TR200000725T2 - Bir monoamin oksidaz inhibitörü ve h5-HT1B antagonistinin bileşimi - Google Patents
Bir monoamin oksidaz inhibitörü ve h5-HT1B antagonistinin bileşimiInfo
- Publication number
- TR200000725T2 TR200000725T2 TR2000/00725T TR200000725T TR200000725T2 TR 200000725 T2 TR200000725 T2 TR 200000725T2 TR 2000/00725 T TR2000/00725 T TR 2000/00725T TR 200000725 T TR200000725 T TR 200000725T TR 200000725 T2 TR200000725 T2 TR 200000725T2
- Authority
- TR
- Turkey
- Prior art keywords
- composition
- alkyl
- monoamine oxidase
- oxidase inhibitor
- formula
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 title abstract 2
- 239000002899 monoamine oxidase inhibitor Substances 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000027534 Emotional disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000030459 obsessive-compulsive personality disease Diseases 0.000 abstract 1
- 208000007656 osteochondritis dissecans Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000004000 serotonin 1B antagonist Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Bulus, monoamin oksidaz inhibitörü olan birinci bilesen (a) ile, formül (I)'e sahip olan ; ki bu formülde, x CH2, O'dir; Y CONH,NHCO, R1,C1-C6 alkil, C3-C6 sikloalkil, R2,H,C1-C6 alkil, C1-C6 alkoksi, halojen; R3 formül (II); R4 ve R5 birbirinden bagimsiz bir biçimde H veya C1-C4 alkil olup, resemat R-enantiyometri veya S-enantiyomeridir, seçici bir 5-HT1B reseptör antagonisti olan ikinci bilesenin (b) bir bilesimi ile ilgilidir ve sözü edilen bilesenler (a) ve (b)'nin serbest bazlari, solvatlari veya farmasötik olarak kabul edilebilir (Ilaç sanayiinde kullanima uygun) tuzlari seklinde olup, bunlarin hazirlanmalari, sözü edilen bilesimleri içeren farmasötik formülasyonlar, sözü edilen bilesimi içeren bir kitin yani sira, sözü edilen bilesim ile deprasyon, anksiyete ve OCD gibi duygusal bozukluklarin tedavisinin yöntemi ve kullanimi ile ilgilidir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703376A SE9703376D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000725T2 true TR200000725T2 (tr) | 2000-08-21 |
Family
ID=20408296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00725T TR200000725T2 (tr) | 1997-09-18 | 1998-09-09 | Bir monoamin oksidaz inhibitörü ve h5-HT1B antagonistinin bileşimi |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6159970A (tr) |
| EP (1) | EP1014986B1 (tr) |
| JP (1) | JP2001516719A (tr) |
| KR (2) | KR20010024087A (tr) |
| CN (1) | CN1278727A (tr) |
| AR (1) | AR013503A1 (tr) |
| AT (1) | ATE270889T1 (tr) |
| AU (1) | AU752719B2 (tr) |
| BR (1) | BR9812236A (tr) |
| CA (1) | CA2302204A1 (tr) |
| DE (1) | DE69825062T2 (tr) |
| DK (1) | DK1014986T3 (tr) |
| EE (1) | EE200000146A (tr) |
| ES (1) | ES2222603T3 (tr) |
| HU (1) | HUP0100621A2 (tr) |
| ID (1) | ID25789A (tr) |
| IL (1) | IL134775A0 (tr) |
| IS (1) | IS5401A (tr) |
| MX (1) | MXPA00002616A (tr) |
| NO (1) | NO20001400L (tr) |
| PL (1) | PL339368A1 (tr) |
| PT (1) | PT1014986E (tr) |
| SE (1) | SE9703376D0 (tr) |
| SK (1) | SK2832000A3 (tr) |
| TR (1) | TR200000725T2 (tr) |
| WO (1) | WO1999013878A1 (tr) |
| ZA (1) | ZA987804B (tr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957948A (en) * | 1988-05-05 | 1990-09-18 | Interface, Inc. | Biocidal protective coating for heat exchanger coils |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| WO2002066454A1 (fr) * | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Derives de chromene |
| DK1408976T5 (da) * | 2001-07-20 | 2011-01-10 | Psychogenics Inc | Behandling af ADHD (Attention deficit hyperactivity disorder) |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| WO2007108742A1 (en) * | 2006-03-17 | 2007-09-27 | Astrazeneca Ab | Novel tetralins as 5-ht6 modulators |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| CA2679446C (en) | 2007-03-01 | 2016-05-17 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| BR112012008346B1 (pt) | 2009-09-11 | 2021-12-21 | Vivoryon Therapeutics N.V. | Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| CN110179988A (zh) * | 2019-07-10 | 2019-08-30 | 王大伟 | 五羟色胺再摄取抑制剂和单胺氧化酶抑制剂联合在制备治疗抑郁症或早泄药物中的应用 |
| EP4633638A1 (en) * | 2022-12-14 | 2025-10-22 | Luminous Mind Inc. | Treatment of psychological factors affecting other medical conditions (pfaomc) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2162792T3 (es) * | 1991-09-18 | 2002-01-16 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d. |
| GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
-
1997
- 1997-09-18 SE SE9703376A patent/SE9703376D0/xx unknown
-
1998
- 1998-08-27 ZA ZA987804A patent/ZA987804B/xx unknown
- 1998-09-09 HU HU0100621A patent/HUP0100621A2/hu unknown
- 1998-09-09 SK SK283-2000A patent/SK2832000A3/sk unknown
- 1998-09-09 ID IDW20000522D patent/ID25789A/id unknown
- 1998-09-09 EP EP98944376A patent/EP1014986B1/en not_active Expired - Lifetime
- 1998-09-09 KR KR1020007002835A patent/KR20010024087A/ko not_active Ceased
- 1998-09-09 MX MXPA00002616A patent/MXPA00002616A/es unknown
- 1998-09-09 AU AU91931/98A patent/AU752719B2/en not_active Ceased
- 1998-09-09 PT PT98944376T patent/PT1014986E/pt unknown
- 1998-09-09 US US09/171,578 patent/US6159970A/en not_active Expired - Fee Related
- 1998-09-09 BR BR9812236-3A patent/BR9812236A/pt not_active IP Right Cessation
- 1998-09-09 AT AT98944376T patent/ATE270889T1/de not_active IP Right Cessation
- 1998-09-09 PL PL98339368A patent/PL339368A1/xx unknown
- 1998-09-09 EE EEP200000146A patent/EE200000146A/xx unknown
- 1998-09-09 IL IL13477598A patent/IL134775A0/xx unknown
- 1998-09-09 ES ES98944376T patent/ES2222603T3/es not_active Expired - Lifetime
- 1998-09-09 JP JP2000511500A patent/JP2001516719A/ja active Pending
- 1998-09-09 DE DE69825062T patent/DE69825062T2/de not_active Expired - Fee Related
- 1998-09-09 DK DK98944376T patent/DK1014986T3/da active
- 1998-09-09 CN CN98811114A patent/CN1278727A/zh active Pending
- 1998-09-09 TR TR2000/00725T patent/TR200000725T2/tr unknown
- 1998-09-09 CA CA002302204A patent/CA2302204A1/en not_active Abandoned
- 1998-09-09 WO PCT/SE1998/001602 patent/WO1999013878A1/en not_active Ceased
- 1998-09-09 KR KR1020007002830A patent/KR20010024084A/ko not_active Withdrawn
- 1998-09-17 AR ARP980104635A patent/AR013503A1/es unknown
-
2000
- 2000-03-14 IS IS5401A patent/IS5401A/is unknown
- 2000-03-17 NO NO20001400A patent/NO20001400L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR013503A1 (es) | 2000-12-27 |
| DK1014986T3 (da) | 2004-10-25 |
| HUP0100621A2 (hu) | 2001-08-28 |
| NO20001400L (no) | 2000-05-05 |
| CA2302204A1 (en) | 1999-03-25 |
| JP2001516719A (ja) | 2001-10-02 |
| NO20001400D0 (no) | 2000-03-17 |
| MXPA00002616A (es) | 2002-04-24 |
| EE200000146A (et) | 2001-02-15 |
| AU752719B2 (en) | 2002-09-26 |
| SE9703376D0 (sv) | 1997-09-18 |
| US6159970A (en) | 2000-12-12 |
| PT1014986E (pt) | 2004-10-29 |
| KR20010024084A (ko) | 2001-03-26 |
| CN1278727A (zh) | 2001-01-03 |
| SK2832000A3 (en) | 2000-09-12 |
| ZA987804B (en) | 1999-03-18 |
| IS5401A (is) | 2000-03-14 |
| BR9812236A (pt) | 2000-07-18 |
| WO1999013878A1 (en) | 1999-03-25 |
| EP1014986A1 (en) | 2000-07-05 |
| ATE270889T1 (de) | 2004-07-15 |
| IL134775A0 (en) | 2001-04-30 |
| EP1014986B1 (en) | 2004-07-14 |
| DE69825062D1 (de) | 2004-08-19 |
| AU9193198A (en) | 1999-04-05 |
| ES2222603T3 (es) | 2005-02-01 |
| ID25789A (id) | 2000-11-02 |
| PL339368A1 (en) | 2000-12-18 |
| KR20010024087A (ko) | 2001-03-26 |
| DE69825062T2 (de) | 2005-08-25 |
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