TR200000727T2 - 5HT geri alım inhibitörü ve h5-HT1B antagonistinin bir bileşimi. - Google Patents
5HT geri alım inhibitörü ve h5-HT1B antagonistinin bir bileşimi.Info
- Publication number
- TR200000727T2 TR200000727T2 TR2000/00727T TR200000727T TR200000727T2 TR 200000727 T2 TR200000727 T2 TR 200000727T2 TR 2000/00727 T TR2000/00727 T TR 2000/00727T TR 200000727 T TR200000727 T TR 200000727T TR 200000727 T2 TR200000727 T2 TR 200000727T2
- Authority
- TR
- Turkey
- Prior art keywords
- combination
- composition
- reuptake inhibitor
- enantiomer
- component
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Replacement Of Web Rolls (AREA)
- Winding, Rewinding, Material Storage Devices (AREA)
Abstract
Bulus, bir 5-HT geri alim inhibitörü olan birinci bilesen (a) ve formül (I)'e sahip olan; ki bu formülde X CH2,O'dir, Y CONH,NHCO,R1,C1-C6 alkil, C3-C6sikloalkil, R2, H, C1-C6alkil, C1-C6alkoksi, halojen, R3 (1), (2), (3), (4), (5); R4 ve R5 birbirinden bagimsiz bir biçimde H ya da C1-C4alkil olup, rasemat R-enantiyomeri veya S-enantiyomeridir, seçici bir 5-HT1B reseptör antagonisti olan ikinci bilesenin (b) bir bilesimi ile ilgilidir ve sözü edilen bilesenler (a) ve (b)'nin serbest bazlari, solvatlari veya farmasötik olarak kabul edilebilir (ilaç sanayiinde kullanima uygun) tuzlari seklinde olup, bunlarin hazirlanmalari, sözü edilen bilesimi içeren farmasötik formülasyonlar, sözü edilen bilesimi içeren bir kitin yani sira, sözü edilen bilesim ile depresyon, anksiyete ve OCD gibi duygusal bozukluklarin tedavisinin yöntemi ve kullanimi ile ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9703375A SE9703375D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200000727T2 true TR200000727T2 (tr) | 2000-09-21 |
Family
ID=20408295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/00727T TR200000727T2 (tr) | 1997-09-18 | 1998-09-09 | 5HT geri alım inhibitörü ve h5-HT1B antagonistinin bir bileşimi. |
Country Status (30)
Country | Link |
---|---|
US (1) | US6159971A (tr) |
EP (1) | EP1014985B1 (tr) |
JP (1) | JP2001516718A (tr) |
KR (1) | KR20010024076A (tr) |
CN (1) | CN1195519C (tr) |
AR (1) | AR015448A1 (tr) |
AT (1) | ATE240733T1 (tr) |
AU (1) | AU752722B2 (tr) |
BR (1) | BR9812088A (tr) |
CA (1) | CA2302382A1 (tr) |
DE (1) | DE69814882T2 (tr) |
DK (1) | DK1014985T3 (tr) |
EE (1) | EE04141B1 (tr) |
ES (1) | ES2200370T3 (tr) |
HK (1) | HK1032739A1 (tr) |
HU (1) | HUP0200602A3 (tr) |
IL (1) | IL134776A0 (tr) |
IS (1) | IS5406A (tr) |
MY (1) | MY116280A (tr) |
NO (1) | NO20001399L (tr) |
NZ (1) | NZ503171A (tr) |
PL (1) | PL339371A1 (tr) |
PT (1) | PT1014985E (tr) |
RU (1) | RU2214824C2 (tr) |
SE (1) | SE9703375D0 (tr) |
SK (1) | SK2852000A3 (tr) |
TR (1) | TR200000727T2 (tr) |
TW (1) | TW589183B (tr) |
WO (1) | WO1999013877A1 (tr) |
ZA (1) | ZA987817B (tr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
AR021155A1 (es) * | 1999-07-08 | 2002-06-12 | Lundbeck & Co As H | Tratamiento de desordenes neuroticos |
UA77650C2 (en) | 1999-12-06 | 2007-01-15 | Lundbeck & Co As H | Use of serotonin reuptake inhibitor in combination with deramcyclane |
WO2002066454A1 (en) * | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Chromene derivatives |
CA2445843A1 (en) * | 2001-05-01 | 2002-11-07 | H. Lundbeck A/S | The use of enantiomeric pure escitalopram |
ATE424825T1 (de) * | 2001-07-20 | 2009-03-15 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
SE0203778D0 (sv) * | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | A new oral immediated release dosage form |
AR047553A1 (es) | 2003-07-04 | 2006-01-25 | Lundbeck & Co As H | La combinacion de un inhibidor de reabsorcion de serotonina y agomelatina |
KR100511288B1 (ko) * | 2003-11-14 | 2005-08-31 | 엘지전자 주식회사 | 4대의 압축기를 구비한 공기조화기의 실외기 |
WO2006091725A1 (en) * | 2005-02-23 | 2006-08-31 | The Silvan S. Tomkins Institute | Treatment of anhedonia |
US8227476B2 (en) | 2005-08-03 | 2012-07-24 | Sprout Pharmaceuticals, Inc. | Use of flibanserin in the treatment of obesity |
FR2890862B1 (fr) * | 2005-09-19 | 2008-01-25 | Sanofi Aventis Sa | Association d'agoniste aux recepteurs beta 3 et d'inhibiteur de la recapture de monoamnies, compostion pharmaceutique la contenant et son utilisation en therapeutique. |
CA2626134C (en) | 2005-10-29 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
US8748419B2 (en) | 2006-06-16 | 2014-06-10 | Theracos, Inc. | Treating obesity with muscarinic receptor M1 antagonists |
RU2477634C2 (ru) * | 2006-06-16 | 2013-03-20 | Теракос, Инк. | Лечение психологических состояний с применением антагонистов m1-мускариновых рецепторов |
US7893053B2 (en) | 2006-06-16 | 2011-02-22 | Theracos, Inc. | Treating psychological conditions using muscarinic receptor M1 antagonists |
WO2008000760A1 (en) | 2006-06-30 | 2008-01-03 | Boehringer Ingelheim International Gmbh | Flibanserin for the treatment of urinary incontinence and related diseases |
CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
EP2054041A2 (en) | 2006-08-14 | 2009-05-06 | Boehringer Ingelheim International GmbH | Formulations of flibanserin and method for manufacturing the same |
AR062321A1 (es) | 2006-08-25 | 2008-10-29 | Boehringer Ingelheim Int | Sistema de liberacion controlada y metodo para fabricarlo |
CL2008002693A1 (es) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2162792T3 (es) * | 1991-09-18 | 2002-01-16 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d. |
GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
-
1997
- 1997-09-18 SE SE9703375A patent/SE9703375D0/xx unknown
-
1998
- 1998-08-27 ZA ZA987817A patent/ZA987817B/xx unknown
- 1998-08-29 TW TW087114344A patent/TW589183B/zh not_active IP Right Cessation
- 1998-09-09 PL PL98339371A patent/PL339371A1/xx unknown
- 1998-09-09 NZ NZ503171A patent/NZ503171A/en unknown
- 1998-09-09 DK DK98944375T patent/DK1014985T3/da active
- 1998-09-09 JP JP2000511499A patent/JP2001516718A/ja active Pending
- 1998-09-09 EE EEP200000141A patent/EE04141B1/xx not_active IP Right Cessation
- 1998-09-09 SK SK285-2000A patent/SK2852000A3/sk unknown
- 1998-09-09 WO PCT/SE1998/001601 patent/WO1999013877A1/en not_active Application Discontinuation
- 1998-09-09 US US09/171,580 patent/US6159971A/en not_active Expired - Fee Related
- 1998-09-09 CN CNB98811206XA patent/CN1195519C/zh not_active Expired - Fee Related
- 1998-09-09 IL IL13477698A patent/IL134776A0/xx unknown
- 1998-09-09 DE DE69814882T patent/DE69814882T2/de not_active Expired - Fee Related
- 1998-09-09 BR BR9812088-3A patent/BR9812088A/pt not_active IP Right Cessation
- 1998-09-09 EP EP98944375A patent/EP1014985B1/en not_active Expired - Lifetime
- 1998-09-09 RU RU2000109563/14A patent/RU2214824C2/ru not_active IP Right Cessation
- 1998-09-09 TR TR2000/00727T patent/TR200000727T2/tr unknown
- 1998-09-09 HU HU0200602A patent/HUP0200602A3/hu unknown
- 1998-09-09 AU AU91930/98A patent/AU752722B2/en not_active Ceased
- 1998-09-09 KR KR1020007002822A patent/KR20010024076A/ko not_active Application Discontinuation
- 1998-09-09 ES ES98944375T patent/ES2200370T3/es not_active Expired - Lifetime
- 1998-09-09 AT AT98944375T patent/ATE240733T1/de not_active IP Right Cessation
- 1998-09-09 CA CA002302382A patent/CA2302382A1/en not_active Abandoned
- 1998-09-09 PT PT98944375T patent/PT1014985E/pt unknown
- 1998-09-16 MY MYPI98004225A patent/MY116280A/en unknown
- 1998-09-17 AR ARP980104634A patent/AR015448A1/es unknown
-
2000
- 2000-03-15 IS IS5406A patent/IS5406A/is unknown
- 2000-03-17 NO NO20001399A patent/NO20001399L/no not_active Application Discontinuation
- 2000-11-21 HK HK00107438A patent/HK1032739A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200000727T2 (tr) | 5HT geri alım inhibitörü ve h5-HT1B antagonistinin bir bileşimi. | |
ATE286500T1 (de) | 1,2,3,4-tetrahydroisochinolin-derivate | |
CY1104993T1 (el) | 4-(πιπεριδυλ- και πυρρολιδινυλ-αλκυλ-ουρεϊδο)-κινολινες ως ανταγωνιστες του υποδοχεα ουροτασινης ii | |
TR200000725T2 (tr) | Bir monoamin oksidaz inhibitörü ve h5-HT1B antagonistinin bileşimi | |
BRPI0408681A (pt) | compostos, composições farmacêuticas, uso de um derivado da 1,2,3,4-tetraidroisoquinolina, método para tratar ou prevenir doenças, processo para a manufatura de composições farmacêuticas, e, uso de um ou mais compostos | |
UA26401C2 (uk) | Заміщеhі 3-аміhохіhуклідиhи | |
DK1337518T3 (da) | Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren | |
NO20034011D0 (no) | Steroider som agonister for FXR | |
IS6658A (is) | Ný efnasambönd | |
NO20034523D0 (no) | Pyrazolderivater for behandling av HIV | |
DE60320012D1 (de) | Aminoheterocyclen als vr-1 antagonisten zur behandlung von schmerzen | |
TR199801594A2 (tr) | CCR-3 reseptör antagonistleri. | |
EA200201179A1 (ru) | Производные 2-аминокарбонил-9h-пурина | |
NO20034230D0 (no) | 1,2,3,4-tetrahydroisokinolin-derivater som urotensin II reseptor-antagonister | |
TR199800883T2 (tr) | Kuinolin-4-Karboksamid türevleri, hazirlanmalari ve nörokinin 3 (NK-3)- ve nörokinin 2 (NK-2) reseptör antagonistleri olarak kullanimlari. | |
PT1263725E (pt) | Novos compostos | |
TR200402293T2 (tr) | Farmasötik kombinasyonlar ve bunların gastrointestinal rahatsızlıkları tedavi etmede kullanımı | |
ATE360004T1 (de) | Imidazopyridine, -pyrimidine und -triazine als gaba-a alpha 5 rezeptor subtyp liganden zur verbesserung kognitiver eigenschaften | |
ITRM20010356A1 (it) | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. | |
PL374019A1 (en) | Benzoxazine derivatives as 5-ht6 modulators and uses thereof | |
DE60230127D1 (de) | Inhibitoren von integrin alpha-v-beta-6 | |
TR199701254T1 (tr) | 5-HT alis inhibitörünün selektif 5-HT1A antagonistiyle kombinasyonu. | |
ATE417838T1 (de) | Arylsulfonyl-derivate mit 5-ht 6-rezeptor- affinität | |
SE0102055D0 (sv) | New Compounds | |
DE60208694D1 (de) | Piperidinylmorpholinylderivate als modulatoren der aktivität des chemokinrezeptors |