TNSN01124A1 - Derives de 1,4-dihydropyridine nouveaux , servant d'antagonistes de la bradykinine, et compositions les contenant - Google Patents
Derives de 1,4-dihydropyridine nouveaux , servant d'antagonistes de la bradykinine, et compositions les contenantInfo
- Publication number
- TNSN01124A1 TNSN01124A1 TNTNSN01124A TNSN01124A TNSN01124A1 TN SN01124 A1 TNSN01124 A1 TN SN01124A1 TN TNSN01124 A TNTNSN01124 A TN TNSN01124A TN SN01124 A TNSN01124 A TN SN01124A TN SN01124 A1 TNSN01124 A1 TN SN01124A1
- Authority
- TN
- Tunisia
- Prior art keywords
- compositions containing
- novel
- dihydropyridine derivatives
- bradykinine
- antagonists
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C—CHEMISTRY; METALLURGY
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
Abstract
L'INVENTION CONCERNE DES COMPOSES DE FORMULE : DANS LAQUELLE R1, R2, R3, R4, R5, A ET Y REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT DES COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSES. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS DANS LE TRAITEMENT ET LA PREVENTION DE L'INFLAMMATION DE L'ASTHME, DE LA RHINITE ALLERGIQUE, DE LA DOULEUR ET D'AUTRES AFFECTIONS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22455800P | 2000-08-10 | 2000-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN01124A1 true TNSN01124A1 (fr) | 2005-11-10 |
Family
ID=22841188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN01124A TNSN01124A1 (fr) | 2000-08-10 | 2001-08-09 | Derives de 1,4-dihydropyridine nouveaux , servant d'antagonistes de la bradykinine, et compositions les contenant |
Country Status (21)
Country | Link |
---|---|
US (1) | US6653313B2 (fr) |
EP (1) | EP1307449B1 (fr) |
JP (1) | JP2004505973A (fr) |
AP (1) | AP2001002238A0 (fr) |
AR (1) | AR034555A1 (fr) |
AT (1) | ATE312099T1 (fr) |
AU (1) | AU2001270947A1 (fr) |
BR (1) | BR0113071A (fr) |
CA (1) | CA2418908C (fr) |
CR (1) | CR6859A (fr) |
DE (1) | DE60115661T2 (fr) |
ES (1) | ES2257422T3 (fr) |
GT (1) | GT200100153A (fr) |
IL (1) | IL153224A0 (fr) |
IS (1) | IS6639A (fr) |
MX (1) | MXPA03001204A (fr) |
PA (1) | PA8525001A1 (fr) |
PE (1) | PE20020467A1 (fr) |
SV (1) | SV2003000588A (fr) |
TN (1) | TNSN01124A1 (fr) |
WO (1) | WO2002012235A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
PL373433A1 (en) * | 2002-08-30 | 2005-08-22 | Altana Pharma Ag | The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis |
SK50642005A3 (sk) * | 2003-01-24 | 2006-02-02 | Elan Pharmaceuticals, Inc. | Kompozícia na liečenie demyelizačných ochorení a paralýzy podávaním remyelizačných látok |
US20060217362A1 (en) * | 2004-12-29 | 2006-09-28 | Tung Jay S | Novel compounds useful for bradykinin B1 receptor antagonism |
EP2300482B1 (fr) * | 2008-06-09 | 2012-01-04 | Bayer Pharma Aktiengesellschaft | DÉRIVÉS CONDENSÉS DE LA 4-(INDAZOLYL)-1,4-DIHYDROPYRIDINE COMME MÉDIATEURS DE c-Met |
WO2010127381A1 (fr) * | 2009-05-08 | 2010-11-11 | James Cook University | Diagnostic, contrôle, pronostic, prévention et traitement des anévrysmes |
JP5637710B2 (ja) * | 2010-03-24 | 2014-12-10 | 株式会社トクヤマ | {2−アミノ−1,4−ジヒドロ−6−メチル−4−(3−ニトロフェニル)−3,5−ピリジンジカルボン酸3−(1−ジフェニルメチルアゼチジン−3−イル)エステル5−イソプロピルエステル}の製造方法 |
US9012450B2 (en) | 2011-12-28 | 2015-04-21 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
CN104135859B (zh) | 2011-12-28 | 2017-06-27 | 全球血液疗法公司 | 取代的苯甲醛化合物及其用于增加组织氧合的方法 |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
MY183637A (en) | 2013-03-15 | 2021-03-04 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
PE20160078A1 (es) | 2013-03-15 | 2016-03-02 | Global Blood Therapeutics Inc | Compuestos y sus usos para modular la hemoglobina |
AP2015008721A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
ES2924111T3 (es) | 2013-10-25 | 2022-10-04 | Blueprint Medicines Corp | Inhibidores del receptor del factor de crecimiento de fibroblastos |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
PT3102208T (pt) | 2014-02-07 | 2021-04-05 | Global Blood Therapeutics Inc | Polimorfos cristalinos da base livre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3 il)metoxi)benzaldeído |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
TW201731509A (zh) | 2015-12-04 | 2017-09-16 | 全球血液治療公司 | 針對2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之劑量方案 |
AR108435A1 (es) | 2016-05-12 | 2018-08-22 | Global Blood Therapeutics Inc | Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído |
TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
CN114867702A (zh) * | 2019-12-13 | 2022-08-05 | 罗地亚经营管理公司 | 苯衍生物的生产 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006083A1 (fr) * | 1994-08-24 | 1996-02-29 | Pfizer Pharmaceuticals Inc. | 2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines utilisees comme antagonistes de bradykinine |
JP2001510439A (ja) | 1996-02-13 | 2001-07-31 | グローバルアート株式会社 | ポリエステル環状化合物、その複合体およびその結合体 |
TNSN97037A1 (fr) * | 1996-02-19 | 2005-03-15 | Pfizer | Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant. |
MX9701245A (es) * | 1996-02-19 | 1998-04-30 | Pfizer | Compuestos de 1,4 dihidropiridina. |
JPH11106375A (ja) * | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | ブラジキニンアンタゴニストとしての光学的に活性な1,4−ジヒドロピリジン化合物 |
DK1106614T3 (da) | 1999-12-10 | 2004-04-13 | Pfizer | 5-leddede, heteroarylsubstituerede 1,4-dihydropyridinforbindelser som bradykininantagonister |
EP1106615B1 (fr) | 1999-12-10 | 2003-03-05 | Pfizer Inc. | Composés de 1,4-dihydropyridines substitués ayant une fonction d'antagonistes bradykinines |
-
2001
- 2001-07-11 US US09/903,157 patent/US6653313B2/en not_active Expired - Fee Related
- 2001-07-26 WO PCT/IB2001/001346 patent/WO2002012235A1/fr active IP Right Grant
- 2001-07-26 AT AT01949836T patent/ATE312099T1/de not_active IP Right Cessation
- 2001-07-26 ES ES01949836T patent/ES2257422T3/es not_active Expired - Lifetime
- 2001-07-26 JP JP2002518210A patent/JP2004505973A/ja active Pending
- 2001-07-26 CA CA002418908A patent/CA2418908C/fr not_active Expired - Fee Related
- 2001-07-26 IL IL15322401A patent/IL153224A0/xx unknown
- 2001-07-26 AP APAP/P/2001/002238A patent/AP2001002238A0/en unknown
- 2001-07-26 MX MXPA03001204A patent/MXPA03001204A/es unknown
- 2001-07-26 EP EP01949836A patent/EP1307449B1/fr not_active Expired - Lifetime
- 2001-07-26 AU AU2001270947A patent/AU2001270947A1/en not_active Abandoned
- 2001-07-26 DE DE60115661T patent/DE60115661T2/de not_active Expired - Fee Related
- 2001-07-26 BR BR0113071-4A patent/BR0113071A/pt not_active IP Right Cessation
- 2001-07-27 GT GT200100153A patent/GT200100153A/es unknown
- 2001-08-08 PE PE2001000796A patent/PE20020467A1/es not_active Application Discontinuation
- 2001-08-09 TN TNTNSN01124A patent/TNSN01124A1/fr unknown
- 2001-08-09 AR ARP010103819A patent/AR034555A1/es not_active Application Discontinuation
- 2001-08-09 SV SV2001000588A patent/SV2003000588A/es not_active Application Discontinuation
- 2001-08-10 PA PA20018525001A patent/PA8525001A1/es unknown
-
2002
- 2002-11-28 IS IS6639A patent/IS6639A/is unknown
- 2002-12-13 CR CR6859A patent/CR6859A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE312099T1 (de) | 2005-12-15 |
AU2001270947A1 (en) | 2002-02-18 |
PE20020467A1 (es) | 2002-06-14 |
JP2004505973A (ja) | 2004-02-26 |
SV2003000588A (es) | 2003-01-13 |
EP1307449B1 (fr) | 2005-12-07 |
PA8525001A1 (es) | 2002-08-26 |
IS6639A (is) | 2002-11-28 |
AR034555A1 (es) | 2004-03-03 |
CR6859A (es) | 2003-11-25 |
EP1307449A1 (fr) | 2003-05-07 |
ES2257422T3 (es) | 2006-08-01 |
US6653313B2 (en) | 2003-11-25 |
DE60115661T2 (de) | 2006-08-24 |
CA2418908A1 (fr) | 2002-02-14 |
WO2002012235A1 (fr) | 2002-02-14 |
DE60115661D1 (de) | 2006-01-12 |
IL153224A0 (en) | 2003-07-06 |
AP2001002238A0 (en) | 2001-09-30 |
US20020161006A1 (en) | 2002-10-31 |
BR0113071A (pt) | 2003-07-01 |
GT200100153A (es) | 2002-07-03 |
CA2418908C (fr) | 2006-05-09 |
MXPA03001204A (es) | 2003-06-30 |
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