ATE418729T1 - Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie - Google Patents
Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategieInfo
- Publication number
- ATE418729T1 ATE418729T1 AT03793347T AT03793347T ATE418729T1 AT E418729 T1 ATE418729 T1 AT E418729T1 AT 03793347 T AT03793347 T AT 03793347T AT 03793347 T AT03793347 T AT 03793347T AT E418729 T1 ATE418729 T1 AT E418729T1
- Authority
- AT
- Austria
- Prior art keywords
- result
- sample
- driven strategy
- characterizing biomolecules
- biomolecules
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8411—Intermediate storage of effluent, including condensation on surface
- G01N2030/8417—Intermediate storage of effluent, including condensation on surface the store moving as a whole, e.g. moving wire
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40557802P | 2002-08-22 | 2002-08-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE418729T1 true ATE418729T1 (de) | 2009-01-15 |
Family
ID=31946899
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03793347T ATE418729T1 (de) | 2002-08-22 | 2003-08-22 | Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie |
Country Status (8)
Country | Link |
---|---|
US (1) | US6940065B2 (de) |
EP (1) | EP1530721B1 (de) |
JP (1) | JP4160558B2 (de) |
AT (1) | ATE418729T1 (de) |
AU (1) | AU2003262824B2 (de) |
CA (1) | CA2495378C (de) |
DE (1) | DE60325482D1 (de) |
WO (1) | WO2004019035A2 (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3817523B2 (ja) * | 2003-02-14 | 2006-09-06 | 株式会社日立製作所 | 質量分析データ解析システム |
US7202473B2 (en) * | 2003-04-10 | 2007-04-10 | Micromass Uk Limited | Mass spectrometer |
US7105806B2 (en) * | 2003-11-26 | 2006-09-12 | Applera Corporation | Method and apparatus for de-convoluting a convoluted spectrum |
EP1723249A4 (de) * | 2004-01-30 | 2008-07-02 | Bio Rad Laboratories | Markierung von rapamycin mit rapamycinspezifischen methylasen |
GB2413695B (en) * | 2004-04-30 | 2009-01-21 | Micromass Ltd | Mass spectrometer |
EP1766394B1 (de) * | 2004-05-20 | 2020-09-09 | Waters Technologies Corporation | System und verfahren zur gruppierung von vorläufer- und fragmentionen unter verwendung ausgewählter ionenchromatogramme |
DE112005001166B4 (de) | 2004-05-20 | 2014-10-09 | Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) | Verfahren und Vorrichtung zum Identifizieren von Proteinen in Gemischen |
DE102004051016A1 (de) * | 2004-10-20 | 2006-05-04 | Protagen Ag | Verfahren und System zur Aufklärung der Primärstruktur von Biopolymeren |
DE102004051043B4 (de) * | 2004-10-20 | 2011-06-01 | Bruker Daltonik Gmbh | Angleichung von Flugzeitmassenspektren |
DE102005018273B4 (de) * | 2005-04-20 | 2007-11-15 | Bruker Daltonik Gmbh | Rückgesteuerte Tandem-Massenspektrometrie |
US7498568B2 (en) * | 2005-04-29 | 2009-03-03 | Agilent Technologies, Inc. | Real-time analysis of mass spectrometry data for identifying peptidic data of interest |
US8581178B2 (en) * | 2005-05-24 | 2013-11-12 | Dh Technologies Development Pte. Ltd. | Combined mass and differential mobility spectrometry and associated methods, systems, and devices |
JP4522910B2 (ja) * | 2005-05-30 | 2010-08-11 | 株式会社日立ハイテクノロジーズ | 質量分析方法及び質量分析装置 |
EP1887351A4 (de) * | 2005-05-31 | 2009-04-08 | Jcl Bioassay Corp | Screening-verfahren für bestimmte proteine bei der umfassenden proteomanalyse |
EP1894018A1 (de) * | 2005-06-03 | 2008-03-05 | MDS Inc. doing business through its MDS Sciex Division | System und verfahren zur analyse von verbindungen unter verwendung eines massenspektrometers |
ATE509329T1 (de) * | 2005-11-10 | 2011-05-15 | Microsoft Corp | Entdeckung biologischer merkmale unter verwendung zusammengesetzter bilder |
WO2007065273A1 (en) * | 2005-12-08 | 2007-06-14 | The University Of British Columbia | Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith |
US20080319678A1 (en) * | 2006-02-15 | 2008-12-25 | University Of Virginia Patent Foundation | Mass Tagging for Quantitative Analysis of Biomolecules using 13C Labeled Phenylisocyanate |
JP5496650B2 (ja) * | 2006-03-21 | 2014-05-21 | メタボロン インコーポレイテッド | サンプル内の個々の要素を識別及び定量化するために分光測定データを分析するシステム、方法及びコンピュータプログラム製品 |
ES2446266T3 (es) | 2006-07-21 | 2014-03-06 | Amgen Inc. | Método de detección y/o de medición de hepcidina en una muestra |
WO2008019492A1 (en) * | 2006-08-15 | 2008-02-21 | Alexei Antonov | Apparatus and method for elemental analysis of particles by mass spectrometry |
GB0622780D0 (en) * | 2006-11-15 | 2006-12-27 | Micromass Ltd | Mass spectrometer |
US7838824B2 (en) * | 2007-05-01 | 2010-11-23 | Virgin Instruments Corporation | TOF-TOF with high resolution precursor selection and multiplexed MS-MS |
US7820964B2 (en) * | 2007-08-06 | 2010-10-26 | Metabolic Analyses, Inc | Method for generation and use of stable isotope patterns in mass spectral data |
US7820963B2 (en) | 2007-08-06 | 2010-10-26 | Metabolic Alayses, Inc. | Method for generation and use of isotopic patterns in mass spectral data of simple organisms |
US8536520B2 (en) * | 2007-08-06 | 2013-09-17 | Iroa Technologies Llc | Method for generation and use of isotopic patterns in mass spectral data of simple organisms |
JP5020742B2 (ja) * | 2007-08-27 | 2012-09-05 | 日本電子株式会社 | Maldiイオン源を備えた質量分析装置およびmaldiイオン源用サンプルプレート |
JP5227556B2 (ja) * | 2007-09-06 | 2013-07-03 | 株式会社日立製作所 | 分析装置 |
US8969251B2 (en) * | 2007-10-02 | 2015-03-03 | Methabolic Analyses, Inc. | Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms |
EP2205342B1 (de) * | 2007-10-02 | 2014-01-22 | IROA Technologies LLC | Erzeugung und verwendung von isotopenmustern beim massenspektrometrischen phänotypenvergleich von organismen |
EP2234686A4 (de) * | 2007-11-30 | 2011-02-09 | Waters Technologies Corp | Bestimmung der anwesenheit unter abwesenheit von mineralcorticoiden in proben |
EP2232524A4 (de) * | 2007-12-04 | 2016-06-08 | Dh Technologies Dev Pte Ltd | Systeme und verfahren zum analysieren von substanzen unter verwendung eines massenspektrometers |
US20090194685A1 (en) * | 2008-01-31 | 2009-08-06 | Mds Analytical Technologies | High-throughput screening of metabolic disorders using a laser desorption ion source coupled to a mass analyzer |
US8148677B2 (en) * | 2008-02-05 | 2012-04-03 | Thermo Finnigan Llc | Peptide identification and quantitation by merging MS/MS spectra |
US8067728B2 (en) * | 2008-02-22 | 2011-11-29 | Dh Technologies Development Pte. Ltd. | Method of improving signal-to-noise for quantitation by mass spectrometry |
JP2011522257A (ja) * | 2008-05-29 | 2011-07-28 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 前駆体および生成物イオンの保持時間一致を実行し、前駆体および生成物イオンスペクトルを構成する技術 |
US8067243B2 (en) * | 2008-09-03 | 2011-11-29 | Oregon Medical Laboratories | Methods and systems for analyzing medication levels in a sample |
US8321144B2 (en) | 2008-10-23 | 2012-11-27 | Microsoft Corporation | Non-contiguous regions processing |
BRPI0805608B1 (pt) * | 2008-12-15 | 2018-11-21 | Embrapa Pesquisa Agropecuaria | método, equipamento e sistema para diagnóstico de estresses e doenças em plantas superiores |
WO2010096713A2 (en) | 2009-02-20 | 2010-08-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for the diagnosis of age-associated vascular disorders |
DE102009030395A1 (de) * | 2009-06-25 | 2011-05-26 | Tecan Trading Ag | Differnziertes chromatographisches Analysenverfahren zur Kompensation von Varianzen in der signalerzeugenden Einheit bei quantifizierenden chromatographischen Analysen |
GB201003566D0 (en) * | 2010-03-03 | 2010-04-21 | Ilika Technologies Ltd | Mass spectrometry apparatus and methods |
DE102011017084B4 (de) | 2010-04-14 | 2020-07-09 | Wisconsin Alumni Research Foundation | Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung |
US10553412B2 (en) | 2010-05-24 | 2020-02-04 | Agilent Technologies, Inc. | System and method of data-dependent acquisition by mass spectrometry |
JP5505110B2 (ja) * | 2010-06-14 | 2014-05-28 | 株式会社島津製作所 | クロマトグラフ質量分析装置 |
CA2806211A1 (en) * | 2010-07-22 | 2012-01-26 | Georgetown University | Mass spectrometric methods for quantifying npy 1-36 and npy 3-36 |
US8809770B2 (en) * | 2010-09-15 | 2014-08-19 | Dh Technologies Development Pte. Ltd. | Data independent acquisition of product ion spectra and reference spectra library matching |
DE102011053684B4 (de) | 2010-09-17 | 2019-03-28 | Wisconsin Alumni Research Foundation | Verfahren zur Durchführung von strahlformstossaktivierter Dissoziation im bereits bestehenden Ioneninjektionspfad eines Massenspektrometers |
JP5609509B2 (ja) * | 2010-10-04 | 2014-10-22 | 富士通株式会社 | 指示システム、指示方法、及び記憶制御装置。 |
WO2012099971A2 (en) * | 2011-01-21 | 2012-07-26 | Massdefect Technologies, Llc | Background subtraction-mediated data-dependent acquisition |
US9040903B2 (en) | 2011-04-04 | 2015-05-26 | Wisconsin Alumni Research Foundation | Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility |
EP2831904B1 (de) * | 2012-03-28 | 2020-01-01 | Ulvac-Phi, Inc. | Vorrichtung zur bereitstellung einer parallelen erfassung von massenspektrometrie/massenspektrometriedaten |
EP2781916A1 (de) * | 2013-03-22 | 2014-09-24 | Biotage AB | Kopplungsmodul |
JP6136771B2 (ja) * | 2013-08-30 | 2017-05-31 | 株式会社島津製作所 | 物質同定方法及び該方法を用いる質量分析装置 |
US10115576B2 (en) * | 2013-12-12 | 2018-10-30 | Waters Technologies Corporation | Method and an apparatus for analyzing a complex sample |
CN107077592B (zh) * | 2014-03-28 | 2021-02-19 | 威斯康星校友研究基金会 | 高分辨率气相色谱-质谱数据与单位分辨率参考数据库的改进谱图匹配的高质量精确度滤波 |
US9720001B2 (en) * | 2014-05-21 | 2017-08-01 | Thermo Finnigan Llc | Methods for mass spectrometric biopolymer analysis using optimized weighted oligomer scheduling |
GB201410470D0 (en) * | 2014-06-12 | 2014-07-30 | Micromass Ltd | Self-calibration of spectra using differences in molecular weight from known charge states |
EP3265823B1 (de) | 2015-03-06 | 2020-05-06 | Micromass UK Limited | Bildgebungsplattform für umgebungsionisierungsmassenspektrometrie für direkte abbildung aus gesamtgewebe |
EP3800657A1 (de) | 2015-03-06 | 2021-04-07 | Micromass UK Limited | Massenspektrometrieanalyse mit desorptionselektrosprayionisation oder desorptionselektrostromfokussierenionisation von biologische probe enthaltende wattestäbchen |
CN107646089B (zh) | 2015-03-06 | 2020-12-08 | 英国质谱公司 | 光谱分析 |
US11282688B2 (en) | 2015-03-06 | 2022-03-22 | Micromass Uk Limited | Spectrometric analysis of microbes |
CN108700590B (zh) | 2015-03-06 | 2021-03-02 | 英国质谱公司 | 细胞群体分析 |
CN107635477B (zh) * | 2015-03-06 | 2021-03-16 | 英国质谱公司 | 用于耦连至快速蒸发电离质谱(“reims”)装置的离子分析仪的入口仪器 |
WO2016196125A1 (en) * | 2015-05-29 | 2016-12-08 | Virgin Instruments Corporation | Method for developing and applying databases for identification of microorganisms by maldi-tof mass spectrometry |
US11454611B2 (en) | 2016-04-14 | 2022-09-27 | Micromass Uk Limited | Spectrometric analysis of plants |
US10049868B2 (en) * | 2016-12-06 | 2018-08-14 | Rapiscan Systems, Inc. | Apparatus for detecting constituents in a sample and method of using the same |
US10741372B2 (en) | 2017-03-06 | 2020-08-11 | Shimadzu Corporation | Tandem mass spectrometer and program for the same |
EP3410109A1 (de) * | 2017-06-02 | 2018-12-05 | Thermo Fisher Scientific (Bremen) GmbH | Systeme und verfahren zur extraktion von massenspuren |
WO2019032049A1 (en) * | 2017-08-07 | 2019-02-14 | Agency For Science, Technology And Research | RAPID ANALYSIS AND IDENTIFICATION OF LIPIDS FROM LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (LC-MS) DATA |
CN107782829A (zh) * | 2017-11-01 | 2018-03-09 | 上海莱士血液制品股份有限公司 | 一种利用离子色谱法检测生物制品中三羟甲基氨基甲烷(Tris)的方法 |
US11393666B2 (en) | 2019-12-19 | 2022-07-19 | Thermo Finnigan Llc | Automatic MS-N characterization of mass spectrometric “dark matter” |
US11624734B2 (en) | 2020-06-29 | 2023-04-11 | Waters Technologies Corporation | Chromatographic dimension selection in multidimensional liquid chromatography |
Family Cites Families (13)
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GB2057826B (en) | 1979-08-31 | 1983-01-12 | Ibm | Multibeam cathode ray tube apparatus |
US5625184A (en) | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
US6002127A (en) | 1995-05-19 | 1999-12-14 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
GB9624927D0 (en) * | 1996-11-29 | 1997-01-15 | Oxford Glycosciences Uk Ltd | Gels and their use |
US6596529B1 (en) | 1997-05-02 | 2003-07-22 | Uab Research Foundation | Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof |
US6175112B1 (en) | 1998-05-22 | 2001-01-16 | Northeastern University | On-line liquid sample deposition interface for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy |
US6348688B1 (en) | 1998-02-06 | 2002-02-19 | Perseptive Biosystems | Tandem time-of-flight mass spectrometer with delayed extraction and method for use |
US6428956B1 (en) * | 1998-03-02 | 2002-08-06 | Isis Pharmaceuticals, Inc. | Mass spectrometric methods for biomolecular screening |
CA2255122C (en) * | 1998-12-04 | 2007-10-09 | Mds Inc. | Improvements in ms/ms methods for a quadrupole/time of flight tandem mass spectrometer |
US6799121B2 (en) * | 2000-03-30 | 2004-09-28 | York University | Sequencing of peptides by mass spectrometry |
EP1317765A2 (de) * | 2000-09-08 | 2003-06-11 | Oxford GlycoSciences (UK) Limited | Automatisierte peptiderkennung |
CA2436503A1 (en) | 2001-02-01 | 2002-08-08 | Huw A. Davies | Improved methods for protein identification, characterization and sequencing by tandem mass spectrometry |
US6977732B2 (en) | 2002-12-26 | 2005-12-20 | National Taiwan University | Miniature three-dimensional contour scanner |
-
2003
- 2003-08-22 JP JP2004529924A patent/JP4160558B2/ja not_active Expired - Fee Related
- 2003-08-22 WO PCT/US2003/026471 patent/WO2004019035A2/en active Application Filing
- 2003-08-22 AU AU2003262824A patent/AU2003262824B2/en not_active Ceased
- 2003-08-22 CA CA2495378A patent/CA2495378C/en not_active Expired - Fee Related
- 2003-08-22 DE DE60325482T patent/DE60325482D1/de not_active Expired - Lifetime
- 2003-08-22 EP EP03793347A patent/EP1530721B1/de not_active Expired - Lifetime
- 2003-08-22 US US10/646,371 patent/US6940065B2/en not_active Expired - Fee Related
- 2003-08-22 AT AT03793347T patent/ATE418729T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2004019035A3 (en) | 2005-02-17 |
US20040108452A1 (en) | 2004-06-10 |
EP1530721B1 (de) | 2008-12-24 |
CA2495378C (en) | 2011-03-01 |
AU2003262824B2 (en) | 2007-08-23 |
EP1530721A2 (de) | 2005-05-18 |
JP4160558B2 (ja) | 2008-10-01 |
AU2003262824A1 (en) | 2004-03-11 |
CA2495378A1 (en) | 2004-03-04 |
DE60325482D1 (de) | 2009-02-05 |
WO2004019035A2 (en) | 2004-03-04 |
US6940065B2 (en) | 2005-09-06 |
JP2005536728A (ja) | 2005-12-02 |
WO2004019035A9 (en) | 2004-12-23 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |