ATE515488T1 - Click-chemie zur herstellung von reportermolekülen - Google Patents

Click-chemie zur herstellung von reportermolekülen

Info

Publication number
ATE515488T1
ATE515488T1 AT07819506T AT07819506T ATE515488T1 AT E515488 T1 ATE515488 T1 AT E515488T1 AT 07819506 T AT07819506 T AT 07819506T AT 07819506 T AT07819506 T AT 07819506T AT E515488 T1 ATE515488 T1 AT E515488T1
Authority
AT
Austria
Prior art keywords
reporter molecules
click chemistry
producing reporter
producing
methods
Prior art date
Application number
AT07819506T
Other languages
English (en)
Inventor
Thomas Carell
Anja Schwoegler
Original Assignee
Baseclick Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baseclick Gmbh filed Critical Baseclick Gmbh
Application granted granted Critical
Publication of ATE515488T1 publication Critical patent/ATE515488T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
AT07819506T 2006-10-31 2007-10-31 Click-chemie zur herstellung von reportermolekülen ATE515488T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85557406P 2006-10-31 2006-10-31
PCT/EP2007/009474 WO2008052775A2 (en) 2006-10-31 2007-10-31 Click chemistry for the production of reporter molecules

Publications (1)

Publication Number Publication Date
ATE515488T1 true ATE515488T1 (de) 2011-07-15

Family

ID=39344631

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07819506T ATE515488T1 (de) 2006-10-31 2007-10-31 Click-chemie zur herstellung von reportermolekülen

Country Status (14)

Country Link
US (1) US8193335B2 (de)
EP (1) EP2089343B1 (de)
JP (1) JP5646172B2 (de)
CN (1) CN101605743A (de)
AT (1) ATE515488T1 (de)
AU (1) AU2007315190B2 (de)
CA (1) CA2667136A1 (de)
DK (1) DK2089343T3 (de)
ES (1) ES2369299T3 (de)
HR (1) HRP20110554T1 (de)
PL (1) PL2089343T3 (de)
PT (1) PT2089343E (de)
SI (1) SI2089343T1 (de)
WO (1) WO2008052775A2 (de)

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PL1877415T3 (pl) * 2005-05-02 2011-02-28 Baseclick Gmbh Nowe strategie znakowania dla czułego wykrywania analitów
CN101605743A (zh) 2006-10-31 2009-12-16 贝瑟克里科有限公司 用于产生报告分子的点击化学
EP2129772B1 (de) 2007-02-27 2016-07-27 Trustees Of Tufts College Gewebegezüchtete seidenorgane
ES2527125T3 (es) 2007-05-29 2015-01-20 Trustees Of Tufts College Método para la gelificación de fibroína de seda usando sonicación
US8618297B2 (en) 2008-07-25 2013-12-31 Basf Se Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions
WO2010039548A2 (en) * 2008-09-23 2010-04-08 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
JP5744743B2 (ja) 2008-11-17 2015-07-08 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 共有結合形成反応ペアを用いた標的分子の粒子ベースの検出における方法および組成物
EP2358897B1 (de) 2008-11-17 2015-02-25 Headway Technologies, Inc. Verfahren und zusammensetzungen bei dem nachweis von zielmolekülen auf partikelbasis unter verwendung von verknüpfungsmolekülen
JP5569768B2 (ja) * 2008-12-02 2014-08-13 国立大学法人九州大学 ヌクレオシド三リン酸誘導体、核酸プローブ、マルチラベル化核酸プローブおよび標的核酸の検出方法
EP2239053A1 (de) 2009-04-09 2010-10-13 baseclick GmbH Click-Chemie auf heterogenen Katalysatoren
JP2013506058A (ja) 2009-09-28 2013-02-21 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ 延伸したシルクｅｇｅｌ繊維およびその製造方法
JP5937092B2 (ja) 2010-10-19 2016-06-22 トラスティーズ オブ タフツ カレッジ シルクフィブロインベースのマイクロニードルおよびその製造方法
CN102010508B (zh) * 2010-10-19 2012-10-03 北京大学 一种阳离子聚合物及其制备方法和应用
CN103476951B (zh) 2011-02-16 2017-07-28 海德威技术公司 用于可检测的标记的靶标定位锚定的方法和组合物
WO2012145652A1 (en) 2011-04-20 2012-10-26 Trustees Of Tufts College Dynamic silk coatings for implantable devices
EP2825546B1 (de) * 2011-09-01 2017-07-12 Case Western Reserve University Nicht-natürliche nukleoside als theranostika
WO2013152619A1 (en) * 2012-04-12 2013-10-17 The Hong Kong University Of Science And Technology Thermosetting poly(siloxane-diphenylbutadiyne) with readily tunable glass transition temperature and high thermal stability
BR112015000236A2 (pt) 2012-07-10 2017-06-27 Baseclick Gmbh moléculas de ácidos nucleicos modificadas por anandamida
CA2891966A1 (en) 2012-12-20 2014-06-26 Sirna Therapeutics, Inc. Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on sirna
US20160159834A1 (en) * 2013-04-22 2016-06-09 Northwestern University Alkyne phosphoramidites and preparation of spherical nucleic acid constructs
CN105705938B (zh) * 2013-08-19 2020-11-06 休斯敦大学系统 磷光报告物
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
CA2968424A1 (en) * 2014-11-20 2016-05-26 Stratos Genomics, Inc. Nucleoside phosphoroamidate esters and derivatives thereof, use and synthesis thereof
US10487103B2 (en) 2015-03-24 2019-11-26 Gifu University Oligonucleotide derivative, oligonucleotide construct using the same, and methods for producing them
CN109312492B (zh) 2016-06-16 2022-10-04 哈斯达克科学公司 寡核苷酸指导和记录的编码探针分子的组合合成
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
CN109490523A (zh) * 2018-10-22 2019-03-19 北京纳晶生物科技有限公司 用于标记的纳米材料、核酸探针及核酸与纳米材料偶联的方法
CN112305227A (zh) * 2019-07-31 2021-02-02 深圳市帝迈生物技术有限公司 自交联蛋白、配体组合物、制备方法、试剂盒及系统
CN111018930A (zh) * 2019-12-06 2020-04-17 深圳大学 Tpe-2’-脱氧核苷、荧光凝胶及其制备方法与应用

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GB2209754A (en) 1987-09-17 1989-05-24 Thomas Lee Mattson Polyaldehydic polynucleotides in use as probes,their preparation and use
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US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
EP2319855B1 (de) 1997-01-08 2016-04-06 Sigma-Aldrich Co. LLC Biokonjugation von Makromolekülen
US7427678B2 (en) 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
US7205105B2 (en) 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
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WO2003101972A1 (en) 2002-05-30 2003-12-11 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
AU2003297859A1 (en) 2002-12-13 2004-07-09 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
KR100540509B1 (ko) 2004-01-07 2006-01-11 학교법인 포항공과대학교 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체
EP1737986A2 (de) 2004-04-08 2007-01-03 Nimblegen Systems, Inc. Vergleichenden genomresequenzierung
KR20080000620A (ko) 2005-04-27 2008-01-02 지멘스 메디컬 솔루션즈 유에스에이, 인크. 분자 이미징 프로브를 합성하기 위한 클릭 화학 방법
PL1877415T3 (pl) * 2005-05-02 2011-02-28 Baseclick Gmbh Nowe strategie znakowania dla czułego wykrywania analitów
WO2007050811A2 (en) 2005-10-27 2007-05-03 The President And Fellows Of Harvard College Methods and compositions for labeling nucleic acids
CN101605743A (zh) 2006-10-31 2009-12-16 贝瑟克里科有限公司 用于产生报告分子的点击化学

Also Published As

Publication number Publication date
EP2089343A2 (de) 2009-08-19
AU2007315190B2 (en) 2012-05-31
US8193335B2 (en) 2012-06-05
CA2667136A1 (en) 2008-05-08
DK2089343T3 (da) 2011-10-24
ES2369299T3 (es) 2011-11-29
JP2010508015A (ja) 2010-03-18
PL2089343T3 (pl) 2011-12-30
WO2008052775A2 (en) 2008-05-08
JP5646172B2 (ja) 2014-12-24
SI2089343T1 (sl) 2011-10-28
EP2089343B1 (de) 2011-07-06
AU2007315190A1 (en) 2008-05-08
WO2008052775A3 (en) 2009-01-15
HRP20110554T1 (hr) 2011-09-30
CN101605743A (zh) 2009-12-16
US20100081137A1 (en) 2010-04-01
PT2089343E (pt) 2011-09-06

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