DE69735547D1 - Verfahren zur induzierung von immunsupprimierten zellen und vorrichtung zu deren kultivierung - Google Patents

Verfahren zur induzierung von immunsupprimierten zellen und vorrichtung zu deren kultivierung

Info

Publication number
DE69735547D1
DE69735547D1 DE69735547T DE69735547T DE69735547D1 DE 69735547 D1 DE69735547 D1 DE 69735547D1 DE 69735547 T DE69735547 T DE 69735547T DE 69735547 T DE69735547 T DE 69735547T DE 69735547 D1 DE69735547 D1 DE 69735547D1
Authority
DE
Germany
Prior art keywords
upprimated
culturing
cells
inducing immune
immune
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69735547T
Other languages
English (en)
Other versions
DE69735547T2 (de
Inventor
Kenji Yamashita
Takeshi Fukuchi
Tomoko Nishino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of DE69735547D1 publication Critical patent/DE69735547D1/de
Application granted granted Critical
Publication of DE69735547T2 publication Critical patent/DE69735547T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Sustainable Development (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69735547T 1996-09-03 1997-08-29 Verfahren zur induzierung von immunsupprimierten zellen und vorrichtung zu deren kultivierung Expired - Fee Related DE69735547T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP23331696 1996-09-03
JP23331696 1996-09-03
PCT/JP1997/003016 WO1998010055A1 (fr) 1996-09-03 1997-08-29 Methode d'activation de cellules immunosuppressives et dispositif de culture utilise a cette fin

Publications (2)

Publication Number Publication Date
DE69735547D1 true DE69735547D1 (de) 2006-05-11
DE69735547T2 DE69735547T2 (de) 2007-03-08

Family

ID=16953228

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69735547T Expired - Fee Related DE69735547T2 (de) 1996-09-03 1997-08-29 Verfahren zur induzierung von immunsupprimierten zellen und vorrichtung zu deren kultivierung

Country Status (5)

Country Link
US (2) US6764688B2 (de)
EP (1) EP0957160B1 (de)
AU (1) AU4031997A (de)
DE (1) DE69735547T2 (de)
WO (1) WO1998010055A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001029067A (ja) * 1999-05-14 2001-02-06 Kanegafuchi Chem Ind Co Ltd 抗原特異的細胞傷害抑制性細胞の誘導方法
US8658773B2 (en) 2011-05-02 2014-02-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
US8980625B2 (en) * 2006-02-24 2015-03-17 National Food Research Institute Cell culture plate and method of manufacturing the same
JP4853637B2 (ja) * 2006-08-08 2012-01-11 Ｋｉｓｃｏ株式会社 細胞培養用基材およびその製造方法
DE102008023545A1 (de) * 2008-05-14 2009-11-19 Roderfeld Und Bora Gmbh & Co.Kg Vorrichtung zur Herstellung einer biologisch aktiven Substanz
EP2304019B1 (de) * 2008-07-16 2019-04-10 EMD Millipore Corporation Schichtiges kolbensystem zur kultivierung von zellen
DK3903829T3 (da) 2009-02-13 2023-06-26 Immunomedics Inc Immunkonjugater med en intracellulær spaltelig binding
US20160095939A1 (en) 2014-10-07 2016-04-07 Immunomedics, Inc. Neoadjuvant use of antibody-drug conjugates
US8287865B2 (en) 2009-09-16 2012-10-16 Immunomedics, Inc. Class I anti-CEA antibodies and uses thereof
ES2978177T3 (es) 2009-12-02 2024-09-06 Immunomedics Inc Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer
EP3586874A1 (de) 2012-08-14 2020-01-01 IBC Pharmaceuticals, Inc. Umleitung t-zell-bispezifischer antikörper zur behandlung von krankheiten
JP6366111B2 (ja) 2012-12-13 2018-08-01 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． 有効性の改善および毒性の減少のための、抗体およびｓｎ−３８からなるイムノコンジュゲートの投薬
WO2017004144A1 (en) 2015-07-01 2017-01-05 Immunomedics, Inc. Antibody-sn-38 immunoconjugates with a cl2a linker
MX2016010683A (es) 2014-02-21 2017-05-11 Ibc Pharmaceuticals Inc Terapia para tratar enfermedades mediante la induccion de respuesta inmune de las células que expresan trop-2.
EP3110445A4 (de) 2014-02-25 2017-09-27 Immunomedics, Inc. Humanisierter rfb4-anti-cd22-antikörper
US9580495B2 (en) 2014-06-24 2017-02-28 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
JP6746845B2 (ja) 2015-04-22 2020-08-26 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． 循環ｔｒｏｐ−２陽性癌細胞の単離、検出、診断及び／または特徴付け
ES2953441T3 (es) 2015-06-25 2023-11-13 Immunomedics Inc Combinación de anticuerpos anti-hla-dr o anti-Trop-2 con inhibidores de microtúbulos, inhibidores de parp, inhibidores de la cinasa de bruton o inhibidores de la fosfoinositida 3-cinasa mejora significativamente el resultado terapéutico en el cáncer
JP7235954B2 (ja) * 2018-12-28 2023-03-09 シンフォニアテクノロジー株式会社 細胞培養システムおよび細胞培養装置
AU2020263959A1 (en) 2019-04-24 2021-11-25 Heidelberg Pharma Research Gmbh Amatoxin antibody-drug conjugates and uses thereof
EP4342497A1 (de) 2021-05-10 2024-03-27 Kawasaki Institute of Industrial Promotion Antikörper mit reduzierter bindungsaffinität für antigen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925919A (en) * 1984-04-25 1990-05-15 Roland Mertelsmann Purified interleukin 2
US5766920A (en) * 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
JP2618497B2 (ja) 1989-10-03 1997-06-11 鐘淵化学工業株式会社 腫瘍障害細胞誘導剤および腫瘍障害細胞誘導デバイス
US5958671A (en) * 1996-04-23 1999-09-28 Presidents And Fellows Of Harvard College Methods and compositions for regulating T cell subsets by modulating transcription factor activity

Also Published As

Publication number Publication date
US20010024822A1 (en) 2001-09-27
EP0957160B1 (de) 2006-03-22
WO1998010055A1 (fr) 1998-03-12
EP0957160A1 (de) 1999-11-17
AU4031997A (en) 1998-03-26
EP0957160A4 (de) 2003-06-11
US6764688B2 (en) 2004-07-20
DE69735547T2 (de) 2007-03-08
US20020045252A1 (en) 2002-04-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee