HUP0402184A2 - 4-(Piperidil- és pirrolidil-alkil-ureido)-kinolin-származékok mint urotenzin II receptor antagonisták és ezeket tartalmazó gyógyszerkészítmények - Google Patents
4-(Piperidil- és pirrolidil-alkil-ureido)-kinolin-származékok mint urotenzin II receptor antagonisták és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0402184A2 HUP0402184A2 HU0402184A HUP0402184A HUP0402184A2 HU P0402184 A2 HUP0402184 A2 HU P0402184A2 HU 0402184 A HU0402184 A HU 0402184A HU P0402184 A HUP0402184 A HU P0402184A HU P0402184 A2 HUP0402184 A2 HU P0402184A2
- Authority
- HU
- Hungary
- Prior art keywords
- aryl
- group
- alkyl
- lower alkyl
- nr2co
- Prior art date
Links
- 102000012327 Urotensin II receptors Human genes 0.000 title 1
- 108050002984 Urotensin II receptors Proteins 0.000 title 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- -1 2-(hydroxymethyl)-quinolin-4-yl- Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- XYLVEBCGEOVYAE-UHFFFAOYSA-N 1-methyl-2,3-dihydropyrrolo[2,3-b]pyridine Chemical compound C1=CN=C2N(C)CCC2=C1 XYLVEBCGEOVYAE-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000877 morphologic effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0114195 | 2001-12-04 | ||
| PCT/EP2002/013577 WO2003048154A1 (en) | 2001-12-04 | 2002-12-02 | 4-(piperidyl- and pyrrolidyl-alkyl-ureido) -quinolines as urotensin ii receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0402184A2 true HUP0402184A2 (hu) | 2005-02-28 |
Family
ID=8164711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0402184A HUP0402184A2 (hu) | 2001-12-04 | 2002-12-02 | 4-(Piperidil- és pirrolidil-alkil-ureido)-kinolin-származékok mint urotenzin II receptor antagonisták és ezeket tartalmazó gyógyszerkészítmények |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7375227B2 (de) |
| EP (1) | EP1499607B1 (de) |
| CN (1) | CN100424082C (de) |
| AT (1) | ATE312090T1 (de) |
| AU (1) | AU2002358071B2 (de) |
| CA (1) | CA2473892C (de) |
| CY (1) | CY1104993T1 (de) |
| DE (1) | DE60207894T2 (de) |
| DK (1) | DK1499607T3 (de) |
| ES (1) | ES2254772T3 (de) |
| HU (1) | HUP0402184A2 (de) |
| IL (1) | IL162851A0 (de) |
| MX (1) | MXPA04006599A (de) |
| NO (1) | NO20042844L (de) |
| NZ (1) | NZ534046A (de) |
| SI (1) | SI1499607T1 (de) |
| WO (1) | WO2003048154A1 (de) |
| ZA (1) | ZA200405348B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006505533A (ja) * | 2002-09-17 | 2006-02-16 | アクテリオン ファマシューティカルズ リミテッド | １−ピリジン−４−イル−尿素誘導体 |
| EP1631565A1 (de) * | 2003-05-07 | 2006-03-08 | Actelion Pharmaceuticals Ltd. | Piperazin-alkyl-harnstoff derivate |
| US20070010516A1 (en) * | 2003-05-08 | 2007-01-11 | Hamed Aissaoui | Novel piperidine derivatives |
| AU2004275488A1 (en) * | 2003-09-26 | 2005-04-07 | Actelion Pharmaceuticals Ltd | Pyridine derivatives and use thereof as urotensin II antagonists |
| DE10358539A1 (de) * | 2003-12-15 | 2005-07-07 | Merck Patent Gmbh | Carbonsäureamidderivate |
| DE602005020314D1 (de) | 2004-08-25 | 2010-05-12 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
| CN101039930B (zh) * | 2004-10-12 | 2010-08-11 | 埃科特莱茵药品有限公司 | 作为结晶硫酸盐的1-[2-(4-甲苯基-4-羟基-哌啶-1-基)-乙基]-3-(2-甲基-喹啉-4-基)-脲 |
| TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| WO2006135694A2 (en) * | 2005-06-10 | 2006-12-21 | Acadia Pharmaceuticals Inc. | Uii-modulating compounds and their use |
| WO2007093540A1 (en) * | 2006-02-17 | 2007-08-23 | F. Hoffmann-La Roche Ag | Benzoyl-piperidine derivatives as 5ht2/d3 modulators |
| WO2007110449A1 (en) * | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
| US8937181B2 (en) | 2006-04-13 | 2015-01-20 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| TW200815353A (en) * | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
| ES2401663T3 (es) | 2006-10-31 | 2013-04-23 | F. Hoffmann-La Roche Ag | Derivados éter moduladores duales de los receptores de 5-HT2a y D3 |
| WO2008124118A1 (en) * | 2007-04-09 | 2008-10-16 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use therof |
| JP2010527367A (ja) | 2007-05-15 | 2010-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウロテンシンｉｉ受容体アンタゴニスト |
| CA2688110A1 (en) * | 2007-05-24 | 2008-12-04 | Wyeth Llc | Azacyclylbenzamide derivatives as histamine-3 antagonists |
| PT2170860T (pt) * | 2007-06-29 | 2017-01-04 | Pfizer | Derivados de benzimidazol |
| US8765736B2 (en) | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| US20090186567A1 (en) * | 2008-01-17 | 2009-07-23 | Xavier Orlhac | Abrasive Tool With Mosaic Grinding Face |
| CN102757447B (zh) * | 2011-07-05 | 2014-12-31 | 北京大学 | 一种尿素通道蛋白抑制剂及其制备方法与应用 |
| KR101468207B1 (ko) | 2013-02-14 | 2014-12-01 | 한국화학연구원 | 신규한 싸이에노[3,2-b]피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR101508214B1 (ko) * | 2013-03-07 | 2015-04-07 | 한국화학연구원 | 신규한 아졸-접합 피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| FR3008619B1 (fr) * | 2013-07-16 | 2018-04-20 | Centre Hospitalier Universitaire De Rouen | Antagonistes, agonistes partiels et agonistes inverses du recepteur de l'urotensine ii pour leur utilisation dans la prevention des deficits neurologiques consecutifs a une hemorragie sous-arachnoidienne |
| WO2016116900A1 (en) * | 2015-01-23 | 2016-07-28 | Gvk Biosciences Private Limited | Inhibitors of trka kinase |
| EP3328847B1 (de) * | 2015-07-29 | 2019-09-11 | Esteve Pharmaceuticals, S.A. | N-(2-(3-(benzyl(methyl)amino)pyrrolidin-1-yl)ethyl)-n-phenyl)propionamid-derivate und verwandte verbindungen als duale sigma 1 und mü opioid-rezeptor-liganden zur behandlung von schmerz |
| CN109306151B (zh) * | 2018-08-31 | 2020-08-14 | 大连理工大学 | 一种不含醚氧键型聚合物阴离子交换膜及其制备方法 |
| CN112830897B (zh) * | 2019-11-22 | 2022-09-09 | 石家庄以岭药业股份有限公司 | 含脲基苯并咪唑类衍生物及其制备方法和应用 |
| CN116139140A (zh) * | 2021-11-19 | 2023-05-23 | 中国医学科学院药物研究所 | 一种化合物在治疗糖皮质激素不良反应中的用途 |
| CN115677551A (zh) * | 2021-12-28 | 2023-02-03 | 武汉市振邦生物科技有限公司 | 一种2-氧代吡咯烷-3-甲酸乙酯的制备工艺 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE903957A1 (en) | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| AUPP003197A0 (en) | 1997-09-03 | 1997-11-20 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
| DE60027011T2 (de) | 1999-07-28 | 2006-12-07 | Kirin Beer K.K. | Harnstoffderivate als CCR-3 Rezeptor-Inhibitoren |
| ES2207566T3 (es) * | 1999-12-21 | 2004-06-01 | Smithkline Beecham Corporation | Derivados carboxamida de pirrolidina y piperidina como antagonistas del receptor de urotensina-ii. |
| JP2003518059A (ja) | 1999-12-21 | 2003-06-03 | スミスクライン・ビーチャム・コーポレイション | ウロテンシン−ｉｉ受容体アンタゴニスト |
| CA2394603A1 (en) | 1999-12-21 | 2001-06-28 | Dashyant Dhanak | Urotensin-ii receptor antagonists |
| AU2001236100A1 (en) | 2000-03-07 | 2001-09-17 | Takeda Chemical Industries Ltd. | Vasoactive agents |
| WO2002002530A1 (fr) | 2000-07-04 | 2002-01-10 | Takeda Chemical Industries, Ltd. | Antagoniste de gpr14 |
| EP1351688A4 (de) | 2000-12-11 | 2006-01-04 | Smithkline Beecham Corp | Urotensin-ii rezeptorantagonisten |
| US6818655B2 (en) | 2001-01-26 | 2004-11-16 | Smithkline Beecham Corporation | Urotensin-II receptor antagonists |
| EP1379237A2 (de) | 2001-03-29 | 2004-01-14 | Smithkline Beecham Corporation | Pyrrolidin-sulfonamide |
| JP2004525156A (ja) | 2001-03-29 | 2004-08-19 | スミスクライン・ビーチャム・コーポレイション | ピロリジンスルホンアミド |
| US20040152692A1 (en) | 2001-03-29 | 2004-08-05 | Dashyant Dhanak | Pyrrolidine sulfonamides |
| WO2002078707A1 (en) | 2001-03-29 | 2002-10-10 | Smithkline Beecham Corporation | Pyrrolidine sulfonamides |
-
2002
- 2002-12-02 MX MXPA04006599A patent/MXPA04006599A/es active IP Right Grant
- 2002-12-02 NZ NZ534046A patent/NZ534046A/en active Application Filing
- 2002-12-02 AT AT02791749T patent/ATE312090T1/de active
- 2002-12-02 EP EP02791749A patent/EP1499607B1/de not_active Expired - Lifetime
- 2002-12-02 SI SI200230270T patent/SI1499607T1/sl unknown
- 2002-12-02 ES ES02791749T patent/ES2254772T3/es not_active Expired - Lifetime
- 2002-12-02 IL IL16285102A patent/IL162851A0/xx unknown
- 2002-12-02 DK DK02791749T patent/DK1499607T3/da active
- 2002-12-02 AU AU2002358071A patent/AU2002358071B2/en not_active Ceased
- 2002-12-02 HU HU0402184A patent/HUP0402184A2/hu unknown
- 2002-12-02 WO PCT/EP2002/013577 patent/WO2003048154A1/en active IP Right Grant
- 2002-12-02 CA CA2473892A patent/CA2473892C/en not_active Expired - Fee Related
- 2002-12-02 US US10/501,054 patent/US7375227B2/en not_active Expired - Fee Related
- 2002-12-02 DE DE60207894T patent/DE60207894T2/de not_active Expired - Lifetime
- 2002-12-02 CN CNB028277767A patent/CN100424082C/zh not_active Expired - Fee Related
-
2004
- 2004-07-05 ZA ZA2004/05348A patent/ZA200405348B/en unknown
- 2004-07-05 NO NO20042844A patent/NO20042844L/no not_active Application Discontinuation
-
2006
- 2006-03-07 CY CY20061100320T patent/CY1104993T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002358071A1 (en) | 2003-06-17 |
| SI1499607T1 (sl) | 2006-06-30 |
| ZA200405348B (en) | 2005-12-28 |
| MXPA04006599A (es) | 2004-12-07 |
| IL162851A0 (en) | 2005-11-20 |
| EP1499607B1 (de) | 2005-12-07 |
| EP1499607A1 (de) | 2005-01-26 |
| NO20042844L (no) | 2004-08-23 |
| DE60207894D1 (en) | 2006-01-12 |
| NZ534046A (en) | 2006-02-24 |
| WO2003048154A1 (en) | 2003-06-12 |
| ES2254772T3 (es) | 2006-06-16 |
| DE60207894T2 (de) | 2006-07-20 |
| ATE312090T1 (de) | 2005-12-15 |
| CA2473892A1 (en) | 2003-06-12 |
| CY1104993T1 (el) | 2010-03-03 |
| AU2002358071B2 (en) | 2008-06-12 |
| CN1617869A (zh) | 2005-05-18 |
| US20050043535A1 (en) | 2005-02-24 |
| CA2473892C (en) | 2010-09-21 |
| CN100424082C (zh) | 2008-10-08 |
| US7375227B2 (en) | 2008-05-20 |
| DK1499607T3 (da) | 2006-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |