MX2019009229A - Novedosas variantes enzimaticas que degradan la nicotina. - Google Patents
Novedosas variantes enzimaticas que degradan la nicotina.Info
- Publication number
- MX2019009229A MX2019009229A MX2019009229A MX2019009229A MX2019009229A MX 2019009229 A MX2019009229 A MX 2019009229A MX 2019009229 A MX2019009229 A MX 2019009229A MX 2019009229 A MX2019009229 A MX 2019009229A MX 2019009229 A MX2019009229 A MX 2019009229A
- Authority
- MX
- Mexico
- Prior art keywords
- degrading enzyme
- enzyme variants
- novel nicotine
- nicotine degrading
- variants
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Addiction (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
Abstract
Se describen variantes enzimáticas que degradan la nicotina que exhiben una mayor actividad de degradación de la nicotina y/o una menor inmunogenicidad en comparación con las enzimas NicA2 y NOX de tipo silvestre, composiciones que comprenden las variantes y métodos que las utilizan.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762454331P | 2017-02-03 | 2017-02-03 | |
US201762535507P | 2017-07-21 | 2017-07-21 | |
PCT/US2018/016664 WO2018144879A1 (en) | 2017-02-03 | 2018-02-02 | Novel nicotine degrading enzyme variants |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019009229A true MX2019009229A (es) | 2019-12-11 |
Family
ID=61193218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009229A MX2019009229A (es) | 2017-02-03 | 2018-02-02 | Novedosas variantes enzimaticas que degradan la nicotina. |
Country Status (10)
Country | Link |
---|---|
US (2) | US11597916B2 (es) |
EP (1) | EP3577218A1 (es) |
JP (1) | JP2020506709A (es) |
KR (1) | KR102551403B1 (es) |
CN (1) | CN110520527A (es) |
AU (1) | AU2018215456A1 (es) |
BR (1) | BR112019015788A2 (es) |
CA (1) | CA3052928A1 (es) |
MX (1) | MX2019009229A (es) |
WO (1) | WO2018144879A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018215456A1 (en) | 2017-02-03 | 2019-08-22 | Antidote Therapeutics, Inc. | Novel nicotine degrading enzyme variants |
WO2019126364A2 (en) * | 2017-12-19 | 2019-06-27 | The Scripps Research Institute | Compositions and methods related to nicotine addiction and cessation |
WO2020027970A1 (en) | 2018-08-02 | 2020-02-06 | Antidote Therapeutics, Inc. | Novel nicotine degrading enzyme variants |
US11331020B2 (en) | 2020-02-06 | 2022-05-17 | Trustees Of Boston University | Enzyme-based electrochemical nicotine biosensor |
WO2021221752A2 (en) | 2020-02-06 | 2021-11-04 | Trustees Of Boston University | High throughput assay for identifying microbial redox enzymes |
US11801000B2 (en) | 2021-04-30 | 2023-10-31 | Trustees Of Boston University | Hormone electrochemical biosensor |
CN116622792B (zh) * | 2022-10-19 | 2024-03-08 | 修实生物医药(南通)有限公司 | 一种使用酶催化合成(s)-烟碱的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1712532A (zh) * | 2004-06-24 | 2005-12-28 | 上海交通大学 | 猪单胺氧化酶b蛋白编码序列 |
CN102131813B (zh) * | 2008-06-24 | 2014-07-30 | 科德克希思公司 | 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法 |
US20150087028A1 (en) * | 2012-03-12 | 2015-03-26 | Codexis, Inc. | Cbh1a variants |
KR101423952B1 (ko) * | 2012-10-10 | 2014-08-06 | 고려대학교 산학협력단 | 바이오제닉 아민의 함량 분석용 단백질 및 그 제조방법 |
CN103012572B (zh) * | 2012-12-05 | 2013-11-27 | 北京师范大学 | 一种降低烟草尼古丁含量的基因及应用 |
CN107613762A (zh) * | 2015-05-05 | 2018-01-19 | 北卡罗莱纳州立大学 | 减少烟草中的烟草特异性亚硝胺nnk的方法和组合物 |
EP3331526A4 (en) | 2015-08-04 | 2019-04-24 | The Scripps Research Institute | NICOTIN-DEGREEING ENZYMES FOR THE TREATMENT OF NICOTINE DEPENDENCE AND NICOTINE POISONING |
CN115806947A (zh) | 2016-04-01 | 2023-03-17 | 上海交通大学 | 一种酶及其应用 |
AU2018215456A1 (en) | 2017-02-03 | 2019-08-22 | Antidote Therapeutics, Inc. | Novel nicotine degrading enzyme variants |
WO2019126364A2 (en) | 2017-12-19 | 2019-06-27 | The Scripps Research Institute | Compositions and methods related to nicotine addiction and cessation |
WO2020027970A1 (en) | 2018-08-02 | 2020-02-06 | Antidote Therapeutics, Inc. | Novel nicotine degrading enzyme variants |
-
2018
- 2018-02-02 AU AU2018215456A patent/AU2018215456A1/en not_active Abandoned
- 2018-02-02 BR BR112019015788-3A patent/BR112019015788A2/pt not_active Application Discontinuation
- 2018-02-02 CN CN201880019066.1A patent/CN110520527A/zh active Pending
- 2018-02-02 US US16/483,380 patent/US11597916B2/en active Active
- 2018-02-02 KR KR1020197025873A patent/KR102551403B1/ko active IP Right Grant
- 2018-02-02 WO PCT/US2018/016664 patent/WO2018144879A1/en unknown
- 2018-02-02 MX MX2019009229A patent/MX2019009229A/es unknown
- 2018-02-02 JP JP2019542413A patent/JP2020506709A/ja active Pending
- 2018-02-02 CA CA3052928A patent/CA3052928A1/en active Pending
- 2018-02-02 EP EP18704845.9A patent/EP3577218A1/en active Pending
-
2023
- 2023-03-02 US US18/116,810 patent/US20230416697A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA3052928A1 (en) | 2018-08-09 |
US11597916B2 (en) | 2023-03-07 |
AU2018215456A1 (en) | 2019-08-22 |
WO2018144879A1 (en) | 2018-08-09 |
US20230416697A1 (en) | 2023-12-28 |
CN110520527A (zh) | 2019-11-29 |
US20200224176A1 (en) | 2020-07-16 |
KR20190129038A (ko) | 2019-11-19 |
BR112019015788A2 (pt) | 2020-03-17 |
EP3577218A1 (en) | 2019-12-11 |
KR102551403B1 (ko) | 2023-07-11 |
JP2020506709A (ja) | 2020-03-05 |
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