ATE554391T1 - Verfahren zur analyse von metaboliten - Google Patents

Verfahren zur analyse von metaboliten

Info

Publication number
ATE554391T1
ATE554391T1 AT04804051T AT04804051T ATE554391T1 AT E554391 T1 ATE554391 T1 AT E554391T1 AT 04804051 T AT04804051 T AT 04804051T AT 04804051 T AT04804051 T AT 04804051T AT E554391 T1 ATE554391 T1 AT E554391T1
Authority
AT
Austria
Prior art keywords
metabolites
biological sample
isotopically labeled
sample
determining
Prior art date
Application number
AT04804051T
Other languages
English (en)
Inventor
Alexander Luedemann
Alexander Erban
Cornelia Wagner
Joachim Kopka
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE554391T1 publication Critical patent/ATE554391T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625—Dilution

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
AT04804051T 2003-12-19 2004-12-17 Verfahren zur analyse von metaboliten ATE554391T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03029370 2003-12-19
PCT/EP2004/014450 WO2005059556A1 (en) 2003-12-19 2004-12-17 Method for analysing metabolites

Publications (1)

Publication Number Publication Date
ATE554391T1 true ATE554391T1 (de) 2012-05-15

Family

ID=34684550

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04804051T ATE554391T1 (de) 2003-12-19 2004-12-17 Verfahren zur analyse von metaboliten

Country Status (8)

Country Link
US (1) US8420406B2 (de)
EP (1) EP1695088B1 (de)
AT (1) ATE554391T1 (de)
AU (1) AU2004299949B2 (de)
CA (1) CA2547755C (de)
DK (1) DK1695088T3 (de)
ES (1) ES2385330T3 (de)
WO (1) WO2005059556A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1695088T3 (da) 2003-12-19 2012-06-25 Max Planck Gesellschaft Fremgangsmåde til at analysere metabolitter
US20060200316A1 (en) * 2005-03-01 2006-09-07 Harin Kanani Data correction, normalization and validation for quantitative high-throughput metabolomic profiling
US20090203145A1 (en) * 2008-02-07 2009-08-13 Min Huang Methods for analysis of vitamins
CA2745839C (en) * 2008-12-05 2017-09-19 C2N Diagnostics Methods for measuring concentrations of biomolecules
WO2011123479A1 (en) * 2010-03-29 2011-10-06 Academia Sinica Quantitative measurement of nano / micro particle endocytosis with cell mass spectrometry
US20130037709A1 (en) * 2010-05-01 2013-02-14 Edward J. Barbieri Method for Clinically Monitoring Niacin and Niacin Metabolites in Serum or Plasma
CN104220873B (zh) * 2012-02-10 2017-12-22 儿童医疗中心公司 基于nmr的代谢物筛选平台
US10607723B2 (en) * 2016-07-05 2020-03-31 University Of Kentucky Research Foundation Method and system for identification of metabolites using mass spectra
AU2018224235A1 (en) * 2017-02-24 2019-08-22 Iroa Technologies, Llc IROA metabolomics workflow for improved accuracy, identification and quantitation
CN107589194B (zh) * 2017-11-02 2019-01-29 武汉迈特维尔生物科技有限公司 一种肺癌早期诊断用小分子标志物及在诊断方面的应用
US20220137057A1 (en) * 2019-03-08 2022-05-05 Basf Se Metabolic analysis method
CN112697894A (zh) * 2020-11-30 2021-04-23 重庆医科大学附属口腔医院 氨基酸同位素标记物的定量分析方法
CN113514531B (zh) * 2021-04-27 2022-10-25 清华大学 一种化合物的碎片离子预测方法及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9117634D0 (en) * 1991-08-15 1991-10-02 Evans Lloyd T Method of treating plants or plant tissues
US6391649B1 (en) * 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
US20030077572A1 (en) * 2001-10-11 2003-04-24 Abramson Fred P. Quantitative differential display using isotope ratio monitoring
US20030180710A1 (en) * 2002-03-22 2003-09-25 Lee Wai-Nang Paul Method of enhancing the efficiency of a pharmaceutical business
SG152923A1 (en) * 2002-09-16 2009-06-29 Univ California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
US20050112706A1 (en) * 2002-11-07 2005-05-26 Susan Kasper Diagnostic and prognostic methods for prostate cancers
US6872516B2 (en) * 2003-04-16 2005-03-29 Advanced Breath Diagnostics, Llc Methods of producing carbon-13 labeled biomass
JP4714584B2 (ja) 2003-11-21 2011-06-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 同位体標識化内部標準物質を用いる定量方法、該定量方法を実行する解析システムおよび該解析のためのプログラム
DK1695088T3 (da) 2003-12-19 2012-06-25 Max Planck Gesellschaft Fremgangsmåde til at analysere metabolitter

Also Published As

Publication number Publication date
ES2385330T3 (es) 2012-07-23
CA2547755A1 (en) 2005-06-30
CA2547755C (en) 2014-06-03
US20070141712A1 (en) 2007-06-21
EP1695088A1 (de) 2006-08-30
WO2005059556A1 (en) 2005-06-30
EP1695088B1 (de) 2012-04-18
US8420406B2 (en) 2013-04-16
DK1695088T3 (da) 2012-06-25
AU2004299949A1 (en) 2005-06-30
AU2004299949B2 (en) 2011-11-24

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