ATE528002T1 - Pyridoncarboxamidderivate zur behandlung hyperproliferativer und angiogenese-vermittelter leiden - Google Patents

Pyridoncarboxamidderivate zur behandlung hyperproliferativer und angiogenese-vermittelter leiden

Info

Publication number
ATE528002T1
ATE528002T1 AT07861312T AT07861312T ATE528002T1 AT E528002 T1 ATE528002 T1 AT E528002T1 AT 07861312 T AT07861312 T AT 07861312T AT 07861312 T AT07861312 T AT 07861312T AT E528002 T1 ATE528002 T1 AT E528002T1
Authority
AT
Austria
Prior art keywords
angiogenesis
hyperproliferative
treatment
mediated diseases
carboxamide derivatives
Prior art date
Application number
AT07861312T
Other languages
English (en)
Inventor
Stephen Boyer
David Cantin
Sidney X Liang
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Application granted granted Critical
Publication of ATE528002T1 publication Critical patent/ATE528002T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07861312T 2006-05-19 2007-05-18 Pyridoncarboxamidderivate zur behandlung hyperproliferativer und angiogenese-vermittelter leiden ATE528002T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80170006P 2006-05-19 2006-05-19
PCT/US2007/011981 WO2008048375A1 (en) 2006-05-19 2007-05-18 Pyridonecarboxamide derivatives useful in treating hyper-proliferative and angiogenesis disorders

Publications (1)

Publication Number Publication Date
ATE528002T1 true ATE528002T1 (de) 2011-10-15

Family

ID=39314319

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07861312T ATE528002T1 (de) 2006-05-19 2007-05-18 Pyridoncarboxamidderivate zur behandlung hyperproliferativer und angiogenese-vermittelter leiden

Country Status (6)

Country Link
US (1) US20090306103A1 (de)
EP (1) EP2023926B1 (de)
JP (1) JP2009537632A (de)
AT (1) ATE528002T1 (de)
CA (1) CA2652417A1 (de)
WO (1) WO2008048375A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2740746A1 (en) * 2008-10-14 2010-04-22 Ning Xi Compounds comprising a spiro-ring and and methods of use
EP2408300B1 (de) * 2009-03-21 2016-05-11 Sunshine Lake Pharma Co., Ltd. Aminoesterderivate, salze daraus und verfahren zu ihrer verwendung
KR101106050B1 (ko) 2009-03-25 2012-01-18 한국과학기술연구원 아미노퀴놀린 화합물, 이의 제조 방법 및 이를 함유하는 의약 조성물
US8569319B2 (en) 2010-04-29 2013-10-29 Deciphera Pharmaceuticals, LLS Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities
RU2568258C2 (ru) 2011-02-28 2015-11-20 Саншайн Лейк Фарма Ко., Лтд Замещенные соединения хинолина и способы их использования
CN102675282B (zh) * 2011-03-15 2014-12-24 广东东阳光药业有限公司 取代的喹啉化合物及其使用方法和用途
AU2014252584B2 (en) * 2013-04-09 2016-10-13 Lan Tech Limited Anti-angiogenesis compound, intermediate and use thereof
TWI649308B (zh) 2013-07-24 2019-02-01 小野藥品工業股份有限公司 喹啉衍生物
ES2896400T3 (es) 2014-08-01 2022-02-24 Nuevolution As Compuestos activos frente a bromdominios
JP6708130B2 (ja) * 2014-12-25 2020-06-10 小野薬品工業株式会社 キノリン誘導体
CN106279147A (zh) * 2015-05-21 2017-01-04 中国科学院上海药物研究所 一种吡啶并氮杂环化合物及其制备方法和用途
CN114456176B (zh) 2016-03-28 2024-08-30 因赛特公司 作为tam抑制剂的吡咯并三嗪化合物
CN106735288B (zh) * 2016-11-30 2018-12-28 燕山大学 一种以醋酸伐普肽为生物模板制备银纳米球壳的方法
CN106735289B (zh) * 2016-11-30 2018-09-04 燕山大学 一种以醋酸奥曲肽为模板制备立方体状银纳米盒的方法
CN106694901B (zh) * 2016-12-27 2018-12-28 燕山大学 一种基于醋酸伐普肽制备银金合金纳米球壳
ES2872923T3 (es) 2017-01-26 2021-11-03 Ono Pharmaceutical Co Sal etanosulfonato de N-{5-[(6,7-dimetoxi-4-quinolinil)oxi]-2-piridinil}-2,5-dioxo-1-fenil-1,2,5,6,7,8-hexahidro-3-quinolinacarboxamida
KR102739325B1 (ko) 2017-09-27 2024-12-09 인사이트 코포레이션 Tam 억제제로서 유용한 피롤로트리아진 유도체의 염
US11826363B2 (en) 2017-10-13 2023-11-28 Ono Pharmaceutical Co., Ltd. Therapeutic agent for solid cancers, which comprises Axl inhibitor as active ingredient
US11241438B2 (en) 2018-06-29 2022-02-08 Incyte Corporation Formulations of an AXL/MER inhibitor
CN110330479A (zh) * 2019-07-19 2019-10-15 南京华威医药科技集团有限公司 一种用作axl抑制剂的抗肿瘤化合物及其用途
CN112625026B (zh) * 2019-09-24 2022-09-09 药捷安康(南京)科技股份有限公司 Tam家族激酶抑制剂的喹啉衍生物
AU2020351782A1 (en) 2019-09-26 2022-04-21 Exelixis, Inc. Pyridone compounds and methods of use in the modulation of a protein kinase
WO2021158071A1 (ko) * 2020-02-06 2021-08-12 웰마커바이오 주식회사 Kras 돌연변이와 관련된 암의 예방 또는 치료용 약학 조성물
PH12022552347A1 (en) 2020-03-06 2024-01-29 Incyte Corp Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors
GB202004960D0 (en) * 2020-04-03 2020-05-20 Kinsenus Ltd Inhibitor compounds
CN116322746A (zh) * 2020-08-07 2023-06-23 石药集团中奇制药技术（石家庄）有限公司 盐酸米托蒽醌脂质体和培门冬酶的用途
WO2022237843A1 (zh) * 2021-05-12 2022-11-17 微境生物医药科技(上海)有限公司 Axl抑制剂
AU2024369826A1 (en) * 2023-10-30 2026-05-14 Pmv Pharmaceuticals, Inc. Plk4 modulators

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Publication number Priority date Publication date Assignee Title
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
US7517994B2 (en) * 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US20050288290A1 (en) * 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
US7732613B2 (en) * 2005-09-14 2010-06-08 Bristol-Myers Squibb Company Met kinase inhibitors

Also Published As

Publication number Publication date
EP2023926A1 (de) 2009-02-18
US20090306103A1 (en) 2009-12-10
WO2008048375A1 (en) 2008-04-24
EP2023926A4 (de) 2010-08-04
JP2009537632A (ja) 2009-10-29
CA2652417A1 (en) 2008-04-24
EP2023926B1 (de) 2011-10-12

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