ATE515488T1 - Click-chemie zur herstellung von reportermolekülen - Google Patents

Click-chemie zur herstellung von reportermolekülen

Info

Publication number
ATE515488T1
ATE515488T1 AT07819506T AT07819506T ATE515488T1 AT E515488 T1 ATE515488 T1 AT E515488T1 AT 07819506 T AT07819506 T AT 07819506T AT 07819506 T AT07819506 T AT 07819506T AT E515488 T1 ATE515488 T1 AT E515488T1
Authority
AT
Austria
Prior art keywords
reporter molecules
click chemistry
producing reporter
producing
methods
Prior art date
Application number
AT07819506T
Other languages
English (en)
Inventor
Thomas Carell
Anja Schwoegler
Original Assignee
Baseclick Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baseclick Gmbh filed Critical Baseclick Gmbh
Application granted granted Critical
Publication of ATE515488T1 publication Critical patent/ATE515488T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AT07819506T 2006-10-31 2007-10-31 Click-chemie zur herstellung von reportermolekülen ATE515488T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85557406P 2006-10-31 2006-10-31
PCT/EP2007/009474 WO2008052775A2 (en) 2006-10-31 2007-10-31 Click chemistry for the production of reporter molecules

Publications (1)

Publication Number Publication Date
ATE515488T1 true ATE515488T1 (de) 2011-07-15

Family

ID=39344631

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07819506T ATE515488T1 (de) 2006-10-31 2007-10-31 Click-chemie zur herstellung von reportermolekülen

Country Status (14)

Country Link
US (1) US8193335B2 (de)
EP (1) EP2089343B1 (de)
JP (1) JP5646172B2 (de)
CN (1) CN101605743A (de)
AT (1) ATE515488T1 (de)
AU (1) AU2007315190B2 (de)
CA (1) CA2667136A1 (de)
DK (1) DK2089343T3 (de)
ES (1) ES2369299T3 (de)
HR (1) HRP20110554T1 (de)
PL (1) PL2089343T3 (de)
PT (1) PT2089343E (de)
SI (1) SI2089343T1 (de)
WO (1) WO2008052775A2 (de)

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ATE479699T1 (de) * 2005-05-02 2010-09-15 Baseclick Gmbh Neue markierungsstrategien für den empfindlichen nachweis von analyten
HRP20100659T1 (hr) 2005-05-02 2011-01-31 Baseclick Gmbh Nove strategije obiljezavanja za osjetljivo otkrivanje analita
CA2667136A1 (en) 2006-10-31 2008-05-08 Baseclick Gmbh Click chemistry for the production of reporter molecules
JP2010522583A (ja) 2007-02-27 2010-07-08 トラスティーズ オブ タフツ カレッジ 組織工学的に作製された絹製臓器
JP2010529230A (ja) 2007-05-29 2010-08-26 トラスティーズ オブ タフツ カレッジ 音波処理を用いた絹フィブロインのゲル化のための方法
US8618297B2 (en) 2008-07-25 2013-12-31 Basf Se Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions
CA2737661C (en) * 2008-09-23 2019-08-20 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
EP2358898B1 (de) 2008-11-17 2016-08-31 Headway Technologies, Inc. Verfahren und zusammensetzungen bei dem nachweis von zielmolekülen auf partikelbasis unter verwendung von kovalente bindungen ausbildenden reaktiven paaren
US9150910B2 (en) 2008-11-17 2015-10-06 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
JP5569768B2 (ja) * 2008-12-02 2014-08-13 国立大学法人九州大学 ヌクレオシド三リン酸誘導体、核酸プローブ、マルチラベル化核酸プローブおよび標的核酸の検出方法
EP2239053A1 (de) 2009-04-09 2010-10-13 baseclick GmbH Click-Chemie auf heterogenen Katalysatoren
US9074302B2 (en) 2009-09-28 2015-07-07 Trustees Of Tufts College Methods of making drawn silk fibers
AU2011317107B2 (en) 2010-10-19 2016-02-25 Trustees Of Tufts College Silk fibroin-based microneedles and methods of making the same
CN102010508B (zh) * 2010-10-19 2012-10-03 北京大学 一种阳离子聚合物及其制备方法和应用
EP2675917B1 (de) 2011-02-16 2017-09-13 Headway Technologies, Inc. Verfahren und zusammensetzungen zur verankerung eines erkennbaren etiketts an einem lokalisierten ziel
WO2012145652A1 (en) 2011-04-20 2012-10-26 Trustees Of Tufts College Dynamic silk coatings for implantable devices
US9988680B2 (en) 2011-09-01 2018-06-05 Case Western Reserve University Non-natural nucleosides as theranostic agents
WO2013152619A1 (en) * 2012-04-12 2013-10-17 The Hong Kong University Of Science And Technology Thermosetting poly(siloxane-diphenylbutadiyne) with readily tunable glass transition temperature and high thermal stability
AU2013288738A1 (en) 2012-07-10 2015-01-29 Baseclick Gmbh Anandamide-modified nucleic acid molecules
AU2013361605A1 (en) 2012-12-20 2015-06-04 Sirna Therapeutics, Inc. Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on siRNA
US20160159834A1 (en) * 2013-04-22 2016-06-09 Northwestern University Alkyne phosphoramidites and preparation of spherical nucleic acid constructs
CN105705938B (zh) * 2013-08-19 2020-11-06 休斯敦大学系统 磷光报告物
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
AU2015349730C1 (en) * 2014-11-20 2020-04-30 F. Hoffmann-La Roche Ag Nulceoside phosphoroamidate esters and derivatives thereof, use and synthesis thereof
JP6667179B2 (ja) * 2015-03-24 2020-03-18 国立大学法人岐阜大学 オリゴヌクレオチド誘導体及びそれを用いたオリゴヌクレオチド構築物並びにそれらの製造方法
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
CN109490523A (zh) * 2018-10-22 2019-03-19 北京纳晶生物科技有限公司 用于标记的纳米材料、核酸探针及核酸与纳米材料偶联的方法
CN112305227A (zh) * 2019-07-31 2021-02-02 深圳市帝迈生物技术有限公司 自交联蛋白、配体组合物、制备方法、试剂盒及系统
CN111018930A (zh) * 2019-12-06 2020-04-17 深圳大学 Tpe-2’-脱氧核苷、荧光凝胶及其制备方法与应用

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GB2209754A (en) 1987-09-17 1989-05-24 Thomas Lee Mattson Polyaldehydic polynucleotides in use as probes,their preparation and use
AU636110B2 (en) 1988-06-08 1993-04-22 Nichols Institute Diagnostics Assays utilizing sensitizer-induced production of detectable signal
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US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US6737236B1 (en) 1997-01-08 2004-05-18 Proligo, Llc Bioconjugation of macromolecules
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AU2003225799A1 (en) * 2002-03-03 2003-09-29 Activx Biosciences, Inc. Tethered activity-based probes and uses thereof
DK2226316T3 (en) 2002-05-30 2016-04-11 Scripps Research Inst Copper catalyzed ligation of azides and acetylenes
AU2003297859A1 (en) 2002-12-13 2004-07-09 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
KR100540509B1 (ko) 2004-01-07 2006-01-11 학교법인 포항공과대학교 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체
EP1737986A2 (de) 2004-04-08 2007-01-03 Nimblegen Systems, Inc. Vergleichenden genomresequenzierung
JP2008540338A (ja) 2005-04-27 2008-11-20 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド 分子画像化プローブのクリックケミストリー合成法
ATE479699T1 (de) * 2005-05-02 2010-09-15 Baseclick Gmbh Neue markierungsstrategien für den empfindlichen nachweis von analyten
JP5430937B2 (ja) 2005-10-27 2014-03-05 プレジデント アンド フェロウズ オブ ハーバード カレッジ 核酸を標識するための方法および組成物
CA2667136A1 (en) 2006-10-31 2008-05-08 Baseclick Gmbh Click chemistry for the production of reporter molecules

Also Published As

Publication number Publication date
WO2008052775A2 (en) 2008-05-08
EP2089343B1 (de) 2011-07-06
US20100081137A1 (en) 2010-04-01
JP5646172B2 (ja) 2014-12-24
PT2089343E (pt) 2011-09-06
HRP20110554T1 (hr) 2011-09-30
CN101605743A (zh) 2009-12-16
WO2008052775A3 (en) 2009-01-15
EP2089343A2 (de) 2009-08-19
AU2007315190B2 (en) 2012-05-31
DK2089343T3 (da) 2011-10-24
PL2089343T3 (pl) 2011-12-30
ES2369299T3 (es) 2011-11-29
SI2089343T1 (sl) 2011-10-28
JP2010508015A (ja) 2010-03-18
US8193335B2 (en) 2012-06-05
CA2667136A1 (en) 2008-05-08
AU2007315190A1 (en) 2008-05-08

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