ATE515702T1 - Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung - Google Patents

Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung

Info

Publication number
ATE515702T1
ATE515702T1 AT04705571T AT04705571T ATE515702T1 AT E515702 T1 ATE515702 T1 AT E515702T1 AT 04705571 T AT04705571 T AT 04705571T AT 04705571 T AT04705571 T AT 04705571T AT E515702 T1 ATE515702 T1 AT E515702T1
Authority
AT
Austria
Prior art keywords
kits
compositions
methods
mixtures
analyte determination
Prior art date
Application number
AT04705571T
Other languages
English (en)
Inventor
Darryl J C Pappin
Michael Bartlet-Jones
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Application granted granted Critical
Publication of ATE515702T1 publication Critical patent/ATE515702T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/15Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555Hetero-N
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555Hetero-N
    • Y10T436/147777Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT04705571T 2003-01-30 2004-01-27 Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung ATE515702T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44361203P 2003-01-30 2003-01-30
PCT/US2004/002077 WO2004070352A2 (en) 2003-01-30 2004-01-27 Methods, mixtures, kits and compositions pertaining to analyte determination

Publications (1)

Publication Number Publication Date
ATE515702T1 true ATE515702T1 (de) 2011-07-15

Family

ID=32850790

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04705571T ATE515702T1 (de) 2003-01-30 2004-01-27 Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung

Country Status (7)

Country Link
US (9) US7195751B2 (de)
EP (1) EP1588145B1 (de)
JP (2) JP4613299B2 (de)
AT (1) ATE515702T1 (de)
AU (2) AU2004209401A1 (de)
CA (1) CA2488584C (de)
WO (1) WO2004070352A2 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1171813B1 (de) * 1999-03-18 2003-06-04 602531 British Columbia Ltd. Dateneingabe für personalrechnergeräte
DE60026321D1 (de) * 1999-08-13 2006-04-27 Univ Yale New Haven Binär kodierte sequenzmarker
US20020106648A1 (en) * 2000-05-05 2002-08-08 Lizardi Paul M. Highly multiplexed reporter carrier systems
US6835545B2 (en) 2000-05-08 2004-12-28 President And Fellows Of Harvard College Methods, products and treatments for diabetes
AU2001283562B2 (en) * 2000-08-11 2006-10-26 Perkin-Elmer Las, Inc. Ultra-sensitive detection systems
CA2488584C (en) * 2003-01-30 2011-10-11 Applera Corporation Methods, mixtures, kits and compositions pertaining to analyte determination
GB0306756D0 (en) * 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
EP1916527A1 (de) * 2003-11-26 2008-04-30 Applera Corporation Analyse von Massenspektraldaten in ruhigen Bereichen
DE602004009824T2 (de) * 2003-11-26 2008-03-06 Applera Corp., Framingham Analyse von massenspektraldaten in den ruhigen gebieten
US20050148087A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
JP4832312B2 (ja) * 2004-01-05 2011-12-07 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 標識試薬および標識化分析物の混合物を含む、標識試薬、標識化分析物、およびそれらに由来するフラグメントイオン、ならびにそれらの分析方法
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US20050148771A1 (en) * 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US7868547B2 (en) 2004-03-01 2011-01-11 Dh Technologies Development Pte. Ltd. Determination of analyte characteristics based upon binding properties
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
EP1766413A2 (de) * 2004-05-19 2007-03-28 Applera Corporation Expressionsquantifizierung mittels massenspektrometrie
US8027791B2 (en) * 2004-06-23 2011-09-27 Medtronic, Inc. Self-improving classification system
US20050287574A1 (en) * 2004-06-23 2005-12-29 Medtronic, Inc. Genetic diagnostic method for SCD risk stratification
US8335652B2 (en) * 2004-06-23 2012-12-18 Yougene Corp. Self-improving identification method
EP1776588A1 (de) * 2004-07-12 2007-04-25 Applera Corporation Massen-tags für quantitative analysen
US20070048752A1 (en) * 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
US7476546B2 (en) 2004-11-15 2009-01-13 University Of North Dakota Method for single oxygen atom incorporation into digested peptides using peptidases
WO2006086098A2 (en) * 2005-01-06 2006-08-17 President And Fellows Of Harvard College Mass spectrometric methods and products
AU2006210551A1 (en) * 2005-02-03 2006-08-10 Perkinelmer Las, Inc. Ultra-sensitive detection systems using multidimension signals
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
JP4242358B2 (ja) 2005-03-14 2009-03-25 ホシザキ電機株式会社 断熱箱体及びその製造方法
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
EP2228656B1 (de) 2005-09-15 2013-10-23 Alk-Abelló A/S Quantifizierung von Allergenen
WO2007078229A1 (en) * 2006-01-05 2007-07-12 Ge Healthcare Bio-Sciences Ab Kit and method for mass labelling
US8975404B2 (en) 2006-01-24 2015-03-10 Dh Technologies Development Pte. Ltd. Labeling reagents for analyte determination and methods and compounds used in making the same
US20070185346A1 (en) * 2006-02-03 2007-08-09 Vaidya Niteen A Kit for automated resolving agent selection and method thereof
US7982070B2 (en) 2006-03-21 2011-07-19 Wisconsin Alumni Research Foundation Ionizable isotopic labeling reagents for relative quantification by mass spectrometry
JP5413836B2 (ja) * 2006-05-26 2014-02-12 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド ヒドロキシル化化合物のためのタグ付け試薬およびその方法
US7906341B2 (en) * 2006-06-30 2011-03-15 Dh Technologies Development Pte, Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US8362242B2 (en) 2006-06-30 2013-01-29 Dh Technologies Development Pte. Ltd. Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
US8580534B2 (en) * 2006-06-30 2013-11-12 The University Of North Dakota Method for incorporation of two oxygen atoms into digested peptides using peptidases
EP1918714A1 (de) * 2006-11-02 2008-05-07 Koninklijke Philips Electronics N.V. Verbindungen und verfahren zur doppel-markierung von polypeptiden zum multiplexen in massenspektrometrie
EP1921081A1 (de) 2006-11-06 2008-05-14 Koninklijke Philips Electronics N.V. Verwendung von Arylboronsäuren zur Proteinmarkierung
US7951608B2 (en) * 2007-05-04 2011-05-31 Perkinelmer Health Sciences, Inc. Detecting succinylacetone
US20110159523A1 (en) * 2007-06-27 2011-06-30 Cedars-Sinai Medical Center N-terminal specific chemical labeling for proteomics applications
US20090028791A1 (en) * 2007-07-25 2009-01-29 Balatoni Julius A Dichloroacetate Analogs as Imaging Agents
US7820964B2 (en) * 2007-08-06 2010-10-26 Metabolic Analyses, Inc Method for generation and use of stable isotope patterns in mass spectral data
US7982180B2 (en) * 2007-09-10 2011-07-19 Dh Technologies Development Pte. Ltd. Methods and systems for analysis and correction of mass spectrometer data
CA2703804C (en) 2007-11-06 2018-06-19 Translational Therapeutics, Inc. Mass spectrometry assay for eif4e and eif4e regulon activity
US8604692B2 (en) 2007-11-06 2013-12-10 Translational Therapeutics, Inc. Mass spectrometry assay for eIF4E and eIF4E regulon activity
US20110143956A1 (en) * 2007-11-14 2011-06-16 Medtronic, Inc. Diagnostic Kits and Methods for SCD or SCA Therapy Selection
US20090131276A1 (en) * 2007-11-14 2009-05-21 Medtronic, Inc. Diagnostic kits and methods for scd or sca therapy selection
EP2108957A1 (de) * 2008-04-07 2009-10-14 Koninklijke Philips Electronics N.V. Verbindungen und Verfahren zur Markierung und Affinitätsauswahl von Proteinen
GB0809488D0 (en) * 2008-05-23 2008-07-02 Electrophoretics Ltd Mass spectrometric analysis
WO2010104981A2 (en) 2009-03-10 2010-09-16 University Of Maryland Biotechnology Institute Deuterium isobaric tag reagents for quantitative analysis
US8592216B2 (en) 2009-04-15 2013-11-26 Wisconsin Alumni Research Foundation Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis
EP2430184A2 (de) * 2009-05-12 2012-03-21 Medtronic, Inc. Sca-risikostratifizierung durch vorhersage des ansprechens von patienten auf antiarrhythmika
US20110003395A1 (en) 2009-05-31 2011-01-06 Dh Technologies Development Pte. Ltd. Specific analysis of analytes using reagent compounds, labeling strategies, and mass spectrometry workflow
GB0916881D0 (en) * 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
CA2784495A1 (en) * 2009-12-15 2011-06-23 Dh Technologies Development Pte. Ltd. Analysis of amino acids and amine-containing compounds using tagging reagents and lc-ms workflow
US8309359B2 (en) * 2010-01-15 2012-11-13 California Institute Of Technology Isobaric tags for analyte detection and quantification
EP2528443B1 (de) * 2010-01-25 2017-01-11 DH Technologies Development Pte. Ltd. Quantitative analyse von vitamin d3, vitamin d2 und metaboliten davon
DE102011017084B4 (de) 2010-04-14 2020-07-09 Wisconsin Alumni Research Foundation Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung
US8658355B2 (en) 2010-05-17 2014-02-25 The Uab Research Foundation General mass spectrometry assay using continuously eluting co-fractionating reporters of mass spectrometry detection efficiency
US8835361B2 (en) * 2010-06-01 2014-09-16 The Curators Of The University Of Missouri High-throughput quantitation of crop seed proteins
WO2012027555A2 (en) 2010-08-25 2012-03-01 President And Fellows Of Harvard College Glycated cd59 peptides, their preparation, and uses thereof
DE102011053684B4 (de) 2010-09-17 2019-03-28 Wisconsin Alumni Research Foundation Verfahren zur Durchführung von strahlformstossaktivierter Dissoziation im bereits bestehenden Ioneninjektionspfad eines Massenspektrometers
JP5711948B2 (ja) * 2010-12-02 2015-05-07 良雄 林 固相担持型sh基選択的標識試薬
JP5454462B2 (ja) * 2010-12-22 2014-03-26 株式会社島津製作所 クロマトグラフ質量分析装置
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
BR112013020274A2 (pt) 2011-02-10 2016-11-22 Harvard College substitutos de proteínas pós-traducionalmente modificadas e usos dos mesmos
DE102012102875B4 (de) 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
US9388132B2 (en) 2011-09-15 2016-07-12 Wisconsin Alumni Research Foundation Isobaric tandem mass tags for quantitative proteomics and peptidomics
JP6324321B2 (ja) * 2012-01-20 2018-05-16 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 標識化学およびlc−msmsを使用するエストラジオールおよびフェノール性ohを有する分析物の分析
US9029086B2 (en) * 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
WO2013171568A1 (en) 2012-05-18 2013-11-21 Dh Technologies Development Pte. Ltd. Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and lc/ms/ms workflow
WO2014013051A1 (en) 2012-07-19 2014-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method of predicting or diagnosing an hepatic encephalopathy in patients with cirrhosis treated with transjugular intra-hepatic porto-systemic shunt (tips)
US9366678B2 (en) 2012-10-25 2016-06-14 Wisconsin Alumni Research Foundation Neutron encoded mass tags for analyte quantification
GB201410523D0 (en) * 2014-06-12 2014-07-30 Electrophoretics Ltd Mass labels
US20170089915A1 (en) * 2015-09-30 2017-03-30 Agilent Technologies, Inc. Methods of analyte derivatization and enhanced soft ionization
GB201521903D0 (en) * 2015-12-11 2016-01-27 Electrophoretics Ltd Isorbaric mass labels
WO2018003652A1 (ja) * 2016-06-29 2018-01-04 株式会社 日立ハイテクノロジーズ 酵素反応及び質量分析方法に用いる化合物
EP3577466B1 (de) 2017-01-31 2026-01-07 Roche Diagnostics GmbH Reagens für massenspektrometrie
CN111512411B (zh) * 2017-11-14 2024-09-20 马克思普朗克科学促进会 同量异序标签在质谱法中的用途
BR112021000983A2 (pt) 2018-07-24 2021-04-20 F. Hoffmann-La Roche Ag composto, composição, kit, aduto covalente, uso de um composto e método para a determinação de espectrometria de massa
CN112449636A (zh) 2018-07-24 2021-03-05 豪夫迈·罗氏有限公司 用于质谱分析的试剂
CN112492881A (zh) * 2018-07-24 2021-03-12 豪夫迈·罗氏有限公司 质谱用试剂
CN112146967A (zh) * 2019-06-28 2020-12-29 Fei 公司 用于制备和递送用于带电粒子分析的生物样品的系统和方法
EP3910341A1 (de) * 2020-05-13 2021-11-17 PreOmics GmbH Probenvorbereitung für massenspektrometrie

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860581A (en) * 1972-12-27 1975-01-14 American Home Prod Preparation of 1,4-benzodiazepines
AU5940186A (en) 1985-07-05 1987-01-08 Institut Fur Pflanzenschutzforschung 2, 6 - dimethyl - morpholine quartenary compounds
US4761415A (en) 1986-08-28 1988-08-02 Smithkline Beckman Corporation Dopamine-β-hydroxylase inhibitors
JPH01125357A (ja) 1987-11-06 1989-05-17 Dainippon Pharmaceut Co Ltd トリペプチドの誘導体
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5087815A (en) * 1989-11-08 1992-02-11 Schultz J Albert High resolution mass spectrometry of recoiled ions for isotopic and trace elemental analysis
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
CA2136717A1 (en) * 1992-05-29 1993-12-09 Brian T. Chait Method and product for the sequence determination of peptides using a mass spectrometer
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
WO1997011958A1 (en) 1995-09-29 1997-04-03 The Scripps Research Institute Protein signature analysis
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
CZ217698A3 (cs) * 1996-04-08 1998-12-16 Glaxo Group Limited Způsob sledování průběhu reakce
US5780232A (en) * 1996-05-28 1998-07-14 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
US6329180B1 (en) 1996-09-13 2001-12-11 Alex M. Garvin Genetic analysis using peptide tagged in-vitro synthesized proteins
GB9620769D0 (en) 1996-10-04 1996-11-20 Brax Genomics Ltd Nucleic acid sequencing
EP0941365B1 (de) 1996-10-04 2003-06-25 Dako A/S Sonden zur detektion von mycobakterien
JP2001524808A (ja) 1996-12-10 2001-12-04 ジーントレイス・システムズ・インコーポレイテッド 放出可能な不揮発性の質量標識分子
WO1998031830A1 (en) 1997-01-15 1998-07-23 Brax Group Limited Mass label linked hybridisation probes
US6156527A (en) * 1997-01-23 2000-12-05 Brax Group Limited Characterizing polypeptides
EP1002128A1 (de) 1997-07-11 2000-05-24 Brax Genomics Limited Charakterisierung von nukleinsäuren
JP4414086B2 (ja) 1997-07-22 2010-02-10 キアジェン ジェノミックス,インコーポレイテッド 質量分析によって核酸を分析するための方法および化合物
GB9718921D0 (en) 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
EP1015632A1 (de) 1997-09-15 2000-07-05 Brax Group Limited Charakterisierung von nukleinsäuren durch massenspektrometrie
GB9823646D0 (en) * 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6428956B1 (en) 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
WO1999049293A2 (en) * 1998-03-24 1999-09-30 Boston Probes, Inc. Methods, kits and compositions pertaining to detection complexes
EP1073767B1 (de) * 1998-04-29 2009-11-25 Boston Probes, Inc. Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen
DE69912444T3 (de) * 1998-08-25 2010-05-06 University Of Washington, Seattle Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US6270976B1 (en) * 1998-09-15 2001-08-07 Brax Group Limited Characterizing nucleic acid by mass spectrometry
GB9821669D0 (en) 1998-10-05 1998-12-02 Glaxo Group Ltd Chemical constructs and their uses
US6319476B1 (en) * 1999-03-02 2001-11-20 Perseptive Biosystems, Inc. Microfluidic connector
US6403309B1 (en) * 1999-03-19 2002-06-11 Valigen (Us), Inc. Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
US6629040B1 (en) * 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
DE60026321D1 (de) * 1999-08-13 2006-04-27 Univ Yale New Haven Binär kodierte sequenzmarker
US6472156B1 (en) * 1999-08-30 2002-10-29 The University Of Utah Homogeneous multiplex hybridization analysis by color and Tm
GB0006141D0 (en) * 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
AUPQ664300A0 (en) * 2000-04-03 2000-05-04 Proteome Systems Ltd Macromolecule detection
US20020106648A1 (en) 2000-05-05 2002-08-08 Lizardi Paul M. Highly multiplexed reporter carrier systems
AU2001283562B2 (en) 2000-08-11 2006-10-26 Perkin-Elmer Las, Inc. Ultra-sensitive detection systems
AU2002241732B2 (en) 2000-10-23 2007-07-12 Genetics Institute, Llc Isotope-coded ionization-enhancing reagents (ICIER) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry
US20020090652A1 (en) * 2000-12-22 2002-07-11 Fu Emil Wei-Ming Inverse labeling method for the rapid identification of marker/target proteins
US7045296B2 (en) * 2001-05-08 2006-05-16 Applera Corporation Process for analyzing protein samples
GB0115581D0 (en) 2001-06-26 2001-08-15 Glaxo Group Ltd Method of mass spectometry
GB0116143D0 (en) * 2001-07-02 2001-08-22 Amersham Pharm Biotech Uk Ltd Chemical capture reagent
EP1425586B1 (de) * 2001-09-14 2007-11-21 Electrophoretics Limited Massenmarker
AU2002340490A1 (en) * 2001-11-09 2003-05-19 Bayer Healthcare Ag Isotopically coded affinity markers 3
ES2284783T3 (es) * 2001-11-16 2007-11-16 Randox Laboratories Ltd. Metodo y estuche para detectar, o determinar la cantidad de,metabolitos de fentanilo y metabolitos de analogos de fentanilo.
GB0130845D0 (en) 2001-12-22 2002-02-06 James Peter Analysis
ES2319634T3 (es) 2002-03-11 2009-05-11 Caprotec Bioanalytics Gmbh Compuestos y metodos para analizar el proteoma.
CN1653333A (zh) 2002-03-11 2005-08-10 萨莫芬尼根有限责任公司 鉴定肽修饰
US7655433B2 (en) 2002-06-04 2010-02-02 The Institute For Systems Biology Methods for high-throughput and quantitative proteome analysis
US7473535B2 (en) 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
US7425451B2 (en) * 2002-12-13 2008-09-16 Agilent Technologies, Inc. Triazine derivatives as universal peptide isotope tag reagents (U-PIT)
CA2488584C (en) * 2003-01-30 2011-10-11 Applera Corporation Methods, mixtures, kits and compositions pertaining to analyte determination
GB0306756D0 (en) 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
US20050148087A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US7355045B2 (en) * 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US20050147982A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US20050148771A1 (en) 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
EP1776588A1 (de) * 2004-07-12 2007-04-25 Applera Corporation Massen-tags für quantitative analysen

Also Published As

Publication number Publication date
US20110045516A1 (en) 2011-02-24
US20080101989A1 (en) 2008-05-01
US20040220412A1 (en) 2004-11-04
JP2007525639A (ja) 2007-09-06
CA2488584C (en) 2011-10-11
US20060105416A1 (en) 2006-05-18
EP1588145A4 (de) 2007-05-16
US20110217720A1 (en) 2011-09-08
US8679773B2 (en) 2014-03-25
JP2010190902A (ja) 2010-09-02
US7799576B2 (en) 2010-09-21
WO2004070352A3 (en) 2006-09-28
CA2488584A1 (en) 2004-08-19
EP1588145A2 (de) 2005-10-26
JP5503358B2 (ja) 2014-05-28
US20100112708A1 (en) 2010-05-06
US7947513B2 (en) 2011-05-24
WO2004070352A2 (en) 2004-08-19
US20040219685A1 (en) 2004-11-04
AU2004209401A1 (en) 2004-08-19
US20070141659A1 (en) 2007-06-21
JP4613299B2 (ja) 2011-01-12
US20040219686A1 (en) 2004-11-04
US7910059B2 (en) 2011-03-22
EP1588145B1 (de) 2011-07-06
US7195751B2 (en) 2007-03-27
AU2008250877A1 (en) 2008-12-18

Similar Documents

Publication Publication Date Title
ATE515702T1 (de) Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung
WO2007100506A3 (en) Mass tags for quantitative analyses
DE602006017365D1 (de) Zusammensetzungen für die identifizierung von adenoviren
DE60230672D1 (de) Nukleinsäureanreicherung
DK1815028T3 (da) Mikrobobler til affinitetsseparation
ATE541054T1 (de) Bio-barcode erkennung für zielmoleküle
GB2451042A (en) Reagents and methods for using human embryonic stem cells to evaluate toxicity of pharmaceutical compounds and other chemicals
PT1206473E (pt) Pirrolocarbazoles e isoindolonas fundidos isomericos
WO2008105896A3 (en) Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
WO2006116127A3 (en) Compositions for use in identification of bacteria
DK1316801T3 (da) Sammensætninger og fremgangsmåder til detektion og behandling af sygdomme og tilstande, som er relateret til kemokinreceptorer
ATE431854T1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
NO20043259L (no) Bindingsproteiner som biosensorer
EP1687283A4 (de) Für die bestimmung von fk506 geeignetes verfahren und zusammensetzung
ATE515488T1 (de) Click-chemie zur herstellung von reportermolekülen
ATE479669T1 (de) Markierungsreagentien, markierte analyten, einschliesslich mischungen davon, und davon abgeleitete fragmentionen und verfahren zu deren analyse
DE602005001302D1 (de) Bestimmung von analytcharakteristika auf der grundlage von bindungseigenschaften
DK1423541T3 (da) Fremgangsmåde til at bestemme multiple analytter
DE602006011756D1 (de) Komplexformierungs- und -trennungsverfahren
CY1108840T1 (el) Μεθοδοι και συνθεσεις για το χαρακτηρισμο ενος ενζυμου συστηματος οξειδοαναγωγικου αντιδραστηριου
DE60220815D1 (de) Nachweis durch serrs in mikrofluidischer umgebung
ATE333521T1 (de) Detektion von vancomycin-resistenten enterococcus-subspezies
DE60228952D1 (de) Nachweis von Legionella durch ein PCR und FRET verwendendes Verfahren
WO2008127839A3 (en) Compositions for use in identification of bacteria
DE69941690D1 (de) Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties