MX2012003603A - Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihid ropiridina fluoro-sustituidos y procedimientos de uso de los mismos. - Google Patents

Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihid ropiridina fluoro-sustituidos y procedimientos de uso de los mismos.

Info

Publication number
MX2012003603A
MX2012003603A MX2012003603A MX2012003603A MX2012003603A MX 2012003603 A MX2012003603 A MX 2012003603A MX 2012003603 A MX2012003603 A MX 2012003603A MX 2012003603 A MX2012003603 A MX 2012003603A MX 2012003603 A MX2012003603 A MX 2012003603A
Authority
MX
Mexico
Prior art keywords
indazol
dicyano
substituted
fluoro
methods
Prior art date
Application number
MX2012003603A
Other languages
English (en)
Inventor
Mario Lobell
Alexandros Vakalopoulos
Katja Zimmermann
Martin Michels
Markus Follmann
Nicole Teusch
Donald Bierer
Karen Engel
Maria Kissel
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MX2012003603A publication Critical patent/MX2012003603A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se refiere a nuevos derivados de 3,5-diciano-4-(IH- indazol-5-il)-2,6-dimetil-1,4-dihidropiridina fluoro-sustituidos que tienen actividad inhibidora de tirosina quinasa de proteínas, a un procedimiento para la aplicación de los mismos y al uso de los mismos para el tratamiento de enfermedades mediadas por c-Met o de afecciones mediadas por c-Met, en particular cáncer y otros trastornos proliferativos.
MX2012003603A 2009-10-06 2010-10-01 Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihid ropiridina fluoro-sustituidos y procedimientos de uso de los mismos. MX2012003603A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09172304 2009-10-06
PCT/EP2010/064648 WO2011042368A1 (en) 2009-10-06 2010-10-01 Fluoro-substituted 3,5-dicyano-4-(1h-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2012003603A true MX2012003603A (es) 2012-04-20

Family

ID=43357944

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012003603A MX2012003603A (es) 2009-10-06 2010-10-01 Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihid ropiridina fluoro-sustituidos y procedimientos de uso de los mismos.

Country Status (27)

Country Link
US (1) US9422263B2 (es)
EP (1) EP2485726B1 (es)
JP (1) JP5753175B2 (es)
KR (1) KR20120091005A (es)
CN (1) CN102573838B (es)
AR (1) AR078486A1 (es)
AU (1) AU2010305550A1 (es)
BR (1) BR112012006842A2 (es)
CA (1) CA2773676C (es)
CL (1) CL2012000753A1 (es)
CR (1) CR20120150A (es)
CU (1) CU20120051A7 (es)
DO (1) DOP2012000085A (es)
EC (1) ECSP12011748A (es)
ES (1) ES2458117T3 (es)
HK (1) HK1172835A1 (es)
IL (1) IL218415A0 (es)
IN (1) IN2012DN02675A (es)
MX (1) MX2012003603A (es)
NZ (1) NZ599006A (es)
PE (1) PE20121392A1 (es)
RU (1) RU2012111695A (es)
SG (1) SG178990A1 (es)
TW (1) TW201124396A (es)
UY (1) UY32922A (es)
WO (1) WO2011042368A1 (es)
ZA (1) ZA201201524B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009056886A1 (de) * 2009-12-03 2011-06-09 Bayer Schering Pharma Aktiengesellschaft cMet-Inhibitoren zur Behandlung der Endometriose

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635977A (en) 1969-11-03 1972-01-18 American Cyanamid Co Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
DK0379917T3 (da) 1989-01-26 1995-12-11 Bayer Ag Optisk aktive (meth)acrylsyre-drivater, deres fremstilling, deres polymerisation til optisk aktive polymere og disses anvendelse
DE19546136A1 (de) 1995-12-11 1997-06-12 Bayer Ag Chirale stationäre Phasen für die chromatographische Trennung von optischen Isomeren
KR20050004214A (ko) 2002-05-31 2005-01-12 에자이 가부시키가이샤 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
WO2005085227A1 (en) 2004-03-02 2005-09-15 Smithkline Beecham Corporation Inhibitors of akt activity
EP1722792A1 (de) 2004-03-03 2006-11-22 Boehringer Ingelheim International GmbH Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
CA2589777A1 (en) 2004-12-13 2006-06-22 Irm Llc Compounds and compositions as modulators of steroidal receptors and calcium channel activities
WO2006074419A2 (en) 2005-01-07 2006-07-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
US7632839B2 (en) * 2005-01-19 2009-12-15 Merck & Co. Inc. Mitotic kinesin inhibitors
WO2008071451A1 (en) * 2006-12-14 2008-06-19 Bayer Schering Pharma Aktiengesellschaft Dihydropyridine derivatives useful as protein kinase inhibitors

Also Published As

Publication number Publication date
PE20121392A1 (es) 2012-10-14
JP5753175B2 (ja) 2015-07-22
KR20120091005A (ko) 2012-08-17
US20120264785A1 (en) 2012-10-18
JP2013506699A (ja) 2013-02-28
RU2012111695A (ru) 2013-10-10
EP2485726A1 (en) 2012-08-15
US9422263B2 (en) 2016-08-23
TW201124396A (en) 2011-07-16
ECSP12011748A (es) 2012-05-30
HK1172835A1 (en) 2013-05-03
NZ599006A (en) 2013-11-29
CR20120150A (es) 2012-08-03
CA2773676C (en) 2017-07-04
IL218415A0 (en) 2012-04-30
UY32922A (es) 2011-04-29
CA2773676A1 (en) 2011-04-14
WO2011042368A1 (en) 2011-04-14
CU20120051A7 (es) 2012-06-29
CL2012000753A1 (es) 2012-09-14
CN102573838A (zh) 2012-07-11
CN102573838B (zh) 2014-09-24
SG178990A1 (en) 2012-04-27
IN2012DN02675A (es) 2015-09-04
ZA201201524B (en) 2013-05-29
EP2485726B1 (en) 2014-03-12
BR112012006842A2 (pt) 2016-06-07
DOP2012000085A (es) 2012-07-15
AU2010305550A1 (en) 2012-03-29
ES2458117T3 (es) 2014-04-30
AR078486A1 (es) 2011-11-09

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Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: BAYER INTELLECTUAL PROPERTY GMBH

FA Abandonment or withdrawal