DE60320012D1 - Aminoheterocyclen als vr-1 antagonisten zur behandlung von schmerzen - Google Patents

Aminoheterocyclen als vr-1 antagonisten zur behandlung von schmerzen

Info

Publication number
DE60320012D1
DE60320012D1 DE60320012T DE60320012T DE60320012D1 DE 60320012 D1 DE60320012 D1 DE 60320012D1 DE 60320012 T DE60320012 T DE 60320012T DE 60320012 T DE60320012 T DE 60320012T DE 60320012 D1 DE60320012 D1 DE 60320012D1
Authority
DE
Germany
Prior art keywords
sub
sup
alkyl
alkoxy
haloc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60320012T
Other languages
English (en)
Other versions
DE60320012T2 (de
Inventor
Peter Blurton
Frank Burkamp
Stephen Robert Fletcher
Gregory John Hollingworth
A Brian Jones
Edward Giles Mciver
Christopher Richard Moyes
Lauren Rogers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of DE60320012D1 publication Critical patent/DE60320012D1/de
Application granted granted Critical
Publication of DE60320012T2 publication Critical patent/DE60320012T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
DE60320012T 2002-11-15 2003-11-14 Aminoheterocyclen als vr-1 antagonisten zur behandlung von schmerzen Expired - Lifetime DE60320012T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0226724 2002-11-15
GBGB0226724.3A GB0226724D0 (en) 2002-11-15 2002-11-15 Therapeutic agents
PCT/GB2003/004969 WO2004046133A1 (en) 2002-11-15 2003-11-14 Amino-heterocycles as vr-1 antagonists for treating pain

Publications (2)

Publication Number Publication Date
DE60320012D1 true DE60320012D1 (de) 2008-05-08
DE60320012T2 DE60320012T2 (de) 2009-06-18

Family

ID=9947930

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60320012T Expired - Lifetime DE60320012T2 (de) 2002-11-15 2003-11-14 Aminoheterocyclen als vr-1 antagonisten zur behandlung von schmerzen

Country Status (9)

Country Link
US (1) US7442701B2 (de)
EP (1) EP1562934B1 (de)
JP (1) JP2006512323A (de)
AT (1) ATE390421T1 (de)
AU (1) AU2003283581B2 (de)
CA (1) CA2506025A1 (de)
DE (1) DE60320012T2 (de)
GB (1) GB0226724D0 (de)
WO (1) WO2004046133A1 (de)

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CA2468544A1 (en) 2001-12-10 2003-06-19 Amgen Inc. Vanilloid receptor ligands
WO2003077656A1 (en) * 2002-03-15 2003-09-25 Ciba Specialty Chemicals Holding Inc. 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces
WO2003099284A1 (en) 2002-05-22 2003-12-04 Amgen Inc. Amino-pyridine, -pyridine and pyridazine derivatives for use as vanilloid receptor ligands for the treatment of pain
AU2003264047B2 (en) 2002-08-08 2008-06-26 Amgen Inc. Vanilloid receptor ligands and their use in treatments
WO2005033105A2 (en) * 2003-09-30 2005-04-14 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JP2007522233A (ja) 2004-02-11 2007-08-09 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び治療におけるそれらの使用
MY139645A (en) 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
JP4602686B2 (ja) * 2004-04-15 2010-12-22 広栄化学工業株式会社 ２，６−ジハロゲノ−４−アリールピリジン類の製造法
AU2005284904A1 (en) 2004-09-13 2006-03-23 Amgen Inc. Vanilloid receptor ligands and their use in treatments
AU2005299489A1 (en) 2004-10-22 2006-05-04 Amgen Inc. Substituted nitrogen-containing heterocycles as vanilloid receptor ligands and their uses as medicament
MX2007006230A (es) 2004-11-30 2007-07-25 Amgen Inc Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer.
US7429608B2 (en) * 2005-01-20 2008-09-30 Amgen Inc. Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments
US7301022B2 (en) 2005-02-15 2007-11-27 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
WO2007044796A2 (en) * 2005-10-11 2007-04-19 Nps Pharmaceuticals, Inc. Pyridazinone compounds as calcilytics
AU2006311826C1 (en) * 2005-11-03 2011-06-16 Redpoint Bio Corporation Hydrazone derivatives and uses thereof
WO2007126957A2 (en) 2006-03-31 2007-11-08 Novartis Ag New compounds
EP2094682A2 (de) * 2006-12-22 2009-09-02 Novartis AG Heteroaryl-heteroaryl-verbindungen als cdk-hemmer zur behandlung von krebs, entzündungen und viralen infektionen
CA2677230A1 (en) * 2007-02-02 2008-08-14 Redpoint Bio Corporation Use of a trpm5 inhibitor to regulate insulin and glp-1 release
US7803810B2 (en) 2007-03-09 2010-09-28 Probiodrug Ag Inhibitors
CA2704125A1 (en) * 2007-12-19 2009-07-09 Genentech, Inc. 8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents
SG176464A1 (en) * 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
WO2010026122A1 (en) * 2008-09-02 2010-03-11 Novartis Ag Heterocyclic pim-kinase inhibitors
CA2737775A1 (en) 2008-10-17 2010-04-22 Abbott Laboratories Trpv1 antagonists
US8604053B2 (en) 2008-10-17 2013-12-10 Abbvie Inc. TRPV1 antagonists
GB0821307D0 (en) * 2008-11-21 2008-12-31 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
EP2462123B1 (de) * 2009-08-04 2013-10-02 Merck Sharp & Dohme Corp. 4,5,6-trisubstituierte pyrimidin- derivate als factor ixa inhibitoren
JP2013502444A (ja) 2009-08-24 2013-01-24 アスセピオン ファーマスーティカル、インコーポレイテッド キナーゼ阻害剤としての５，６−ビシクロヘテロアリール含有尿素化合物
AR077999A1 (es) 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
JP5934778B2 (ja) 2011-03-25 2016-06-15 アッヴィ・インコーポレイテッド Ｔｒｐｖ１拮抗薬
US8969325B2 (en) 2011-12-19 2015-03-03 Abbvie Inc. TRPV1 antagonists
US8796328B2 (en) 2012-06-20 2014-08-05 Abbvie Inc. TRPV1 antagonists
KR20170137165A (ko) * 2015-04-10 2017-12-12 베이진 엘티디 인돌아민 및/또는 트립토판 2,3-디옥시게나아제로서 신규한 5 또는 8-치환된 이미다조[1,5-a]피리딘
DK3484528T3 (da) 2016-07-18 2021-02-15 Janssen Pharmaceutica Nv Tau-pet-billeddannelsesligander
CN109952300B (zh) 2016-09-24 2022-01-18 百济神州有限公司 5或8-取代的咪唑并[1,5-a]吡啶
CN111386114A (zh) 2017-11-25 2020-07-07 百济神州有限公司 作为吲哚胺2,3-双加氧酶的选择性抑制剂的新颖苯并咪唑
CN112638899B (zh) * 2018-08-01 2023-09-05 上海轶诺药业有限公司 一类具有免疫调节功能的芳香化合物的制备和应用
CN109809977A (zh) * 2019-01-17 2019-05-28 江苏理工学院 一种2-溴-4-氟苯甲醛的制备方法
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

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Publication number Priority date Publication date Assignee Title
NZ337424A (en) * 1997-03-18 2001-08-31 Smithkline Beecham P Substituted isoquinoline derivatives and their use as anticonvulsants and in the treatment and/or prophylaxis of other neurological disorders
WO2002008221A2 (en) * 2000-07-20 2002-01-31 Neurogen Corporation Capsaicin receptor ligands
AR038420A1 (es) * 2002-02-15 2005-01-12 Glaxo Group Ltd Compuesto de amida, procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende
GB0206876D0 (en) * 2002-03-22 2002-05-01 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
AU2003283581A1 (en) 2004-06-15
ATE390421T1 (de) 2008-04-15
JP2006512323A (ja) 2006-04-13
GB0226724D0 (en) 2002-12-24
AU2003283581B2 (en) 2009-05-28
DE60320012T2 (de) 2009-06-18
EP1562934A1 (de) 2005-08-17
CA2506025A1 (en) 2004-06-03
US20060040947A1 (en) 2006-02-23
EP1562934B1 (de) 2008-03-26
US7442701B2 (en) 2008-10-28
WO2004046133A1 (en) 2004-06-03

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