PE20030719A1 - Derivados de 8-[bis(2-halofenil)metil]-3-heteroaril-8-azabiciclo[3.2.1] octan-3-ol como agonistas del receptor de nociceptina orl-1 - Google Patents

Derivados de 8-[bis(2-halofenil)metil]-3-heteroaril-8-azabiciclo[3.2.1] octan-3-ol como agonistas del receptor de nociceptina orl-1

Info

Publication number
PE20030719A1
PE20030719A1 PE2002001078A PE2002001078A PE20030719A1 PE 20030719 A1 PE20030719 A1 PE 20030719A1 PE 2002001078 A PE2002001078 A PE 2002001078A PE 2002001078 A PE2002001078 A PE 2002001078A PE 20030719 A1 PE20030719 A1 PE 20030719A1
Authority
PE
Peru
Prior art keywords
methyl
octan
bis
azabicyclo
alkyl
Prior art date
Application number
PE2002001078A
Other languages
English (en)
Inventor
Ginny D Ho
Deen Tulshian
Fay W Ng
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20030719A1 publication Critical patent/PE20030719A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A DERIVADOS DE HETEROARILO DE FORMULA I DONDE R ES R4-HETEROARILO, ENTRE OTROS; R1 ES H, ALQUILO C1-C6; R2 Y R3 SON METILO, METOXI, HALO; R4 ES H, HALO, ALQUILO C1-C6, -CN, CF3, OCF3, ENTRE OTROS; R5 Y R6 SON H, ALQUILO C1-C3; R7 ES ALQUILO C1-C3, AMINOALQUILO C1-C3. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. SON COMPUESTOS PREFERIDOS 8-[BIS(2-CLOROFENIL)METIL]-3-(2-PIRIMIDINIL)-8-AZABICICLO[3.2.1]OCTAN-3-OL, 8-[BIS(2-CLOROFENIL)METIL]-3-(5-ETIL-2-PIRIMIDINIL)-8-AZABICICLO[3.2.1]OCTAN-3-OL, 8-[BIS(2-CLOROFENIL)METIL]-3-(4-(1-PIPERAZINIL)-2-PIRIMIDINIL)-8-AZABICICLO[3.2.1]OCTAN-3-OL, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON LIGANDOS SUPERIORES PARA EL RECEPTOR DE NOCIPEPTINA ORL-1 Y SON UTILES PARA EL TRATAMIENTO DE LA TOS, DOLOR, ANSIEDAD, ASMA
PE2002001078A 2001-11-07 2002-11-05 Derivados de 8-[bis(2-halofenil)metil]-3-heteroaril-8-azabiciclo[3.2.1] octan-3-ol como agonistas del receptor de nociceptina orl-1 PE20030719A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33328401P 2001-11-07 2001-11-07

Publications (1)

Publication Number Publication Date
PE20030719A1 true PE20030719A1 (es) 2003-08-28

Family

ID=23302135

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001078A PE20030719A1 (es) 2001-11-07 2002-11-05 Derivados de 8-[bis(2-halofenil)metil]-3-heteroaril-8-azabiciclo[3.2.1] octan-3-ol como agonistas del receptor de nociceptina orl-1

Country Status (27)

Country Link
US (1) US6727254B2 (es)
EP (1) EP1442036B1 (es)
JP (2) JP4246066B2 (es)
KR (1) KR100596261B1 (es)
CN (1) CN1252068C (es)
AR (1) AR037211A1 (es)
AT (1) ATE315566T1 (es)
BR (1) BR0213907A (es)
CA (1) CA2465871C (es)
CY (1) CY1105208T1 (es)
DE (1) DE60208724T2 (es)
DK (1) DK1442036T3 (es)
EC (1) ECSP045096A (es)
ES (1) ES2256590T3 (es)
HK (1) HK1063019A1 (es)
HU (1) HUP0402329A2 (es)
IL (2) IL161120A0 (es)
MX (1) MXPA04004276A (es)
MY (1) MY126268A (es)
NO (1) NO329026B1 (es)
NZ (1) NZ532088A (es)
PE (1) PE20030719A1 (es)
PL (1) PL370269A1 (es)
RU (1) RU2327698C2 (es)
TW (1) TWI317360B (es)
WO (1) WO2003039469A2 (es)
ZA (1) ZA200403404B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
US20040067950A1 (en) * 1998-07-27 2004-04-08 Schering-Plough Corporation High affinity ligands for nociceptin receptor ORL-1
ATE443699T1 (de) 2002-12-06 2009-10-15 Purdue Research Foundation Pyridine zur behandlung von verletztemsäugetiernervengewebe
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
WO2005089761A1 (en) * 2004-03-17 2005-09-29 Pfizer Limited Combination for treating inflammatory diseases
CN100577661C (zh) * 2004-09-15 2010-01-06 先灵-普劳有限公司 取代的8-氮杂双环[3.2.1]辛-3-醇的制备方法
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
PE20071159A1 (es) * 2005-10-31 2007-11-30 Schering Corp Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
BRPI0911031B8 (pt) * 2008-07-21 2021-05-25 Purdue Pharma Lp compostos de piperidina ligada do tipo quinoxalina substituídos e os usos destes
GB201004311D0 (en) 2010-03-15 2010-04-28 Proximagen Ltd New enzyme inhibitor compounds
GB201115853D0 (en) 2011-09-14 2011-10-26 Proximagen Ltd New enzyme inhibitor compounds
US9724340B2 (en) * 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352707A (en) 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
TW590268U (en) * 2000-08-08 2004-06-01 Wistron Corp Heat dissipating device

Also Published As

Publication number Publication date
KR20050043725A (ko) 2005-05-11
JP2005508367A (ja) 2005-03-31
CN1252068C (zh) 2006-04-19
DE60208724D1 (de) 2006-04-06
DK1442036T3 (da) 2006-05-15
US20030119847A1 (en) 2003-06-26
JP4246066B2 (ja) 2009-04-02
BR0213907A (pt) 2004-09-28
TW200301765A (en) 2003-07-16
CA2465871C (en) 2009-01-20
MXPA04004276A (es) 2004-08-11
JP2009035556A (ja) 2009-02-19
ECSP045096A (es) 2004-06-28
CY1105208T1 (el) 2010-03-03
WO2003039469A2 (en) 2003-05-15
AR037211A1 (es) 2004-10-27
DE60208724T2 (de) 2006-11-02
CA2465871A1 (en) 2003-05-15
ZA200403404B (en) 2005-08-15
RU2004117542A (ru) 2006-01-10
ATE315566T1 (de) 2006-02-15
HK1063019A1 (en) 2004-12-10
NO329026B1 (no) 2010-08-02
IL161120A0 (en) 2004-08-31
TWI317360B (en) 2009-11-21
EP1442036B1 (en) 2006-01-11
HUP0402329A2 (hu) 2005-02-28
ES2256590T3 (es) 2006-07-16
NO20042294L (no) 2004-07-15
KR100596261B1 (ko) 2006-06-30
CN1582288A (zh) 2005-02-16
IL161120A (en) 2010-11-30
PL370269A1 (en) 2005-05-16
NZ532088A (en) 2006-05-26
WO2003039469A3 (en) 2003-10-16
EP1442036A2 (en) 2004-08-04
RU2327698C2 (ru) 2008-06-27
US6727254B2 (en) 2004-04-27
MY126268A (en) 2006-09-29

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