HUP0201834A2 - Thyromimetikus vegyületek alkalmazása hajhullás kezelésére szolgáló gyógyszerkészítmény előállítására és ilyen készítmények - Google Patents

Thyromimetikus vegyületek alkalmazása hajhullás kezelésére szolgáló gyógyszerkészítmény előállítására és ilyen készítmények

Info

Publication number
HUP0201834A2
HUP0201834A2 HU0201834A HUP0201834A HUP0201834A2 HU P0201834 A2 HUP0201834 A2 HU P0201834A2 HU 0201834 A HU0201834 A HU 0201834A HU P0201834 A HUP0201834 A HU P0201834A HU P0201834 A2 HUP0201834 A2 HU P0201834A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
hydrogen
atom
optionally substituted
Prior art date
Application number
HU0201834A
Other languages
English (en)
Inventor
Yuan-Ching Phoebe Chiang
Peter Cornelius
Niall Stephen Doherty
Robert Lee Dow
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HU0201834D0 publication Critical patent/HU0201834D0/hu
Publication of HUP0201834A2 publication Critical patent/HUP0201834A2/hu
Publication of HUP0201834A3 publication Critical patent/HUP0201834A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4966—Triazines or their condensed derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Abstract

A találmány szerinti (I) általános képletű vegyületek, képletében R1,R2 és R3 jelentése hidrogén-, halogénatom, alkil-, trifluormetil-, -CN, adott esetben szubsztituált alkoxicsoport, R4 jelentésehidrogénatom vagy adott esetben szubsztituált alkilcsoport vagy R3 ésR4 együtt adott esetben szubsztituált alkiléncsoport vagyheteroatomként oxigén-, kén- vagy nitrogénatomot tartalmazóheterociklusos gyűrű; R5 jelentése fluoratom, hidroxil-, alkoxi- vagy-OC(O)R9 csoport vagy R4 és R5 együtt heteroatomként oxigén-, kén-vagy nitrogénatomot tartalmazó telítetlen heterociklusos gyűrű; R6jelentése hidrogén-, halogénatom, alkil- vagy trifluormetilcsoport; R7 jelentése hidrogénatom vagy alkilcsoport; R8 jelentése -OR9 vagy- NR19R20 csoport; R9 jelentése hidrogénatom, adott esetbenszubsztituált alkil-, cikloalkil-, aril-r Hetcsoport vagyalkenilcsoport; R19 és R20 jelentése hidrogénatom vagy alkilcsoport; W jelentése -O-, -S(O)d,-CH2- vagy -NR9; Het jelentése 4-8 tagú,telített vagy telítetlen, a nitrogén-, oxigén- vagy kénatomok közülkiválasztott 1-4 heteroatomot tartalmazó heterociklusos gyűrű; dértéke 0, 1 vagy 2. Ó
HU0201834A 2001-05-31 2002-05-30 Use of thyromimetic compounds for the manufacture of a pharmaceutical composition for the treatment of hair loss and such compositions HUP0201834A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29496201P 2001-05-31 2001-05-31

Publications (3)

Publication Number Publication Date
HU0201834D0 HU0201834D0 (hu) 2002-08-28
HUP0201834A2 true HUP0201834A2 (hu) 2003-01-28
HUP0201834A3 HUP0201834A3 (en) 2004-03-29

Family

ID=23135661

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201834A HUP0201834A3 (en) 2001-05-31 2002-05-30 Use of thyromimetic compounds for the manufacture of a pharmaceutical composition for the treatment of hair loss and such compositions

Country Status (19)

Country Link
US (2) US20030007941A1 (hu)
EP (1) EP1262177B1 (hu)
JP (1) JP4051230B2 (hu)
KR (1) KR100523503B1 (hu)
CN (1) CN1314393C (hu)
AT (1) ATE337009T1 (hu)
AU (1) AU784806B2 (hu)
CA (1) CA2387198C (hu)
CY (1) CY1105221T1 (hu)
DE (1) DE60214080T2 (hu)
DK (1) DK1262177T3 (hu)
ES (1) ES2267945T3 (hu)
HK (1) HK1049285B (hu)
HU (1) HUP0201834A3 (hu)
IL (2) IL149843A (hu)
PL (1) PL354216A1 (hu)
PT (1) PT1262177E (hu)
TW (1) TWI278313B (hu)
ZA (1) ZA200204189B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
US7485298B2 (en) 2002-05-23 2009-02-03 Michael Powell Diagnosis and treatment of human dormancy-related sequellae
WO2003099105A2 (en) * 2002-05-23 2003-12-04 Powell Michael J Diagnosis and treatment of human dormancy syndrome
US7622103B1 (en) * 2003-03-27 2009-11-24 Cielo Jill M Hair and scalp toxin remover composition and method of its making
CA2964111A1 (en) * 2005-03-29 2006-10-05 The Trustees Of The University Of Pennsylvania Methods for generating new hair folicles, treating baldness, and hair removal
US8147815B2 (en) * 2005-12-16 2012-04-03 Celmatrix Corporation Topical administration carrier composition and therapeutic formulations comprising same
CN102459185B (zh) 2009-04-20 2015-06-03 田边三菱制药株式会社 新型甲状腺激素β受体激动剂
BR112013014021A8 (pt) 2010-12-06 2017-10-03 Follica Inc Métodos para tratamento de calvície e promoção de crescimento de cabelos
JP6156371B2 (ja) * 2012-06-08 2017-07-05 大正製薬株式会社 発毛組成物
PL2695611T3 (pl) * 2012-08-06 2015-03-31 Dr August Wolff Gmbh & Co Kg Arzneimittel Eprotirom do stosowania w profilaktyce i/lub leczeniu zaburzeń włosów oraz jego kompozycje
US9827181B2 (en) 2013-06-05 2017-11-28 Industrial Technology Research Institute Method and pharmaceutical composition for hair growth
US9402876B2 (en) 2013-11-27 2016-08-02 Industrial Technology Research Institute Method and pharmaceutical composition for hair growth
CN104306168B (zh) * 2014-10-15 2017-05-24 华东师范大学 氮‑(4‑氯‑2,5‑二甲氧基苯基)‑5‑异丙基‑2‑甲氧基苯磺酰胺在促进毛发生长的应用
AU2017295038B2 (en) 2016-07-15 2022-09-22 Centre Hospitalier Sainte Anne Paris 5-hydroxytryptamine 1B receptor-stimulating agent for skin and/or hair repair
US9962444B2 (en) 2016-09-27 2018-05-08 Shane Malek Pharmacokinetically extended action topical hair growth formulation, and administration method
JP7360583B2 (ja) 2017-09-14 2023-10-13 国立研究開発法人理化学研究所 網膜組織の製造方法
CN108727344A (zh) * 2018-05-14 2018-11-02 嘉兴特科罗生物科技有限公司 一种化合物及其合成方法和应用
US11628132B2 (en) 2018-10-05 2023-04-18 Jupiter Wellness, Inc. Minoxidil adjuvant therapies
US11766392B2 (en) * 2018-10-05 2023-09-26 Jupiter Wellness, Inc. Minoxidil adjuvant therapies
EP3939662A4 (en) 2019-03-13 2023-03-15 Sumitomo Pharma Co., Ltd. METHOD FOR ASSESSING THE QUALITY OF A TRANSPLANT NEURAL RETINA, AND TRANSPLANT NEURAL RETINA SHEET
US11091467B2 (en) 2019-05-08 2021-08-17 Aligos Therapeutics, Inc. Modulators of THR-β and methods of use thereof
AU2021208027A1 (en) 2020-01-13 2022-07-28 Eccogene (Shanghai) Co., Ltd. Substituted triazinones as thyroid hormone receptor agonists
CN114075173A (zh) * 2020-08-19 2022-02-22 成都凡诺西生物医药科技有限公司 腈代三嗪类衍生物及其制备方法和应用
CA3194226A1 (en) 2020-09-11 2022-03-17 Riken Complex containing neural retina-containing cell aggregates and matrix, and method for manufacturing same
WO2022054924A1 (ja) 2020-09-11 2022-03-17 大日本住友製薬株式会社 移植用組織のための媒体
CN116327765A (zh) * 2023-03-27 2023-06-27 广州许愿树毛发医学科技有限公司 莲心碱类化合物作为β2-肾上腺素受体阻断剂的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ209246A (en) * 1983-08-17 1989-04-26 Wellcome Found Monoclonal hormone antibody formulations which potentiate or mimic hormone administration in vertebrates
JPS61165311A (ja) * 1985-01-14 1986-07-26 Takeo Kinji 養毛化粧料
US5061798A (en) * 1985-01-18 1991-10-29 Smith Kline & French Laboratories, Ltd. Benzyl pyridyl and pyridazinyl compounds
US5284971A (en) * 1992-07-16 1994-02-08 Syntex (U.S.A.) Inc. 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents
WO1994023717A1 (en) * 1993-04-20 1994-10-27 The Procter & Gamble Company Methods of using hesperetin for sebum control and treatment of acne
TW382595B (en) * 1993-10-15 2000-02-21 Merck & Co Inc Pharmaceutical composition for use in arresting and reversing androgenic alopecia
AU729411B2 (en) * 1997-01-23 2001-02-01 Taisho Pharmaceutical Co., Ltd. Sustained release hair growth preparation
CZ20013117A3 (cs) * 1999-03-01 2002-06-12 Pfizer Products Inc. Oxamové kyseliny a jejich deriváty jako ligandy thyreoidního receptoru
CO5160290A1 (es) * 1999-03-29 2002-05-30 Novartis Ag Derivados de acido fenoxifeniloxamico sustituido .
AU3507600A (en) * 1999-06-01 2000-12-18 University Of Texas Southwestern Medical Center, The Substituted biaryl ether compounds
CA2375667A1 (en) * 1999-06-01 2000-12-07 The University Of Texas Southwestern Medical Center Sulfur-containing thyroxane derivatives and their use as hair growth promotors
AU3712100A (en) * 1999-06-01 2000-12-18 University Of Texas Southwestern Medical Center, The Method of treating hair loss using sulfonyl thyromimetic compounds
US6525094B1 (en) * 1999-06-01 2003-02-25 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylether derivatives
JP2003500483A (ja) * 1999-06-01 2003-01-07 ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター ビアリール化合物
ATE297905T1 (de) * 1999-09-30 2005-07-15 Pfizer Prod Inc 6-azauracilderivate als liganden der thyroidrezeptoren
CA2403806A1 (en) * 2000-03-23 2002-09-20 Bayer Aktiengesellschaft Indoles for treating diseases that can be treated using thyroid hormones
AU2002223626A1 (en) * 2000-10-20 2002-04-29 Novartis Ag Combinations of a thyromimetic compound and a statin

Also Published As

Publication number Publication date
US20080125433A1 (en) 2008-05-29
DE60214080D1 (de) 2006-10-05
CA2387198C (en) 2007-02-13
KR100523503B1 (ko) 2005-10-26
EP1262177A3 (en) 2003-09-03
ES2267945T3 (es) 2007-03-16
HK1049285A1 (en) 2003-05-09
AU784806B2 (en) 2006-06-29
CY1105221T1 (el) 2010-03-03
AU4446202A (en) 2002-12-05
EP1262177A2 (en) 2002-12-04
IL149843A (en) 2008-11-26
IL188110A0 (en) 2008-03-20
CN1314393C (zh) 2007-05-09
PT1262177E (pt) 2006-12-29
CN1389203A (zh) 2003-01-08
TWI278313B (en) 2007-04-11
HK1049285B (zh) 2007-08-24
IL149843A0 (en) 2002-11-10
DE60214080T2 (de) 2007-01-04
HUP0201834A3 (en) 2004-03-29
KR20020092247A (ko) 2002-12-11
ZA200204189B (en) 2003-11-27
HU0201834D0 (hu) 2002-08-28
JP2002370978A (ja) 2002-12-24
ATE337009T1 (de) 2006-09-15
US20030007941A1 (en) 2003-01-09
CA2387198A1 (en) 2002-11-30
JP4051230B2 (ja) 2008-02-20
PL354216A1 (en) 2002-12-02
EP1262177B1 (en) 2006-08-23
DK1262177T3 (da) 2006-11-20

Similar Documents

Publication Publication Date Title
HUP0201834A2 (hu) Thyromimetikus vegyületek alkalmazása hajhullás kezelésére szolgáló gyógyszerkészítmény előállítására és ilyen készítmények
TR200400541T4 (tr) Terapide faydalı tropan türevleri.
SE0203754D0 (sv) New compounds
NZ518144A (en) Piperazine Compounds
DE69902634T2 (de) Substituierte aminophenylisoxazolinderivate verwendbar als antimikrobielle agenzien
HUP0401303A2 (hu) Fungicid hatással rendelkező jódbenzopirán-4-on-származékok, előállításuk, alkalmazásuk és ilyeneket tartalmazó készítmények
AR040031A1 (es) Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienen
CY1106497T1 (el) Νεες αρυλοξυ-αλκυλ-διαλκυλαμινες
AR034268A1 (es) Compuestos derivados de piperidina, su uso en preparacion de medicamentos, composicion farmaceutica, metodo de tratamiento y proceso para su preparacion
DK526188D0 (da) Benzimidazolin-2-oxo-1-carboxylsyrederivater til anvendelse som 5-ht receptorantagonister i farmaceutiske praeparater
SE7906722L (sv) Merkaptoacylderivat av substituerade proliner
HUP0300922A2 (hu) Új vegyületek, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
PE20030610A1 (es) Derivados de 3-azabiciclo[3.1.0]hexano con afinidad a los receptores opioides
BR9307580A (pt) Compostos processo para a preparação dos mesmos composições farmacêuticas uso de um composto e processo de tratamento de um mamífero que inclui o ser humano
SE9703377D0 (sv) New compounds
AR041246A1 (es) Derivados de piridina; un procedimiento de preparacion de los mismos y composicion farmaceutica que los contiene
NZ528997A (en) Sulfonamides
SE9703378D0 (sv) New compounds
TR200000725T2 (tr) Bir monoamin oksidaz inhibitörü ve h5-HT1B antagonistinin bileşimi
PE20020444A1 (es) Antagonistas de receptores de taquiquinina zwitterionica
PE20030719A1 (es) Derivados de 8-[bis(2-halofenil)metil]-3-heteroaril-8-azabiciclo[3.2.1] octan-3-ol como agonistas del receptor de nociceptina orl-1
CO5540322A2 (es) Nuevos derivados heterociclicos que comprenden un anillo de tetrahidroisoquinolina y uso farmaceutico de los mismos
HUP0400238A2 (hu) Pirrolidin-oxadiazol- és tiadiazolszármazékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
CO5540342A2 (es) Compuestos derivados de tetraisoquinolina que son agentes hipoglicemiantes e hipolipidemicos, y composiciones farmaceuticas que los contienen
HK1042697A1 (en) Process to prepare cyclic-sulfur fluorine containing oxazolidinones

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees