DE60325482D1 - Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie - Google Patents

Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie

Info

Publication number
DE60325482D1
DE60325482D1 DE60325482T DE60325482T DE60325482D1 DE 60325482 D1 DE60325482 D1 DE 60325482D1 DE 60325482 T DE60325482 T DE 60325482T DE 60325482 T DE60325482 T DE 60325482T DE 60325482 D1 DE60325482 D1 DE 60325482D1
Authority
DE
Germany
Prior art keywords
result
sample
controlled strategy
characterizing biomolecules
biomolecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60325482T
Other languages
English (en)
Inventor
Armin Graber
Dale H Patterson
Peter Juhasz
Stephen A Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordion Inc
Applied Biosystems LLC
Original Assignee
MDS Inc
MDS Inc
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MDS Inc, MDS Inc, Applera Corp filed Critical MDS Inc
Application granted granted Critical
Publication of DE60325482D1 publication Critical patent/DE60325482D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/84Preparation of the fraction to be distributed
    • G01N2030/8411Intermediate storage of effluent, including condensation on surface
    • G01N2030/8417Intermediate storage of effluent, including condensation on surface the store moving as a whole, e.g. moving wire
DE60325482T 2002-08-22 2003-08-22 Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie Expired - Lifetime DE60325482D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40557802P 2002-08-22 2002-08-22
PCT/US2003/026471 WO2004019035A2 (en) 2002-08-22 2003-08-22 Method for characterizing biomolecules utilizing a result driven strategy

Publications (1)

Publication Number Publication Date
DE60325482D1 true DE60325482D1 (de) 2009-02-05

Family

ID=31946899

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60325482T Expired - Lifetime DE60325482D1 (de) 2002-08-22 2003-08-22 Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie

Country Status (8)

Country Link
US (1) US6940065B2 (de)
EP (1) EP1530721B1 (de)
JP (1) JP4160558B2 (de)
AT (1) ATE418729T1 (de)
AU (1) AU2003262824B2 (de)
CA (1) CA2495378C (de)
DE (1) DE60325482D1 (de)
WO (1) WO2004019035A2 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3817523B2 (ja) * 2003-02-14 2006-09-06 株式会社日立製作所 質量分析データ解析システム
US7202473B2 (en) * 2003-04-10 2007-04-10 Micromass Uk Limited Mass spectrometer
US7105806B2 (en) * 2003-11-26 2006-09-12 Applera Corporation Method and apparatus for de-convoluting a convoluted spectrum
JP2007523323A (ja) * 2004-01-30 2007-08-16 サイファージェン バイオシステムズ インコーポレイテッド スペクトルにおけるシグナルをクラスタにする方法
GB2413695B (en) * 2004-04-30 2009-01-21 Micromass Ltd Mass spectrometer
JP5008564B2 (ja) * 2004-05-20 2012-08-22 ウオーターズ・テクノロジーズ・コーポレイシヨン 混合物中のタンパク質を同定する方法および装置
JP4818270B2 (ja) * 2004-05-20 2011-11-16 ウオーターズ・テクノロジーズ・コーポレイシヨン 選択されたイオンクロマトグラムを使用して先駆物質および断片イオンをグループ化するシステムおよび方法
DE102004051016A1 (de) * 2004-10-20 2006-05-04 Protagen Ag Verfahren und System zur Aufklärung der Primärstruktur von Biopolymeren
DE102004051043B4 (de) * 2004-10-20 2011-06-01 Bruker Daltonik Gmbh Angleichung von Flugzeitmassenspektren
DE102005018273B4 (de) * 2005-04-20 2007-11-15 Bruker Daltonik Gmbh Rückgesteuerte Tandem-Massenspektrometrie
US7498568B2 (en) * 2005-04-29 2009-03-03 Agilent Technologies, Inc. Real-time analysis of mass spectrometry data for identifying peptidic data of interest
WO2006127974A1 (en) * 2005-05-24 2006-11-30 Sionex Corporation Combined mass and differential mobility spectrometry
JP4522910B2 (ja) * 2005-05-30 2010-08-11 株式会社日立ハイテクノロジーズ 質量分析方法及び質量分析装置
WO2006129401A1 (ja) * 2005-05-31 2006-12-07 Jcl Bioassay Corporation プロテオーム網羅的解析における特異的蛋白質のスクリーニング方法
EP1894018A1 (de) * 2005-06-03 2008-03-05 MDS Inc. doing business through its MDS Sciex Division System und verfahren zur analyse von verbindungen unter verwendung eines massenspektrometers
ATE509329T1 (de) * 2005-11-10 2011-05-15 Microsoft Corp Entdeckung biologischer merkmale unter verwendung zusammengesetzter bilder
WO2007065273A1 (en) * 2005-12-08 2007-06-14 The University Of British Columbia Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith
WO2007095378A2 (en) * 2006-02-15 2007-08-23 University Of Virginia Patent Foundation Mass tagging for quantitative analysis of biomolecules using 13c labeled phenylisocyanate
JP5496650B2 (ja) * 2006-03-21 2014-05-21 メタボロン インコーポレイテッド サンプル内の個々の要素を識別及び定量化するために分光測定データを分析するシステム、方法及びコンピュータプログラム製品
ES2446266T3 (es) 2006-07-21 2014-03-06 Amgen Inc. Método de detección y/o de medición de hepcidina en una muestra
WO2008019492A1 (en) * 2006-08-15 2008-02-21 Alexei Antonov Apparatus and method for elemental analysis of particles by mass spectrometry
GB0622780D0 (en) 2006-11-15 2006-12-27 Micromass Ltd Mass spectrometer
US7838824B2 (en) * 2007-05-01 2010-11-23 Virgin Instruments Corporation TOF-TOF with high resolution precursor selection and multiplexed MS-MS
US8536520B2 (en) * 2007-08-06 2013-09-17 Iroa Technologies Llc Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US7820964B2 (en) * 2007-08-06 2010-10-26 Metabolic Analyses, Inc Method for generation and use of stable isotope patterns in mass spectral data
US7820963B2 (en) * 2007-08-06 2010-10-26 Metabolic Alayses, Inc. Method for generation and use of isotopic patterns in mass spectral data of simple organisms
JP5020742B2 (ja) 2007-08-27 2012-09-05 日本電子株式会社 Maldiイオン源を備えた質量分析装置およびmaldiイオン源用サンプルプレート
JP5227556B2 (ja) * 2007-09-06 2013-07-03 株式会社日立製作所 分析装置
CA2701476C (en) * 2007-10-02 2017-10-10 Metabolic Analyses, Inc. Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms
US8969251B2 (en) * 2007-10-02 2015-03-03 Methabolic Analyses, Inc. Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms
JP2011505560A (ja) * 2007-11-30 2011-02-24 ウオーターズ・テクノロジーズ・コーポレイシヨン サンプル中におけるミネラルコルチコイドの存在または不存在の決定
CA2707166C (en) * 2007-12-04 2016-04-12 Dh Technologies Development Pte. Ltd. Systems and methods for analyzing substances using a mass spectrometer
EP2248147A1 (de) * 2008-01-31 2010-11-10 DH Technologies Development Pte. Ltd. Hochdurchsatz-screening metabolischer erkrankungen unter verwendung einer mit einem massenanalysator gekoppelten laserdesorptions-ionenquelle
US8148677B2 (en) * 2008-02-05 2012-04-03 Thermo Finnigan Llc Peptide identification and quantitation by merging MS/MS spectra
US8067728B2 (en) * 2008-02-22 2011-11-29 Dh Technologies Development Pte. Ltd. Method of improving signal-to-noise for quantitation by mass spectrometry
JP2011522257A (ja) * 2008-05-29 2011-07-28 ウオーターズ・テクノロジーズ・コーポレイシヨン 前駆体および生成物イオンの保持時間一致を実行し、前駆体および生成物イオンスペクトルを構成する技術
US8067243B2 (en) * 2008-09-03 2011-11-29 Oregon Medical Laboratories Methods and systems for analyzing medication levels in a sample
US8321144B2 (en) 2008-10-23 2012-11-27 Microsoft Corporation Non-contiguous regions processing
BRPI0805608B1 (pt) * 2008-12-15 2018-11-21 Embrapa Pesquisa Agropecuaria método, equipamento e sistema para diagnóstico de estresses e doenças em plantas superiores
EP2399131B1 (de) 2009-02-20 2014-08-27 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Verfahren zur diagnose von altersbedingten gefässerkrankung
DE102009030395A1 (de) * 2009-06-25 2011-05-26 Tecan Trading Ag Differnziertes chromatographisches Analysenverfahren zur Kompensation von Varianzen in der signalerzeugenden Einheit bei quantifizierenden chromatographischen Analysen
GB201003566D0 (en) * 2010-03-03 2010-04-21 Ilika Technologies Ltd Mass spectrometry apparatus and methods
US8455818B2 (en) 2010-04-14 2013-06-04 Wisconsin Alumni Research Foundation Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation
US10553412B2 (en) * 2010-05-24 2020-02-04 Agilent Technologies, Inc. System and method of data-dependent acquisition by mass spectrometry
JP5505110B2 (ja) * 2010-06-14 2014-05-28 株式会社島津製作所 クロマトグラフ質量分析装置
US9269550B2 (en) * 2010-07-22 2016-02-23 Georgetown University Mass spectrometric methods for quantifying NPY 1-36 and NPY 3-36
CN106055895B (zh) * 2010-09-15 2021-02-19 Dh科技发展私人贸易有限公司 产物离子谱的数据独立获取及参考谱库匹配
DE102011053684B4 (de) 2010-09-17 2019-03-28 Wisconsin Alumni Research Foundation Verfahren zur Durchführung von strahlformstossaktivierter Dissoziation im bereits bestehenden Ioneninjektionspfad eines Massenspektrometers
JP5609509B2 (ja) * 2010-10-04 2014-10-22 富士通株式会社 指示システム、指示方法、及び記憶制御装置。
CA2825280A1 (en) * 2011-01-21 2012-07-26 Massdefect Technologies, Llc Background subtraction-mediated data-dependent acquisition
DE102012102875B4 (de) 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
WO2013148181A2 (en) * 2012-03-28 2013-10-03 Ulvac-Phi, Inc. Method and apparatus to provide parallel acquisition of mass spectrometry/mass spectrometry data
EP2781916A1 (de) * 2013-03-22 2014-09-24 Biotage AB Kopplungsmodul
JP6136771B2 (ja) * 2013-08-30 2017-05-31 株式会社島津製作所 物質同定方法及び該方法を用いる質量分析装置
US10115576B2 (en) * 2013-12-12 2018-10-30 Waters Technologies Corporation Method and an apparatus for analyzing a complex sample
US10153146B2 (en) * 2014-03-28 2018-12-11 Wisconsin Alumni Research Foundation High mass accuracy filtering for improved spectral matching of high-resolution gas chromatography-mass spectrometry data against unit-resolution reference databases
US9720001B2 (en) * 2014-05-21 2017-08-01 Thermo Finnigan Llc Methods for mass spectrometric biopolymer analysis using optimized weighted oligomer scheduling
GB201410470D0 (en) * 2014-06-12 2014-07-30 Micromass Ltd Self-calibration of spectra using differences in molecular weight from known charge states
EP3726562B1 (de) 2015-03-06 2023-12-20 Micromass UK Limited Bildgebungsplattform für umgebungsionisierungsmassenspektrometrie für direkte abbildung aus gesamtgewebe
US10026599B2 (en) 2015-03-06 2018-07-17 Micromass Uk Limited Rapid evaporative ionisation mass spectrometry (“REIMS”) and desorption electrospray ionisation mass spectrometry (“DESI-MS”) analysis of swabs and biopsy samples
CA2978166A1 (en) * 2015-03-06 2016-09-15 Micromass Uk Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device
CN107667288B (zh) 2015-03-06 2022-02-01 英国质谱公司 微生物的谱分析
WO2016142674A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Cell population analysis
GB2554180B (en) 2015-03-06 2022-04-13 Micromass Ltd Spectrometric analysis
WO2016196125A1 (en) * 2015-05-29 2016-12-08 Virgin Instruments Corporation Method for developing and applying databases for identification of microorganisms by maldi-tof mass spectrometry
US11454611B2 (en) 2016-04-14 2022-09-27 Micromass Uk Limited Spectrometric analysis of plants
US10049868B2 (en) * 2016-12-06 2018-08-14 Rapiscan Systems, Inc. Apparatus for detecting constituents in a sample and method of using the same
JP6702501B2 (ja) * 2017-03-06 2020-06-03 株式会社島津製作所 タンデム型質量分析装置及び該装置用プログラム
EP3410109A1 (de) * 2017-06-02 2018-12-05 Thermo Fisher Scientific (Bremen) GmbH Systeme und verfahren zur extraktion von massenspuren
WO2019032049A1 (en) * 2017-08-07 2019-02-14 Agency For Science, Technology And Research RAPID ANALYSIS AND IDENTIFICATION OF LIPIDS FROM LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (LC-MS) DATA
CN107782829A (zh) * 2017-11-01 2018-03-09 上海莱士血液制品股份有限公司 一种利用离子色谱法检测生物制品中三羟甲基氨基甲烷(Tris)的方法
US11393666B2 (en) 2019-12-19 2022-07-19 Thermo Finnigan Llc Automatic MS-N characterization of mass spectrometric “dark matter”
WO2022005950A1 (en) 2020-06-29 2022-01-06 Waters Technologies Corporation Chromatographic dimension selection in multidimensional liquid chromatography

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2057826B (en) 1979-08-31 1983-01-12 Ibm Multibeam cathode ray tube apparatus
US5625184A (en) * 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US6002127A (en) 1995-05-19 1999-12-14 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
GB9624927D0 (en) * 1996-11-29 1997-01-15 Oxford Glycosciences Uk Ltd Gels and their use
US6596529B1 (en) 1997-05-02 2003-07-22 Uab Research Foundation Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof
US6175112B1 (en) 1998-05-22 2001-01-16 Northeastern University On-line liquid sample deposition interface for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy
US6348688B1 (en) 1998-02-06 2002-02-19 Perseptive Biosystems Tandem time-of-flight mass spectrometer with delayed extraction and method for use
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
CA2255122C (en) * 1998-12-04 2007-10-09 Mds Inc. Improvements in ms/ms methods for a quadrupole/time of flight tandem mass spectrometer
US6799121B2 (en) * 2000-03-30 2004-09-28 York University Sequencing of peptides by mass spectrometry
AU2001286059A1 (en) 2000-09-08 2002-03-22 Oxford Glycosciences (Uk) Ltd. Automated identification of peptides
KR20030074773A (ko) 2001-02-01 2003-09-19 싸이퍼젠 바이오시스템즈, 인코포레이티드 탠덤 질량 분광계에 의한 단백질 확인, 특성화 및 서열결정을 위한 개선된 방법
US6977732B2 (en) 2002-12-26 2005-12-20 National Taiwan University Miniature three-dimensional contour scanner

Also Published As

Publication number Publication date
CA2495378A1 (en) 2004-03-04
JP4160558B2 (ja) 2008-10-01
WO2004019035A2 (en) 2004-03-04
US20040108452A1 (en) 2004-06-10
ATE418729T1 (de) 2009-01-15
WO2004019035A9 (en) 2004-12-23
WO2004019035A3 (en) 2005-02-17
EP1530721A2 (de) 2005-05-18
CA2495378C (en) 2011-03-01
EP1530721B1 (de) 2008-12-24
US6940065B2 (en) 2005-09-06
AU2003262824B2 (en) 2007-08-23
AU2003262824A1 (en) 2004-03-11
JP2005536728A (ja) 2005-12-02

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: MURGITROYD & COMPANY, 48149 MUENSTER

8327 Change in the person/name/address of the patent owner

Owner name: APPLIED BIOSYSTEMS INC. (N.D.GES.D. STAATES DE, US

Owner name: MDS INC., TORONTO, CONN., US

8328 Change in the person/name/address of the agent

Representative=s name: MURGITROYD & COMPANY, 48149 MUENSTER

8327 Change in the person/name/address of the patent owner

Owner name: MDS INC., TORONTO, CONN., US

Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US

8364 No opposition during term of opposition