ATE312090T1 - 4-(piperidyl- und pyrrolidyl-alkyl-ureido)- chinoline als urotensin ii rezeptor antagonisten - Google Patents
4-(piperidyl- und pyrrolidyl-alkyl-ureido)- chinoline als urotensin ii rezeptor antagonistenInfo
- Publication number
- ATE312090T1 ATE312090T1 AT02791749T AT02791749T ATE312090T1 AT E312090 T1 ATE312090 T1 AT E312090T1 AT 02791749 T AT02791749 T AT 02791749T AT 02791749 T AT02791749 T AT 02791749T AT E312090 T1 ATE312090 T1 AT E312090T1
- Authority
- AT
- Austria
- Prior art keywords
- urotensin
- quinolines
- pyrrolidyl
- ureido
- piperidyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0114195 | 2001-12-04 | ||
| PCT/EP2002/013577 WO2003048154A1 (en) | 2001-12-04 | 2002-12-02 | 4-(piperidyl- and pyrrolidyl-alkyl-ureido) -quinolines as urotensin ii receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE312090T1 true ATE312090T1 (de) | 2005-12-15 |
Family
ID=8164711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02791749T ATE312090T1 (de) | 2001-12-04 | 2002-12-02 | 4-(piperidyl- und pyrrolidyl-alkyl-ureido)- chinoline als urotensin ii rezeptor antagonisten |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7375227B2 (de) |
| EP (1) | EP1499607B1 (de) |
| CN (1) | CN100424082C (de) |
| AT (1) | ATE312090T1 (de) |
| AU (1) | AU2002358071B2 (de) |
| CA (1) | CA2473892C (de) |
| CY (1) | CY1104993T1 (de) |
| DE (1) | DE60207894T2 (de) |
| DK (1) | DK1499607T3 (de) |
| ES (1) | ES2254772T3 (de) |
| HU (1) | HUP0402184A2 (de) |
| IL (1) | IL162851A0 (de) |
| MX (1) | MXPA04006599A (de) |
| NO (1) | NO20042844L (de) |
| NZ (1) | NZ534046A (de) |
| SI (1) | SI1499607T1 (de) |
| WO (1) | WO2003048154A1 (de) |
| ZA (1) | ZA200405348B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05002839A (es) * | 2002-09-17 | 2005-05-27 | Actelion Pharmaceuticals Ltd | Derivados de 1-piridin-4-il-urea. |
| WO2004099179A1 (en) * | 2003-05-07 | 2004-11-18 | Actelion Pharmaceuticals Ltd | Piperazine-alkyl-ureido derivatives |
| CN1784394A (zh) * | 2003-05-08 | 2006-06-07 | 埃科特莱茵药品有限公司 | 新型哌啶衍生物 |
| EP1670470B1 (de) | 2003-09-26 | 2009-04-08 | Actelion Pharmaceuticals Ltd. | Pyridin-derivate und ihre verwendung als urotensin ii antagonisten |
| DE10358539A1 (de) * | 2003-12-15 | 2005-07-07 | Merck Patent Gmbh | Carbonsäureamidderivate |
| CA2577084A1 (en) | 2004-08-25 | 2006-03-02 | Olivier Bezencon | Bicyclononene derivatives as renin inhibitors |
| AR051213A1 (es) | 2004-10-12 | 2006-12-27 | Actelion Pharmaceuticals Ltd | 1-(2-(4-bencil-4-hidroxi-piperidin-1-il)-etil)-3-(2-metil-quinolin-4-il)-urea como una sal sulfato cristalina |
| TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| US20070043104A1 (en) * | 2005-06-10 | 2007-02-22 | Luthman Ingrid K | UII-modulating compounds and their use |
| JP4855485B2 (ja) | 2006-02-17 | 2012-01-18 | エフ．ホフマン−ラ ロシュ アーゲー | ５ｈｔ２／ｄ３モジュレーターとしてのベンゾイル−ピペリジン誘導体 |
| US8247442B2 (en) * | 2006-03-29 | 2012-08-21 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use |
| WO2007118854A1 (en) | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and the use thereof |
| TW200815353A (en) * | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
| WO2008052899A1 (en) | 2006-10-31 | 2008-05-08 | F. Hoffmann-La Roche Ag | Ether derivatives dual modulators of the 5-ht2a and d3 receptors |
| WO2008124118A1 (en) | 2007-04-09 | 2008-10-16 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use therof |
| CA2684147A1 (en) | 2007-05-15 | 2008-11-27 | Boehringer Ingelheim International Gmbh | Urotensin ii receptor antagonists |
| CN101778838A (zh) * | 2007-05-24 | 2010-07-14 | 惠氏有限责任公司 | 作为组胺-3拮抗剂的氮杂环基苯甲酰胺衍生物 |
| MY148636A (en) * | 2007-06-29 | 2013-05-15 | Pfizer | Benzimidazole derivatives |
| US8765736B2 (en) * | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| US20090186567A1 (en) * | 2008-01-17 | 2009-07-23 | Xavier Orlhac | Abrasive Tool With Mosaic Grinding Face |
| CN102757447B (zh) * | 2011-07-05 | 2014-12-31 | 北京大学 | 一种尿素通道蛋白抑制剂及其制备方法与应用 |
| KR101468207B1 (ko) | 2013-02-14 | 2014-12-01 | 한국화학연구원 | 신규한 싸이에노[3,2-b]피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR101508214B1 (ko) * | 2013-03-07 | 2015-04-07 | 한국화학연구원 | 신규한 아졸-접합 피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| FR3008619B1 (fr) * | 2013-07-16 | 2018-04-20 | Centre Hospitalier Universitaire De Rouen | Antagonistes, agonistes partiels et agonistes inverses du recepteur de l'urotensine ii pour leur utilisation dans la prevention des deficits neurologiques consecutifs a une hemorragie sous-arachnoidienne |
| EP3247692B1 (de) * | 2015-01-23 | 2022-09-07 | GVK Biosciences Private Limited | Inhibitoren der trka-kinase |
| CN107922384A (zh) * | 2015-07-29 | 2018-04-17 | 埃斯蒂文博士实验室股份有限公司 | 对疼痛具有多模式活性的酰胺衍生物 |
| CN109306151B (zh) * | 2018-08-31 | 2020-08-14 | 大连理工大学 | 一种不含醚氧键型聚合物阴离子交换膜及其制备方法 |
| CN112830897B (zh) * | 2019-11-22 | 2022-09-09 | 石家庄以岭药业股份有限公司 | 含脲基苯并咪唑类衍生物及其制备方法和应用 |
| CN116139140A (zh) * | 2021-11-19 | 2023-05-23 | 中国医学科学院药物研究所 | 一种化合物在治疗糖皮质激素不良反应中的用途 |
| CN115677551A (zh) * | 2021-12-28 | 2023-02-03 | 武汉市振邦生物科技有限公司 | 一种2-氧代吡咯烷-3-甲酸乙酯的制备工艺 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE903957A1 (en) | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| AUPP003197A0 (en) | 1997-09-03 | 1997-11-20 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
| AU6339200A (en) | 1999-07-28 | 2001-02-19 | Kirin Beer Kabushiki Kaisha | Urea derivatives as inhibitors of ccr-3 receptor |
| CA2394603A1 (en) | 1999-12-21 | 2001-06-28 | Dashyant Dhanak | Urotensin-ii receptor antagonists |
| WO2001045700A1 (en) | 1999-12-21 | 2001-06-28 | Smithkline Beecham Corporation | Urotensin-ii receptor antagonists |
| DE60005401T2 (de) * | 1999-12-21 | 2004-05-06 | Smithkline Beecham Corp. | Carboxamidderivate von pyrrolidine und piperidine als urotensin-ii rezeptorantagonisten |
| WO2001066143A1 (fr) | 2000-03-07 | 2001-09-13 | Takeda Chemical Industries, Ltd. | Agents vasoactifs |
| EP1310490A4 (de) | 2000-07-04 | 2004-03-17 | Takeda Chemical Industries Ltd | Gpr14-antagonisten |
| JP2004515530A (ja) | 2000-12-11 | 2004-05-27 | スミスクライン・ビーチャム・コーポレイション | ウロテンシン−ｉｉ受容体アンタゴニスト |
| WO2002058702A1 (en) | 2001-01-26 | 2002-08-01 | Smithkline Beecham Corporation | Urotensin-ii receptor antagonists |
| US20040142923A1 (en) | 2001-03-29 | 2004-07-22 | Dashyant Dhanak | Pyrrolidine sulfonamides |
| JP2004524355A (ja) | 2001-03-29 | 2004-08-12 | スミスクライン・ビーチャム・コーポレイション | ピロリジンスルホンアミド |
| EP1379519A1 (de) | 2001-03-29 | 2004-01-14 | SmithKline Beecham Corporation | Pyrrolidinsulfonamide |
| US20040152692A1 (en) | 2001-03-29 | 2004-08-05 | Dashyant Dhanak | Pyrrolidine sulfonamides |
-
2002
- 2002-12-02 IL IL16285102A patent/IL162851A0/xx unknown
- 2002-12-02 ES ES02791749T patent/ES2254772T3/es not_active Expired - Lifetime
- 2002-12-02 CN CNB028277767A patent/CN100424082C/zh not_active Expired - Fee Related
- 2002-12-02 DK DK02791749T patent/DK1499607T3/da active
- 2002-12-02 SI SI200230270T patent/SI1499607T1/sl unknown
- 2002-12-02 WO PCT/EP2002/013577 patent/WO2003048154A1/en active IP Right Grant
- 2002-12-02 MX MXPA04006599A patent/MXPA04006599A/es active IP Right Grant
- 2002-12-02 DE DE60207894T patent/DE60207894T2/de not_active Expired - Lifetime
- 2002-12-02 EP EP02791749A patent/EP1499607B1/de not_active Expired - Lifetime
- 2002-12-02 AT AT02791749T patent/ATE312090T1/de active
- 2002-12-02 HU HU0402184A patent/HUP0402184A2/hu unknown
- 2002-12-02 US US10/501,054 patent/US7375227B2/en not_active Expired - Fee Related
- 2002-12-02 AU AU2002358071A patent/AU2002358071B2/en not_active Ceased
- 2002-12-02 NZ NZ534046A patent/NZ534046A/en active Application Filing
- 2002-12-02 CA CA2473892A patent/CA2473892C/en not_active Expired - Fee Related
-
2004
- 2004-07-05 ZA ZA2004/05348A patent/ZA200405348B/en unknown
- 2004-07-05 NO NO20042844A patent/NO20042844L/no not_active Application Discontinuation
-
2006
- 2006-03-07 CY CY20061100320T patent/CY1104993T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0402184A2 (hu) | 2005-02-28 |
| AU2002358071A1 (en) | 2003-06-17 |
| CA2473892A1 (en) | 2003-06-12 |
| SI1499607T1 (sl) | 2006-06-30 |
| US7375227B2 (en) | 2008-05-20 |
| WO2003048154A1 (en) | 2003-06-12 |
| NO20042844L (no) | 2004-08-23 |
| DE60207894T2 (de) | 2006-07-20 |
| EP1499607B1 (de) | 2005-12-07 |
| IL162851A0 (en) | 2005-11-20 |
| CY1104993T1 (el) | 2010-03-03 |
| CN1617869A (zh) | 2005-05-18 |
| NZ534046A (en) | 2006-02-24 |
| CN100424082C (zh) | 2008-10-08 |
| DE60207894D1 (en) | 2006-01-12 |
| CA2473892C (en) | 2010-09-21 |
| AU2002358071B2 (en) | 2008-06-12 |
| US20050043535A1 (en) | 2005-02-24 |
| ZA200405348B (en) | 2005-12-28 |
| EP1499607A1 (de) | 2005-01-26 |
| ES2254772T3 (es) | 2006-06-16 |
| DK1499607T3 (da) | 2006-04-18 |
| MXPA04006599A (es) | 2004-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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