stanford Junior University | Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same |
US10752903B2 (en) | 2015-05-04 | 2020-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same |
KR20180016396A (ko) | 2015-05-08 | 2018-02-14 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 에피머라제 및 벤질아이소퀴놀린 알칼로이드를 제조하는 방법 |
KR20190084262A (ko) | 2016-10-18 | 2019-07-16 | 앤테이아 인코포레이티드 | 노르-오피오이드 및 날-오피오이드 벤질이소퀴놀린 알칼로이드를 생산하는 방법 |
BR112020002050A2 (pt) | 2017-08-03 | 2020-09-08 | Antheia, Inc. | epimerases engenheiradas alcaloides benzilisoquinolina e métodos de produção de alcaloides benzilisoquinolina |
WO2019243624A1 (en) | 2018-06-22 | 2019-12-26 | Valorbec, Limited Partnership | Production of benzylisoquinoline alkaloids in recombinant hosts |
AU2020205462A1 (en) | 2019-01-11 | 2021-07-01 | River Stone Biotech Aps | Recombinant host cells with improved production of L-DOPA, dopamine, (S)-Norcoclaurine or derivatives thereof. |
US20240102061A1 (en) * | 2020-11-19 | 2024-03-28 | Antheia, Inc. | Methods of improving production of morphinan alkaloids and derivatives |
CN113502302A (zh) * | 2021-07-30 | 2021-10-15 | 江西科苑生物股份有限公司 | 一种(s)-2-氯-1-(3,4-二氟苯基)乙醇的生物合成方法 |
WO2024100063A1 (en) | 2022-11-08 | 2024-05-16 | River Stone Biotech Aps | Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
WO2011058446A2 (en) * | 2009-11-12 | 2011-05-19 | Uti Limited Partnership | Thebaine 6-o-demethylase and codeine o-demethylase from papaver somniferum |
EP3770267A1 (en) * | 2013-11-04 | 2021-01-27 | The Board of Trustees of the Leland Stanford Junior University | Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same |
US10752903B2 (en) | 2015-05-04 | 2020-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same |
KR20180016396A (ko) * | 2015-05-08 | 2018-02-14 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 에피머라제 및 벤질아이소퀴놀린 알칼로이드를 제조하는 방법 |
-
2017
- 2017-08-09 AU AU2017309313A patent/AU2017309313B2/en active Active
- 2017-08-09 EP EP17754315.4A patent/EP3497212A1/en active Pending
- 2017-08-09 US US16/324,284 patent/US11060071B2/en active Active
- 2017-08-09 MX MX2019001558A patent/MX2019001558A/es unknown
- 2017-08-09 WO PCT/EP2017/070253 patent/WO2018029282A1/en unknown
- 2017-08-09 CA CA3033246A patent/CA3033246A1/en active Pending
-
2021
- 2021-06-18 US US17/351,381 patent/US11965181B2/en active Active
-
2023
- 2023-10-05 AU AU2023241335A patent/AU2023241335A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20190338255A1 (en) | 2019-11-07 |
WO2018029282A1 (en) | 2018-02-15 |
US20210340505A1 (en) | 2021-11-04 |
AU2023241335A1 (en) | 2023-10-26 |
US11060071B2 (en) | 2021-07-13 |
EP3497212A1 (en) | 2019-06-19 |
AU2017309313A1 (en) | 2019-02-21 |
CA3033246A1 (en) | 2018-02-15 |
US11965181B2 (en) | 2024-04-23 |
AU2017309313B2 (en) | 2023-11-02 |
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