EA201590796A1 - Фибринолитические композиции, включающие бромелаин и наттокиназу, для предотвращения и лечения флеботромботических состояний - Google Patents

Фибринолитические композиции, включающие бромелаин и наттокиназу, для предотвращения и лечения флеботромботических состояний

Info

Publication number
EA201590796A1
EA201590796A1 EA201590796A EA201590796A EA201590796A1 EA 201590796 A1 EA201590796 A1 EA 201590796A1 EA 201590796 A EA201590796 A EA 201590796A EA 201590796 A EA201590796 A EA 201590796A EA 201590796 A1 EA201590796 A1 EA 201590796A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phlebothrombotic
nattokinaz
bromelein
prevention
treatment
Prior art date
Application number
EA201590796A
Other languages
English (en)
Other versions
EA027753B1 (ru
Inventor
Франческо Ди Пьерро
Original Assignee
Веллея Рисерч С.Р.Л.
Ньосис С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Веллея Рисерч С.Р.Л., Ньосис С.П.А. filed Critical Веллея Рисерч С.Р.Л.
Publication of EA201590796A1 publication Critical patent/EA201590796A1/ru
Publication of EA027753B1 publication Critical patent/EA027753B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22032—Stem bromelain (3.4.22.32)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

Раскрыты композиции, включающие бромелаин и наттокиназу в качестве единственных активных ингредиентов.
EA201590796A 2012-11-23 2013-11-06 Фибринолитические композиции, включающие бромелаин и наттокиназу, для предотвращения и лечения флеботромботических состояний EA027753B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001997A ITMI20121997A1 (it) 2012-11-23 2012-11-23 Composizioni fibrinolitiche per la prevenzione e il trattamento degli stati flebotrombotici
PCT/EP2013/073160 WO2014079689A1 (en) 2012-11-23 2013-11-06 Fibrinolytic compositions comprising bromelain and nattokinase for the prevention and treatment of phlebothrombotic states

Publications (2)

Publication Number Publication Date
EA201590796A1 true EA201590796A1 (ru) 2015-09-30
EA027753B1 EA027753B1 (ru) 2017-08-31

Family

ID=47633139

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590796A EA027753B1 (ru) 2012-11-23 2013-11-06 Фибринолитические композиции, включающие бромелаин и наттокиназу, для предотвращения и лечения флеботромботических состояний

Country Status (25)

Country Link
US (1) US20150297685A1 (ru)
EP (1) EP2922567B1 (ru)
JP (1) JP6319592B2 (ru)
KR (1) KR20150100641A (ru)
CN (1) CN104955474B (ru)
AU (1) AU2013349898B2 (ru)
BR (1) BR112015011693A2 (ru)
CA (1) CA2892426A1 (ru)
CY (1) CY1119064T1 (ru)
DK (1) DK2922567T3 (ru)
EA (1) EA027753B1 (ru)
ES (1) ES2637847T3 (ru)
GE (1) GEP201706717B (ru)
HR (1) HRP20170987T1 (ru)
HU (1) HUE034096T2 (ru)
IL (1) IL238937A0 (ru)
IT (1) ITMI20121997A1 (ru)
LT (1) LT2922567T (ru)
MX (1) MX2015006454A (ru)
PH (1) PH12015501131A1 (ru)
PL (1) PL2922567T3 (ru)
PT (1) PT2922567T (ru)
SI (1) SI2922567T1 (ru)
WO (1) WO2014079689A1 (ru)
ZA (1) ZA201503604B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ748875A (en) * 2016-05-27 2022-07-01 Nattocat Llc Compositions and methods for thromboembolism dissolution
CN105944091A (zh) * 2016-06-24 2016-09-21 方捷 抗血栓的纳豆激酶组合物及其制备方法
IT201600109433A1 (it) * 2016-10-28 2018-04-28 Difass Int S R L Composizioni gastroresistenti comprendenti bromelina associata a un estratto secco di ananas comosus (l.)
WO2020214033A1 (en) * 2019-04-17 2020-10-22 Erasmus University Medical Center Rotterdam Papain-like cysteine peptidase medicaments and uses thereof
JP2021017423A (ja) 2019-07-23 2021-02-15 株式会社Ｓｃｒｅｅｎホールディングス 灌流液および灌流方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1476143A1 (en) * 2002-02-15 2004-11-17 DSM IP Assets B.V. Compositions comprising lycopene for the treatment and prevention of angiogenesis associated pathologies
JP2005220025A (ja) * 2004-02-03 2005-08-18 Kenko Tsusho Kk 経口摂取組成物
RU2318466C1 (ru) 2006-06-23 2008-03-10 Давид Георгиевич Кочиев Лазерная установка для абляции тканей и литотрипсии
US8287858B2 (en) * 2006-08-10 2012-10-16 Jon Barron Proteolytic enzyme formulations
AT504159A1 (de) * 2006-08-16 2008-03-15 Marlyn Nutraceuticals Inc Verwendung von proteasen
US8574625B2 (en) * 2007-05-30 2013-11-05 Wockhardt Ltd. Tablet dosage form
AT506095A1 (de) * 2007-12-03 2009-06-15 Volopharm Gmbh Verwendung von proteasen
EP3037102A1 (en) * 2009-11-23 2016-06-29 Stephen F. Olmstead Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions

Also Published As

Publication number Publication date
KR20150100641A (ko) 2015-09-02
US20150297685A1 (en) 2015-10-22
CA2892426A1 (en) 2014-05-30
BR112015011693A2 (pt) 2017-07-11
MX2015006454A (es) 2015-12-03
EP2922567A1 (en) 2015-09-30
PT2922567T (pt) 2017-08-28
CN104955474B (zh) 2017-09-19
JP6319592B2 (ja) 2018-05-09
DK2922567T3 (en) 2017-07-24
JP2016504287A (ja) 2016-02-12
PL2922567T3 (pl) 2017-10-31
HRP20170987T1 (hr) 2017-09-22
HUE034096T2 (en) 2018-01-29
GEP201706717B (en) 2017-08-10
WO2014079689A1 (en) 2014-05-30
SI2922567T1 (sl) 2017-07-31
CN104955474A (zh) 2015-09-30
LT2922567T (lt) 2017-07-25
ZA201503604B (en) 2016-08-31
EP2922567B1 (en) 2017-05-24
ITMI20121997A1 (it) 2014-05-24
PH12015501131B1 (en) 2015-08-03
ES2637847T3 (es) 2017-10-17
EA027753B1 (ru) 2017-08-31
AU2013349898B2 (en) 2018-05-10
AU2013349898A1 (en) 2015-06-11
CY1119064T1 (el) 2018-01-10
IL238937A0 (en) 2015-07-30
PH12015501131A1 (en) 2015-08-03

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU