SE9703376D0 - A new combination - Google Patents
A new combinationInfo
- Publication number
- SE9703376D0 SE9703376D0 SE9703376A SE9703376A SE9703376D0 SE 9703376 D0 SE9703376 D0 SE 9703376D0 SE 9703376 A SE9703376 A SE 9703376A SE 9703376 A SE9703376 A SE 9703376A SE 9703376 D0 SE9703376 D0 SE 9703376D0
- Authority
- SE
- Sweden
- Prior art keywords
- combination
- pct
- alkyl
- enantiomer
- sec
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Priority Applications (28)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703376A SE9703376D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
| ZA987804A ZA987804B (en) | 1997-09-18 | 1998-08-27 | A combination of a monoamine oxidase inhibitor and a H5-HT1b antagonists or agonist |
| SK283-2000A SK2832000A3 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A H5-HT1Bì (54) ANTAGONIST OR PARTIAL AGONIST |
| KR1020007002835A KR20010024087A (ko) | 1997-09-18 | 1998-09-09 | 모노아민 옥시다제 억제제 및 ｈ5-ＨＴ1Ｂ 길항제 또는부분 작용제의 배합물 |
| TR2000/00725T TR200000725T2 (tr) | 1997-09-18 | 1998-09-09 | Bir monoamin oksidaz inhibitörü ve h5-HT1B antagonistinin bileşimi |
| DK98944376T DK1014986T3 (da) | 1997-09-18 | 1998-09-09 | Kombination af en inhibitor for monoaminoxidase og en antagonist eller delvis agonist for h5-HT 1 beta |
| PL98339368A PL339368A1 (en) | 1997-09-18 | 1998-09-09 | Composition of monoamine oxidase inhibitor and antagonist or partial agonist of h5-ht 1b |
| IDW20000522D ID25789A (id) | 1997-09-18 | 1998-09-09 | KOMBINASI DARI INHIBITOR MONOAMINA OKSIDASI DAN ANTAGONIS ATAU SEBAGIAN AGONIS h5-HT1B |
| PCT/SE1998/001602 WO1999013878A1 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A h5-HT1B ANTAGONIST OR PARTIAL AGONIST |
| HU0100621A HUP0100621A2 (hu) | 1997-09-18 | 1998-09-09 | Monoamin oxidáz inhibitor hatású vegyületek és h5-HT1B antagonista vagy részleges agonista hatású vegyületek kombinációját tartalmazó gyógyászati készítmények |
| EP98944376A EP1014986B1 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A h5-HT 1 BETA ANTAGONIST OR PARTIAL AGONIST |
| US09/171,578 US6159970A (en) | 1997-09-18 | 1998-09-09 | Combination of a monoamine oxidase inhibitor and a h5-HT1B antagonist or partial agonist |
| BR9812236-3A BR9812236A (pt) | 1997-09-18 | 1998-09-09 | Combinação de componentes, uso desta, processos para a preparação da mesma, para o tratamento de distúrbios afetivos, para o tratamento de depressão, e para melhorar o inìcio de ação terapêutica, formulação farmacêutica, e, kit |
| KR1020007002830A KR20010024084A (ko) | 1997-09-18 | 1998-09-09 | 모노아민 옥시다제 억제제 및 ｈ5-ＨＴ1Ｂ 길항제 또는부분 작용제의 배합물 |
| IL13477598A IL134775A0 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A h5-HT1B ANTAGONIST OR PARTIAL AGONIST |
| CA002302204A CA2302204A1 (en) | 1997-09-18 | 1998-09-09 | A combination of a monoamine oxidase inhibitor and a h5-ht1b antagonist or partial agonist |
| CN98811114A CN1278727A (zh) | 1997-09-18 | 1998-09-09 | 单胺氧化酶抑制剂和h5－ht1B拮抗剂或部分激动剂的组合 |
| DE69825062T DE69825062T2 (de) | 1997-09-18 | 1998-09-09 | Monoaminoxidase inhibitor- und h5-ht 1 beta antagonist oder partiellagonist enthaltende mischung |
| AU91931/98A AU752719B2 (en) | 1997-09-18 | 1998-09-09 | A combination of a monoamine oxidase inhibitor and a h5-HT 1B antagonist or partial agonist |
| JP2000511500A JP2001516719A (ja) | 1997-09-18 | 1998-09-09 | モノアミンオキシダーゼ阻害剤およびｈ５−ＨＴ１Ｂアンタゴニストまたは部分的アゴニストの組み合わせ |
| EEP200000146A EE200000146A (et) | 1997-09-18 | 1998-09-09 | Monoamiini oksüdaasi inhibiitori kombinatsioon h5-HT 1B antagonisti või osalise agonistiga |
| PT98944376T PT1014986E (pt) | 1997-09-18 | 1998-09-09 | Uma combinacao de um inibidor da monoamino-oxidase e de um antagonista ou de umagonista parcial do h5-ht 1 beta |
| MXPA00002616A MXPA00002616A (es) | 1997-09-18 | 1998-09-09 | Combinacion de un inhibidor de la monoamina-oxidasa y un antagonista o agonista parcial de h5-ht1b. |
| AT98944376T ATE270889T1 (de) | 1997-09-18 | 1998-09-09 | Monoaminoxidase inhibitor- und h5-ht 1 beta antagonist oder partiellagonist enthaltende mischung |
| ES98944376T ES2222603T3 (es) | 1997-09-18 | 1998-09-09 | Una combinacion de un inhibidor de la monoamino-oxidasa y un antagonista o agonista parcial de h5-ht1 beta. |
| ARP980104635A AR013503A1 (es) | 1997-09-18 | 1998-09-17 | Una combinacion de un inhibidor de la monoamina oxidasa y un antagonista o agonista parcial selectivo de h5-ht(1b), formulacion farmaceutica, usos ymetodo de preparacion |
| IS5401A IS5401A (is) | 1997-09-18 | 2000-03-14 | Samsetning mónóamínoxídasa hemils og h5-HT1B mótlyfs eða gerandefnis með hlutaverkun |
| NO20001400A NO20001400L (no) | 1997-09-18 | 2000-03-17 | Kombinasjon av en monoaminooksidaseinhibitor og en h5-HT1B antagonist eller partiell agonist |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703376A SE9703376D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE9703376D0 true SE9703376D0 (sv) | 1997-09-18 |
Family
ID=20408296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9703376A SE9703376D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6159970A (xx) |
| EP (1) | EP1014986B1 (xx) |
| JP (1) | JP2001516719A (xx) |
| KR (2) | KR20010024087A (xx) |
| CN (1) | CN1278727A (xx) |
| AR (1) | AR013503A1 (xx) |
| AT (1) | ATE270889T1 (xx) |
| AU (1) | AU752719B2 (xx) |
| BR (1) | BR9812236A (xx) |
| CA (1) | CA2302204A1 (xx) |
| DE (1) | DE69825062T2 (xx) |
| DK (1) | DK1014986T3 (xx) |
| EE (1) | EE200000146A (xx) |
| ES (1) | ES2222603T3 (xx) |
| HU (1) | HUP0100621A2 (xx) |
| ID (1) | ID25789A (xx) |
| IL (1) | IL134775A0 (xx) |
| IS (1) | IS5401A (xx) |
| MX (1) | MXPA00002616A (xx) |
| NO (1) | NO20001400L (xx) |
| PL (1) | PL339368A1 (xx) |
| PT (1) | PT1014986E (xx) |
| SE (1) | SE9703376D0 (xx) |
| SK (1) | SK2832000A3 (xx) |
| TR (1) | TR200000725T2 (xx) |
| WO (1) | WO1999013878A1 (xx) |
| ZA (1) | ZA987804B (xx) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957948A (en) * | 1988-05-05 | 1990-09-18 | Interface, Inc. | Biocidal protective coating for heat exchanger coils |
| SE9601110D0 (sv) | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| WO2002066454A1 (en) * | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Chromene derivatives |
| US7504395B2 (en) * | 2001-07-20 | 2009-03-17 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US20090054453A1 (en) * | 2006-03-17 | 2009-02-26 | Lilian Alcaraz | Novel Tetralins as 5-HT6 Modulators |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| MX2012002993A (es) | 2009-09-11 | 2012-04-19 | Probiodrug Ag | Derivados heterociclicos como inhibidores de ciclasa glutaminilo. |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| MX2012010470A (es) | 2010-03-10 | 2012-10-09 | Probiodrug Ag | Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5). |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| CN110179988A (zh) * | 2019-07-10 | 2019-08-30 | 王大伟 | 五羟色胺再摄取抑制剂和单胺氧化酶抑制剂联合在制备治疗抑郁症或早泄药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE204262T1 (de) * | 1991-09-18 | 2001-09-15 | Glaxo Group Ltd | Benzanilidderivate als 5-ht1d-antagonisten |
| GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
-
1997
- 1997-09-18 SE SE9703376A patent/SE9703376D0/xx unknown
-
1998
- 1998-08-27 ZA ZA987804A patent/ZA987804B/xx unknown
- 1998-09-09 CA CA002302204A patent/CA2302204A1/en not_active Abandoned
- 1998-09-09 ES ES98944376T patent/ES2222603T3/es not_active Expired - Lifetime
- 1998-09-09 BR BR9812236-3A patent/BR9812236A/pt not_active IP Right Cessation
- 1998-09-09 KR KR1020007002835A patent/KR20010024087A/ko active Search and Examination
- 1998-09-09 AU AU91931/98A patent/AU752719B2/en not_active Ceased
- 1998-09-09 MX MXPA00002616A patent/MXPA00002616A/es unknown
- 1998-09-09 HU HU0100621A patent/HUP0100621A2/hu unknown
- 1998-09-09 EE EEP200000146A patent/EE200000146A/xx unknown
- 1998-09-09 DK DK98944376T patent/DK1014986T3/da active
- 1998-09-09 IL IL13477598A patent/IL134775A0/xx unknown
- 1998-09-09 SK SK283-2000A patent/SK2832000A3/sk unknown
- 1998-09-09 AT AT98944376T patent/ATE270889T1/de not_active IP Right Cessation
- 1998-09-09 JP JP2000511500A patent/JP2001516719A/ja active Pending
- 1998-09-09 EP EP98944376A patent/EP1014986B1/en not_active Expired - Lifetime
- 1998-09-09 ID IDW20000522D patent/ID25789A/id unknown
- 1998-09-09 CN CN98811114A patent/CN1278727A/zh active Pending
- 1998-09-09 WO PCT/SE1998/001602 patent/WO1999013878A1/en active IP Right Grant
- 1998-09-09 PT PT98944376T patent/PT1014986E/pt unknown
- 1998-09-09 DE DE69825062T patent/DE69825062T2/de not_active Expired - Fee Related
- 1998-09-09 KR KR1020007002830A patent/KR20010024084A/ko not_active Application Discontinuation
- 1998-09-09 PL PL98339368A patent/PL339368A1/xx unknown
- 1998-09-09 TR TR2000/00725T patent/TR200000725T2/xx unknown
- 1998-09-09 US US09/171,578 patent/US6159970A/en not_active Expired - Fee Related
- 1998-09-17 AR ARP980104635A patent/AR013503A1/es unknown
-
2000
- 2000-03-14 IS IS5401A patent/IS5401A/is unknown
- 2000-03-17 NO NO20001400A patent/NO20001400L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK2832000A3 (en) | 2000-09-12 |
| DE69825062D1 (de) | 2004-08-19 |
| PT1014986E (pt) | 2004-10-29 |
| DE69825062T2 (de) | 2005-08-25 |
| EP1014986A1 (en) | 2000-07-05 |
| AR013503A1 (es) | 2000-12-27 |
| JP2001516719A (ja) | 2001-10-02 |
| NO20001400L (no) | 2000-05-05 |
| TR200000725T2 (tr) | 2000-08-21 |
| ID25789A (id) | 2000-11-02 |
| AU9193198A (en) | 1999-04-05 |
| IS5401A (is) | 2000-03-14 |
| ES2222603T3 (es) | 2005-02-01 |
| IL134775A0 (en) | 2001-04-30 |
| EP1014986B1 (en) | 2004-07-14 |
| CA2302204A1 (en) | 1999-03-25 |
| BR9812236A (pt) | 2000-07-18 |
| WO1999013878A1 (en) | 1999-03-25 |
| CN1278727A (zh) | 2001-01-03 |
| AU752719B2 (en) | 2002-09-26 |
| KR20010024084A (ko) | 2001-03-26 |
| DK1014986T3 (da) | 2004-10-25 |
| KR20010024087A (ko) | 2001-03-26 |
| HUP0100621A2 (hu) | 2001-08-28 |
| ATE270889T1 (de) | 2004-07-15 |
| US6159970A (en) | 2000-12-12 |
| PL339368A1 (en) | 2000-12-18 |
| EE200000146A (et) | 2001-02-15 |
| ZA987804B (en) | 1999-03-18 |
| NO20001400D0 (no) | 2000-03-17 |
| MXPA00002616A (es) | 2002-04-24 |
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