CY1104993T1 - 4-(πιπεριδυλ- και πυρρολιδινυλ-αλκυλ-ουρεϊδο)-κινολινες ως ανταγωνιστες του υποδοχεα ουροτασινης ii - Google Patents

4-(πιπεριδυλ- και πυρρολιδινυλ-αλκυλ-ουρεϊδο)-κινολινες ως ανταγωνιστες του υποδοχεα ουροτασινης ii

Info

Publication number
CY1104993T1
CY1104993T1 CY20061100320T CY061100320T CY1104993T1 CY 1104993 T1 CY1104993 T1 CY 1104993T1 CY 20061100320 T CY20061100320 T CY 20061100320T CY 061100320 T CY061100320 T CY 061100320T CY 1104993 T1 CY1104993 T1 CY 1104993T1
Authority
CY
Cyprus
Prior art keywords
urotasine
quinolines
ureido
piperidyl
pyrrolidinyl
Prior art date
Application number
CY20061100320T
Other languages
English (en)
Inventor
Hamed DR. AISSAOUI
Christoph Binkert
Martine Clozel
Boris Mathys
Claus Mueller
Oliver Nayler
Michael Dr. Scherz
Jörg Velker
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of CY1104993T1 publication Critical patent/CY1104993T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Η εφεύρεση αναφέρεται σε νέα παράγωγα 1-πυριδιν 4-υλουρίας και συγγενείς ενώσεις και στην χρήση αυτών ως δραστικά συστατικά στην παρασκευή φαρμακευτικών συνθέσεων. Η εφεύρεση αφορά επίσης σε σχετικές απόψεις που περιλαμβάνουν μεθόδους για την παρασκευή των ενώσεων φαρμακευτικές συνθέσεις που περιέχουν μία ή περισσότερες από αυτές τις ενώσεις και ειδικά στην χρήση αυτών ως νευρο-ορμονικές ανταγωνιστές.
CY20061100320T 2001-12-04 2006-03-07 4-(πιπεριδυλ- και πυρρολιδινυλ-αλκυλ-ουρεϊδο)-κινολινες ως ανταγωνιστες του υποδοχεα ουροτασινης ii CY1104993T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP0114195 2001-12-04
PCT/EP2002/013577 WO2003048154A1 (en) 2001-12-04 2002-12-02 4-(piperidyl- and pyrrolidyl-alkyl-ureido) -quinolines as urotensin ii receptor antagonists
EP02791749A EP1499607B1 (en) 2001-12-04 2002-12-02 4-(piperidyl- and pyrrolidyl-alkyl-ureido)-quinolines as urotensin ii receptor antagonists

Publications (1)

Publication Number Publication Date
CY1104993T1 true CY1104993T1 (el) 2010-03-03

Family

ID=8164711

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100320T CY1104993T1 (el) 2001-12-04 2006-03-07 4-(πιπεριδυλ- και πυρρολιδινυλ-αλκυλ-ουρεϊδο)-κινολινες ως ανταγωνιστες του υποδοχεα ουροτασινης ii

Country Status (18)

Country Link
US (1) US7375227B2 (el)
EP (1) EP1499607B1 (el)
CN (1) CN100424082C (el)
AT (1) ATE312090T1 (el)
AU (1) AU2002358071B2 (el)
CA (1) CA2473892C (el)
CY (1) CY1104993T1 (el)
DE (1) DE60207894T2 (el)
DK (1) DK1499607T3 (el)
ES (1) ES2254772T3 (el)
HU (1) HUP0402184A2 (el)
IL (1) IL162851A0 (el)
MX (1) MXPA04006599A (el)
NO (1) NO20042844L (el)
NZ (1) NZ534046A (el)
SI (1) SI1499607T1 (el)
WO (1) WO2003048154A1 (el)
ZA (1) ZA200405348B (el)

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US20060094716A1 (en) * 2002-09-17 2006-05-04 Actelion Pharmaceuticals Ltd 1-Pyridin-4-yl-urea derivatives
WO2004099179A1 (en) * 2003-05-07 2004-11-18 Actelion Pharmaceuticals Ltd Piperazine-alkyl-ureido derivatives
WO2004099180A1 (en) * 2003-05-08 2004-11-18 Actelion Pharmaceuticals Ltd Novel piperidine derivatives
WO2005030209A1 (en) * 2003-09-26 2005-04-07 Actelion Pharmaceuticals Ltd Pyridine derivatives and use thereof as urotensin ii antagonists
DE10358539A1 (de) * 2003-12-15 2005-07-07 Merck Patent Gmbh Carbonsäureamidderivate
US8138340B2 (en) 2004-08-25 2012-03-20 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives
AU2005293196B2 (en) * 2004-10-12 2012-03-22 Actelion Pharmaceuticals Ltd 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as crystalline sulfate salt
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
WO2006135694A2 (en) * 2005-06-10 2006-12-21 Acadia Pharmaceuticals Inc. Uii-modulating compounds and their use
BRPI0707960A2 (pt) * 2006-02-17 2011-05-10 Hoffmann La Roche derivados de benzoil-piperidina como moduladores de 5ht2/d3, medicamento e uso dos mesmos
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
US8937181B2 (en) 2006-04-13 2015-01-20 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
TW200815353A (en) 2006-04-13 2008-04-01 Euro Celtique Sa Benzenesulfonamide compounds and their use
AU2007316249B2 (en) 2006-10-31 2013-01-24 F. Hoffmann-La Roche Ag Ether derivatives dual modulators of the 5-HT2A and D3 receptors
US8399486B2 (en) * 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
EP2155748A1 (en) 2007-05-15 2010-02-24 Boehringer Ingelheim International GmbH Urotensin ii receptor antagonists
WO2008147945A1 (en) * 2007-05-24 2008-12-04 Wyeth Azacyclylbenzamide derivatives as histamine-3 antagonists
NZ581889A (en) * 2007-06-29 2011-05-27 Pfizer Benzimidazole derivatives
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US20090186567A1 (en) * 2008-01-17 2009-07-23 Xavier Orlhac Abrasive Tool With Mosaic Grinding Face
CN102757447B (zh) * 2011-07-05 2014-12-31 北京大学 一种尿素通道蛋白抑制剂及其制备方法与应用
KR101468207B1 (ko) 2013-02-14 2014-12-01 한국화학연구원 신규한 싸이에노[3,2-b]피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물
KR101508214B1 (ko) * 2013-03-07 2015-04-07 한국화학연구원 신규한 아졸-접합 피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물
FR3008619B1 (fr) * 2013-07-16 2018-04-20 Centre Hospitalier Universitaire De Rouen Antagonistes, agonistes partiels et agonistes inverses du recepteur de l'urotensine ii pour leur utilisation dans la prevention des deficits neurologiques consecutifs a une hemorragie sous-arachnoidienne
CN107531589A (zh) * 2015-01-23 2018-01-02 Gvk生物科技私人有限公司 TrkA激酶抑制剂
MX2018000418A (es) * 2015-07-29 2018-08-14 Esteve Labor Dr Derivados de amida que tienen actividad multimodal contra el dolor.
CN109306151B (zh) * 2018-08-31 2020-08-14 大连理工大学 一种不含醚氧键型聚合物阴离子交换膜及其制备方法
CN112830897B (zh) * 2019-11-22 2022-09-09 石家庄以岭药业股份有限公司 含脲基苯并咪唑类衍生物及其制备方法和应用
CN116139140A (zh) * 2021-11-19 2023-05-23 中国医学科学院药物研究所 一种化合物在治疗糖皮质激素不良反应中的用途
CN115677551A (zh) * 2021-12-28 2023-02-03 武汉市振邦生物科技有限公司 一种2-氧代吡咯烷-3-甲酸乙酯的制备工艺

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EP1379519A1 (en) 2001-03-29 2004-01-14 SmithKline Beecham Corporation Pyrrolidine sulfonamides
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JP2004525155A (ja) 2001-03-29 2004-08-19 スミスクライン・ビーチャム・コーポレイション ピロリジンスルホンアミド
EP1381365A4 (en) 2001-03-29 2005-03-23 Smithkline Beecham Corp SULFONAMIDES PYRROLIDINES

Also Published As

Publication number Publication date
CN100424082C (zh) 2008-10-08
MXPA04006599A (es) 2004-12-07
CA2473892A1 (en) 2003-06-12
IL162851A0 (en) 2005-11-20
NZ534046A (en) 2006-02-24
US7375227B2 (en) 2008-05-20
SI1499607T1 (sl) 2006-06-30
WO2003048154A1 (en) 2003-06-12
CA2473892C (en) 2010-09-21
DE60207894T2 (de) 2006-07-20
AU2002358071B2 (en) 2008-06-12
AU2002358071A1 (en) 2003-06-17
EP1499607B1 (en) 2005-12-07
HUP0402184A2 (hu) 2005-02-28
NO20042844L (no) 2004-08-23
EP1499607A1 (en) 2005-01-26
ATE312090T1 (de) 2005-12-15
ZA200405348B (en) 2005-12-28
CN1617869A (zh) 2005-05-18
DK1499607T3 (da) 2006-04-18
DE60207894D1 (en) 2006-01-12
ES2254772T3 (es) 2006-06-16
US20050043535A1 (en) 2005-02-24

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