DE60325482D1 - Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie - Google Patents
Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategieInfo
- Publication number
- DE60325482D1 DE60325482D1 DE60325482T DE60325482T DE60325482D1 DE 60325482 D1 DE60325482 D1 DE 60325482D1 DE 60325482 T DE60325482 T DE 60325482T DE 60325482 T DE60325482 T DE 60325482T DE 60325482 D1 DE60325482 D1 DE 60325482D1
- Authority
- DE
- Germany
- Prior art keywords
- result
- sample
- controlled strategy
- characterizing biomolecules
- biomolecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8411—Intermediate storage of effluent, including condensation on surface
- G01N2030/8417—Intermediate storage of effluent, including condensation on surface the store moving as a whole, e.g. moving wire
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40557802P | 2002-08-22 | 2002-08-22 | |
PCT/US2003/026471 WO2004019035A2 (en) | 2002-08-22 | 2003-08-22 | Method for characterizing biomolecules utilizing a result driven strategy |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60325482D1 true DE60325482D1 (de) | 2009-02-05 |
Family
ID=31946899
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60325482T Expired - Lifetime DE60325482D1 (de) | 2002-08-22 | 2003-08-22 | Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie |
Country Status (8)
Country | Link |
---|---|
US (1) | US6940065B2 (de) |
EP (1) | EP1530721B1 (de) |
JP (1) | JP4160558B2 (de) |
AT (1) | ATE418729T1 (de) |
AU (1) | AU2003262824B2 (de) |
CA (1) | CA2495378C (de) |
DE (1) | DE60325482D1 (de) |
WO (1) | WO2004019035A2 (de) |
Families Citing this family (73)
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JP3817523B2 (ja) * | 2003-02-14 | 2006-09-06 | 株式会社日立製作所 | 質量分析データ解析システム |
US7202473B2 (en) * | 2003-04-10 | 2007-04-10 | Micromass Uk Limited | Mass spectrometer |
US7105806B2 (en) * | 2003-11-26 | 2006-09-12 | Applera Corporation | Method and apparatus for de-convoluting a convoluted spectrum |
JP2007523323A (ja) * | 2004-01-30 | 2007-08-16 | サイファージェン バイオシステムズ インコーポレイテッド | スペクトルにおけるシグナルをクラスタにする方法 |
GB2413695B (en) * | 2004-04-30 | 2009-01-21 | Micromass Ltd | Mass spectrometer |
JP5008564B2 (ja) * | 2004-05-20 | 2012-08-22 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 混合物中のタンパク質を同定する方法および装置 |
JP4818270B2 (ja) * | 2004-05-20 | 2011-11-16 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 選択されたイオンクロマトグラムを使用して先駆物質および断片イオンをグループ化するシステムおよび方法 |
DE102004051016A1 (de) * | 2004-10-20 | 2006-05-04 | Protagen Ag | Verfahren und System zur Aufklärung der Primärstruktur von Biopolymeren |
DE102004051043B4 (de) * | 2004-10-20 | 2011-06-01 | Bruker Daltonik Gmbh | Angleichung von Flugzeitmassenspektren |
DE102005018273B4 (de) * | 2005-04-20 | 2007-11-15 | Bruker Daltonik Gmbh | Rückgesteuerte Tandem-Massenspektrometrie |
US7498568B2 (en) * | 2005-04-29 | 2009-03-03 | Agilent Technologies, Inc. | Real-time analysis of mass spectrometry data for identifying peptidic data of interest |
WO2006127974A1 (en) * | 2005-05-24 | 2006-11-30 | Sionex Corporation | Combined mass and differential mobility spectrometry |
JP4522910B2 (ja) * | 2005-05-30 | 2010-08-11 | 株式会社日立ハイテクノロジーズ | 質量分析方法及び質量分析装置 |
WO2006129401A1 (ja) * | 2005-05-31 | 2006-12-07 | Jcl Bioassay Corporation | プロテオーム網羅的解析における特異的蛋白質のスクリーニング方法 |
EP1894018A1 (de) * | 2005-06-03 | 2008-03-05 | MDS Inc. doing business through its MDS Sciex Division | System und verfahren zur analyse von verbindungen unter verwendung eines massenspektrometers |
ATE509329T1 (de) * | 2005-11-10 | 2011-05-15 | Microsoft Corp | Entdeckung biologischer merkmale unter verwendung zusammengesetzter bilder |
WO2007065273A1 (en) * | 2005-12-08 | 2007-06-14 | The University Of British Columbia | Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith |
WO2007095378A2 (en) * | 2006-02-15 | 2007-08-23 | University Of Virginia Patent Foundation | Mass tagging for quantitative analysis of biomolecules using 13c labeled phenylisocyanate |
JP5496650B2 (ja) * | 2006-03-21 | 2014-05-21 | メタボロン インコーポレイテッド | サンプル内の個々の要素を識別及び定量化するために分光測定データを分析するシステム、方法及びコンピュータプログラム製品 |
ES2446266T3 (es) | 2006-07-21 | 2014-03-06 | Amgen Inc. | Método de detección y/o de medición de hepcidina en una muestra |
WO2008019492A1 (en) * | 2006-08-15 | 2008-02-21 | Alexei Antonov | Apparatus and method for elemental analysis of particles by mass spectrometry |
GB0622780D0 (en) | 2006-11-15 | 2006-12-27 | Micromass Ltd | Mass spectrometer |
US7838824B2 (en) * | 2007-05-01 | 2010-11-23 | Virgin Instruments Corporation | TOF-TOF with high resolution precursor selection and multiplexed MS-MS |
US8536520B2 (en) * | 2007-08-06 | 2013-09-17 | Iroa Technologies Llc | Method for generation and use of isotopic patterns in mass spectral data of simple organisms |
US7820964B2 (en) * | 2007-08-06 | 2010-10-26 | Metabolic Analyses, Inc | Method for generation and use of stable isotope patterns in mass spectral data |
US7820963B2 (en) * | 2007-08-06 | 2010-10-26 | Metabolic Alayses, Inc. | Method for generation and use of isotopic patterns in mass spectral data of simple organisms |
JP5020742B2 (ja) | 2007-08-27 | 2012-09-05 | 日本電子株式会社 | Maldiイオン源を備えた質量分析装置およびmaldiイオン源用サンプルプレート |
JP5227556B2 (ja) * | 2007-09-06 | 2013-07-03 | 株式会社日立製作所 | 分析装置 |
CA2701476C (en) * | 2007-10-02 | 2017-10-10 | Metabolic Analyses, Inc. | Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms |
US8969251B2 (en) * | 2007-10-02 | 2015-03-03 | Methabolic Analyses, Inc. | Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms |
JP2011505560A (ja) * | 2007-11-30 | 2011-02-24 | ウオーターズ・テクノロジーズ・コーポレイシヨン | サンプル中におけるミネラルコルチコイドの存在または不存在の決定 |
CA2707166C (en) * | 2007-12-04 | 2016-04-12 | Dh Technologies Development Pte. Ltd. | Systems and methods for analyzing substances using a mass spectrometer |
EP2248147A1 (de) * | 2008-01-31 | 2010-11-10 | DH Technologies Development Pte. Ltd. | Hochdurchsatz-screening metabolischer erkrankungen unter verwendung einer mit einem massenanalysator gekoppelten laserdesorptions-ionenquelle |
US8148677B2 (en) * | 2008-02-05 | 2012-04-03 | Thermo Finnigan Llc | Peptide identification and quantitation by merging MS/MS spectra |
US8067728B2 (en) * | 2008-02-22 | 2011-11-29 | Dh Technologies Development Pte. Ltd. | Method of improving signal-to-noise for quantitation by mass spectrometry |
JP2011522257A (ja) * | 2008-05-29 | 2011-07-28 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 前駆体および生成物イオンの保持時間一致を実行し、前駆体および生成物イオンスペクトルを構成する技術 |
US8067243B2 (en) * | 2008-09-03 | 2011-11-29 | Oregon Medical Laboratories | Methods and systems for analyzing medication levels in a sample |
US8321144B2 (en) | 2008-10-23 | 2012-11-27 | Microsoft Corporation | Non-contiguous regions processing |
BRPI0805608B1 (pt) * | 2008-12-15 | 2018-11-21 | Embrapa Pesquisa Agropecuaria | método, equipamento e sistema para diagnóstico de estresses e doenças em plantas superiores |
EP2399131B1 (de) | 2009-02-20 | 2014-08-27 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Verfahren zur diagnose von altersbedingten gefässerkrankung |
DE102009030395A1 (de) * | 2009-06-25 | 2011-05-26 | Tecan Trading Ag | Differnziertes chromatographisches Analysenverfahren zur Kompensation von Varianzen in der signalerzeugenden Einheit bei quantifizierenden chromatographischen Analysen |
GB201003566D0 (en) * | 2010-03-03 | 2010-04-21 | Ilika Technologies Ltd | Mass spectrometry apparatus and methods |
US8455818B2 (en) | 2010-04-14 | 2013-06-04 | Wisconsin Alumni Research Foundation | Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation |
US10553412B2 (en) * | 2010-05-24 | 2020-02-04 | Agilent Technologies, Inc. | System and method of data-dependent acquisition by mass spectrometry |
JP5505110B2 (ja) * | 2010-06-14 | 2014-05-28 | 株式会社島津製作所 | クロマトグラフ質量分析装置 |
US9269550B2 (en) * | 2010-07-22 | 2016-02-23 | Georgetown University | Mass spectrometric methods for quantifying NPY 1-36 and NPY 3-36 |
CN106055895B (zh) * | 2010-09-15 | 2021-02-19 | Dh科技发展私人贸易有限公司 | 产物离子谱的数据独立获取及参考谱库匹配 |
DE102011053684B4 (de) | 2010-09-17 | 2019-03-28 | Wisconsin Alumni Research Foundation | Verfahren zur Durchführung von strahlformstossaktivierter Dissoziation im bereits bestehenden Ioneninjektionspfad eines Massenspektrometers |
JP5609509B2 (ja) * | 2010-10-04 | 2014-10-22 | 富士通株式会社 | 指示システム、指示方法、及び記憶制御装置。 |
CA2825280A1 (en) * | 2011-01-21 | 2012-07-26 | Massdefect Technologies, Llc | Background subtraction-mediated data-dependent acquisition |
DE102012102875B4 (de) | 2011-04-04 | 2024-04-18 | Wisconsin Alumni Research Foundation | Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben |
WO2013148181A2 (en) * | 2012-03-28 | 2013-10-03 | Ulvac-Phi, Inc. | Method and apparatus to provide parallel acquisition of mass spectrometry/mass spectrometry data |
EP2781916A1 (de) * | 2013-03-22 | 2014-09-24 | Biotage AB | Kopplungsmodul |
JP6136771B2 (ja) * | 2013-08-30 | 2017-05-31 | 株式会社島津製作所 | 物質同定方法及び該方法を用いる質量分析装置 |
US10115576B2 (en) * | 2013-12-12 | 2018-10-30 | Waters Technologies Corporation | Method and an apparatus for analyzing a complex sample |
US10153146B2 (en) * | 2014-03-28 | 2018-12-11 | Wisconsin Alumni Research Foundation | High mass accuracy filtering for improved spectral matching of high-resolution gas chromatography-mass spectrometry data against unit-resolution reference databases |
US9720001B2 (en) * | 2014-05-21 | 2017-08-01 | Thermo Finnigan Llc | Methods for mass spectrometric biopolymer analysis using optimized weighted oligomer scheduling |
GB201410470D0 (en) * | 2014-06-12 | 2014-07-30 | Micromass Ltd | Self-calibration of spectra using differences in molecular weight from known charge states |
EP3726562B1 (de) | 2015-03-06 | 2023-12-20 | Micromass UK Limited | Bildgebungsplattform für umgebungsionisierungsmassenspektrometrie für direkte abbildung aus gesamtgewebe |
US10026599B2 (en) | 2015-03-06 | 2018-07-17 | Micromass Uk Limited | Rapid evaporative ionisation mass spectrometry (“REIMS”) and desorption electrospray ionisation mass spectrometry (“DESI-MS”) analysis of swabs and biopsy samples |
CA2978166A1 (en) * | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device |
CN107667288B (zh) | 2015-03-06 | 2022-02-01 | 英国质谱公司 | 微生物的谱分析 |
WO2016142674A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Cell population analysis |
GB2554180B (en) | 2015-03-06 | 2022-04-13 | Micromass Ltd | Spectrometric analysis |
WO2016196125A1 (en) * | 2015-05-29 | 2016-12-08 | Virgin Instruments Corporation | Method for developing and applying databases for identification of microorganisms by maldi-tof mass spectrometry |
US11454611B2 (en) | 2016-04-14 | 2022-09-27 | Micromass Uk Limited | Spectrometric analysis of plants |
US10049868B2 (en) * | 2016-12-06 | 2018-08-14 | Rapiscan Systems, Inc. | Apparatus for detecting constituents in a sample and method of using the same |
JP6702501B2 (ja) * | 2017-03-06 | 2020-06-03 | 株式会社島津製作所 | タンデム型質量分析装置及び該装置用プログラム |
EP3410109A1 (de) * | 2017-06-02 | 2018-12-05 | Thermo Fisher Scientific (Bremen) GmbH | Systeme und verfahren zur extraktion von massenspuren |
WO2019032049A1 (en) * | 2017-08-07 | 2019-02-14 | Agency For Science, Technology And Research | RAPID ANALYSIS AND IDENTIFICATION OF LIPIDS FROM LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (LC-MS) DATA |
CN107782829A (zh) * | 2017-11-01 | 2018-03-09 | 上海莱士血液制品股份有限公司 | 一种利用离子色谱法检测生物制品中三羟甲基氨基甲烷(Tris)的方法 |
US11393666B2 (en) | 2019-12-19 | 2022-07-19 | Thermo Finnigan Llc | Automatic MS-N characterization of mass spectrometric “dark matter” |
WO2022005950A1 (en) | 2020-06-29 | 2022-01-06 | Waters Technologies Corporation | Chromatographic dimension selection in multidimensional liquid chromatography |
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US6596529B1 (en) | 1997-05-02 | 2003-07-22 | Uab Research Foundation | Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof |
US6175112B1 (en) | 1998-05-22 | 2001-01-16 | Northeastern University | On-line liquid sample deposition interface for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy |
US6348688B1 (en) | 1998-02-06 | 2002-02-19 | Perseptive Biosystems | Tandem time-of-flight mass spectrometer with delayed extraction and method for use |
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CA2255122C (en) * | 1998-12-04 | 2007-10-09 | Mds Inc. | Improvements in ms/ms methods for a quadrupole/time of flight tandem mass spectrometer |
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AU2001286059A1 (en) | 2000-09-08 | 2002-03-22 | Oxford Glycosciences (Uk) Ltd. | Automated identification of peptides |
KR20030074773A (ko) | 2001-02-01 | 2003-09-19 | 싸이퍼젠 바이오시스템즈, 인코포레이티드 | 탠덤 질량 분광계에 의한 단백질 확인, 특성화 및 서열결정을 위한 개선된 방법 |
US6977732B2 (en) | 2002-12-26 | 2005-12-20 | National Taiwan University | Miniature three-dimensional contour scanner |
-
2003
- 2003-08-22 AT AT03793347T patent/ATE418729T1/de not_active IP Right Cessation
- 2003-08-22 CA CA2495378A patent/CA2495378C/en not_active Expired - Fee Related
- 2003-08-22 WO PCT/US2003/026471 patent/WO2004019035A2/en active Application Filing
- 2003-08-22 EP EP03793347A patent/EP1530721B1/de not_active Expired - Lifetime
- 2003-08-22 AU AU2003262824A patent/AU2003262824B2/en not_active Ceased
- 2003-08-22 JP JP2004529924A patent/JP4160558B2/ja not_active Expired - Fee Related
- 2003-08-22 DE DE60325482T patent/DE60325482D1/de not_active Expired - Lifetime
- 2003-08-22 US US10/646,371 patent/US6940065B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2495378A1 (en) | 2004-03-04 |
JP4160558B2 (ja) | 2008-10-01 |
WO2004019035A2 (en) | 2004-03-04 |
US20040108452A1 (en) | 2004-06-10 |
ATE418729T1 (de) | 2009-01-15 |
WO2004019035A9 (en) | 2004-12-23 |
WO2004019035A3 (en) | 2005-02-17 |
EP1530721A2 (de) | 2005-05-18 |
CA2495378C (en) | 2011-03-01 |
EP1530721B1 (de) | 2008-12-24 |
US6940065B2 (en) | 2005-09-06 |
AU2003262824B2 (en) | 2007-08-23 |
AU2003262824A1 (en) | 2004-03-11 |
JP2005536728A (ja) | 2005-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8328 | Change in the person/name/address of the agent |
Representative=s name: MURGITROYD & COMPANY, 48149 MUENSTER |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: APPLIED BIOSYSTEMS INC. (N.D.GES.D. STAATES DE, US Owner name: MDS INC., TORONTO, CONN., US |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MURGITROYD & COMPANY, 48149 MUENSTER |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: MDS INC., TORONTO, CONN., US Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US |
|
8364 | No opposition during term of opposition |